histones role in controlling gene expression
Báo cáo y học: " Transcriptome analysis of murine thymocytes reveals age-associated changes in thymic gene expression"
... immunoglobulin chains were also found to be significantly increased in aged thymocytes Understanding the changes in gene expression in thymocytes with age may hold the key in determining thymocyte ... S25058 Ig kappa chain- mouse, partial (86%) [TC1067460] Immunoglobulin kappa chain Immunoglobulin joining chain Immunoglobulin heavy chain (heavy chain of IgM) Immunoglobulin kappa chain variable 28 ... Most of the genes with the greatest increase were immunoglobulin-associated genes This was a very interesting finding, given that the number of immunoglobu- lin-producing cells within the thymus...
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Báo cáo khoa học: Expression profiling reveals differences in metabolic gene expression between exercise-induced cardiac effects and maladaptive cardiac hypertrophy pot
... protein Integrin alpha Laminin receptor Cystatin B Cystatin C Cathepsin L Cathepsin S Cytoskeletal Sarcosin Fast myosin alkali light chain (MYL1) Talin Actinin alpha associated LIM protein Arg ... upregulation of genes involved in extracellular matrix remodeling (biglycan, matrix gla protein, cathepsins, cystatins, integrin a7 and laminin receptor) These genes are consistently upregulated in pathological ... C C Strøm et al Gene expression in exercise-induced cardiac hypertrophy Table (Continued) Gene Cathechol-O-methyltransferase Guanine nucleotide binding protein, alpha inhibiting polypeptide N-myristoyltransferase...
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Báo cáo khoa học: DNA-binding and transcription characteristics of three cloned sigma factors from mustard (Sinapis alba L.) suggest overlapping and distinct roles in plastid gene expression doc
... HTH-motif [20] in region 4.2 is involved in binding of the )35 promoter element [7] As shown in Fig 7A, two conserved amino acids, E13 and R16, can be identified in all three SASIG proteins within the ... effect of the resulting sigma mutant SASIG1–455R/H in competition EMSAs (Fig 6) The maltose binding portion of the recombinant proteins did not interfere with core or promoter binding (data not shown) ... both in EMSA DNA binding (Fig 3B) and in vitro transcription experiments (Fig 4) In the gel shift assays each of the three proteins was found to interact with E coli core enzyme, resulting in a...
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Báo cáo hóa học: " Changes in the gene expression profile of Arabidopsis thaliana after infection with Tobacco etch virus" potx
... repeat-binding protein DNA binding domain: a new fold with an additional C-terminal helix J Mol Biol 2006, 356:72-85 Kirik V, Bäumlein H: A novel leaf-specific myb-related protein with a single binding ... repeat-binding protein (TRP1), which also contains the typical MYB motifs [26] Eight out of these nine genes were also included in the response to auxin stimulus, being At1g71030 (MYBL2) the missing ... identify individual genes whose expression was altered after the infection with TEV A total of 1727 genes showed a significant alteration in their level of expression in infected plants Indeed,...
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Báo cáo hóa học: " The Local Maximum Clustering Method and Its Application in Microarray Gene Expression Data Analysis" docx
... array—a cluster centering at this gene would be created Additionally, for the thousands of genes arrayed on a gene chip, generally, only a handful of genes show varying expression levels, which ... B.S and M.S degrees in electrical engineering from Fudan University, Shanghai, China, in 1983 and 1986, respectively, and his Ph.D degree in imaging science from Rochester Institute of Technology, ... Computer Engineering, Rochester Institute of Technology From 1995 to 1996, he joined Hewlett Packard Company as a Research Engineer, specialized in digital halftoning and color image processing Currently,...
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báo cáo khoa học: "Gene-expression and network-based analysis reveals a novel role for hsa-mir-9 and drug control over the p38 network in Glioblastoma Multiforme progression" ppsx
... taking a pathway with two genes as input and one gene as output, the algorithm calculates their probability of being in an "up" state (by taking into account the expression levels of those genes ... finding firm prognostic biomarkers In the work presented here, we analyzed gene- expression data in five independent publicly available Glioblastoma datasets Four datasets obtained from the Gene ... critically involved in disease outcome (e.g [33]) The transition from the gene- disease network-disease thinking is in need of further evidence A careful clinical follow-up on findings such as...
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báo cáo khoa học: " Light has a specific role in modulating Arabidopsis gene expression at low temperature" potx
... zinc finger protein, AN1-like At2g45820 remorin, a non-specific DNA binding protein At3g52800 zinc finger – like protein zinc finger protein, AN1-like At2g22430 homeobox-leucine zipper protein ATHB-6 ... LHCB genes At3g27690 light harvesting chlorophyll A/B binding protein, LHCB 2.4 (Down) At2g05070 light-harvesting chlorophyll A/B binding protein, LHCB 2.2 (Down) At3g08940 chlorophyll a/b-binding ... Yamaguchi-Shinozaki K: Organization and expression of two Arabidopsis DREB2 genes encoding DRE-binding proteins involved in dehydration- and high-salinity-responsive gene expression Plant Mol Biol 2000,...
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THE ROLE OF DNA METHYLATION IN REGULATING LHX3 GENE EXPRESSION
... protein isoforms contain a DNA-binding homeodomain, two LIM domains, which participate in protein-protein interactions, and a carboxyl terminus (C-terminus) trans-activation domain The DNA-binding ... silencing involve alterations in protein-DNA interactions, and thus implicated histones and other transcription factors in the mechanism Studies examining the interactions of methyl-binding proteins ... other binding proteins, such as methyl CpG-binding proteins Methyl-CpG binding proteins (MBPs) bind methylated DNA and recruit regulatory proteins to modulate chromatin structure and gene activity...
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Báo cáo y học: "Differential gene expression in HIV/SIV-associated and spontaneous lymphomas"
... the interleukin gene; λIg: the λ-chain of immunoglobulin gene; γIg: the γ-chain of immunoglobulin gene; IFN-ind: the interferon-inducible gene 6-16; IL4R: the interleukin receptor gene; TAP2: ... of immunoglobulin gene, γIg – the γ-chain of immunoglobulin gene, IFN-ind – the interferone-inducible gene 6-16, IL4R – the interleukin receptor gene, TAP2 – the transport protein gene, hnRNP A1 ... oncogene, constant part of the λIg gene, the mitochondrial genes of NADH dehydrogenase subunit (ND4), the interferon-inducible gene 6-16 (Inf-ind), the 16S rRNA gene (most probably the humanin gene...
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Báo cáo y học: "Transporter Molecules influence the Gene Expression in HeLa Cells"
... the ordinates represent the linear ratio of differential gene expression Genes detected and in following investigated for validation A) an induced expression of the PKN1 gene B) a repressed expression ... cannot determine the global players involved in such complex phenotypes Integration of the gene expression profiling with specific modulation of gene expression in relevant signalling pathway ... the genetic consequences of targeted gene therapy in vitro (and in vivo) Microarray Study Differential Gene Expression Differential gene expression profiling is routinely used to detect genes...
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Tài liệu Báo cáo khoa học: Mixed lineage leukemia: roles in gene expression, hormone signaling and mRNA processing docx
... that includes a DNA-binding domain, a ligand-binding domain and a transactivation domain The DNA-binding domain is responsible for DNA binding specificity and dimerization, and the ligand-binding ... domain involved in protein–protein interactions FYRC and FYRN domains are involved in heterodimerization between MLLN and MLLC terminal fragments High-mobility group (HMG) domains are involved in ... fusion proteins results in balanced transactivation of target genes In addition to the catalytic SET domain, several other protein–DNA or protein–protein interacting domains present in MLL peptides...
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Tài liệu Báo cáo khoa học: Time-dependent regulation analysis dissects shifts between metabolic and gene-expression regulation during nitrogen starvation in baker’s yeast doc
... proteolysis of ubiquitin-tagged proteins [41] Ubiquitination of proteins is catalysed by three enzymes: ubiquitin-activating enzyme (E1), ubiquitin-conjugating enzyme (E2) and ubiquitin protein ligase (E3) ... Table S1 C-flux in mmolÆCÆmin)1ÆgÆprotein)1 during fermentative capacity assay in samples from the nitrogen-starvation experiments Table S2 C-flux in mmolÆCÆmin)1ÆgÆprotein)1 during fermentative ... Smit AB (2004) Morphine exposure and abstinence define specific stages of gene expression in the rat nucleus accumbens FASEB J 18, 848–850 Supporting information The following supplementary material...
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Tài liệu Báo cáo khoa học: Modulation of oat arginine decarboxylase gene expression and genome organization in transgenic Trypanosoma cruzi epimastigotes docx
... containing DNA spots (5 lg each) corresponding to internal fragments of ADC or cruzipain genes The latter (used as a control) is a housekeeping gene that encodes the main cysteine proteinase ... oat ADC gene in T cruzi In order to study the expression of the foreign ADC gene in T cruzi epimastigotes, we transformed wildtype parasites with the recombinant plasmid, pADC-8 [10], bearing the ... wild-type T cruzi epimastigotes with a recombinant plasmid containing the oat ADC cDNA coding region [10] In the present Foreign ADC gene expression in T cruzi work we used ADC-transgenic protozoa...
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Tài liệu Báo cáo khoa học: Modulation of cyclin D1 and early growth response factor-1 gene expression in interleukin-1b-treated rat smooth muscle cells by n-6 and n-3 polyunsaturated fatty acids pdf
... caveolin proteins [22] Several studies have shown that caveolin, a 21–24 kDa integral membrane protein, plays a critical role in the regulation of cell proliferation, including SMC, by inhibiting ... incubation in medium containing fetal bovine serum In parallel to their effects on the cyclin D1 gene promoter, EPA and DHA also reduced the egr-1 gene promoter activity stimulated by the coexpression ... SMC, by inhibiting signalling molecules [45–47] Caveolin-3 is the main isoform in muscle cells, including SMC [30] Caveolin-1 and caveolin-3 seem to act as scaffolding proteins that negatively regulate...
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Tài liệu Báo cáo Y học: The b-1,4-endogalactanase A gene from Aspergillus niger is specifically induced on arabinose and galacturonic acid and plays an important role in the degradation of pectic hairy regions pdf
... the true inducers of galA expression This indicates that galA is coexpressed with both the pectinolytic genes encoding main chain cleaving enzymes as well as with the arabinanolytic genes [1] ... as indicated in Fig Expression of galA was only detected in the presence of sugar beet pectin, whereas expression of lacA was detected in the presence of L-arabinose, D-xylose, sugar beet pectin ... by introducing an NsiI site at the translation start point of galA and by then cloning a fragment, starting at this NsiI site and containing the galA gene and approximately 700 bp 3¢-flanking...
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Ambient particulate air pollution induces oxidative stress and alterations of mitochondria and gene expression in brown and white adipose tissues ppt
... examined in mice As shown in Figure 3, PM 2.5 exposure induced a marked increase in macrophage (F4/80+ cells) infiltration in eWAT Next, we analyzed the changes in uncoupling protein (UCP1) in ... long chain fatty acids (Elovl3), type iodothyronine deiondinase (Dio2), homeobox C9 (Hoxc9), insulin-like growth factor binding protein (Igfbp3), dermatopontin (Dpt), and b-actin are showed in Table ... also increased in mBAT in response to PM2.5 exposure We did not observe significant differences in the gene expressions of Hoxc9 or Igfbp3 in the WAT, neither was the gene expression of Dpt in...
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Báo cáo khoa học: Nuclear actin and actin-binding proteins in the regulation of transcription and gene expression docx
... Table Role of nuclear actin-binding proteins interacting with the androgen receptor AR, androgen receptor; LBD, ligand-binding domain Actin-binding protein Targeting sequence Gelsolin Direct or indirect ... Direct a-actinin-2 ()) Bundling proteins Coactivator Supervillin NLS F-actin- and membraneassociated scaffolding protein Filamin NLS? Cross-linking proteins Filamin A NLS? Cross-linking proteins Transgelin ... occurring C-terminal 100 kDa fragment of filamin, interacting with the motor protein dynein, may exert its inhibitory effect by interfering with interactions between the N- and C-terminal domains,...
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Báo cáo khoa học: Gene expression silencing with ‘specific’ small interfering RNA goes beyond specificity – a study of key parameters to take into account in the onset of small interfering RNA off-target effects potx
... differences in exposure times during western blotting We also observed a slight increase in SREBF1 protein level triggered in the presence of the NT siRNA, in agreement with the slight increase in SREBF1 ... expressed in the presence of both siRNAs specific for the same target are indicated in diagram intersections allowing the expression analysis, at the transcriptomic level, of genes mainly involved in ... cellular processes in a cell type-dependent manner For instance, an increase in the cell cycle timing could be expected following the downregulation of PCNA, coding for a protein involved in the control...
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Báo cáo khoa học: VEGF gene expression is regulated post-transcriptionally in macrophages pdf
... plays a role in VEGF gene expression in mouse macrophages under in ammatory conditions We have introduced the 3¢ UTR of mouse VEGF (mVEGF) into the 3¢ UTR of the luciferase reporter gene and ... CSD ⁄ PTB binding site (nt 1727–39) [28] are shown in bold ⁄ underlined type Additional AU-rich sequences, including all AUUUA pentamers and nonomers, are shown in bold type Engineering of reporter ... VEGF also plays a role in vascular permeability and as a chemoattractant [11,12,14], suggesting that the role of VEGF in inflamed joints may be complex Macrophages in rheumatoid joints produce VEGF...
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Báo cáo khoa học: Diverging regulation of pyruvate dehydrogenase kinase isoform gene expression in cultured human muscle cells pot
... protein kinase kinase (MEK) inhibitor, U0126 [32,33] Therefore, the role of the MAPK pathway in regulating PDK mRNA expression was investigated by incubating myoblasts for h in the presence of insulin ... used to examine the role of PtdIns3K in regulating PDK transcript abundance in response to insulin (Fig 2) Incubation with either LY294002 (50 lm) or wortmannin (100 nm) significantly inhibited ... of insulin (1 lm) Insulin markedly decreased PDK2 and PDK4 mRNA levels below basal values In order to investigate the mechanisms by which insulin regulates PDK mRNA expression, selective inhibitors...
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