g— neural regulation of postprandial gallbladder motility

Báo cáo khoa học: Submembraneous microtubule cytoskeleton: regulation of microtubule assembly by heterotrimeric G proteins pptx

Ngày tải lên : 30/03/2014, 10:20

... new understanding of the mechanism of action of the anti-mitotic ⁄ anti-cancer drugs and allow for the development of new drugs that might be more effective in the treatment of cancer c-Tubulin–Gbc ... to the GDP bound form of Gia and inhibit the exchange of GDP-bound for GTP-bound Ga [73–75] These signaling partners of G proteins might also be involved in the regulation of microtubule assembly ... promote the GTPase activity of tubulin and subsequent regulation of microtubule assembly [19] Thus, the modulation of microtubule assembly by G proteins may require activation of G proteins by either...

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Báo cáo y học: " Signaling and regulation of G protein-coupled receptors in airway smooth muscle" ppsx

Ngày tải lên : 13/08/2014, 13:20

... principal effector of Gqmediated signaling Eleven different isoforms of PLC exist and exhibit distinct patterns of regulation; members of the PLCβ subfamily tend to mediate the actions of activated ... ASM, the trafficking of GPCRs to their degradation fate has not been studied in ASM cells tures and by the emergence of models of ASM phenotype regulation [27,93] Up -regulation of GPCR expression ... is often difficult in many cell types (including ASM), despite the suggestion of specific isoform expression in parallel analyses of AC mRNA levels However, expression of recombinant AC isoforms...

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Asymmetric cell division in the regulation of neural stem cell self renewel in drosophila melanogaster

Ngày tải lên : 11/09/2015, 14:32

... viii List of Figures and Table LIST OF FIGURES AND TABLES FIGURES Chapter PAGE Figure Life cycle of Drosophila melanogaster Figure Regulation of stem cell division Figure Asymmetric neural stem ... developing central nervous system (CNS) of Drosophila adopt this intrinsic regulation of asymmetric cell division to self-renew and to differentiate Figure Regulation of stem cell division A Symmetric ... to the control of proliferation and maintenance of stem cells, and how perturbation of normal stem cell behavior can lead to cancer have been key areas of research in the field of stem cell biology...

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Regulation of S Phase

Ngày tải lên : 25/10/2013, 21:20

... initiation (Fig 1) The chromatin loading of MCM2-7 depends on the loading of Cdt1 and Cdc6, which in turn depend on the loading of ORC This step- Fig Regulation of the pre-RC The pre-RC functions to ... is also co-dependent with Cdc45, Dpb11, and Sld3; binding of any of Regulation of S Phase 47 these proteins depended on the presence of the others (Kubota et al., 2003; Takayama et al., 2003) ... characterization of Xlinked mutants of Drosophila melanogaster which are sensitive to mutagens Genetics 84:485–506 Brown GW, Kelly TJ (1999) Cell cycle regulation of Dfp1, an activator of the Hsk1...

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Regulation of navigation and vessel-source pollution in the Northern Sea Route - Article 234 and state practice

Ngày tải lên : 01/11/2013, 09:20

... accompaniment of the CCGS John A 40 41 42 43 See Arts and 10 of the NSR Regulations; Arts 14 and 15 of the Economic Zone Edict; Arts and 15 of the Environmental Edict; and Art 11 of the Decree of the ... the Decree of the Council of Ministers of the USSR, June 1990, ‘On Measures of Securing the Implementation of the Edict of the Presidium of the USSR Supreme Soviet of 26 November 1984 “On Intensifying ... the NSR Regulations, as stated in Article (quoted above), include regulation of navigation, on the basis of non-discrimination These regulations are to apply to all vessels, regardless of nationality,84...

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Tài liệu Báo cáo khoa học: miRNAs and regulation of cell signaling pptx

Ngày tải lên : 14/02/2014, 19:20

... repression of their target genes Indeed, several examples of feedback regulation that involve miRNAs have been reported Below, we attempt to summarize our recent understanding of feedback regulation of ... ﬁnding that TPAinduced upregulation of miR-34a depends on the activation of the ERK signal cascade and that miR-34a downregulates MEK1, which is one of the main regulators of ERK signaling, indicates ... expression of estrogen receptor-a (ERa) is autoregulated by miR-18a, -19b and -20b, which in turn are upregulated by the activation of ERa This mechanism of regulation provides a wide range of coordinated...

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Tài liệu Báo cáo khoa học: Regulation of DNA fragmentation: the role of caspases and phosphorylation doc

Ngày tải lên : 14/02/2014, 22:20

... direct dephosphorylation of Ser112 and negative regulation of the ERK pathway via p38 MAPK, both of which lead to impaired phosphorylation of Ser112 [70] After dephosphorylation of Ser112, Ser136 becomes ... translocation of Bax and Bad to mitochondria independently of caspase activation [77,87] Phosphorylation of caspases Phosphorylation of caspases switches the cellular apoptotic signal on and off Caspase ... regulating the activity of an isoform of PP1, PP1a [3] Similarly, activation of caspase-8 and -3 is regulated through their phosphorylation and dephosphorylation Phosphorylation of caspase-8 at Tyr397...

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Tài liệu Regulation of cancer cell metabolism docx

Ngày tải lên : 15/02/2014, 04:20

... splicing The inclusion of exon in the PK mrnA leads to translation of the PKM1 isoform, whereas inclusion of exon 10 produces PKM2 (ReF 71) MyC upregulates the expression of heterogeneous nuclear ... required for the assembly of the cytochrome c oxidase complex of the electron transport chain61 Thus, the loss of p53 might also be a major force behind the acquisition of the glycolytic phenotype ... Publishers Limited All rights reserved REVIEWS of genes that increase glucose metabolism and reduce mitochondrial respiration One of these genes encodes an isoform of PDK (PDK4) that has the same function...

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Tài liệu Báo cáo khoa học: The central role of CDE/CHR promoter elements in the regulation of cell cycle-dependent gene transcription pdf

Ngày tải lên : 16/02/2014, 09:20

... general context of a promoter appears to be relevant because inversion of the site in the human Cdc25C promoter resulted in a deregulation of cell cycle-dependent transcription Deregulation is ... promoters, mutation of the CHR leads to a more pronounced deregulation than the alteration of the CDE [40] Another gene tested for its cell cycle regulation is the cellular inhibitor of apoptosis protein ... investigating downregulation of the cyclin B2 promoter is that after deletion or mutation of constitutively activating sites, such as the destruction of CCAAT-boxes, small levels of reporter activity...

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Tài liệu Báo cáo khoa học: Roles of AP-2 transcription factors in the regulation of cartilage and skeletal development doc

Ngày tải lên : 16/02/2014, 09:20

... genetic diseases [47] Most analyses of the regulation of AP-2 and the interactions of the transcription factor with binding partners, as well as of the regulation of target gene expression, have ... treatment of the chick face with RA, and this is accompanied by an increase in apoptosis [73] The authors of this study ascribe the regulation of outgrowth of limb buds and patterning of the digits ... region [17,18] Studies of earlier embryonic stages of these mice indicate a failure of cranial neural tube closure and defects in cranial ganglia development Another role of AP-2a previously masked...

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Tài liệu I MMIGRANT S MALL B USINESS OWNERS: A S IGNIFICANT AND G ROWING PART OF THE E CONOMY pdf

Ngày tải lên : 18/02/2014, 00:20

... percent of the $29 trillion total receipts of all businesses The balance of the private-sector economy— about two thirds of private-sector workers and about 80 percent of receipts—is made up of publicly ... bottom of the list of immigrant share of population (3 percent) and labor force (4 percent), but is in the top half of the 50 states plus the District of Columbia (at 20th) in the ratio of foreign-born ... distinguished professor of sociology at Hunter College and the Graduate Center of the City University of New York, and author of From Ellis Island to JFK: New York’s Two Great Waves of Immigration...

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Tài liệu Báo cáo khoa học: Regulation of the members of the mammalian heat shock factor family doc

Ngày tải lên : 18/02/2014, 04:20

... strict regulation becomes necessary for the correct expression of HSF2 target genes Indeed, when miR18-mediated regulation of HSF2 was disrupted in male germ cells in vivo, expression of HSF2 ... certain aspects of the neural development although, to date, no lucid co-localization has been reported Regulation of HSFs HSF1–HSF4: competitors and collaborators The ﬁrst example of interplay ... modiﬁcations of HSFs in different tissues and organs during development of an organism or differentiation of certain cell types This lack of knowledge severely hampers the understanding of the physiological...

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Tài liệu Báo cáo khoa học: A role of miR-27 in the regulation of adipogenesis ppt

Ngày tải lên : 18/02/2014, 08:20

... the regulation of miR-27 expression Our data suggest that the miR-27 gene family is potentially an important class of negative regulators of adipogenesis and may play a role in the regulation of ... relevant role of miR-27 in the regulation of adipose tissue functions in vivo, we examined the expression of miR-27 in the genetically obese ob ⁄ ob mice The 2352 expression levels of both miR-27a ... suggesting that downregulation of miR-27 is not sufﬁcient to promote adipogenesis We performed a time course study to gain further insights into the role of miR-27 during different stages of adipogenesis...

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Tài liệu Báo cáo khoa học: Regulation of cathepsin B activity by 2A2 monoclonal antibody docx

Ngày tải lên : 18/02/2014, 11:20

... molecular weights of 161.8, 28.2 and 13.2 kDa, respectively Regulation of cathepsin B activity The formation of the cathepsin B ⁄ cystatin C complex was seen as a shift of the elution peak of cathepsin ... the presence of various concentrations of 2A2 mAb The binding of 2A2 mAb was followed by native gel electrophoresis Increasing the concentration of 2A2 mAb at a ﬁxed molar ratio of cathepsin ... the conformational changes of the active site of cathepsin B, the results obtained in the present study provide a speciﬁc mechanism for the regulation of the activity of cathepsin B, which can...

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Tài liệu Báo cáo khoa học: Mixed lineage leukemia histone methylases play critical roles in estrogen-mediated regulation of HOXC13 docx

Ngày tải lên : 18/02/2014, 14:20

... level of MLL1 mRNA Interestingly, upon downregulation of MLL1, E2-mediated upregulation of HOXC13 was slightly decreased (Fig 4A, lane 3) Similar results were observed for MLL2 and MLL4 downregulation ... ERE2, ERE3 and ERE4 of the HOXC13 promoter As seen in Fig 5A, no significant binding of actin was observed in any of the EREs, irrespective of the absence and presence of E2 Binding of ERa and ERb ... amount of binding of MLL1 was observed in ERE3, no significant E2-dependent binding of any of the MLLs was observed in ERE3 and ERE4 (Fig 5A, lanes 5–8) Significant amounts of constitutive binding of...

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Tài liệu Báo cáo khoa học: Regulation of dCTP deaminase from Escherichia coli by nonallosteric dTTP binding to an inactive form of the enzyme ppt

Ngày tải lên : 18/02/2014, 16:20

... with dCTP (grey) and dTTP (yellow, cyan and magenta) (B) Stereoview of a superposition of one of the subunits of the E138A variant of E coli dCTP deaminase in complex with dTTP (yellow; chain B), ... Mutational analysis of amino acid residues involved in dTTP regulation of dCTP deaminase The design of the mutant enzymes H121A and V122G was inspired by the results from analysis of crystal structures ... roles of His121 and Val122 in catalysis and regulation of dCTP deaminase Removal of the imidazole ring in H121A was anticipated to relieve or reduce inhibition by dTTP by preventing expulsion of...

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Tài liệu Báo cáo khoa học: Osmosensing and signaling in the regulation of mammalian cell function docx

Ngày tải lên : 18/02/2014, 16:20

... swelling-induced inhibition of proteolysis in perfused rat liver J Nutr 126, 395–402 Haussinger D & Schliess F (1999) Osmotic induction of ¨ signaling cascades: role in regulation of cell function Biochem ... activation of the p38-type MAPK and thereby inhibition of 5800 autophagic proteolysis [14] Thus, integrin-dependent cell volume sensing and signaling integrates into the overall context of insulin ... of 3T3 ﬁbroblasts to growth factors [17,18] Activation of Na+ ⁄ K+ ⁄ 2Cl– cotransport via NKCC1 was shown to be essential for cell cycle progression in 3T3 ﬁbroblasts [17,19] The importance of...

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Tài liệu Báo cáo khoa học: Down-regulation of reduced folate carrier may result in folate malabsorption across intestinal brush border membrane during experimental alcoholism docx

Ngày tải lên : 18/02/2014, 16:20

... malabsorption of folate was observed over the entire course of ethanol treatment of months Determination of the kinetic constants of [3H]folic acid uptake in BBMVs V(pmol/30 sec/mg protein) The effect of ... primary absorptive site of folic acid, i.e the small intestine Expression of the RFC protein in BBM of the intestine The effect of chronic alcoholism on the level of expression of the RFC protein ... expression of a major folate transporter, RFC, was studied The investigation of the regulation of folate transport via RFC expression in absorptive epithelia may aid in the development of future...

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Tài liệu Báo cáo khoa học: Redox regulation of dimerization of the receptor proteintyrosine phosphatases RPTPa, LAR, RPTPl and CD45 pdf

Ngày tải lên : 18/02/2014, 17:20

... role of oxidation in dimerization of a panel of four different RPTPs We compared four RPTPs from different subtypes, i.e RPTPa, RPTPl, CD45 and LAR We found that the cytoplasmic domains of these ... ectodomains of LAR and RPTPl may drive homophilic interactions [35–38] To remove contributions of the ectodomains to dimerization, we generated chimeras consisting of the extracellular domain of RPTPa ... consequence of 2600 oxidation of the catalytic site cysteines Taken together, these limited tryptic proteolysis suggest that oxidation induced a change in conformation of the intracellular domain of this...

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Tài liệu REGULATION OF MOTOR VEHICLE REPAIRS ppt

Ngày tải lên : 19/02/2014, 04:20

... replaced as the result of a collision "Department" means the department of commerce and consumer affairs "Hydrochlorofluorocarbon" or "HCFC" means any member of the family of substances containing ... the certification tests in any or all of the certification specialties set forth in this chapter "Chlorofluorocarbon" or "CFC" means any member of the family of substances containing carbon, fluorine, ... incidence of fraud or deceptive practices, or involves a part of the vehicle essential to its safe operation §437B-2 Applicability of chapter This chapter does not apply to: (1) Employees of the...

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