ht2a d2 ratio hypothesis and antipsychotic potential of 5 ht2a antagonism alone or in combination with d2 antagonists
In vitro and in vivo study of ABT 869 in treatment acute myeloid leukemia (AML) alone or in combination with chemotherapy or HDAC inhibitors insight into molecular mechanism and biologic characterization
... In vitro and In vivo study of ABT-869 in treatment acute myeloid leukemia (AML) alone or in combination with chemotherapy or HDAC inhibitors: insight into molecular mechanism and biologic ... Nanjing, M.sc National University of Singapore) A THESIS SUBMITTED FOR THE DEGREE OF DORCTOR OF PHILOSOPHY DEPARTMENT OF MEDICINE YONG LOO LIN SCHOOL OF MEDICINE NATIONAL UNIVERSITY OF SINGAPORE ... ED50, ED 75 and ED90 12 points (Figure 1.4E and 1.4F) The CI values obtained for ABT-869 in combination with Ara-C and Dox employing three sequences are shown in Table To determine whether the combination...
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Báo cáo y học: "Mild hypothermia alone or in combination with anesthetic post-conditioning reduces expression of inflammatory cytokines in the cerebral cortex of pigs after cardiopulmonary resuscitation" ppt
... suggesting that a disproportionate and persistent production of cytokines can significantly increase the risk and extent of brain injury [5, 24] In terms of a systemic inflammatory response, increased ... Germany) and the following setting: a FiO2 of 0.3 at 20 breaths/minute, a tidal volume of mL/kg to maintain normocapnia, and a positive end-expiratory pressure of mm Hg Ventilation was monitored using ... guidelines [13] ROSC was defined as maintenance of an unassisted pulse and a systolic aortic blood pressure of ≥60 mm Hg lasting for 10 consecutive minutes according to the Utstein-style guidelines...
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Báo cáo y học: " Dimensionality and scale properties of the Edinburgh Depression Scale (EDS) in patients with type 2 diabetes mellitus: the DiaDDzoB study" pot
... 57 - 61 difficulty sleeping 51 53 55 - - 55 - - 59 - - 61 sad/miserable 56 58 61 - - 61 - 58 - - 63 crying 47 48 50 - - 50 - - 55 us us 10 thought of self harm 44 44 - 47 - us us us H 46 49 55 ... 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 Postnatal Depression Scale, and assessment of risk factors for postnatal depression J Affect Disord 2003, 76: 151 - 156 Pop VJ, Komproe IH, ... general factor Comparison of the item factor loadings under the full information one-factor model and the factor loadings under the full information bifactor model provides diagnostic information...
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Báo cáo y học: " Increased prevalence of vulnerable atherosclerotic plaques and low levels of natural IgM antibodies against phosphorylcholine in patients with systemic lupus erythematosus" docx
... in collecting and managing the database, analysing statistics with JF and MV, and participating in drafting of the manuscript TG performed and analysed physiological investigations with TJ, and ... low incidence of CVD, in addition to more favourable metabolic and other risk factors, except smoking, surprisingly enough Diet factors and exposure to infectious agents including nematodes and ... Karolinska Institute research ethics committee and is in accordance Page of with the Helsinki Declaration All subjects gave informed consent before entering the study Study protocol The investigation...
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Báo cáo khoa học: " Mass transfer, clearance and plasma concentration of procalcitonin during continuous venovenous hemofiltration in patients with septic shock and acute oliguric renal failure" ppsx
... beginning of CVVH (T0) and at the following times, according to the kinetics of PCT and to the lowest degree of clotting formation on the dialyzer membrane during these intervals of sampling: ... concentrations at different SOFA scores during the course of sepsis and MODS Crit Care 1999, 3: 45- 50 Brunkhorst FM, Heinz U, Forycki ZF: Kinetics of procalcitonin in iatrogenic sepsis Intensive ... 19,122 10,713 ± 19 ,57 1 6438 ± 12 ,59 5 750 3 ± 13962 753 8 ± 15, 558 102 ± 154 170 ± 2 65 526 ± 764 4122 ± 6263 359 1 ± 54 01 2647 ± 3901 Plasma clearance (ml/min) 37.4 ± 8.7* 34.7 ± 4.16* 31 .5 ± 7* Ultrafiltrate...
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Báo cáo khoa học: "Acute toxicity of second generation HIV protease-inhibitors in combination with radiotherapy: a retrospective case series" pptx
... Suppression of Hypoxia-inducible Factor and Vascular Endothelial Page of 43 44 45 46 47 48 49 50 51 52 53 54 55 Growth Factor by siRNA Does not Affect the Radiation Sensitivity of Multicellular Tumor ... protease inhibitor induces growth arrest and apoptosis of human prostate cancer LNCaP cells in vitro and in vivo in conjunction with blockade of androgen receptor STAT3 and AKT signaling Cancer ... management of high risk, clinically localized prostate cancer? Urologic Oncology-Seminars and Original Investigations 2010, 28 (5) :55 7 -56 7 Du XL, Freeman JL, Nattinger AB, Goodwin JS: Survival of women...
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Tài liệu Medicinal Chemistry and Pharmacological Potential of Fullerenes and Carbon Nanotubes docx
... RO OR O O O O HN OO NH OR O O OR O O OR O O OR OR OR RO Dendrofullerene Fig 1.2 Tris-malonic acids D3 and C3, and dendrofullerene ones The authors analyzed the interactions with cytochrome c and ... use of CNTs as adsorbent, combined with casein as enzyme inhibitor and Labrasol as absorption enhancer, gave the best bioavailability of EPO, opening many possibilities for the oral administration ... not inhibit IgE binding to mast cells In in vivo experiments, the administration of ng/g of fullerene derivatives into mice inhibits anaphylaxis, without presenting toxic effects Considering...
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Pollution haven hypothesis and Environmental impacts of foreign direct investment: The Case of Industrial Emission of Sulfur Dioxide (SO2) in Chinese provinces doc
... JIANGSU LIAONING SHANDONG : INNER MO TIANJIN ZHEJIANG × 9? $9= 87 @ ; = ' , >5 SHANXI D: A ×A + ) F:D @ :@ hainan 85. 4767 : CC A A 9? 8 >5 B CC A A A GUANGDON E:F ; F:D FUJIAN halshs-0 056 4699, version ... YUNNAN JILIN JIANGXI HEILONGJ ANHUI QINGHAI hainan FUJIAN hainan 2.42249 1.406 95 85. 4767 fdi_gdp 1.406 95 NINGXIA C: E:F : SO2PC-FDIK/GDP ×$9= ,@ = ; = ' ,> SHANXI 85. 4767 fdi_gdp FDIK/GDP-GDPPC 29.9789 ... XINJIANG JILIN HUBEI HEILONGJ HEBEI XINJIANG INNER MO ANHUI SHANXI HUNAN QINGHAIJIANGXI HENAN NINGXIASHAANXI GUANGXI Sichuan+ YUNNAN GANSU 1709.91 GUIZHOU BEIJING HUNAN HUBEI HENAN YUNNAN JILIN...
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Báo cáo sinh học: "The immunological potency and therapeutic potential of a prototype dual vaccine against influenza and Alzheimer’s disease" pdf
... 14 of 15 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 dependent modulation of Th1 and Th2 responses to immunization with beta-amyloid Int Immunol 2003, 15: 5 05- 514 ... viruses formulated in Quil A Lines and error bars indicate the average ± s.d (n = for groups immunized with and 25 μg and n = 16 for groups immunized with 50 μg killed viruses (*P < 0. 05; ***P ... technique [26] and generate a dual vaccine expressing the short B-cell epitope of amyloid within the HA of influenza virus The HA and NA glycoproteins of influenza A viruses contain the major antigenic...
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Báo cáo lâm nghiệp: "Seasonal variations and acclimation potential of the thermostability of photochemistry in four Mediterranean conifers" doc
... recorded four times (beginning of April, beginning of May, end of August and end of October, i.e., days of year 109, 138, 241, and 297) on needles of potted seedlings of C sempervirens, C atlantica, ... supported by a grant from the French Ministery for Education and Research Didier Bethored and Arnaud Jouinau produced and maintained the plant material at INRA Avignon, and Jean Marie Gioria at INRA ... recorded during days before the sampling dates ranged from 14.3 °C during Spring to 23.7 °C during August (Fig 3a) The amplitude of changes in mean temperature was 7.3 for minimal and 10.3 °C for...
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Báo cáo toán học: "Adult neurogenesis, neuroinflammation and therapeutic potential of adult neural stem cells" ppsx
... serotonin reuptake inhibitors In HD, in brains of HD patients and after quinolinic acid striatal lesioning of adult brain the enhanced neurogenesis in the SVZ leads to the migration of neuroblasts and ... a thymidine analog that incorporates DNA of dividing cells during the S-phase of the cell cycle and is used for birthdating and monitoring cell proliferation [51 ] There are limitations and pitfalls ... to examine the proliferation, migration and time of origin of cells in the central nervous system Brain Res 1988; 457 : 44 -52 [52 ] Parent JM, Tada E, Fike JR, Lowenstein DH Inhibition of dentate...
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Báo cáo y học: "Proliferation and differentiation potential of chondrocytes from osteoarthritic patients" ppt
... bone and to withstand the mechanical forces applied within the joint R567 The results in this paper give hopes for finding a cell-based autologous biological treatment for young active patients with ... by the increased intensity in staining with Alcian blue/van Gieson and in staining for type II collagen (Fig 5) Discussion Chondrocytes isolated from OA cartilage are able to proliferate in a monolayer ... subchondral bleeding, for example by microfracture However, the importance of an uninjured subchondral bone plate for the integrity of the articular cartilage and the ability to withstand mineralization...
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PHOSPHO-REGULATION AND METASTATIC POTENTIAL OF MURINE DOUBLE MINUTE 2
... activate p53 (34) There are numerous splice variants of mdm2 mRNA and multiple isoforms of the Mdm2 protein have been identified in tumors and normal tissues ( 35) Two of these isoforms, p 75 and p90, ... of Mdm2 Binding Inhibits p73 transcriptional activity (does not degrade) (51 , 52 ) Blocks Mdm2/p53 binding(42) Inhibits Mdm2-E2F1 binding (53 ) Stabilizes E2F1 protein levels (54 ) Ubiquitinates and ... results in inactivation due to intermolecular binding between phosphorylated Y530 and the SH2 domain, resulting in a “closed” conformation of the protein ( 25, 26) (Figure 5) The v-Src protein has...
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Evaluation of the chemotherapeutic and chemopreventive potential of triterpenoids from poria cocos
... 71 1 .5. 3.1 The role of MMP-2 and MMP-9 in tumor invasion …… 71 1 .5. 3.2 Regulation of MMP-2 and MMP-9……………………….73 1 .5. 3.3 MMP-2 and MMP-9 as target for control of tumor invasion.76 1.6 Aims of study ... glyceraldehyde-3-phosphate dehydrogenase inhibitors of apoptosis proteins inhibitor of caspase activated DNase or DNA fragmentation factor 45 IκB kinase inhibitor of kappaBα c-Jun NH2-terminal kinase Lactate dehydrogenase ... enzymes involved in the origination of tumors (as demonstrated by its inhibition on phorbol ester-induced expression of pro-inflammatory enzyme cyclooxygenase-2 and ornithinedecarboxylase in mouse...
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Prophylactic and therapeutic potential of synthetic peptides against enterovirus 71
... Professor Lu Jinhua, Assistant Professor Kevin Tan Shyong Wei and Assistant Professor Theresa Tan May Chin for being my PhD qualifying examiners and the opportunity for me to continue with my postgraduate ... (EV71) 50 1.9 Specific aims 53 CHAPTER 2.1 MATERIALS AND METHODS Microbiology 55 2.1.1 Bacterial work 55 2.1.1.1 Bacterial strains and plasmids 55 2.1.1.2 Culture and storage of bacterial cells 55 ... identification of human CD4+ T-cell epitopes within a protein vaccine candidate is of great interest as it provides a better understanding of the mechanisms involved in protective immunity and may therefore...
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Báo cáo y học: "Effects of p-Synephrine alone and in Combination with Selected Bioflavonoids on Resting Metabolism, Blood Pressure, Heart Rate and Self-Reported Mood Changes"
... hesperidin and 600 mg naringin After remaining seated and resting for 45 min., participants completed a second self report rating scale After 75 min., a third and final self report rating scale ... hesperidin in combination with 50 mg p-synephrine plus 600 mg naringin It may be that in this case, more is not better, and increasing the amount of hesperidin constitutes an example of hormesis ... effects of p-synephrine alone and in combination with different amounts of hesperidin and naringin on: (1) resting metabolism, (2) blood pressure, (3) resting heart-rate, and (4) self-reported...
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Báo cáo y học: "Segment-orientated analysis of two-dimensional strain and strain rate as assessed by velocity vector imaging in patients with acute myocardial infarction"
... strain between segments with LE ≥ 51 % and LE 1 -50 % 15 By using the previously proposed cut-off value 15 for strain of –6 .5 % a sensitivity of 23 % and specificity of 87 % was calculated for the ... detection of infarcted segments (AUC 0.6, confidence interval 0 .53 – 0.64) A 111 cut-off value of –10.34% resulted in a sensitivity of 54 % and specificity of 59 % (see Table 6) The intra- and inter-observer ... (LE-MRI) Deformation imaging after AMI Table 4: Comparison of deformation and tissue velocities in AMI according to the categorization of the segments as infarcted, adjacent and non-infarcted (see methods)...
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Experimental investigations and CFD study of temperature distribution during oscillating combustion in a crucible furnace
... be independently determined The standard k- ε model in FLUENT falls within this class of turbulence model and has become the workhorse of practical engineering flow calculations in the time since ... Engineering and Management from JBIET ( JNTU Hyderabad) in 2009 and B.Tech., in Mechanical Engineering from Vasavi College of Engineering (OU) in 2003 His area of interest is in the field of combustion ... National Project with participation of BHEL and BARC of DAE For 23 years in BHEL served in different Engineering areas and R&D His main areas of interest are combustion, gasification and new energy...
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