... genomic alterations of CLL cells, and "extrinsic factors" , responsible for direct micro -environmental interactions of CLL cells Intrinsic factors Under the terms "intrinsic factors" are gathered ... expression of high levels of surface molecules, such as CD38 and CD49d, may facilitate the trafficking of CLL cells in the context of bone marrow and/ or lymph nodes where interactions with microenvironmental ... half of the cases [4] The deletion is often interstitial and can be homozygous in up to 15% of the cases [4] When it represents the only lesion it is associated with a good clinical outcome, and...
... is a vectorof observations; (3 is a vectorof fixed effects including age and herd-year-season of calving (natural trimester); s is as vectorof random sire effects and e is a vectorof random ... fixed effect of a combination of herd and i year which was absorbed; M is a fixed effect of month of calving (or month of j pregnancy) for j= 1, 12; A,! is a fixed effect of number of calvings ... number of the sire of the cow and birth date of the cow As a consequence of this process, the new data set has a total of 232 291 records with the information of each cow The number of calvings was...
... Fraction of Cancer Attributable to Lifestyle andEnvironmentalFactors in the UK in 2010 Authors Dr D Max Parkin with Lucy Boyd Professor Sarah C Darby David Mesher Professor Peter Sasieni and Dr ... cases of cancer in the UK (approximately 134 000 new cases in 2010), and about 50% of all cancer deaths Most of these cases of cancer (excluding a few thousand due to the natural background of ionising ... lifestyle andenvironmentalfactors in the UK in 2010: Summary and conclusions DM Parkin, L Boyd and LC Walker Cancers attributable to dietary factors in the UK in 2010: III Low consumption of fibre...
... accounts for a further 11% of the variability, and consists in the Asn, Ser, Glu and Thr amino acids, and in skin resistance The fifth and sixth factors explained 11% and 8% of total variability, ... Axes of two-dimensional plots are derived from (A) PC-1 and PC-2, (B) PC-1 and PC-3 These factors were chosen for the best visualization of field and genotype separation and include 50% of the ... organoleptic quality and to the perception of sensory attributes were identified [21] In order to gain a clearer understanding of the biochemical and genetic control of the generation of flavour compounds...
... lung function and different combinations of infection The impact of different types of infection on progression of lung function is shown in Figure Age and the most frequent types of infection ... sequencing of the variants, thus permitting rapid and sensitive detection of 97 – 98% of known and novel (newly identified) CF mutations, as previously described [34,44,45] Microbiology Sputum and throat ... computation and statistical evaluation In order to present individual values of lung function numerically and independent of gender, age and growth status, all lung function data were expressed as standard...
... analysis of gene–environment interactions to date is hypothesis driven The difficulties in quantifying and characterizing environmental risk factors for atopy (including onset and length of period of ... Atopy and asthma genes — where we stand? Allergy 2000, 55:803-817 Cookson W: The alliance of genes and environment in asthma and allergy Nature 1999, 402:B5-B11 Ober C, Moffatt MF: Contributing factors ... polymorphisms in candidate genes for asthma/atopy have been identified Linkage and candidate gene studies in asthma and atopy Linkage studies Results from linkage studies (genome-wide searches and candidate...
... size a, the quantities and shapes of inclusions, and the physical properties of the phases (see equation 1) (The effects of the shape and multiplicity of particles, andof some other variables ... coefficient of constraint, ρ- density of the first phase, K(µ) – coefficient of phase interaction, µ1 and µ2 – viscosi- ties of the first and second phases, f2 – the volume fraction of the second ... ratio of the velocity of sedimentation of the Vc = f2 µm a−2 ( V1 − V2 ) = 2 ( ρ2 − ρ1 ) g a µ1 ( 14 ) ( 15 ) group of particles to the velocity of sedimentation of a single particle, and χc...
... Biomechanics and motor control of human gait: normal, elderly and pathological Woollacott, M., & Shumway-Cook, A (2002) Attention and the control of posture and gait: A review of an emerging area of research ... the following as examplesof ‘other causes of falls’ (15% of the falls): pestering someone next to me, trying to pick up a document off the printer, pushing a car out of the snow, and jumping Approximately ... of participants (11 of 89 participants) reported an injury due to a fall (two participants had two injuries in two falls), and 3% of participants (3 of 89) received medical treatment for an injury...
... (i.e parent trees and cloned progenies), f is a vectorof random full-sib family effects, c is a vectorof random effects of clones within full-sib families, and e is a vectorof random residual ... where y is a vectorof observations on height growth, b is a vectorof fixed effects (i.e overall mean, trials and replicates within trials), a is a vectorof random genetic effects of individual ... properties of minimum prediction error variance and unbiasedness of the BLUP predictors of genetic value will hold if the variances and covariances of all the observations are properly specified and...
... ring-width and maximum-density series of all cores that was due to climatic and regional nonclimatic factors was extracted by this standardization procedure Standardization of the ring-width and maximum-density ... the effects of both climatic and nonclimatic factors on the radial growth of trees It is possible to evaluate the effects of nonclimatic factors on the radial growth of trees in the past by comparing ... one of the species that provides the longest tree-ring chronologies in Hokkaido, Japan However, no dendrochronological approach to an understanding of the effects of climatic and nonclimatic factors...
... detect the presence of CIC and determine the serum levels of C3 and C4 in patients and to see if a correlation existed between these parameters and allergic rhinitis Methods Subjects and blood specimens ... pathogenesis of atopic allergy, a number of studies have indicated that CIC and activation of the complement system might be involved Brostoff et al [12,13], Pagenilli et al [14] and Carini et ... to the signs and symptoms observed in rhinitis Table 1: Specific IgE (sIgE) antibodies, circulating immune complexes (CIC) and mean complement C3 and C4 levels in selected groups of patients with...
... assessment of pupils, the training of teachers and the funding of schools Time and opportunity issues such as the scheduling of school time, the supervision of time scheduled (for teaching and for ... array and complexity of teacher and teaching processes Teacher outcomes, when considered as the result of classroom processes, are usually defined in terms of pupils‘ standardised gain on standardised ... of children of the same age‖ and have ―a disability that prevents or hinders them from making use of educational facilities of a kind generally provided for children of the same age.‖ Leroy and...
... combination of national and international education programs with high level of English and Vietnamese language proficiency VAS will create a community of national and international managers, teachers and ... medium of training and the number of international teachers and students No one can deny that the diversified courses offered depend on the number of years of establishment The more variety of study’s ... growth and peak experiences] ! Consumer motivation andbehavior Consumer motivation is the drive to satisfy needs and wants, both physiological and psychological, through the purchase and use of...
... in-depth understanding of human behaviorand the reasons that govern such behavior The qualitative method investigates 22 the why and how of the linguistic and socio-cultural factors influences ... beautiful flows of thoughts and feelings, and new concepts of space and time, light and darkness It also introduces the American readers a wide range of stories about memories of war, “utilize ... are none but two kinds of people Some strictly believe the holiness of the original text and others the absoluteness of the unity of meaning and form in a certain language And they, idealistically,...
... Dextran esters of ketoprofen, diclofenac, ibuprofen and fenoprofen have been studied, showing that the dextran ester prodrug approach provides selective colon delivery systems of drugs possessing ... inhomogeneity and the variability of its physiological activities [472] A summary of bioactive polysaccharide esters is given in Table 10.4 Investigations of sulphuric acid half esters of cellulose and ... devices is one of the major developments in the field of therapeutics In addition to controlled release mechanisms accom- 188 10 SelectedExamplesof New Applications Fig 10.4 Percentage of released...
... the type of relief, this is a part of broken highlands of folded and faulted structures and intrusive igneous rocks of Czech highlands The bedrock is intrusive igneous acid granodiorite of the ... over 40% of its total area) covering mainly the highlands Drahanská and Konická vrchovina as well as the Moravian Karst of Devonian origin and a part of the Adamovská vrchovina highland As regards ... from the young and the old stands was studied so that the influence of age could be analyzed Biotic environmentalfactors are measured on these plots regularly, and temperature and humidity aspects...
... ligand of CXCR4 [107,108] As with β-chemokines and CCR5, occupation of CXCR4 by SDF-1 induces internalization of the receptor [109] Both CXCR4 and SDF-1 are essential during development, and ... alpha-, beta-, and theta defensins, and differ in their size and distribution of disulfide bridges [135] Alpha and β-defensins are peptides typically composed of 30–45 residues, and both display ... of the co-receptor in vivo and block HIV entry of R5 strains in vitro [56] Anti-CCR5 antibodies have also been detected in the milk of 66% and 83% of HIV-seronegative and seropositive women, respectively...
... rural and remote areas of Pakistan The phenomenon of micro finance is yet to attract the attention from the low income groups, mainly because of lack of its awareness and non existence of such ... populated and largest metropolitan city of Pakistan, Karachi The city of Karachi comprises a diverse The sample size was drawn from three towns of Karachi, which included Landhi, Korangi, and Orangi ... different parts of Khyber Pakhtoonkhwa province Major reason of migration to Karachi was in search of job and business opportunities A sample size of 150 respondents (30 from each town) was selected...
... Breast Cancer andEnvironmental Risk Factors in New York State Printed on recycled paper with soy-based ink Program on Breast Cancer andEnvironmental Risk Factors (BCERF) College of Veterinary ... by the US Department of Agriculture/Cooperative State Research, Education and Extension Service, The New York State Departments of Health andEnvironmental Conservation, and Cornell University ... kidney, pancreas, stomach, and some types of leukemia FACT SHEET #46 Cornell University Program on Breast Cancer andEnvironmental Risk Factors in New York State The effects of passive exposure to...