heritable factors in the regulation of epigenetic profile
Tài liệu Báo cáo khoa học: Roles of AP-2 transcription factors in the regulation of cartilage and skeletal development doc
... genetic diseases [47] Most analyses of the regulation of AP-2 and the interactions of the transcription factor with binding partners, as well as of the regulation of target gene expression, have ... of the differentiation stages during chondrogenesis and the involvement of transcription factors (henatoxylin and eosin-stained section of an embryonic cartilaginous limb) of the development of ... treatment of the chick face with RA, and this is accompanied by an increase in apoptosis [73] The authors of this study ascribe the regulation of outgrowth of limb buds and patterning of the digits...
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Báo cáo y học: "Science review: Redox and oxygen-sensitive transcription factors in the regulation of oxidant-mediated lung injury: κ role for nuclear factor-κ" pdf
... [26–37] In a murine hyperoxia model, the effects of lisofylline on the activation of NF-κB and CREB, on the expression of proinflammatory cytokines in the lungs and on the circulating levels of oxidized ... to increasing intracellular stores of GSSG, a potent inhibitor of NF-κB transcription factor DNA binding The pathway leading to the formation of GSH by the action of γ-glutamylcysteine synthetase ... is interesting to observe that IL-11 did not affect the BALF content of the CXC chemokines, of the macrophage inflammatory protein-2 and of the cytokine-inducible neutrophil chemoattractant The...
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Báo cáo y học: "Science review: Redox and oxygen-sensitive transcription factors in the regulation of oxidant-mediated lung injury: α role for hypoxia-inducible factor-1α" pptx
... Hellwig-Bürgel et al investigated the effects of these cytokines on the activation of the HIF-1 DNA-binding complex and the amount of HIF-1α protein in human hepatoma cells in culture [47] Under normoxic ... potential mediator of increased pulmonary vascular permeability in this model of acute lung injury Further elaborating on the mechanisms involving HIF-1 in regulating the inflammatory response, ... however, to indicate HIF-1 as a possible regulator of the evolution and propagation of the inflammatory process The rate of transcription of several genes encoding proteins involved in oxygen and...
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Báo cáo khoa học: Alternative initiation of transcription of the humanpresenilin 1gene in SH-SY5Y and SK-N-SH cells The role of Ets factors in the regulation ofpresenilin 1 pptx
... flanking the +1 site (A) The binding of nuclear factors is eliminated by mutations in Ets motifs The binding of nuclear factors present in SK-N-SH (K) or SH-SY5Y (H) nuclear extracts over the ... ERM being the most related [35] PEA3 members all contain the highly conserved ETS domain ERM contains two DNA binding inhibitory domains flanking the Ets domain: the central 87 amino acid inhibitory ... marks the position of supershifted complexes (B) The binding of in vitro translated ERM is eliminated by mutations in Ets motifs The binding of in vitro translated ERM over the PS1 promoter was...
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Tài liệu Báo cáo khoa học: The central role of CDE/CHR promoter elements in the regulation of cell cycle-dependent gene transcription pdf
... In G0, proteins appear to bind to the CDE ⁄ CHR, as monitored by in vivo footprinting According to these early experiments all binding is lost in G2 ⁄ M In contrast, constitutive binding to the ... confirmed by Lin-54 binding to the CHR, cooperating with E2F4 binding to the CDE in EMSAs in vitro [86] ChIP experiments on the Cdc2 gene also provided insights into the association of other cell ... proteins with the promoter E2F4 binding during the cell cycle coincides with the binding of p107 or p130 [61,85] Another E2F site distal to the E2F ⁄ CDE acts as an activating element binding...
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Tài liệu Báo cáo khoa học: A role of miR-27 in the regulation of adipogenesis ppt
... or without hematoxylin staining In hypoxia experiments, 3T3-L1 cells were maintained in a hypoxia chamber (Invivo 400; Ruskinn Inc., Cincinnati, OH, USA) constantly maintained at 1% O2 Culture ... relevant role of miR-27 in the regulation of adipose tissue functions in vivo, we examined the expression of miR-27 in the genetically obese ob ⁄ ob mice The 2352 expression levels of both miR-27a ... IDM (10 lgÆmL)1 insulin, lm dexamethasone, and 0.5 mm IDM) Cells were then maintained in DMEM containing 10% fetal bovine serum and lgÆmL)1insulin The medium was replaced every other day Mature...
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Tài liệu Báo cáo khoa học: Osmosensing and signaling in the regulation of mammalian cell function docx
... Thus, integrin-dependent cell volume sensing and signaling integrates into the overall context of insulin signaling Similarly, sensing of glutamine-induced hepatocyte swelling by integrins feeds into ... swelling [12,13], insulin-induced hepatocyte swelling is registrated by the integrin system, leading to a Src-dependent activation of the p38-type MAPK and thereby inhibition of 5800 autophagic ... Osmosensing and signaling in mammalian cell function F Schliess et al [7] On the other hand, hyperosmotic shrinkage prevents insulin-induced hepatocyte swelling and proteolysis inhibition, indicating...
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Báo cáo khoa học: Roles of the SH2 and SH3 domains in the regulation of neuronal Src kinase functions pptx
... application of SH2 domain binding peptides, which results in blocking of the binding of the SH2 domain to the substrate and thereby preventing interaction of the substrate with the kinase domain For ... bovine serum albumin, all of the n-Src proteins were able to bind the NR2A C-tail with similar binding affinities in the nanomolar range (Fig 5) This indicates that the ability of n-Src protein ... C-terminus Kinase domain and C-terminus SH3 domain and C-terminus SH2 domain and C-terminus SH3, SH2 domain and C-terminus N-terminal, SH3, SH2 domain and C-terminus N-terminal, SH3, SH2, kinase...
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Báo cáo khoa học: Nuclear actin and actin-binding proteins in the regulation of transcription and gene expression docx
... actin is involved in recruiting Pol II to the PIC [19]; (b) decreased actin levels resulting from antiactin Ig inhibit PIC formation by preventing the binding of TBP to the TATA box, indicating that ... with rDNA genes, and microinjection of anti-actin Ig into the nuclei of HeLa cells inhibits pre-rRNA synthesis in vivo [25,34] The interaction of NM1 with actin in the initiation complex may trigger ... actin-binding site located in the hnRNP U C-terminus and associate with the phosphorylated C-terminal domain of Pol II [43] Injection of a peptide acting as a competitive inhibitor of protein–protein...
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Báo cáo khoa học: Use of lithium and SB-415286 to explore the role of glycogen synthase kinase-3 in the regulation of glucose transport and glycogen synthase pdf
... of GSK3 (using Li or SB-415286) appears to be sufficient for inducing activation of GS in muscle and fat cells, and that inhibition of the kinase potentiates insulin action in muscle of insulin-resistant ... GSK3 inhibition improves insulin responsiveness in muscle of insulin resistant animals it had no insulin potentiating effect in skeletal muscle of lean animals [39,41] To assess whether chronic inhibition ... (1994) The inhibition of glycogen synthase kinase-3 by insulin or IGF-1 in the rat skeletal muscle cell line L6 by wortmannin, but not rapamycin: evidence that wortmannin blocks activation of the...
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Báo cáo Y học: Elucidation of the role of fructose 2,6-bisphosphate in the regulation of glucose fluxes in mice usingin vivo 13 C NMR measurements of hepatic carbohydrate metabolism docx
... > h from the start of glucose infusion For the calculation of glycogen C6 changes, data acquired within h of the start of the glucose infusion was not included to avoid any in uence of transient ... the initial rate of label incorporation into glycogen C6 relative to the rate of label incorporation into glycogen C1 reflects the relative isotopic enrichment of Glc6P in the C6 relative to the ... should the tail vein fail, which was the case in only three animals, the data of which were included After the lines were inserted, pentobarbital was infused continuously at 4.8–6.0 mgÆkg)1Æh)1 The...
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Báo cáo Y học: Identification of mammalian-type transglutaminase in Physarum polycephalum Evidence from the cDNA sequence and involvement of GTP in the regulation of transamidating activity potx
... form Initially, determination of the amino-terminal amino acid sequence of purified protein was attempted, but no information was obtained, probably due to the protein modification Therefore, the ... because of the attachment of the hexahistidine, the recombinant PpTGase protein appeared to be slightly larger These results indicate that the cDNA obtained covered the entire coding region Involvement ... terminus that is required for binding to the plasma membrane, thereby being involved in the formation of the corneum [47] Additional amino-terminal residues of TGase include the sequences that are post-translationally...
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The Constitution of Private Governance Product Standards in the Regulation of Integrating Markets pptx
... over the content and use of these standards––either by the participation of officials in the elaboration and approval of the standard, or because of the threat of public intervention in case the ... much codifications of ways of doing, but the prescription of the best way to something, finding its roots not in society but in the nature of things The corollary of this theory is, then, that divergent ... WIDESPREAD SCHOLARLY neglect of the phenomenon of the use of standards in modern market regulation seems all the more striking in the light of the preoccupation of modern theorising in sociology, political...
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Báo cáo khoa học: Huntington’s disease: roles of huntingtin-interacting protein 1 (HIP-1) and its molecular partner HIPPI in the regulation of apoptosis and transcription pptx
... Some of the Htt-interacting proteins also alter the pathogenicity in the Drosophila model of HD [13] Among 300 Htt-interacting proteins described so far, HIP-1 is one of the most studied The ... it, resulting in a decrease of the amount of HIP-1–HIPPI heterodimer and apoptosis induction The effect of HIP-1 may depend not only on the amount of the interacting proteins but also on the affinities ... affinities of interacting proteins The uncreased expression of caspase-1 observed in HD may be mediated through HIPPI The role of HIP-1 in translocation of HIPPI into the nucleus and that of other...
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Common factors in the performance of European corporate bonds – evidence before and after financial crisis pdf
... observations, N is the number of bond indices, or intercepts tested, K is the number of risk factors in the asset pricing model, µ is a column vector of mean returns of the risk factors, Ω is the unbiased ... T is the number of observations, N is the number of bond indices, or intercepts tested, K is the number of risk factors in the asset pricing model, µ is a column vector of mean returns of the ... smaller As the fourth column reveals, the average remaining time to maturity of each index falls in the middle of the respective maturity-bracket A Jarque-Bera test rejects the null hypothesis of a...
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AN INCREASING ROLE FOR COMPETITION IN THE REGULATION OF BANKS doc
... as the development of offshore financial centers and off-balance-sheet methods of financing); • the diminishing effectiveness of traditional controls due to financial innovation (including the ... 1980s In the case of S&Ls the insurance premium was set by statute in 1950 at 1/12 of 1% of the assessable deposits and was the same for all insured institutions regardless of the riskiness of their ... to being changed and enforced in the interest of the regulated industry, rather than in the interest of the economy at large General laws, on the other hand, tend to be more immune and therefore...
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Báo cáo khoa học: A new pathway encompassing calpain 3 and its newly identified substrate cardiac ankyrin repeat protein is involved in the regulation of the nuclear factor-jB pathway in skeletal muscle pdf
... are involved in the transmission of mechanical signals to signaling pathways In the M line, mechanical stimulation activates the interaction of a protein complex with the kinase domain of titin, ... pathway and an increase in muscle fiber apoptosis [8] The participation of NF-jB signaling in the pathogenesis of LGMD2A is therefore an interesting possibility The findings obtained in the present ... the binding to titin by improving the accessibility of the titin-binding domain Interestingly, the importance of CARP interaction for its function was recently demonstrated in a FEBS Journal...
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Báo cáo Y học: Molecular characterization of MRG19 of Saccharomyces cerevisiae Implication in the regulation of galactose and nonfermentable carbon source utilization pdf
... the binding site of the repressor Therefore, the possibility that Mrg19p could be a member of Hap1p complex remains to be tested If MRG19 were a repressor of CYC1 involved in the regulation of ... role in maintaining the GAL gene induction at optimal levels to ensure near complete utilization of galactose when the concentration of galactose is decreasing in the medium To explain the mechanism ... that the energy status of the cell is an important determinant of GAL gene induction [15,25–27] This suggests that the availability of metabolic energy is a rate-limiting step in the synthesis of...
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Báo cáo sinh học: " Risk factors in the development of stem cell therapy" pdf
... therapies An example is the use of stem cell therapy in the treatment of myocardial infarction (MI) One of the main safety concerns is the occurrence of arrhythmias [98,104] These were seen in ... source of harm [35,37] Examples of risk factors are the type of stem cells used, their procurement and culturing history, the level of manipulation and site of injection Because of the variety of ... contributed to the writing and discussion of the manuscript The views expressed in this article are the personal views of the authors Competing interests All authors declare no competing interest The views...
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báo cáo hóa học: " Aging and selective sensorimotor strategies in the regulation of upright balance" docx
... the decline in the integrity of many postural regulating systems [14-16], but its effect on the sensory inputs recalibration process remains to be determined One question of interest is whether ... ability to maintain balance was observed in older adults The ability to anticipate the physical constraints of the environment and adapt the balance behaviour accordingly is the result of intricate ... stability depends on the characteristics of the visual environment, and of the support surface, including the size of the base of support, its rigidity or compliance [12,13] Within physiological...
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