handbook of practical x ray fluorescence analysis

Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 17)

Ngày tải lên : 18/10/2013, 00:15

... treatment of angina pectoris many years ago [2]; the pharmacological e ect of the dilation of the coronary arteries was found due to the action of nitrogen monoxide produced by decomposition of alkyl ... eld of forensic toxicology. In this chapter, the methods for analysis of the compounds by headspace (HS)-gas chromatography (GC) and liquid-liquid extraction-GC are presented. Determination of ... ingestion of 10–15 mL of each alkyl nitrite causes serious methe- moglobinemia [6].  e LD 50 value for an alkyl nitrite is reported to be 205 mg/kg.  ere are not many cases of analysis of alkyl...

6
580
0

Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 67)

Ngày tải lên : 18/10/2013, 00:15

... Identification of metabolites of nerve agent VX in serum collected from victim of VX murder. J Anal Toxicol 22:383–388 3) Katagi M, Nishikawa M, Tatsuno M et al. (1997) Determination of the main ... spectrum of VX as the base peak [9], it is easy to examine the coexis- tence of VX and DAEMS by SIM measurements at m/z 114. 8.28.2 © Springer-Verlag Berlin Heidelberg 2005 II.8.2 VX and its ... 1994, VX was sprayed on the back of the neck of the victim using a syringe (the exposure amount not known); he died 10 days later. As VX poisoning symptoms, marked miosis and lowered levels of...

9
548
0

Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 20)

Ngày tải lên : 24/10/2013, 19:15

... to dryness. ii. Solid-phase extraction [10] i. A 2-mL volume of the hydrolyzed urine obtained a er step i) of the above procedure is mixed with a  xed amount of IS h , and poured into a Bond ... cannabinoids exist in the carboxylated form.  ey are easily de- carboxylated at 250 °C. d)  ere are reviews dealing with GC/MS analysis of ∆ 9 -THC-11-oic acid in human urine [15, 16]. e) A method of ... spectra of ∆ 9 -THC-11-oic acid a er the TMS and methyl ester-TMS derivatizations. GC/MS analysis of ∆ 9 -THC-11-oic acid in urine 188 Cannabinoids and their metabolites GC analysis of cannabinoids...

8
509
0

Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 21)

Ngày tải lên : 24/10/2013, 19:15

... method Qualitative analysis is made by the comparison of the retention time of a peak of a specimen with that of the authentic standard and also by the con rmation of the absence of such a peak ... the oxidoreductive potential of the hydroxyl group of the phenol moiety, it is not suitable for analysis codeine or M-3-G. For cautions and cuto values upon detection of trace levels of morphine, ... main tool for analysis of opiates and their metabolites. However, at the present time, GC/MS is being widely used for opiate analysis. For HPLC analysis of the conjugated forms of opiates, the...

12
479
0

Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 70)

Ngày tải lên : 24/10/2013, 19:15

... vortex mixed for 1 min. vi. A er centrifugation at 3,000 rpm for 2 min, 1- or 4-µL of the supernatant solution is in- jected into GC. vii.  e above procedure consists of the oxidation of nitrite ... should be worn, considering the rare accident of leakage of the mixture due to the exothermic phenomenon. However the author et al. have no experience of such accidents. References 1) Haddad LM, ... the mixture, appreciable heat is produced.  e addition of the acid should be as slow as possible, followed by airtight capping of the polypropylene tube. Upon nitri cation with vortex-mixing,...

6
489
0

Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 71 and End)

Ngày tải lên : 24/10/2013, 19:15

... rule 429 X xanthine derivatives 491 X- ray di raction pro le 635 X- ray  uorescence 42, 637, 639 XTI-5 160 xylene 149, 151 xylene isomers 150 2,4-xylenol 583 xylenol 583 Xylocaine™ 386 Xylocaine™ ... poisoning 104 hydroxyl aprenolol 373 14-hydroxy-LSD 228 4-hydroxy-3-methoxyamphetamine 230 4-hydroxy-3-methoxyethylamphetamine 238 4-hydroxy-3-methoxy- methamphetamine 230 9-hydroxymethyl-10- ... 353 hydroxyl metoprolol 373 hydroxyl oxprenolol 373 hydroxyl penbutolol 373 4-hydroxyl propranolol 373 hydroxyl propranolol 373 4-hydroxytriazolam 283, 287, 289, 290 6-hydroxywarfarin 601 7-hydroxywarfarin...

17
559
0

Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 22)

Ngày tải lên : 29/10/2013, 01:15

... and Extrelut®. b)  e Bond Elut Certify® column is composed of a mixture of non-polar phase and a cation exchanger phase; the mechanisms are reversed-phase extraction plus cation-exchanging ... polar solvent mixture of chloroform and isopropanol or ethanol should be used.  e simultaneous analysis can be made using chloroform/isopropanol (9:1) or (3:1), and using columns of Bond Elut ... conversion of amounts of EME and BE into those of cocaine Poisoning case 209 a) Procedure I (Bond Elut Certify ® ) [6–8] i. Extraction from urine and derivatization i. A 5-mL volume of urine is mixed...

12
479
0

Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 23)

Ngày tải lên : 29/10/2013, 02:15

... 15 mg of free pentazocine.  e solution is transferred to a small glass centrifuge tube with a ground-in stopper, followed by addition of several mg of solid K 2 CO 3 and 3 mL of chloroform. ... Toxicology for Clinical, Forensic and Pharmaceutical Chemists. Walter de Gruyter, Berlin, pp 707–718 10) Association of Medical Examiners, NAME, Pediatric Toxicology Registry, USA (1994) Dextromethorphan ... [8]. In this chapter, a simple method for GC/MS analysis of pentazocine in human whole blood and urine is presented. Structures of pentazocine and dextromethorphan (IS). ⊡ Figure 5.1 Reagents and...

5
428
0

Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 24)

Ngày tải lên : 08/11/2013, 01:15

... one of the most powerful hallucinogenic drugs of abuse. LSD was explosively abused in U.S.A. in the latter half of the 1960s. In Japan, the amount of seizure of LSD is much smaller than that of ... tartarate extract solutions are combined. A er the pH of the solution is adjusted to 8.5, the solution is extracted with an appropriate amount of chloroform four times.  e combined chloroform extract ... manufacturers). Developing solvents: (A) acetone/chloroform (4:1, v/v); (B) chloroform/methanol/n-hexane (4:2:1, v/v). Assessment of the method  e R f values of LSD were 0.29 with the (A) solvent system...

4
465
0

Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 25)

Ngày tải lên : 08/11/2013, 01:15

... metabolite of MDMA [6–9]. For more reliable and e ective proof of the use of MDAs, their metabolites with the cleavage of methylenedioxy rings, such as HMMA, HMA and 4-hydroxy-3-methoxyethylamphetamine, ... procedure. ii. Extraction Liquid-liquid extraction: i.  e above hydrolyzed solution is mixed with 2 mL of carbonate bu er solution (pH 10) i and extracted with 5 mL of chloroform/isopropanol ... analyses of MDAs in the forms of tablets and those for GC/MS analysis of MDAs and their main metabolites 4-hydroxy-3-me- thoxymethamphetamine ( HMMA) and 4-hydroxy-3-methoxyamphetamine ( HMA) in urine...

11
509
0

Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 26)

Ngày tải lên : 08/11/2013, 01:15

... 25-ng/ mL cutoff. J Anal Toxicol 16:107–108 8) Diosi DT, Harvey DC (1993) Analysis of whole blood for drugs of abuse using EMIT d.a.u. reagents and a Mon- arch 1000 chemistry analyzer. J Anal Toxicol ... gentle streams of nitrogen at room temperature. ii. A 1-mL volume of blank blood or distilled water is added to each test tube and mixed on the vortex mixer h . iii. Each mixture is then processed ... Phencyclidine-related deaths: a report of nine fatal cases. J Anal Toxicol 3:199–201 253 10) ElSohly MA, Lee LF, Halzhauer LB et al. (2001) Analysis of urine samples in cases of alleged sexual assault: case history....

12
492
0

Tài liệu Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 27) ppt

Ngày tải lên : 15/12/2013, 12:15

... solution b . Many of the phenothiazine drugs are in the forms of hydrochloride salt. For example, to prepare 1 mg/mL solution of the free form of chlorpromazine, the amount of chlorpromazine ... concentrations of the compound are prepared to construct a calibration curve, consisting of drug concentration on the horizontal axis and of peak area ratio of a drug to IS on the vertical axis.  ... appropriate amount of IS, 3 mL distilled water and 0.5 mL of 1 M sodium bicarbonate solution. A er well mixing, the mixture is centrifuged at 3,000 rpm for 10 min. For IS, one of other phenothiazine...

7
458
0

Tài liệu Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 28) pptx

Ngày tải lên : 15/12/2013, 12:15

... volume of urine or blood, 0.05 mL IS and 0.5 mL of 1 M NaOH are placed in a 15-mL volume glass centrifuge tube with a ground-in stopper and mixed well, followed by addition of 6 mL of the mixture ... aqueous phase is again washed with 1 mL of the mixture of n-hexane/isopropanol by shaking it for 30 s. iv. A er centrifugation at 600 g for 5 min, 1.2 mL of the lower aqueous phase is transferred ... glass centrifuge tube with a ground-in stopper, followed by addition of 0.2 mL of 1 M NaOH and 1 mL of the n-hexane/isopropanol mixture, and vigorous shaking for 30 s. v. A er centrifugation at...

8
592
0

Tài liệu Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 29) ppt

Ngày tải lên : 15/12/2013, 12:15

... mobile phase (B). With the use of the Eclipse XDB-C 8 column, the peak top of nortriptyline (D) could be separated from that of amoxapine (E), but major parts of their peaks could not be separated. ... higher to enable detection of the peak of lofepramine. Poisoning cases, and toxic and fatal concentrations In > Table 3.1, the therapeutic and toxic blood concentrations of each compound are shown ... control of her respiration and circulation, but she died in spite of the in- tensive care on the second day.  e analysis of blood sampled about 15 h a er ingestion showed 71.3 µg/mL of carbamazepine,...

11
464
0

Tài liệu Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 30) doc

Ngày tải lên : 15/12/2013, 12:15

... spectra of triazolam, 4-hydroxytriazolam and α-hydroxytriazolam. ⊡ Figure 4.2 Toxic and fatal concentrations 290 Benzodiazepines Mass chromatograms of triazolam, 4-hydroxytriazolam, α-hydroxytriazolam ... the decomposition of drugs due to heat frequently takes place.  e decomposition is marked especially for oxazolam, cloxazolam, mexazolam,  utazolam and haloxazolam having oxazolo rings in their ... application of a crude specimen without any prior deproteinization process. “Internal surface reversed phase column” is one of the columns of this type. In this section, a method of LC/MS analysis of...