human studies in clinical pharmacology
ROUTLEDGE STUDIES IN SCIENCE, TECHNOLOGY AND SOCIETY: Human-animal relations and the rise of veterinary medicine pot
Ngày tải lên :
06/03/2014, 16:20
... and discipline in other domains In addition to changes in individual conduct and power relations within human societies, the transitions from foraging to farming and hunting to herding had significant ... hereafter invented, including photocopying and recording, or in any information storage or retrieval system, without permission in writing from the publishers British Library Cataloguing in Publication ... all In recent years, for example, health concernshave increasingly led to an apparent decline in the consumption of red meat and an increase in poultry and fish eating Furthermore, an increasing...
- 204
- 432
- 0
Báo cáo khoa học: "Lack of evidence for qualitative treatment by disease severity interactions in clinical studies of severe sepsis" docx
Ngày tải lên :
12/08/2014, 22:22
... proteins An increase in the incidence of serious cardiac adverse events was noted in a study of a nitric oxide synthase inhibitor None of the studies listed detected an increase in the incidence ... harmful in patients with evidence of less coagulopathy or inflammation 12 13 14 Clinical studies in severe sepsis should continue to enroll patients over a wide range of disease severity Competing interests ... manuscript The final search was conducted on 29 November 2004 Studies were included in this analysis if they met the following criteria: randomized, double blind, placebo controlled clinical trial;...
- 16
- 294
- 0
Báo cáo y học: "The basophil activation test by flow cytometry: recent developments in clinical studies, standardization and emerging perspectives" pot
Ngày tải lên :
13/08/2014, 13:22
... crucial in determining the magnitude of basophil responses during allergic processes since prostaglandin D2 is known to be involved in allergic diseases and asthma Using a similar approach, Heinemann ... need for inter-laboratory standardization in clinical decision-making Each allergen has to be assessed one by one to determine its optimal concentration (i.e., inducing maximal activation in vitro) ... They have to be further investigated in clinical studies either by their own or in combination with CD63 or CD203c CRTH2/DP2 as a new marker for basophil recognition Finally, the last drawback...
- 8
- 249
- 0
Food, Animal production and Human Comsumption in the Asian Region
Ngày tải lên :
08/04/2013, 10:35
... Science based solutions to emerging issues 49 Livestock in a changing world Genetics and breeding Feed resources and Utilization Human resource International trading 50 Thanks for your attention ... such as buying a tractor, children Marriage or other essentials B: Social: Religious ceremonies, Racing, bull fighting 21 22 Percentage of rural household owning livestock, share of income from ... Percentage of rural households owning livestock, by expenditure quintile (FAO, 2009) 24 Share of income from livestock activity in rural households, by expenditurequintile (FAO,2009) 25 Livestock...
- 51
- 453
- 0
The human element in airline service quality
Ngày tải lên :
11/09/2013, 11:44
... childrena IN2 Airline’s employees paying attention to what customers have to say IN3 Providing individual attention to customers IN4 This airline has employees who give passengers individual ... 0.032 IN1 Airline providing special services for the elderly, disabled, and families with small childrena IN2 Airline’s employees paying attention to what customers have to say IN3 Providing individual ... Each Construct - Principal Axis Factoring - Oblimin Rotation Exploratory Methods, n = 170 810 Examining Reliability - Cronbach’s alpha Examining Unidimensionality: External & Internal Perspective...
- 28
- 284
- 0
CLINICAL PHARMACOLOGY 2003 (PART 25B)
Ngày tải lên :
18/10/2013, 00:15
... 23.3 Venn diagram illustrating intersections of three overlapping clinical states defined in the text Methyldopa: follow-up studies show no intellectual impairment in children up to age 7.5 years ... Both alteplase and streptokinase bind plasminogen and convert it to plasmin, which lyses fibrin Alteplase has a much higher affinity for plasminogen bound to fibrin than in the circulation This ... after leaving hospital In particular, patients need to reduce saturated fat intake, and there is increasing evidence of the benefit of increased intake of fish and olive oil incidence of reinfarction...
- 18
- 260
- 0
CLINICAL PHARMACOLOGY 2003 (PART 28)
Ngày tải lên :
24/10/2013, 19:15
... stopping the drug Possible human metabolites are carcinogenic in rodents; it seems unlikely after many years of clinical experience that the drug is carcinogenic in humans In the UK, spironolactone ... of urine • is used as a test for renal tubular acidosis • increases elimination of amphetamine, methylene dioxymethamphetamine (MDMA or 'Ecstasy'), dexfenfluramine, quinine and phencyclidine, ... caused by hydralazine, procainamide, sulfasalazine Drugs may thus induce any of the common clinical syndromes of renal injury, namely: Acute renal failure, e.g aminoglycosides, cisplatin Nephrotic...
- 19
- 237
- 0
CLINICAL PHARMACOLOGY 2003 (PART 29)
Ngày tải lên :
24/10/2013, 19:15
... (approximately 1000-fold) and inhibition is essentially instantaneous Heparin binding to antithrombin induces a conformational change in antithrombin that locks the heparin in place and is followed ... pharmacokinetics Mode of action Heparin depends for its anticoagulant action on the presence in plasma of a single chain glycoprotein, antithrombin (formerly antithrombin III), a naturally-occurring inhibitor ... the intrinsic and common pathways including thrombin, factor Xa and factor IXa (Fig 28.1) Antithrombin is homologous to members of the a-antitrypsin family of serine protease inhibitors (serpins)...
- 22
- 224
- 0
CLINICAL PHARMACOLOGY 2003 (PART 30)
Ngày tải lên :
29/10/2013, 02:15
... probably involving a protein DMT1 though the precise details have not been established Two other proteins, hephaestin and ferroportin 1, appear to be involved in intracellular transport and release into ... given by deep i.m injection, which can be painful It stains the skin (for up to years) but this can be minimised by inserting the needle through the skin and then moving the skin and subcutaneous ... ANAEMIAS ing the stomach, desferrioxamine 10 g in 50-100 ml water should be left in the stomach to chelate any remaining iron in the intestinal lumen; it is not absorbed Subsequently, desferrioxamine...
- 15
- 275
- 0
CLINICAL PHARMACOLOGY 2003 (PART 31)
Ngày tải lên :
29/10/2013, 02:15
... doxorubicin (Adriamycin) + vincristine EP: etoposide + cisplatin MIC: mitomycin + ifosfamide + cisplatin MVP: mitomycin + vinblastine + cisplatin Cisplatin + gemcitabine;vinorelbine MOPP: mustine ... (chlormethine) + vincristine + procarbazine + prednisolone; ABVD: doxorubicin (Adriamycin) + bleomycin + vinblastine + dacarbazine CHOP: cyclophosphamide + doxorubicin* + vincristine (Oncovin) + ... irinotecan may be complicated by an acute cholinergic reaction, reversible by administering atropine s.c SPINDLE POISONS The plant alkaloids (vincristine, vinblastine, vindesine and vinorelbine)...
- 19
- 296
- 0
Human evolution in the Pleistocene
Ngày tải lên :
01/11/2013, 07:20
... Modern Humans in Italy (Manzi et al., 2001) in this latter category, i.e a divergent lineage that became extinct The question of interbreeding between mainstream H sapiens and divergent lineages ... shall see in this book, are in effect extremes of a continuum Much of the debate that has raged in the last two decades in this respect has been due to differences in the understanding of the ... approach, bearing in mind the limitations of the available data, we observe a changing pattern of global distribution of Homo in the Pleistocene There are two apparently contrasting models that,...
- 8
- 220
- 0
The use of hypothesis-testing statistics in clinical trials
Ngày tải lên :
01/11/2013, 11:20
... often intuitively more understandable by clinicians Thus, it is typical for a clinical treatment study in psychiatry to be designed mainly 46 Chapter 8: Clinical trials to describe a change in depressive ... analyses in such a large sample The primary outcome of the study was a comparison of aspirin versus streptokinase for prevention of myocardial infarction, with a finding in favor of aspirin In subgroup ... has its limits, and where clinicians should use statistical data with judgment (not simply rejecting nor unthinkingly accepting them) Clinical example: maintenance studies of bipolar disorder...
- 16
- 504
- 0
CLINICAL PHARMACOLOGY 2003 (PART 32)
Ngày tải lên :
08/11/2013, 01:15
... used in the hope of improving the blood circulation to the inner ear in Meniere's syndrome; also cinnarizine GUIDETO FURTHER READING Agreus L, Talley N 1997 Challenges in managing dyspepsia in ... low therapeutic index that is inactivated by these isoenzymes, e.g warfarin, phenytoin, lidocaine, propranolol, 5-fluorouracil and theophylline Ranitidine, famotidine, nizatidine The modes of ... vitamin B12 and increased susceptibility to gastrointestinal infections as a result of prolonged hypochlorhydria There is as yet no real evidence for these being a clinical problem Proton pump inhibitors...
- 15
- 247
- 0
CLINICAL PHARMACOLOGY 2003 (PART 33)
Ngày tải lên :
08/11/2013, 01:15
... Sulfasalazine (salicylazosulfapyridine, Salazopyrin) consists of two compounds, sulphapyridine and 5-aminosalicylic acid, joined by an azo-bond Sulfasalazine is poorly absorbed from the small intestine ... manifested by a variety of gastrointestinal symptoms including disordered bowel habit (constipation, diarrhoea or both), abdominal pain and bloating Upper gastrointestinal symptoms manifest as nonulcer ... gastrointestinal bleeding Selective COX-2 inhibitors may possess advantage in this situation ANAL FISSURE Anal fissures are often intensely painful due to sphincter spasm Anaesthetic ointments...
- 12
- 251
- 0
CLINICAL PHARMACOLOGY 2003 (PART 34)
Ngày tải lên :
08/11/2013, 01:15
... interval between doses of such drugs may need to be lengthened, and the time to reach steady-state concentration in the plasma (5 x t1/,) is increased 652 PLASMA PROTEIN-BINDING OF DRUG Binding ... drugs eliminated predominantly by the kidney Where facilities exist, dosing should be guided by plasma concentration monitoring, e.g of theophylline, lidocaine and phenytoin These changes in drug ... MANAGEMENT OF DRUG-INDUCED LIVER INJURY • Always bear in mind the possibility Take a careful drug history, including over-the-counter and alternative complementary medicine remedies • In patients with...
- 10
- 305
- 0
Tài liệu CLINICAL PHARMACOLOGY 2003 (PART 1) docx
Ngày tải lên :
15/12/2013, 12:15
... problem of combining practical clinical utility with some account of the principles on which clinical practice rests How much practical technical detail to include is difficult to decide In general, ... enjoyed, reading Clinical Pharmacology The world of clinical pharmacology has greatly changed since 1957 when I took up my pen, and I wish my successors well D R Laurence, Professor Emeritus of Pharmacology ... continuously or intermittently to maintain health without attaining cure (as in hypertension, diabetes mellitus, epilepsy, asthma) or to control symptoms (such as pain and cough) whilst awaiting...
- 30
- 394
- 0
Tài liệu CLINICAL PHARMACOLOGY 2003 (PART 35) doc
Ngày tải lên :
15/12/2013, 12:15
... saltlosing syndrome of renal origin, e.g following an episode of interstitial nephritis Aldosterone (tl/2 20 min), the principal natural saltretaining hormone, has been used i.m in acute adrenal insufficiency ... sodium-retaining activity • For local administration (skin, lung), more potent, fluorinated steroids may be required Uses Corticotropin is used principally in diagnosis and rarely in treatment It is inactive ... measles should be avoided Gastrointestinal Patients taking continuous steroid, especially in combination with a nonsteroidal antiinflammatory drug (NSAID), have an excess incidence of peptic ulcer...
- 17
- 337
- 0
Tài liệu CLINICAL PHARMACOLOGY 2003 (PART 36) doc
Ngày tải lên :
15/12/2013, 12:15
... Modified Porcine), prb (Proinsulin Recombinant in Bacteria) and pyr (Precursor insulin Yeast Recombinant) Although one of the incentives for introducing human insulin was avoidance of insulin antibody ... crystalline Longer duration of action: Insulin Zinc Suspension, crystalline, or Protamine Zinc Insulin (insulin in suspension with both zinc and protamine) A mixture of soluble and isophane insulins, ... of animal insulin are likely to require 10% less human insulin, and if taking > 100 units animal insulin, 25% less human insulin There has been concern that patients taking human insulin may experience...
- 20
- 318
- 0
Tài liệu CLINICAL PHARMACOLOGY 2003 (PART 38) pptx
Ngày tải lên :
15/12/2013, 12:15
... 342 Alfuzosin, 473 Alginic acid, 627 Alimentary tract, see Gastrointestinal tract Alimenzamine, 555 Alkalinisation, urinary, 540 in poisoning, 156 Alkalinity, see pH Alkaloids cholinergic, 434, ... stimulation, 552 Aminoquinolones 4-aminoquinolones, 269 8-aminoquinolones, 269 interactions, 285 5-Aminosalicylic acid, 645-6 alone, see Mesalazine in Crohn's disease, 647 dimer of, see Olsalazine prodrug, ... analgesics anticoagulants interacting with, 572 choice and ranking (mild / moderate / severe / overwhelming pain), 324-5 clinical evaluation, 323-4 combining, 324 definition, 319 mechanisms of...
- 21
- 345
- 0