hsp105aand hsp105bare mammalian members of the hsp105⁄110 family
Tài liệu Báo cáo khoa học: Regulation of the members of the mammalian heat shock factor family doc
... of biological processes. Here, we havefocused on describing the regulatory mechanisms steer-ing the different members of the mammalian HSF family. The family provides an excellent example of how ... HSF4promotes the DNA-binding activity of another mem-ber of the HSF family, through modulating the chro-matin status [106].Conclusions and perspectivesNearly 10% of the genes in the human genome ... features among the HSF family members Similarly to most transcription factors, the members of the HSF family are modular proteins composed of functional domains (see figure 2 in [4]). The most con-served...
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Tài liệu Báo cáo khoa học: Arabidopsis thaliana BTB⁄ POZ-MATH proteins interact with members of the ERF⁄AP2 transcription factor family ppt
... in the central cylinder of the root, but not in the lower parts of the hypocotyl (a). Rosette leaves werestained in the vascular tissue of the leaf blade, whereas the petiole and older parts of ... with members of the ERF ⁄ AP2 family. (A) Y2H assays demonstrate the assembly of BPM1(1–189) and BPM3with RAP2.4 and RAP2.13, respectively. (B) Schematic drawing of the BPM1 fragment used for the ... AP2 proteins is restricted to the A-6 subfamilyand, in this case, even to a subset of eight members. The finding that, within the A-6 subfamily, not all of its members interact with BPM1 indicates...
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Tài liệu Báo cáo khoa học: Structural and functional specificities of PDGF-C and PDGF-D, the novel members of the platelet-derived growth factors family docx
... lymphoid cell infiltrates of the lung and fibro-sis in the liver [110].Conclusions The novel members, PDGF-C and -D, of the PDGFsubfamily of the cystine knot family of growth factorsare potent ... 2005 The Authors Journal compilation ª 2005 FEBSendothelial growth factors (VEGF) and the family istherefore often referred to as the PDGF ⁄ VEGF family. The PDGF family of growth factors The ... The current information on theiractivities points to a wide scope of biological effects;however further understanding of how these factorsinterplay with other members of the cystine knot family and...
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Báo cáo khoa học: Differential recognition of heat shock elements by members of the heat shock transcription factor family ppt
... promoters. These results show that the configuration of nGAAn units in the promoter isimportant in determining which hHSF members areinvolved in the regulation of the gene.Footprint analysis of the ... withoutchanging the magnitude of the heat shock response(cp3). The mutational analysis of the CRYGA andCRYGC HSEs suggests that the nucleotide sequencesand configuration of nGAAn-like units ... as judged from the amount andmobility of the complex (Fig. 1B). Notably, the amount of complex formed with hHSF4 and HSEgapor HSEstep was more than 70% that of hHSF4–HSE3P. Therefore, like...
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Báo cáo khoa học: The Vps4 C-terminal helix is a critical determinant for assembly and ATPase activity and has elements conserved in other members of the meiotic clade of AAA ATPases pdf
... not the b domain. The distinguishing feature of members of the meioticclade of AAA ATPases is the SRH motif, which dif-fers from that of other AAA ATPases [24]. The pair of Arg residues in the ... for the RDF sequence in modulating the function of the SRH. The C-terminal region of human VPS4B contains the b domain (b strands 7 and 8), the final helix of the AAA domain (a helix 10) and the ... we address the role of the yeast Vps4p C-ter-minal helix. In the 3D structure of mammalian andyeast Vps4, this helix lies close to the catalytic domain[31]. The close proximity of the C-terminal...
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Báo cáo khoa học: Relation between domain evolution, specificity, and taxonomy of the a-amylase family members containing a C-terminal starch-binding domain pot
... determinations of family members with yet otherspecificities are in progress (e.g. [17,18]). Furthermore,prediction of the presence of this (b/a)8-barrel fold in other family members has been ... illustrating the arrangement of alldomains in the five-domain members of the GH 13, canbe taken as an approximation of the first three domains in the four-domain members. It also shows the typicalTable ... between the hydrolases and transglycosi-dases, but rather there may be one between the compactcluster of Bacillus and Thermoanaerobacter CGTases and the remaining enzymes. The positions of the...
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Tài liệu Báo cáo khoa học: Bioinformatics of the glycoside hydrolase family 57 and identification of catalytic residues in amylopullulanase from Thermococcus hydrothermalis doc
... data).Therefore, in attempt to provide the first elementstowards the understanding of the functionality of the potentially valuable, heat stable GH-57 enzymes, especiallythat of the T. hydrothermalis ... and, in the case of equal lengt hs, a lphabe tically. The division is based on the evolutionary tree s(Fig. 4). For the amylopullulanase from Thermococcus hydrothermalis (Q9Y8I8_THEHY), the numbering ... half of the family is formedby ORFs coding for putative proteins of uncharacterizedactivity and specificity. A s triking feature of GH-57 is the sequence and length diversity of the individual members. Indeed,...
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Tài liệu Báo cáo khoa học: Evolutionary relationships of the prolyl oligopeptidase family enzymes docx
... ancestor of life. With respect to the studied enzymes of the POP family, POP seems to be the most conserved enzyme. Ten conserved amino acids werefound at the active site of the enzyme of each of the ... proposed that the b-propeller of P. furiosus POP does not perform the same function as the mammalian enzyme, i.e. the exclusion of large peptidesfrom the active site [25]. Clearly the role of the b-propellerhas ... sequences of POP family members are located in the C-terminal third of the alignment [20]. Of these conservedresidues, Ser554, Asp641 and His680 form the catalytic triad of POP and the small residues...
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Tài liệu Báo cáo Y học: Analyses of the CYP11B gene family in the guinea pig suggest the existence of a primordial CYP11B gene with aldosterone synthase activity docx
... evolutionand function of the hormonal system. We first cloned the genes of the CYP11B family of the guinea pig. The 11b-hydroxylase of the guinea pig showed higher substratespecificity than the aldosterone ... Thus, the proteins of the CYP11Bsubfamily catalysing the last biosynthetic steps are the keyenzymes for the synthesis of both mineralocorticoids andglucocorticoids.From molecular cloning of the ... with the size of the C17 substituent of the substrate. Furthermore, analyseswith the electron transfer protein adrenodoxin indicate dif-ferential sensitivity of CYP11B1 and CYP11B2 as well as the three...
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Báo cáo khoa học: Structure analysis of the flavoredoxin from Desulfovibrio vulgaris Miyazaki F reveals key residues that discriminate the functions and properties of the flavin reductase family pdf
... of the structure of NADP+-bound FeRrevealed that the nicotinamide moiety of NADP+faces the re-side of the isoalloxazine ring, and that the 2¢-P-AMP moiety is held in the groove between the ... direction along the b10 of the other mono-mer, forming an anti-parallel intermolecular b sheet(Fig. 2A). The subsequent residues of the loop (Ala7–Pro13) turn into the interior of the dimer interface,and ... fulgidusFeR is one of the candidates for the ferric ion-bindingresidue based on the structure of the mercury-boundderivative, although a ferric ion was not found at the site of either the native or...
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Báo cáo khoa học: Analysis of the NADH-dependent retinaldehyde reductase activity of amphioxus retinol dehydrogenase enzymes enhances our understanding of the evolution of the retinol dehydrogenase family pot
... FEBSTo analyze the contribution of protein domains to the ER anchorage, the localization of the full-lengthenzyme was compared with those of five truncatedforms. The pattern of the full-length ... enzymes. The most significant difference between the amphi-oxus and the other retinal reductases was, nevertheless,their preference for the NADH cofactor. To ourknowledge, these are the first ... [29]. The overall analysis, examining the topology of the phylogenetic tree and the position of each gene inside the cluster, was informative regard-ing the orthology relationships of the distinct...
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Tài liệu Báo cáo khoa học: The role of the ESSS protein in the assembly of a functional and stable mammalian mitochondrial complex I (NADH-ubiquinone oxidoreductase) pptx
... must still be determined whetherits absence in the V79-G18 mutant is the result of the missingESSS subunit alone, or whether the absence of ESSS causes the f ailure of other integral membrane subunits ... and the effect of the absence of intact complex I, but the results are toopreliminary in this regard.Heterologous expression of the ESSS-HA subunit The localization of the ESSS subunit in the ... as a nother identification of the complex at the position o f the histochemical stain in the left panel. Antisera against the SDHC subunit of complex IIand against the Rieske protein of complex...
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