hormone actions in the regulation of calcium and phosphorus metabolism
Tài liệu Báo cáo khoa học: Roles of AP-2 transcription factors in the regulation of cartilage and skeletal development doc
... genetic diseases [47] Most analyses of the regulation of AP-2 and the interactions of the transcription factor with binding partners, as well as of the regulation of target gene expression, have ... apoptosis [73] The authors of this study ascribe the regulation of outgrowth of limb buds and patterning of the digits to the chicken AP-2 The role of AP-2a was further studied in zebrafish It ... role of AP-2a and AP-2e in chondrogenesis Overview of the differentiation stages during chondrogenesis and the involvement of transcription factors (henatoxylin and eosin-stained section of an...
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Báo cáo khoa học: Nuclear actin and actin-binding proteins in the regulation of transcription and gene expression docx
... that the RPEL domain of MRTF-A binds actin more strongly than the RPEL domain of myocardin, and that the RPEL motif itself is an actin-binding element RPEL1 and RPEL2 of myocardin bind actin weakly ... ABPs in transcription regulation B Zheng et al Table Role of nuclear actin-binding proteins interacting with the androgen receptor AR, androgen receptor; LBD, ligand-binding domain Actin-binding ... and perinuclear areas of the cell via its N-terminal ABD In the absence of ligand, AR is localized predominantly in the cytoplasm, and its hinge domain and the LBD are tethered to the C-terminal...
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Báo cáo khoa học: Huntington’s disease: roles of huntingtin-interacting protein 1 (HIP-1) and its molecular partner HIPPI in the regulation of apoptosis and transcription pptx
... the amount of the interacting proteins but also on the affinities of interacting proteins The uncreased expression of caspase-1 observed in HD may be mediated through HIPPI The role of HIP-1 in ... Conclusions HIP-1 and its interacting partner HIPPI together induce apoptosis by the intrinsic and extrinsic pathways Homer 1c, an interactor of HIPPI, and the wild-type N-terminal Htt, which interacts ... [29] The ANTH ⁄ ENTH domain of HIP-1 interacts with 3-phosphate containing inositol lipids and stabilizes the growth factor receptor tyrosine kinases by increasing their half-life following ligand...
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Báo cáo Y học: Molecular characterization of MRG19 of Saccharomyces cerevisiae Implication in the regulation of galactose and nonfermentable carbon source utilization pdf
... the binding site of the repressor Therefore, the possibility that Mrg19p could be a member of Hap1p complex remains to be tested If MRG19 were a repressor of CYC1 involved in the regulation of ... utilization of galactose when the concentration of galactose is decreasing in the medium To explain the mechanism of MRG19 in facilitating GAL gene induction, under low induction signal, we consider the ... b-galactosidase activity in wild-type and MRG19 disrupted strains bearing the indicated fusion constructs Transformants were grown to D600 of 0.5 and 1.5, in minimal synthetic medium containing glycerol...
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Tài liệu Báo cáo khoa học: Osmosensing and signaling in the regulation of mammalian cell function docx
... Thus, integrin-dependent cell volume sensing and signaling integrates into the overall context of insulin signaling Similarly, sensing of glutamine-induced hepatocyte swelling by integrins feeds into ... Osmosensing and signaling in mammalian cell function F Schliess et al [7] On the other hand, hyperosmotic shrinkage prevents insulin-induced hepatocyte swelling and proteolysis inhibition, indicating ... swelling [12,13], insulin-induced hepatocyte swelling is registrated by the integrin system, leading to a Src-dependent activation of the p38-type MAPK and thereby inhibition of 5800 autophagic...
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Báo cáo khoa học: Roles of the SH2 and SH3 domains in the regulation of neuronal Src kinase functions pptx
... application of SH2 domain binding peptides, which results in blocking of the binding of the SH2 domain to the substrate and thereby preventing interaction of the substrate with the kinase domain For ... C-terminus Kinase domain and C-terminus SH3 domain and C-terminus SH2 domain and C-terminus SH3, SH2 domain and C-terminus N-terminal, SH3, SH2 domain and C-terminus N-terminal, SH3, SH2, kinase ... mutations therefore inhibit interactions with ligands of the SH3 and SH2 domains, respectively, both intra- and intermolecularly, and thereby disrupt the overall functions of Src kinase [3,18–21]...
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Báo cáo khoa học: Use of lithium and SB-415286 to explore the role of glycogen synthase kinase-3 in the regulation of glucose transport and glycogen synthase pdf
... of GSK3 (using Li or SB-415286) appears to be sufficient for inducing activation of GS in muscle and fat cells, and that inhibition of the kinase potentiates insulin action in muscle of insulin-resistant ... by insulin Regulation of GS activity To establish the importance of GSK3 inhibition on GS activity we monitored the effects of insulin, Li, SB-415286 and wortmannin (a PI3K inhibitor) on the incorporation ... greater than that by insulin Since the activity of GS depends on the relative activities of GS kinases and PP1G, inhibiting GSK3 (one of the principal GS kinases) will shift the balance towards...
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Báo cáo Y học: Identification of mammalian-type transglutaminase in Physarum polycephalum Evidence from the cDNA sequence and involvement of GTP in the regulation of transamidating activity potx
... form Initially, determination of the amino-terminal amino acid sequence of purified protein was attempted, but no information was obtained, probably due to the protein modification Therefore, the ... indicates the stop codon Three amino acid residues of the catalytic triad are boxed The single and double lines indicate the putative Ca2+- and GTP-binding sites, respectively That sequence included ... because of the attachment of the hexahistidine, the recombinant PpTGase protein appeared to be slightly larger These results indicate that the cDNA obtained covered the entire coding region Involvement...
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Báo cáo khoa học: Interactions of ultraspiracle with ecdysone receptor in the transduction of ecdysone- and juvenile hormone-signaling pdf
... receptors, including human RXR (which is the ortholog of USP) have shown that an area on the surface of the ligand binding domain involving the C-terminus of a-helix 3, a-helix 4, and the N-terminus of ... promoter reporter These two motifs (DR1 and IR1) contain identical half sites and the same intervening single base, the difference being the orientation of the second half site as in the same direction ... both the dEcR and USP in nuclear extracts are in the complex that binds to the DR1 motif in EMSA, and this overexpression of EcR increases the activation of DR1JHECore by 20OHE We infer from these...
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Báo cáo khoa học: A new pathway encompassing calpain 3 and its newly identified substrate cardiac ankyrin repeat protein is involved in the regulation of the nuclear factor-jB pathway in skeletal muscle pdf
... are involved in the transmission of mechanical signals to signaling pathways In the M line, mechanical stimulation activates the interaction of a protein complex with the kinase domain of titin, ... before amino acid 71, the region of cleavage would be between amino acids 65 and 71 Considering the location of the N-terminal extremity of DNter2 on the structure of CARP and the presence of the ... a deregulation of the NF-jB pathway and an increase in muscle fiber apoptosis [8] The participation of NF-jB signaling in the pathogenesis of LGMD2A is therefore an interesting possibility The...
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báo cáo hóa học: " Aging and selective sensorimotor strategies in the regulation of upright balance" docx
... young and old adults Aging affects the interaction of the somatosensory and visual systems on the ability of the CNS to resolve sensory conflicts and to maintain upright stance equilibrium Therefore, ... the decline in the integrity of many postural regulating systems [14-16], but its effect on the sensory inputs recalibration process remains to be determined One question of interest is whether ... stability depends on the characteristics of the visual environment, and of the support surface, including the size of the base of support, its rigidity or compliance [12,13] Within physiological...
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báo cáo hóa học: " Hypoxia-inducible factor-1 (HIF-1) is involved in the regulation of hypoxia-stimulated expression of monocyte chemoattractant protein-1 (MCP-1/CCL2) and MCP-5 (Ccl12) in astrocytes" pdf
... across the BBB to the sites of axonal injury in the brain [33,37] Both in vitro and in vivo findings suggest that hypoxia/ischemia-induced infiltration of monocytes and macrophages contributes to the ... of inflammatory cytokines and chemokines during hypoxia; whereas NFκB is mainly involved in transcriptional regulation of these genes during the phase of reoxygenation [8,40] The temporal interplay ... molecules (ICAM-1) in the brain and in cultured astrocytes and brain endothelial cells [510] These inflammatory mediators play a critical role not only in the initiation and propagation of ischemica/...
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Báo cáo y học: "Interactions among type I and type II interferon, tumor necrosis factor, and -estradiol in the regulation of immune response-related gene expressions in systemic lupus erythematosus" potx
... in SLE Interactions between IFN and one of TNF, IFN, or E2 had a suggested involvement in the pathogenesis of SLE Competing interests 10 11 The authors declare that they have no competing interests ... complicated interactions with various cytokines and E2 This encouraged us to further examine the effects of interactions between IFN and one of TNF, IFN, or E2 on IFI gene expression Gathering the above ... expression in PBMCs We suggest that the direct suppressive effect of TNF on the IFN signature induced by IFN, at least, exists in the network regulation of cytokines in vivo The results of the co-stimulating...
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Báo cáo y học: " Tumour necrosis factor-α stimulates dehydroepiandrosterone metabolism in human fibroblast-like synoviocytes: a role for nuclear factor-κB and activator protein-1 in the regulation of expression of cytochrome p450 enzyme 7b" doc
... (Allard Kaptein) helped in conceiving the study and helped to draft the manuscript AK (Annemieke Kavelaars) and CH were involved in drafting and revising the article AB helped in conceiving the study, ... the TNF-α-induced increase in Cyp7b activity The R1276 absence of an effect of the MAPK inhibitors PD98059 and SB203580 on TNF-α-induced Cyp7b activity is in accordance with our findings at the ... with the findings in this report that NF-κB and AP-1 are involved in the TNF-α-enhanced Cyp7b activity Figure NF-κB and AP-1 binding sites within the Cyp7b promoter Putative promoter binding sites...
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Báo cáo y học: " Interactions among type I and type II interferon, tumor necrosis factor, and -estradiol in the regulation of immune response-related gene expressions in systemic lupus erythematosus" pptx
... in SLE Interactions between IFN and one of TNF, IFN, or E2 had a suggested involvement in the pathogenesis of SLE Competing interests 10 11 The authors declare that they have no competing interests ... complicated interactions with various cytokines and E2 This encouraged us to further examine the effects of interactions between IFN and one of TNF, IFN, or E2 on IFI gene expression Gathering the above ... expression in PBMCs We suggest that the direct suppressive effect of TNF on the IFN signature induced by IFN, at least, exists in the network regulation of cytokines in vivo The results of the co-stimulating...
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báo cáo khoa học: "The grapevine guard cell-related VvMYB60 transcription factor is involved in the regulation of stomatal activity and is differentially expressed in response to ABA and osmotic stress" ppt
... MYB60 proteins and other closely related proteins from subgroup 1: a distinctive PHEEG signature in the MYB domain, located in the loop connecting the R2 and R3 repeats, and the lack of the first ... stage, the onset of ripening and the accumulation of sugars are correlated to increasing levels of ABA in the berry [30], suggesting a possible negative effect of the hormone on the expression of ... primordia in (A), showing staining at the base of trichomes (C) Detail of an emerging later root (D) 15-day-old pVvMYB60:GUS seedling (E) Magnification of leaf primordia in (D), showing staining of...
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Báo cáo y học: "Science review: Redox and oxygen-sensitive transcription factors in the regulation of oxidant-mediated lung injury: κ role for nuclear factor-κ" pdf
... the iNOS inhibitor N6-(iminoethyl)-L-lysine or using iNOS knockout mice that the activation of NF-κB and the signal transducer and activator of transcription, and that increases in IL-6 and granulocyte ... to increasing intracellular stores of GSSG, a potent inhibitor of NF-κB transcription factor DNA binding The pathway leading to the formation of GSH by the action of γ-glutamylcysteine synthetase ... is interesting to observe that IL-11 did not affect the BALF content of the CXC chemokines, of the macrophage inflammatory protein-2 and of the cytokine-inducible neutrophil chemoattractant The...
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Báo cáo y học: "Science review: Redox and oxygen-sensitive transcription factors in the regulation of oxidant-mediated lung injury: α role for hypoxia-inducible factor-1α" pptx
... to the VEGF gene, Hellwig-Bürgel et al investigated the effects of these cytokines on the activation of the HIF-1 DNA-binding complex and the amount of HIF-1α protein in human hepatoma cells in ... Targeting the NF-κB pathway may therefore be a promising therapy to reduce injury and to improve lung function play a central role in initiating the innate immune system and in activating NF-κB ... synthase and production of prostaglandins [53] Induction of inducible nitric oxide synthase during the ischemic phase of HS may involve the activation of HIF-1 Increased expression of cyclooxygenase-2...
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Báo cáo y học: "Advances in understanding the regulation of apoptosis and mitosis by peroxisome-proliferator activated receptors in pre-clinical models: relevance for human health and disease" potx
... illustration of the domain structure of PPARs The most conserved region is C, which consists of a highly conserved DNA-binding domain The E/F domain is the ligand-binding domain, which contains the AF2 ... lipoprotein lipase, fatty acid transport protein, and the fatty acid translocase [53] Recently, the idea of a link between PPARγ and the insulin signaling has been reinforced by the finding that the ... the AF2 ligand-dependent activation domain The amino-terminal A/B domain contains the AF1 ligand-independent activation domain The D domain consists of a highly flexible hinge region and non-rodent...
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ELUCIDATING THE ROLE OF REDOX EFFECTS AND THE KU80 C-TERMINAL REGION IN THE REGULATION OF THE HUMAN DNA REPAIR PROTEIN KU
... Preliminary work was performed to determine the elution volume of Ku70/80C and Ku80CTR independent of the other protein Individual proteins were pre-incubated in running buffer and applied to the ... to the lack of the linker region tethering together two molecules that are simply within range of the linker arm and possibly not involved in a genuine interaction (41) 10 Materials and Methods ... redox regulation that has the potential to influence the DNA binding activity of Ku (51) To further understand the role of the C-terminus of Ku80, we created two mutants The first mutant contains...
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Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản khảo sát chương trình đào tạo gắn với các giáo trình cụ thể điều tra đối với đối tượng giảng viên và đối tượng quản lí điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu nội dung cụ thể cho từng kĩ năng ở từng cấp độ xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct mở máy động cơ lồng sóc các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến dòng điện stato i1 fi p2 động cơ điện không đồng bộ một pha sự cần thiết phải đầu tư xây dựng nhà máy thông tin liên lạc và các dịch vụ từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008 chỉ tiêu chất lượng 9 tr 25