hormonal influences in the expression of systemic lupus erythematosus 1

Báo cáo y học: "Effect of dsDNA binding to SmD-derived peptides on clinical accuracy in the diagnosis of systemic lupus erythematosus" potx

Ngày tải lên : 09/08/2014, 10:20

... 34249 348 14 0 8 .1 4.6 >200.0 13 .4 5 .1 Positive 35784 494 553 8.9 5.6 >200.0 >10 0.0 8.3 Positive Number/ number positive 19 /19 19 /19 18 /19 16 /19 14 /19 9 /19 19 /19 19 /19 aThe sample value in luminescence ... 1. 6 71. 2 0.7 11 .1 Positive 28746 14 3 16 9 4.3 2.6 18 1.3 1. 1 9.2 Positive 29236 98 16 4 5.9 1. 7 18 2 264 6.8 Positive 29354 450 225 4.0 2 .1 32.4 4.2 12 .1 Positive 29659 16 1 13 2 4.9 2.2 30 .1 3.3 11 .6 ... contain sDMA, and this constitutes a major autoepitope within the C-terminus of SmD1 and SmD3 [14 ,18 ,37] In one of these studies, a synthetic peptide of SmD1 (amino acids 95 11 9) containing sDMA...

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Báo cáo y học: "Autoantibodies predate the onset of systemic lupus erythematosus in northern Sweden" potx

Ngày tải lên : 12/08/2014, 15:22

... Talal N, Winchester RJ: The 19 82 revised criteria for the classification of systemic lupus erythematosus Arthritis Rheum 19 82, 25 :12 71- 1277 18 Hochberg MC: Updating the American College of Rheumatology ... (2.5) 8 .1 (2.3) RNP 5.9 (2.5) 7.5 (2.5) Histones 5.0 (1. 5) 6.5 (1. 9) ANA La/SSB 16 4 .1 (0.8) 4.0 (1. 0) 7.5 (1. 2) 7.0 (0.6) dsDNA 3.6 (1. 2) 6.6 (2.0) Jo -1 2.4 (1. 1) 3 .1 (1. 1) Scl-70 1. 4 (0.6) 2 .1 (0.9) ... 2):ii28-ii 31 doi :10 .11 86/ar3258 Cite this article as: Eriksson et al.: Autoantibodies predate the onset of systemic lupus erythematosus in northern Sweden Arthritis Research & Therapy 2 011 13 :R30...

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Báo cáo y học: "The in vivo expression of actin/salt-resistant hyperactive DNase I inhibits the development of anti-ssDNA and anti-histone autoantibodies in a murine model of systemic lupus erythematosus" ppt

Ngày tải lên : 09/08/2014, 07:20

... pathogenic autoantibody-inducing T cells of lupus J Exp Med 19 93, 17 7 :13 67 -13 81 Gardner WD, Hoch SO: Binding specificity of the two major DNA-binding proteins in human serum J Biol Chem 19 79, 254:5238-5242 ... induced in mice by the administration of a single high dose of LPS This induces a pulse of nucleosomes and chromatin in the plasma within the first 12 hours post-injection accompanied by an increase ... Dnase1 and the plasminogen system Arthritis Rheum 2004, 50 :18 73 -18 83 Puccetti A, Madaio MP, Bellese G, Migliorini P: Anti-DNA antibodies bind to DNase I J Exp Med 19 95, 18 1 :17 97 -18 04 Page 11 of 11 ...

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Báo cáo y học: "Association of the diplotype configuration at the N-acetyltransferase 2 gene with adverse events with co-trimoxazole in Japanese patients with systemic lupus erythematosus" pps

Ngày tải lên : 09/08/2014, 10:20

... Talal N, Winchester RJ: The 19 82 revised criteria for the classification of systemic lupus erythematosus Arthritis Rheum 19 82, 25 :12 71- 1277 20 Hochberg MC: Updating the American College of Rheumatology ... Society for the Promotion of Science Available online http://arthritis-research.com/content/9/2/R23 References 10 11 12 13 14 15 16 17 18 19 Bozzette SA, Finkelstein DM, Spector SA, Frame P, ... We also investigated the involvement of genetic polymorphisms of the GSTT1 and GSTM1 genes in the occurrence of adverse events with co-trimoxazole (data not shown) Nevertheless, none of the GST...

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Tài liệu Báo cáo khoa học: Adaptive changes in the expression of nuclear and mitochondrial encoded subunits of cytochrome c oxidase and the catalytic activity during hypoxia pptx

Ngày tải lên : 20/02/2014, 23:20

... (lmolÆmin )1 mg protein )1) Hexokinase (lmolÆmin )1 mg protein )1) Phosphofructokinase (lmolÆmin )1 mg protein )1) Hypoxia 10 .3 ± 1. 132 36 ± 3.24 0.022 0 .15 7 0. 016 0.026 ± ± ± ± We also tested other mitochondrial ... gene expression in yeast Adv Exp Med Biol 475, 17 7 18 4 11 Burke, P.A & Poyton, R.O (19 98) Structure/function of oxygenregulated isoforms in cytochrome c oxidase J Exp Biol 2 01, 11 63 11 75 12 Vijayasarathy, ... gene expression in higher eucaryotes Resp Physiol 11 5, 11 9 13 3 33 Chinenov, Y., Schmidt, T., Yang, X.Y & Martin, M.E (19 98) Identiﬁcation of redox-sensitive cysteines in GA-binding proteinalpha...

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báo cáo hóa học:" Decrease in the expression of the type 1 PTH/PTHrP receptor (PTH1R) on chondrocytes in animals with osteoarthritis" potx

Ngày tải lên : 20/06/2014, 04:20

... Macroscopic grading of OA PTH1R staining by immunohistochemistry Immunohistochemical staining of PTH1R showed marked staining of the cell membrane in all cases PTH1R was expressed mainly in the middle ... and bone tissue according to the Mankin scale [16 ] The Mankin score included assessments of the structure, cellularity, Safranin stainability, and integrity of the tidemark The scores for structure ... knee joints were opened using a medial paramedian skin incision of cm in length and a medial parapatellar incision of the capsule In animals of group 1, the ACL was resected using a tapering scalpel...

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Báo cáo y học: "Hypoxia in the pathogenesis of systemic sclerosis" ppt

Ngày tải lên : 09/08/2014, 01:22

... [16 ,17 ] In contrast, levels of HIF -1 decreased when deacetylation was inhibited Finally, mRNA and protein levels of ARD -1 are diminished under hypoxia, resulting in less acetylated HIF -1 [16 ] ... is inhibited and HIF -1 protein accumulates Binding of HIF -1 to HIF binding sites, formation of the transcriptional complex and regulation of HIF -1 transactivation After translocation into the ... online http://arthritis-research.com/content /11 /2/220 in the epidermis of healthy individuals, whereas the expression of HIF -1 in SSc patients was restricted to single keratinocytes HIF -1 protein...

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Báo cáo y học: "Treatment of hypertriglyceridemia and HIV: fenofibrate-induced changes in the expression of chemokine genes in circulating leukocytes" ppsx

Ngày tải lên : 10/08/2014, 05:21

... (B) The use of fenofibrate was related to significant decreases in the expression in circulating leukocytes of CX3CL1 and CCR2 genes and a significant increase in the expression of SDF -1 Page of ... significant effect of fenofibrate in the MCP -1/ CCL2 gene expression However, there was a significant decrease in the gene expression of the CX3CL1/ Fractalkine in patients treated with fenofibrate with ... to the risk of atherosclerosis considering their well documented role in the local accumulation of monocytes [8,9] However, fenofibrate had an intriguing effect in SDF -1 expression neutralizing...

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báo cáo khoa học: " Field transcriptome revealed critical developmental and physiological transitions involved in the expression of growth potential in japonica rice" potx

Ngày tải lên : 11/08/2014, 11:21

... 2 011 , 11 :10 http://www.biomedcentral.com /14 71- 2229 /11 /10 genes based on their time, place and level of expression in the plant Although rapid progress has been made during the last decade in ... allocation, and the PHR1 binding motif is often found in the upstream regions of Arabidopsis genes induced by Pi-starvation [52] The PHR1 binding motif was enriched in the 1- kb upstream regions of the Sato ... Biology 2 011 , 11 :10 http://www.biomedcentral.com /14 71- 2229 /11 /10 333 downregulated genes, further supporting the alteration of Pi homeostasis (See Additional file 14 ) The expression of many Pi-response...

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Báo cáo y học: "Development and management of systemic lupus erythematosus in an HIV-infected man with hepatitis C and B co-infection following interferon therapy: a case report" doc

Ngày tải lên : 11/08/2014, 17:21

... Sánchez-Tapias JM, Ingelmo M: Hepatitis C virus infection mimicking systemic lupus erythematosus: study of hepatitis C virus infection in a series of 13 4 Spanish patients with systemic lupus erythematosus ... problem of increasing clinical significance Interferon (INF) therapy is the mainstay of HCV treatment HCV and HIV have been associated with the development of autoimmune markers and disease; INF therapy ... effect of HIV DCs can be infected by HIV, and TLR9 signalling-changes in pDC function may be reduced indirectly by HIV gp120 [14 ] Loss of pDC in HIV infection usually parallels the loss of CD4 [15 ],...

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Báo cáo y học: " Dissemination of Strongyloides stercoralis in a patient with systemic lupus erythematosus after initiation of albendazole: a case report" docx

Ngày tải lên : 11/08/2014, 23:21

... images A copy of the written consent is available for review by the Editor -in- Chief of this journal References 10 11 12 13 Conclusion Clinicians should be aware that the S stercoralis hyperinfection ... corticosteroid administration for this disease [8] Dissemination may involve gut, stomach, lung and/or cerebrospinal fluid [9 ,10 ] Furthermore, larval penetration of the intestinal wall during dissemination ... occur several days into appropriate antihelminth therapy and should remain vigilant for signs of sepsis even during the early days of therapy Our findings are based on a single case report, and...

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Báo cáo y học: "B cells from rheumatoid arthritis patients show important alterations in the expression of CD86 and FcgRIIb, which are modulated by anti-tumor necrosis factor therapy" potx

Ngày tải lên : 12/08/2014, 12:20

... together with a blockage of FcgRIIb is sufficient to induce an increase in the expression of CD86 [38,39], whereas the overexpression of this receptor on murine B cells reverses the induction of ... by means of CD19 and CD27 staining, we detected similar percentages of these subsets in the two groups of individuals (Figure 1) Higher frequency of activated naïve and memory B cells in rheumatoid ... participated in the recruitment and clinical evaluations of patients LS participated in the recruitment of patients and clinical data analysis MC participated in the design and coordination of the study...

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Báo cáo y học: "Changes in the expression of NO synthase isoforms after ozone: the effects of allergen exposure" doc

Ngày tải lên : 12/08/2014, 18:21

... communication Biochem Pharmacol 19 89, 11 :17 09 -17 15 Page of (page number not for citation purposes) Respiratory Research 2004, 5 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 Moncada S, Palmer RMJ, ... Penh 3 .12 : 1. 14 ± 0 .10 vs 1. 23 ± 0.02, Penh 6.25: 1. 23 ± 0 .12 vs 1. 53 ± 0 .10 , Penh 12 .5: 1. 71 ± 0.27 vs 1. 88 ± 0 .16 , Penh 25: 1. 97 ± 0.34 vs 2 .10 ± 0 .14 , Penh 50: 2.26 ± 0.40 vs 2.59 ± 0 .14 , P ... (Model 49C; Thermo Environmental Instruments Inc., Franklin, Mass) The air-sampling probes were placed in the breathing zone of the mice The mean chamber ozone concentration ( ± SEM) during the hr...

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Báo cáo y học: " Alterations in the expression of DEAD-box and other RNA binding proteins during HIV-1 replication" potx

Ngày tải lên : 13/08/2014, 13:20

... shows the expression profile of genes encoding ABC transporter proteins The bottom of the figure shows a scale indicating the color values corresponding to the expression ratio in HIV infected/HIV ... concerning the statistical analyses 23 References 10 11 12 13 14 15 16 17 Rocak S, Linder P: DEAD-box proteins: the driving forces behind RNA metabolism Nat Rev Mol Cell Biol 2004, 5:232-2 41 Lorsch ... [26] Other genes encoding proteins with RNA splicing/binding and RNA transport activity were also up regulated during this period, including the methylated mRNA cap binding proteins EIF4G1 [27]...

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Báo cáo sinh học: "Changes in the expression of genetic characteristics across cohorts in skeletal deformations of farmed salmonids" potx

Ngày tải lên : 14/08/2014, 13:22

... 75, 15 0 47, 10 8 65, 79 98, 12 2 n dams per sire: mean (range) 4.5 (1 9) 2.0 (1 4) 2.3 (1 4) 2.9 (1 5) 2.0 (1 5) n sires per dam: mean (range) 2.7 (1 3) 1. 0 (1 1) 1. 0 (1 1) 2.4 (1 3) 1. 6 (1 3) ... ﬁsh are individually tagged, and their pedigree is maintained over multiple generations [19 ] The data included a total of 41 286 individuals in ﬁve generations hatched in 19 93, 19 96, 19 97, 19 99, ... estimates from these previous studies, the pattern found in the Finnish data remained (Fig 1) In the regression model of the combined data (R2 = 79.2%, n = 12 ), both the linear (5.9 ± 1. 08, t = 5.44,...

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THE STUDY OF THE EFFECTS OF a CHANGE IN THE EXPRESSION OF MIXED LINEAGE LEUKEMIA 5 ON TRANSCRIPTION REGULATION

Ngày tải lên : 12/10/2015, 17:35

... SantaCruz sc -13 130 - - 1: 200 CTD4H8 Millipore 05-623 1: 1000 - 1: 3000 H5 Covance MMS -12 9R 1: 50 - 1: 250 H14 Covance MMS -13 4R 1: 50 - 1: 250 8WG16 Covance MMS -12 6R 1: 50 - 1: 250 Cyclin T1 SantaCruz sc- 812 7 ... 5µg 1: 200 H3K4-3Me Abcam Ab1 012 1: 100 - 1: 2000 H3K4-2Me Abcam Ab32356 - - 1: 1000 H3K4-1Me Abcam Ab8895-25 - - 1: 1000 H3K9-3Me Abcam Ab8898 1: 250 - 1: 1000 47 Histone H3 Cell Signalling 9 715 - - 1: 1000 ... Lipofectamine ™ RNAiMAX (μl) in serumfree DMEM(μl) Total Final siRNA volume of concentration antibiotics- (nM) free plating medium (ml) 12 in1 00 1. 6 in 10 0 1. 0 12 2.5 24 in 200 3.2 in 200 2.0 12 5.5...

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Báo cáo y học: "Vitamin D receptor gene BsmI polymorphisms in Thai patients with systemic lupus erythematosus" potx

Ngày tải lên : 09/08/2014, 07:20

... important intellectual content and have given final approval of the version to be published All authors read and approved the final manuscript 10 11 12 13 14 15 16 17 18 19 20 21 Acknowledgements The ... gamma-interferon production in patients with systemic lupus erythematosus Arthritis Rheum 19 86, 29 :12 10 -12 15 Kelley VR, Wuthrich RP: Cytokines in the pathogenesis of systemic lupus erythematosus ... (8 /10 1) Renal disorder 50 (1/ 2) 68 .18 (15 /22) 64.93 (50/77) 65.34 (66 /10 1) Neurologic disorder (0/2) 9.09 (2/22) 20.77 (16 /77) 17 .82 (18 /10 1) - Seizure (0/2) 9.09 (2/22) 15 .58 (12 /77) 13 .86 (14 /10 1)...

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Báo cáo y học: "Correction: Initial clinical trial of epratuzumab (humanized anti-CD22 antibody) for immunotherapy of systemic lupus erythematosus" pps

Ngày tải lên : 09/08/2014, 13:21

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Báo cáo y học: "Culture-negative bivalvular endocarditis with myocardial destruction in a patient with systemic lupus erythematosus: a case report." ppsx

Ngày tải lên : 10/08/2014, 09:22

... edited the manuscript All authors participated in approving the final manuscript Competing interests The authors declare that they have no competing interests Received: April 2 011 Accepted: 14 September ... Study in 819 New Cases CID 2 010 , 51( 2) :13 1 -14 0 doi :10 .11 86 /17 49-8090-6 -10 9 Cite this article as: Laurence and Suh: Culture-negative bivalvular endocarditis with myocardial destruction in a patient ... Journal of Cardiothoracic Surgery 2 011 , 6 :10 9 http://www.cardiothoracicsurgery.org/content/6 /1/ 109 blood urea nitrogen was at baseline of 53 mg/dL [10 -20 mg/dL] The ferritin level was 2055 ng/mL [10 ...

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Báo cáo y học: " Extragonadal germ cell tumor presenting in a woman with systemic lupus erythematosus: a case report" ppt

Ngày tải lên : 11/08/2014, 12:20

... Br J Cancer 19 95, 71( 2): 416 -420 McMurray RW, May W: Sex hormones and systemic lupus erythematosus: review and meta-analysis Arthritis Rheum 2003, 48: 210 0 doi :10 .11 86 /17 52 -19 47-4-97 Cite this ... germ cell tumor presenting in a woman with systemic lupus erythematosus: a case report Journal of Medical Case Reports 2 010 4:97 Figure An image of our patient’s pituitary showing polymorphic cells ... advantage of: Authors’ contributions All the authors contributed to the management of the patient Additionally, MS was the primary author of the manuscript All authors read and approved the final...

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