human and animal models
Bacteria are often maligned as the causes of human and animal disease (like this one, Leptospira, which causes serious disease in livestock)
... gorilla and chimpanzee populations - The outbreaks coincided with the outbreaks in wild animals - The same distinct viral strains were isolated in animal carcasses and in the bodies of those who handled ... in liver and spleen Fruit bats not show any symptoms Best candidate to be the reservoir More research needs to be done Geography The link between human infection by the Ebola virus and their ... Biogeograophical Ethics is defined as motivation based on ideas of right and wrong when dealing with the geographical distribution of animals and plants This concept of can be used to explain the world’s...
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Báo cáo sinh học: "Inequality of maximum a posteriori estimators with equivalent sire and animal models for threshold traits" pps
... !i)/!! and or the 0’ error standard deviation (sire model) environmental standard deviation (animal model) For the heritability value of 0.20 the estimators from the sire model and the animal ... scale of the progenies and 2, and v and v represent the additive genetic effects of their sires and = Under these conditions v is a priori normally distributed with mean and variance-covariance ... use of equivalent sire and animal models for the underlying variable and the use of the same estimation method lead to different estimators may be counterintuitive Under the animal model the maximum...
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amino acid chelation in human and animal nutrition
... studies of animal and human amino acid mineral chelate digestion and absorption but also alternative interpretations One cannot help but admire the clarity of writing and the logical and stepwise ... from Patrick, H, and Schaible, P, Poultry Feeds and Nutrition (Westport, CT: AVI) 144, 1980; and Levander, O, and Cheng, L, eds., Micronutrient Interactions: Vitamins, Minerals and Hazardous Elements ... adverb, verb, or noun The ligands are the chelating agents, and the metalligand compounds that they form are metal chelates 19 20 Amino Acid Chelation in Human and Animal Nutrition NH2 NH2 H2C...
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Báo cáo khoa học: Recent insights into cerebral cavernous malformations: animal models of CCM and the human phenotype pptx
... experimental animal models, as discussed below Human phenotype Although humans are generally not considered in the category of animal models of disease, one can view the field of human genetics ... other animal models are relevant to disease to the degree that they help us further understand the human phenotype Recent investigations have further refined our understanding of this phenotype, and ... and lesion biology By exploring the function of the CCM genes in animal models this gap is being CCM animal models bridged Animal models have demonstrated the central importance of endothelial...
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Báo cáo y học: "Cartilage-specific autoimmunity in animal models and clinical aspects in patients – focus on relapsing polychondritis" ppsx
... response in RA Animal models for RP have been described as those immunized with either collagen type II (CII) or matrilin-1 and as models that appear spontaneously [1–3] These models differ in ... arthritis models and spontaneous models Several other models for arthritis have been reported but these will not be discussed here We believe that they should be considered as alternative models ... terms of genotype and phenotype to RA might help us to highlight some pathways of common importance in the two diseases Animal models of both RP and RA have been reproduced and are now powerful...
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Báo cáo y học: " Epitope spreading in animal models: array of hope in rheumatoid arthritis and multiple sclerosis" pot
... Therapy Vol 10 No Lundberg and Venables reported in one previous study of collagen-induced arthritis [5], though other studies have found equal binding to both citrullinated and arginine-containing ... citrullinated antigens associated with the anti-CCP response and the requirement for specific MHC alleles, the use of transgenic animals could go a long way to analyse the autoimmune response ... JL, Steinman L, Robinson WH: Epitope spreading to citrullinated antigens in mouse models of autoimmune arthritis and demyelination Arthritis Res Ther 2008, 10:R119 Kinloch A, Lundberg K, Venables...
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Báo cáo sinh học: "Estimating variances and covariances for bivariate animal models using scaling and transformation" pot
... with and var(e l ) l and var(e I and e and e are uncorrelated, and the ) e Q ’;1 fixed effects #i and (3 have no elements in common, and the random effects u , i 2 l , l u e and e normally distributed ... extended to fit these and other models, by the introduction of scaling and transformation models The models considered included those for bivariate traits when different fixed effect models are appropriate ... vectors Yl and y are of length n and n and matrices X X Z and Z are of size n t n x m and n x m Our 2 , x, l2 i x n t ,, l2l motivation was a case when a trait Yl was measured on males and y was...
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Báo cáo y học: " Characterization of protein tyrosine phosphatase H1 knockout mice in animal models of local and systemic inflammation" docx
... light phase and animals were allowed 1-hour habituation to the test room, if different from the holding room, before testing Testing sequence was randomized between KO and WT animals, and all apparatus ... MCP-1 and IL10 between WT and KO LPS-treated animals Both WT and KO mice displayed a LPS-induced increase in TNFα, MCP-1 and IL10; IL6 level was significantly increased by LPS in both WT and KO ... injection Genotype-related difference in MCP-1 and IL10 between WT and KO LPS-treated animals WT animals displayed a LPS-induced increase in IL10 and IL6; dot line indicates the detection limit...
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Báo cáo khoa học: "Acute renal failure – definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group" doc
... these principles and other guidelines for the use of animal models in the study of ARF Despite their limitations, animal models remain fundamental to improving our understanding of human ARF [28-30] ... clinical use Animal models of ARF We fully adopt the general recommendations, outlined by Piper and colleagues [27], in planning, conducting and critically evaluating studies utilizing animal models ... [28-30] There are three basic types of animal models in use for study of ARF: ischemia; toxins and sepsis models; and several subtypes Each has its own advantages and disadvantages, which are summarized...
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Báo cáo y học: "Anti-inflammatory effects of Radix Gentianae Macrophyllae (Qinjiao), Rhizoma Coptidis (Huanglian) and Citri Unshiu Pericarpium (Wenzhou migan) in animal models" doc
... as it inhibits the production of NO and PGE2 in LPS/IFN-γ-stimulated peritoneal macrophages and reduces edema and the amount of infiltrated cells in animal models Abbreviations CMC: carboxymethyl ... contributions KSK and HIR conducted the experiments and data analysis EKP conducted the in vitro experiments KJ and HJJ prepared herbal extracts JHK and HY assisted the in vivo experiments CKH, YBC and CJR ... manner KHU14 (100 μg/ml) inhibited NO and PGE2 production by 27% and 49% respectively In vivo effects of KHU14 on acute inflammation We employed three animal models of acute inflammation to evaluate...
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Báo cáo sinh học: " Equivalence of multibreed animal models and hierarchical Bayes analysis for maternally influenced traits" potx
... Institute, New Zealand, and consists of 3749 weaning weight records and the corresponding genealogy (Table 1) Records were collected between 1973 and 1990 on both purebred and crossbred individuals, ... an animal model with maternal effects J Anim Sci 2003, 81:101-108 doi:10.1186/1297-9686-42-20 Cite this article as: Munilla Leguizamón and Cantet: Equivalence of multibreed animal models and ... extended to correlated traits as presented by Cantet and Fernando [2] We will use subscripts “o“ and “m“ to differentiate between direct and maternal effects, respectively Then, using the approach...
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Báo cáo y học: "New animal models for evolution and development" pdf
... it arose and how each major parasitic lineage and the various life history and developmental strategies radiated requires a combination of phylogenetics, comparative life-cycle data and the need ... the function of cad in the growth zone and in posterior segmentation is ancestral for bilaterians (animals with bilateral symmetry, including both insects and vertebrates) Averof also reported ... on tapeworms and liver flukes To be a successful parasite, the interaction between host and parasite must be finely balanced Parasites have to circumvent the host’s immune response and to adapt...
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Báo cáo sinh học: "Estimating variances and covariances for multivariate animal models by restricted maximum likelihood" pot
... number of animals), as the only random effects in the model, ie r = and s q(q + 1) Assume effects are ordered i according to traits within animals, and let a be the subvector for the ith animal ... search Such models, which also all information on relationships between animals are usually referred incorporate to as animal models (AM) The derivative-free approach provides a flexible and powerful ... loglal and are constants and not need to be evaluated As above, (9) and (10) also apply, with an appropriate logIDI modification fo T if a second random effect, m, is fitted for each animal ,...
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An experimental study on the thermal valorization of municipal and animal wastes
... corrosion, slagging and fouling of boilers and agglomeration when used in fluidized beds [12] On the other hand, RDF ash is richer in calcium and silicon, while poorer in phosphorus and alkali, indicating ... masses and sizes and gas flow rates were carried out, in order to check the influence of heat and mass transfer Small masses (20-25mg) of each material, thinly distributed in the crucible and particle ... investigating the thermal behavior of PW and RDF under non-isothermal thermogravimetric conditions and at developing kinetic models for the pyrolysis and combustion of these fuels, for which...
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Tài liệu Báo cáo khoa học: Animal models of amyloid-b-related pathologies in Alzheimer’s disease docx
... develop animal models of AD, and also contributed significantly to the understanding of molecular pathogenesis Today a wide range of animal models are available for mechanistic, therapeutic and functional ... Alzheimer’s disease O Philipson et al Transgenic animal models Models devoid of any disease-causing APP mutations Animal models expressing wild-type (wt) human APP are of interest because the great ... and predominantly Ab42-immunoreactive diffuse and neuritic plaques in aged animals, compared with models harboring the Swedish mutation Impaired long-term potentiation in hippocampal slices and...
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Tài liệu Báo cáo Y học: Human and Drosophila UDP-galactose transporters transport UDP-N-acetylgalactosamine in addition to UDP-galactose doc
... anti-(rat IgG) Ig (a and i), pMKIT-neo; b and j, pMKIT-neohCST-cHA; (c and k), pMKIT-neo-hUGT1cHA; (d and l), pMKIT-neo-hUGT1(V45L)cHA; e and m, pMKIT-neo-hUGT1(N47A)cHA; (f and n), pMKIT-neohUGT1(L174M)-cHA; ... (lanes and 2) and Lec8 (lanes and 4) cells Cell extracts were prepared from cells transfected with appropriate plasmids as speci®ed below, and were subjected to Western blot analysis Lanes and 3, ... Alignment of DmNST/DmUGT and human NST sequences hUGT1, human UDP-Gal transporter (GenBank accession number D84454) [10]; hCST, human CMP-Sia transporter (D87969) [11]; hUGlcNAcT, human UDP-GlcNAc transporter...
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Copulas and credit models doc
... assertion we review the concept of copulas and state a simple proposition which is the basis of comparing existing models and defining new and structurally different models Copulas Copulas are simply the ... function of a standard d-dimensional normal random vector with correlation matrix R, and Φ is the distribution function of univariate Ga standard normal CR is known as the Gaussian copula, and this ... Variable Models To understand that the use of the Gaussian copula leads to models that are structurally equivalent we introduce a formal definition of equivalence for latent variable models and present...
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Báo cáo khoa học: cGMP transport by vesicles from human and mouse erythrocytes potx
... Effect of pH on MTX and cGMP transport into membrane vesicles from humans and from WT and KO mice (A) Effect of pH on MTX transport Erythrocyte membrane vesicles from humans and WT and KO mice were ... one hand, PGE1 and PGE2 reduced cGMP transport to only 57% and 59% of the control value, and the inhibitory effect of dipyridamole and indomethacin was also less pronounced On the other hand, ... AEBSF, aprotinin and leupeptin on cGMP transport into membrane vesicles from humans and from WT and KO mice (A) Effect of three different protease inhibitors on cGMP transport by human erythrocyte...
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INTERNATIONAL STANDARD Microbiology of food and animal feeding stuffs — Horizontal method for the detection of Salmonella spp docx
... other than milk and milk products, meat and meat products, and fish and fishery products [4] ISO/TR 11133-1, Microbiology of food and animal feeding stuffs — Guidelines on preparation and production ... International Standard is applicable to products intended for human consumption and the feeding of animals; environmental samples in the area of food production and food handling WARNING ... of ISO and IEC maintain registers of currently valid International Standards ISO 6887-1, Microbiology of food and animal feeding stuffs — Preparation of test samples, initial suspension and decimal...
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