hdr and non homologous end joining nhej

ANTI CANCER EFFECTS OF THYMOQUINONE IN BREAST CANCER CELLS INVOLVEMENT OF NON HOMOLOGOUS END JOINING AND TELOMERE TELOMERASE HOMEOSTASIS

Ngày tải lên : 30/09/2015, 13:41

... pathway – Non- homologous end- joining (NHEJ) Non- homologous end- joining (NHEJ) pathway is one of the major DNA DSB repair pathways in mammalian cells (Jackson, 2002; Lieber et al., 2004) NHEJ mediates ... 1.1 DNA damage and repair 1.2 DNA repair pathway – Non- homologous end- joining (NHEJ) 1.2.1 Major players in the NHEJ pathway 1.3 Telomeres and its structure ... (Gibco, Grand Island, NY, USA) supplemented with 10 % fetal bovine serum (Gibco, Grand Island, NY, USA) and 100 U/mL penicillin/streptomycin (Gibco, Grand Island, NY, USA) An immortalised but non- transformed...

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DETERMINING MOLECULAR MECHANSIMS OF DNA NON-HOMOLOGOUS END JOINING PROTEINS

Ngày tải lên : 24/08/2014, 13:50

... research is showing that joining of two non- homologous DNA ends by NHEJ is in fact a sophisticated and complex mechanism of DNA repair 1.2.1 Non- homologous end joining NHEJ, found to be active ... activity on single-strand DNA, DNA-PK and ATP dependent endonuclease activity on DNA hairpin structures, and DNA-PK and ATP dependent endonuclease processing of 3’ and 5’ single-strand overhangs, with ... strand breaks (DSB) Figure 2: The Non- Homologous End Joining (NHEJ) pathway Figure 3: DNA-PK synaptic complex Figure 4: Ku 80 C-term interactions Figure 5: Effect of DNA strand orientation and...

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Báo cáo y học: " Bedside measurement of changes in lung impedance to monitor alveolar ventilation in dependent and non-dependent parts by electrical impedance tomography during a positive end-expiratory pressure trial in mechanically ventilated intensive

Ngày tải lên : 13/08/2014, 20:22

... stepwise decrease in PEEP, and the response differs between dependent and non- dependent lung regions (Figure 4) This is in accordance with the common understanding of gravity-dependent tidal volume ... symmetrical non- overlapping ventral to dorsal oriented layers defined as dependent and non- dependent regions of interest (ROI) fEIT images before each PEEP step were subtracted from fEIT images at the end ... PEEP steps and can differentiate between dependent and non- dependent lung regions There was a significant difference in response to a stepwise decrease in PEEP between patients with and without...

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1801-1807 - the other post-Kantian Jacob Friedrich Fries and non-Romantic Sentimentalism

Ngày tải lên : 01/11/2013, 08:20

... between the unconditional demands of duty and the conditional, sensible facts of our desires, there is only a “conﬂict of ends,” which is resolved by assuming God and immortality on the basis ... the whole of nature a kind of beauty and sublimity that engenders a sense of worship and love This sense of “religiosity,” as Fries describes it, is only engendered when nature is appreciated aesthetically ... series; it is also a moral principle, a demand to respect the autonomy of others; and it is a political principle, the right to pursue one’s own ends and happiness by one’s own lights. However,...

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Tài liệu BANK AND NON BANK FINANCIAL INTERMEDIATION pdf

Ngày tải lên : 17/02/2014, 21:20

... outstanding debt is noncontingent Likewise, more recent explanations such as those of Holmstr¨ m and Tirole o (1997) and Diamond and Rajan (2000) assume that deposit claims are noncontingent and ... comparable nonconglomerate firms (see, e.g., Graham, Lemmon, and Wolf (2002) and Campa and Kedia (2002)) Consequently, conglomerates will tend to trade at a discount relative to stand-alone firms ... that the left-hand side of inequality (23) is reduced by εPr(HH) Bank and Nonbank Financial Intermediation 2513 detail by Fluck and Lynch The main difference between this paper and theirs is...

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Tài liệu Báo cáo khoa học: Aggregative organization enhances the DNA end-joining process that is mediated by DNA-dependent protein kinase pdf

Ngày tải lên : 19/02/2014, 06:20

... mobilized onto DNA with ends in a cell-free system, and that it produces the characteristic ‘coacervate-like organization’, which greatly stimulates DNA end- joining Results and Discussion Aberrant ... of DNA afﬁnity fraction or 0.7 lg of Mono Q bound fraction (lanes and 14) model system the rejoining reaction of DNA ends (end- joining; EJ), which has been characterized as the primary repair ... (lanes and 8) ssDNA induced a noticeable accumulation of 95 k and nucleolinD proteins in addition to DNA-PKcs, Ku80 and Ku70 (lane 9) On the other hand, a relaxed form of closed circular doublestrand...

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Tài liệu Allergic and Non‐Allergic Sinusitis for the Primary Care Physician: Pathophysiology, Evaluation and Treatment pdf

Ngày tải lên : 19/02/2014, 08:20

... NASAL ENDOSCOPY, AND NASOPHARYNGOLARYNGOSCOPY Nasal endoscopy allows for more detailed examination of the nasal cavities and can be performed with a flexible fiberoptic or rigid endoscope. Endoscopic examination enables the doctor to identify specific areas of ... not only artificially pollinates the seeds but because grass pollen is somewhat sticky and clings to long hair and outerwear. To reduce exposure, it is recommended that the mouth and nose be covered with a mask, and removing all clothes after mowing and immediately showering. Patients who reside close to golf courses should inquire when ... will benefit from simple, targeted medical treatments. (7, 12‐16) SMELL AND TASTE DYSFUNCTION Smell and taste sensation go hand in hand. Patients who lose their sense of smell probably also find that food is bland or tasteless. Although annoying, this can actually be a more serious problem because the patient ...

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Permitted water pollution discharges and population cancer and non-cancer mortality: toxicity weights and upstream discharge effects in US rural-urban areas doc

Ngày tải lên : 06/03/2014, 23:20

... disease and total noncancer mortality, however, the significant effects observed for Set (Table 2) are significant only in nonadjacent non- metropolitan areas Death rates for total noncancer and ... non- white Hispanic, percent Asian American, percent other non- white race (percent white serving as the referent), metropolitan county, and non- metropolitan adjacent county (non- metropolitan and ... mortality and non- carcinogen discharges were used in models of noncancer mortality In Set 4, models were cross-validated by using carcinogen discharges in noncancer mortality models, and by using non- carcinogen...

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Báo cáo khoa học: "A FRIENDLY AND FLEXIBLE FRONT-END FOR DATA MANAGEMENT SYSTEMS" pptx

Ngày tải lên : 08/03/2014, 18:20

... "SECRETARY" AND CLASS - "EXECUTIVE" WHEN R2 PRINT ql PRINT Q2 END REF~E~CES W ~ IL: RETRIEVE [JOB.EMPLOYEE,JOB.ADDRESS] WHERE (DIV.DNAME - "R&D") AND (DIV.DIV JOB CH - J O B D I V _ J O B C H ) AND ... (JOB.JNAME - "SECRETARY") AND (JOB.CLASS - "EXECUTIVE") CONCLUSION Kameny, I., Welner, J., Crilley, M., Burger, J., Gates, R., and Brill, D "EUFID: The End User Friendly Interface to Data Management ... Workshop on Distributed Data Management and Computer Networks, May 25-27 1977, Berkeley, CA SECURITY Burger, J., Leal, A., and Shoshanl, A "Semantic Based Parsing and a Natural-Language Interface for...

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RECRUITMENT IN EXECUTIVE AND NON-EXECUTIVE CADRE pot

Ngày tải lên : 09/03/2014, 00:20

... Constitution (Andarnan and Nicobar Islands) Scheduled Tribes Order, 1959 @ as amended by the Scheduled Castes and Scheduled Tribes Order (Amendment)Act, 1976 The Constitution (Dadra and Nagar Haveli) ... verification The candidate’s identity will be verified with respect to his / her details on the call letter and in the Attendance List If identity of the candidate is in doubt, the candidate may not ... Rules of the Company (19) Candidates selected both in executive and non- executive cadre and appointed will be placed on probation for a period of one year which may be extended for a further maximum...

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Doctor of Philosophy in Mathematics Linear and Non-linear Operators, and The Distribution of Zeros of Entire Functions

Ngày tải lên : 10/03/2014, 16:15

... (z), where α ≥ and ϕ1 (z) has genus or 1, and g(z) = m k=1 (z +αk ) be an even polynomial with non- negative real coefficients and at least one non- real zero Then for all z ∈ R and all non- negative ... Definition 22 and the leading coefficients of f and g are of the same sign, or (2) f and g have interlacing zeros with form (ii) or (iii) in Definition 22, and the leading coefficients of f and g are ... Legendre polynomials (cf Example 16) Unlike the generalized Hermite and Laguerre polynomials that depend on one parameter, the Jacobi polynomials depend on two parameters (cf Definition 27), and...

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Comparision between background concentration of arsenic in urban and non urban areas of florida

Ngày tải lên : 15/03/2014, 23:22

... between cities and land-use categories, hence comparisons of the combined land-use categories from the two cities from non- urban areas were not possible Nonetheless, all four land-use classes ... concentrations and total Fe and Al concentrations in non- urban soils (Table 4) Both Fe and Al react with the arsenate to form stable, immobile compounds in the soil, and oxides and hydroxides ... the standard deviation of the log-transformed data, n is the number of samples, H1ya and Ha are the H-statistic from tables provided by Land (1975) for the UCL The UCL depends on xy, n and the...

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Valuing Traded and Non-traded Commodities in Benefit-Cost Analysis pptx

Ngày tải lên : 16/03/2014, 01:20

... commodity will be non- traded if: f.o.b price < domestic price < c.i.f price If we wanted to allow for the effect of tariffs and export taxes, we could amend the condition for non- tradeability ... consumption by a/2 units of food and (1-a)/2 units of clothing, where a lies between zero and (Why does a lie between and 1?) e.g if a=0, the loss is 0.5 unit of clothing, and if a=1, the loss is 0.5 ... before-subsidy and tax supply curve of foreign exchange (Area ABQ0Q1s under supply curve S in Figure 8.4) It is clear from Figure 8.4 that the market demand and supply curves for foreign exchange, Dt and...

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Measuring Innovation in OECD and NON-OECD Countries doc

Ngày tải lên : 16/03/2014, 11:20

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Báo cáo khoa học: Substrate recognition and ®delity of strand joining by an archaeal DNA ligase docx

Ngày tải lên : 17/03/2014, 11:20

... 72, 9142±9149 23 Sriskanda, V & Shuman, S (1998) Speci®city and ®delity of strand joining by Chlorella virus DNA ligase Nucleic Acids Res 26, 3536±3541 24 Bhagwat, A.S., Sanderson, R.J & Lindahl, ... T-DNA, and 200 nM LigTk The enzyme and other constituents of the reaction mixture were incubated separately at the desired temperature, and reactions were initiated by mixing the two solutions Standard ... 15 mM [3], and those for Mn2+, Sr2+ and Ca2+ were 25 mM, 25 mM and mM, respectively (data not shown) As little difference was found in activity levels between concentrations of mM and 25 mM,...

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Báo cáo khoa học: "CATEGORIAL AND NON-CATEGORIAL LANGUAGES" doc

Ngày tải lên : 17/03/2014, 20:20

... Aravind K Joshi, "Factoring reeursion and dependencies: an aspect of tree adjoining grammars and a comparison of some formal properties of TAGs, GPSGs, PLGs and LFGs," 21st Ann Meeting of the Assn ... Since we have Bs rule, c occurs on the left of d and all occurrences of a and b on the left of c get assigned A and B respectively Similarly all a and b on the right of c, get assigned to the complex ... Meera Blattner and Michel Latteux, " P a r i k h Bounded Languages," in Automata, Languages and Programming, LNCS 115, ed Shimon Even and Oded Kariv, Springer-Verlag, 1981 Harry R Lewis and Christos...

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Báo cáo khoa học: "Unsupervised Recognition of Literal and Non-Literal Use of Idiomatic Expressions" potx

Ngày tải lên : 17/03/2014, 22:20

... a chain linking child and play which points to the literal usage here 756 “fire AND coal” would be expanded to “fire AND coal”, “fires AND coal”, “fire AND coals”, and “fires AND coals”) The inflected ... suited for distinguishing literal and nonliteral usages, even for expressions in canonical form which tend to be largely idiomatic and would all be classified as nonliteral by the previously proposed ... knowledge base and/ or by looking at word overlap in the glosses (see Budanitsky and Hirst (2006) for an overview) Distributional approaches, on the other hand, rely on text corpora, and model relatedness...

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Reproductive Health of Urban American Indian and Alaska Native Women: Examining Unintended Pregnancy, Contraception, Sexual History and Behavior, and Non-Voluntary Sexual Intercourse ppt

Ngày tải lên : 22/03/2014, 12:20

... Tribal and Native Epidemiology Centers, and Tribal Colleges and Universities to collect data and to assure the proper distribution and utilization of findings • Resources must be identified and ... history and behavior, contraceptive use, non- voluntary sexual intercourse, and unintended pregnancies among urban AI/AN in order to help fill a need for baseline information and to better understand ... consider this publication easy to understand and use? c Yes No What would have made it easier to understand and use? How you intend to use this publication and the information it contains? (Check...

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Báo cáo khoa học: "Why Initialization Matters for IBM Model 1: Multiple Optima and Non-Strict Convexity" pptx

Ngày tải lên : 23/03/2014, 16:20

... EM-LP-32 EM-LP-128 EM-rand-1 EM-rand-8 EM-rand-32 EM-rand-128 EM-rand-1K 0.1 0.2 0.3 0.4 0.5 0.6 0.7 0.8 0.9 EM-rand-10K 32 128 1K 10K 100 83.6 77.8 67.8 52.6 30.3 non- unique c non- c 100 89.0 81.8 ... less than 95 The percent of non- unique types are reported overall, as well as only among coupled words (c.) and non- coupled words (non- c.) The last two columns show the standard deviation in test ... the end of Model training, and at iterations of HMM When random initialization is used, we run 20 random trials with different initialization, and report the min, max, and mean AER achieved in...

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