hvj e with intrinsic anti tumor activities
Báo cáo y học: "Effectiveness and safety of adalimumab in patients with ankylosing spondylitis or psoriatic arthritis and history of anti-tumor necrosis factor therapy" pdf
... loss of initial response (loss of response), adverse effects (intolerance), and other Answers were not mutually exclusive Evaluations of effectiveness and safety were conducted at weeks 2, 6, 12, ... outcome measures However, response rates were generally lesser than those for patients who had not received prior anti- TNF therapy Unadjusted and adjusted logistic regressions indicated that the ... anti- TNF therapy Fewer patients were in the PsA study than in the AS study; therefore, the likelihood of detecting statistically important differences was less The studies were not powered to detect...
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Báo cáo khoa học: Impact of cyclic hypoxia on HIF-1a regulation in endothelial cells – new insights for anti-tumor treatments doc
... does not influence endothelial cells located at the beginning of the O2 gradient, heterogeneities in tumor blood flow directly influence the endothelium of tumor vessels Here, we provide mechanistic ... (i .e H3) in endothelial cells exposed or not to lM rotenone; these experiments were repeated three times with similar results **P < 0.01 versus control conditions (D) Representative HIF-1a immunoblots ... and determination of the difference in Ct (DDCt) between the various conditions tested Clonogenic assay Experimental procedures Cell culture Human umbilical vein endothelial cells were routinely...
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báo cáo hóa học:" Anti-tumor activity of patient-derived NK cells after cell-based immunotherapy – a case report" doc
... *The data of the patient represent mean values of at least independent experiments, the healthy individuals were determined with commercial ELISA kits markers were only determined in leukapheresis ... 145 percentage of CD3+ T cells remained unaffected by the stimulation with TKD/IL-2 however, between leukapheresis L3 and L6 the mean fluorescence intensity (mfi) of CD3 appeared to be elevated ... dehydrogenase, Quick, and aPTT were determined before each leukapheresis Blood counts, electrolytes and coagulation tests were measured before and after each cycle of cell re-infusion Differential...
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Báo cáo hóa học: " Boosting high-intensity focused ultrasoundinduced anti-tumor immunity using a sparse-scan strategy that can more effectively promote dendritic cell maturation" ppt
... periphery and the center of thermal lesion, respectively For convenience, these exposure conditions were referred to hereafter as “55°C-HIFU” and “80°C-HIFU”, respectively After HIFU treatment, ... or when mice became visibly unwell, or when the tumor became ulcerated ELISPOT Assay [20] Spleens were harvested from euthanized tumor- bearing mice 14 days after HIFU treatment Splenocytes from ... drying before counting individual spots with a Zeiss automated ELISPOT reader The results were expressed as the number of spot-forming cells per 106 input cells Overall, three independent experiments...
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Báo cáo hóa học: "Comparison of anti-CD3 and anti-CD28-coated beads with soluble anti-CD3 for expanding human T cells: Differing impact on CD8 T cell phenotype and responsiveness to restimulation" pot
... explain CD45RA and CD27 loss Neither CD45RA nor CD27 were reexpressed on bead-treated cells even after several weeks after bead removal suggesting more durable differences in CD8 T cell expression ... *The results represent the mean ± SE for matched pairs of cultures with the number of experiments marked in parentheses Paired t-test was used to assess significance The phenotype of CD4 T cells ... compared to bead treated cells expressing an effector phenotype On the other hand, although these cells express more CD27 and CCR7, they also often express less CD28 than comparable bead-treated cells,...
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Báo cáo hóa học: " Studies on Preparation of Photosensitizer Loaded Magnetic Silica Nanoparticles and Their Anti-Tumor Effects for Targeting Photodynamic Therap" ppt
... plates were set up as dark control and experimental group for the MTT assay and these plates were seeded, exposed identically to the plates prepared for the biosafety assessment The cells of experimental ... mL ethanol The absorbance at 409 nm was used to validate the PS presence and estimate the PS encapsulation efficiency Each measurement was repeated three times The standard curve was established ... cuvette with cm path length Fluorescence spectra were recorded on a HITACHIH FL-4500 spectrofluorimeter Encapsulation Efficiency Measurements The UV–Vis measurements of the PHPP-SMNPs were carried...
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Báo cáo y học: "Regeneration of the immunoglobulin heavy-chain repertoire after transient B-cell depletion with an anti-CD20 antibody" docx
... greater variety of genes used in the VH4 rearrangements after therapy Seven different gene segments were used before treatment, whereas nine different gene segments were found after treatment ... gene families could be detected in the sequences analysed Before treatment, the four-member D1 family was under-represented compared with its representation in the genome (3% versus 16% expected) ... cells regenerated well after B-cell depletion, and showed a diverse and polyclonal repertoire Nevertheless, changes in the Ig-VH genes were detected, with the most profound effects observed months...
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Báo cáo khoa học: "Middle bile duct cancer with portal vein tumor thrombus" pps
... Paul Nurse, Cancer Research UK Your research papers will be: available free of charge to the entire biomedical community peer reviewed and published immediately upon acceptance cited in PubMed and ... the main tumor, in the present case the connection between the BDC and PVTT was unclear and there was no clear direct invasion to the PV Therefore, combined resection of the PV including the ... and is currently doing well without any signs of recurrence 18 months after surgery Conclusion We have described the first reported case of BDC with PVTT, with special reference to the diagnostic...
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Báo cáo khoa học: "Cationized gelatin-HVJ envelope with sodium borocaptate improved the BNCT efficacy for liver tumors in vivo" pptx
... kidney and spleen were removed after whole-body perfusion with heparinized saline, and weighted The extracted tissues were digested with the M-Per mammalian protein extraction reagent (Pierce Chemical ... Transfection efficiency of HVJ- E complexes into tumor cells The various HVJ- E complexes were incubated with tumor cells to evaluate their transfection efficiency LM8G5 cells (2 × 104) were seeded ... mice were severely damaged by the radical spread of tumors (about 50% of the untreated mice were dead) Therefore, we sacrificed the tumor- bearing mice that were alive until that time to evaluate...
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Báo cáo khoa học: " Radical stereotactic radiosurgery with real-time tumor motion tracking in the treatment of small peripheral lung tumors" docx
... cancer patients and such patients required supplemental home oxygen prior to receiving treatment Sixty-seven percent of the tumors involved the upper lobes Fifteen were inoperable primary lung tumors ... weeks, developed in of 11 patients with lesions within mm of the pleura Grade III pneumonitis was observed in patients (8%) One of the patients received concurrent Gefitinib treatment She developed ... low despite the radical treatment intent On average, 55 paired x-ray images were taken each day to confirm the accuracy of the correlation model Twenty-five percent of the patients received concurrent...
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Báo cáo y học: "Serum levels of biomarkers of bone and cartilage destruction and new bone formation in different cohorts of patients with axial spondyloarthritis with and without tumor necrosis factor-alpha blocker treatment" ppt
... years, mean disease duration: 3.58 ± 2.91 years) were included in this analysis These patients either were part of other studies that have been reported elsewhere [22,23] or were treated open-label ... Correlation between differences in serum levels of VEGF, MMP-3, BALP, and C-reactive protein before and after 36 to 52 weeks of treatment with adalimumab Next, we correlated the differences of biomarker ... biomarker serum levels at baseline and after 36 to 52 weeks of treatment with adalimumab (Figure 3) Interestingly, the difference of serum levels of VEGF between weeks 36 to 52 and baseline (d_VEGF)...
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Báo cáo y học: "Blood autoantibody and cytokine profiles predict response to anti-tumor necrosis factor therapy in rheumatoid arthriti" pps
... but were not completely identical between array screening experiments While all of the antigens presented in Table were identified as top scorers in multiple array experiments, a few were ranked ... representative RA patients Yellow features are false-colored features utilized for array orientation, while green features represent autoantibody reactivities Selected autoantibody reactivities ... peptide antigens, several native and citrulline-substituted peptides were tested in ELISA experiments We observed moderate to strong correlations for these peptide antigens, with correlation coefficients...
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Báo cáo y học: "Predicting the future of anti-tumor necrosis factor therapy" potx
... Arthritis Research & Therapy Vol 11 No Verweij were associated with good clinical responses [4,5] Moreover, baseline differences between responders and nonresponders were found [6] Pharmacogenetic ... IL-6, revealed higher baseline serum concentrations in responders, although the latter lacked predictive value in itself These results partly corroborated findings reported by Fabre and colleagues ... population Page of (page number not for citation purposes) Moreover, the true value of independent and combinatorial biomarker sets can be tested in a prospective setting only Therefore, combined efforts...
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Báo cáo y học: " Allele-specific copy number analysis of tumor samples with aneuploidy and tumor heterogeneity" ppt
... sample These were 35 large regions, representative of all types of copy number aberrations in the sample, and covered the majority of the genome We then observed whether the four methods, for each ... For each sample, we performed segmentation of the genome with respect to allele-specific intensities We then visualized each segment relative to the full-sample background using TAPS Five samples ... were found to have an average copy number above 2½ In all seven we were able to validate the average ploidy with the SKY karyotypes The SKY karyotype of cell line H1395 reported two heterogeneous...
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Báo cáo y học: "Malignant pleural mesothelioma with long-term tumor disappearance of a local relapse after surgery: a case report" doc
... elucidate the mechanism of regression of the tumor Initially, the disappearance of the tumor was viewed as a result of the delayed effect of postoperative chemotherapy; however, by reviewing the clinical ... patient with MPM experienced a complete tumor regression of a local relapse after cytoreduction surgery It is possible that this unique favorable event was due to the effect of combined complementary ... pleurectomy, it also seemed that this medication had had little effect on the observed tumor regression Next, a so-called “spontaneous regression” of the tumor was considered, because the patient...
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Báo cáo y học: "B cells from rheumatoid arthritis patients show important alterations in the expression of CD86 and FcgRIIb, which are modulated by anti-tumor necrosis factor therapy" potx
... (c) Expression was quantified as mean fluorescence intensity (MFI) The differences in the FcgRIIb expression levels between B-cell subpopulations were analyzed with the two-tailed paired Student ... whether the levels of autoantibodies on RA patients were related to the expression of this inhibitory receptor on B cells For this purpose, we measured serum anti- MCV antibodies since they have been ... (EULAR) response criteria were used to establish the degree of response to treatment [21] Thirteen healthy women were recruited as a control group, with a mean ± SD age of 39.4 ± 9.7 years For the analyses...
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Báo cáo y học: "Maintenance of cytomegalovirus-specific CD4pos T-cell response in rheumatoid arthritis patients receiving anti-tumor necrosis factor treatments" potx
... when tested in two patients seropositive for CMV in three consecutive samples (onset of anti- TNF treatment, week 6, and week 12) As expected, the response for CMV Ags was undetectable in seronegative ... percentages, obtained by using infected cell lysates, were lower than those observed when using synthetic peptides [17] However, they were within the range of and in accordance with those reported ... against varicella-zoster Ags have not been performed Several cases of CMV infection have been reported during the course of anti- TNF treatments [3,40,41] However, because patients received concomitant...
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Báo cáo y học: "Anti-tetherin activities in Vpu-expressing primate lentiviruses" doc
... HeLa cells was caused by incompatibility between their Vpu proteins and human tetherin or, instead, reflected some other differences between human and macaque cells, we repeated these analyses ... chimpanzee, or (C) human tetherin expressed in 293A cells Mean fold-enhancement of HIV-1 VLP release in presence of Nef-EGFP is shown relative to baseline (control) levels for n = or independent experiments ... chimpanzee tetherin Anti- tetherin activities of indicated viral proteins were examined by measurement of HIV-1 VLP release, detected by Western blotting of cell lysate and VLP fractions with anti- p24...
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Báo cáo sinh học: "Anti-tumor effects of a human VEGFR-2-based DNA vaccine in mouse models" pps
... cross-reaction between the xenogeneic homologue and the selfmolecule Anti- cancer vaccines have been extensively studied in animal models and clinical trials Anti- cancer vaccine strategies have included immunization ... were determined as described previously[18] Frozen sections were used to determine vessel density with an anti- CD31 antibody Page of 10 (page number not for citation purposes) Genetic Vaccines ... visualized with chemiluminescence reagents Immunohistochemistry To explore whether the anti- tumor immunity involved the inhibition of angiogenesis, vessel density in the tumor tissue, and angiogenesis...
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Anti tumor properties of lactobacilli are mediated by immuno modulation and direct cytotoxicity
... used for cancer immunotherapy are raised against tumor antigens Once bound, the foreign cells are destroyed either by antibody dependent cell mediated cytotoxicity (ADCC) or complement dependent ... carcinoma cell lines either exhibited anti- proliferative [95] or cytotoxic effects [96-98] These effects seem to target cancer cells more than normal cells like Vero cells (African green monkey kidney ... characterize the molecules responsible for the cytotoxic effect To evaluate the effect of the cytotoxic molecules on gene expression, survival and proliferation in cancer cells To determine the specificity...
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