guided trojan horse for systemic oncolytic virus delivery

Báo cáo sinh học: " Clostridial spores as live ''''Trojan horse'''' vectors for cancer gene therapy: comparison with viral delivery systems" pptx

... enables them to serve as "Trojan horses" for the delivery of genes for cancer therapy Indeed, clostridial spores that were genetically manipulated to harbour genes for cancerstatic factors, prodrug ... with a helper virus and then separating the helper virus with sedimentation techniques were developed Improvements in helper virus have also been trialled that reduces "floxed" helper virus production ... initiated These trials have used different vector systems for gene transfer (retrovirus and adenovirus), different routes of vector delivery (intratumoural injection and bronchial lavage), and...

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Báo cáo y học: "Bovine herpesvirus 4 based vector as a potential oncolytic-virus for treatment of glioma" pps

Danh mục: Báo cáo khoa học

... were first perfused with PBS for 15 and then with 4% formalin in PBS for 30 Brains were carefully removed, post-fixed for hours in 4% formalin in PBS, equilibrated for 24 h in 30% sucrose in PBS ... the tumour area shows the selectivity of the virus for the tumour cells and its oncolytic properties Moreover the non-replicative behaviour of the virus in the Redaelli et al Virology Journal ... affinity for the glioma cells in vivo set BoHV-4 up as a candidate for gene delivery and oncolyses to the glial tumours of the nervous system List of abbreviations BoHV-4: Bovine herpesvirus 4;...

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Oncolytic Virus – an Effective Targeting Therapy for Cancer Treatment

Danh mục: Tổng hợp

... this era using viruses as a therapy for cancer treatment including Hepatitis B virus [8], Egypt 101 virus [9], Adenovirus adenoidal pharyngeal-conjuctival virus (APC) [10], and Mumps virus [11] In ... replication and carrier cellmediated delivery of oncolytic viruses Biochim Biophys Acta, 2008 1785(2): p 217-31 Cerullo, V., et al., Chapter eight Oncolytic adenoviruses for cancer immunotherapy: data ... approval recommendation for treating melanoma in April, 2015 [19] This recommendation may lead to a great opportunity for TVEC to become the first oncolytic virus approved by FDA for widely using on...

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Tài liệu BUILDING HIGH AVAILABILITY BROADBAND NETWORKS FOR VALUE-ADDED SERVICE DELIVERY ppt

Danh mục: Phần cứng

... success for your HABN project We've completed more than 20 successful HABN ring deployments for a large U.S.based Tier carrier, making us one of the most experienced systems integrators for HABN ... specifications for each project The final document in the engineering phase is ADC's Ring Design Package (RDP), which contains all the engineering information about the ring Used for maintenance ... positions our customers for advanced services delivery ADC is a world leader in providing global network infrastructure products, services and software that enable the profitable delivery of high-speed...

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Oncolytic virus therapy

Danh mục: Sinh học

... Adeno Virus  Protects the oncolytic virus from patient immune system  (Oxford University) Oncolytic Viral Therapy: Specialized Trials  Polymer-coated Adeno Virus  Protects the oncolytic virus ... modified viruses into tumor site Oncolytic Viral Therapy: Challenges  Main challenge is patient’s own immune system killing the virus before the virus can kill the cancer  Solutions  Fast acting virus ... host) Virus: Structure  Protein shell called a capsid contains DNA  Arrangement of one or more protein fibers for bonding with host cell Virus: Structure Virus: Structure Virus: Structure Virus: ...

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Báo cáo khoa học: "A Best Practices Guided Development Environment for Information Extraction" doc

Danh mục: Báo cáo khoa học

... step forward towards enabling extractor development for novice IE developers In order to formally evaluate WizIE, we are currently conducting a formal study of using WizIE to create extractors for ... each rule, or performing certain runtime operations After 113 3.4 Delivery and Deployment Once satisﬁed with both the result quality and runtime performance, the developer is guided by WizIE’s ... user to select a type for the new rule, from predeﬁned sets for each of the three categories The types of rules exposed in each category are informed by best practices For example, the Basic...

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SAFE: An Early Warning System for Systemic Banking Risk ppt

Danh mục: Ngân hàng - Tín dụng

... distance from systemic stress) Long-lag forecasts Long-lag models allow us to forecast stress at longer horizons, which is an advantage for exante policy actions The value of a forecast with ... Center (for the return data), Compustat databases (for some structural data), and Moody’s KMV (for some risk data) We also replicate data from some publicly available models and datasets, for example, ... long-lag (six quarters or more) forecasting specifications to give policymakers enough time for ex-ante policy action, and a set of short-lag forecasting specifications for verification and adjustment...

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ACCOUNTING FOR CAPITAL PROJECTS: Financial Policies and Procedures for the Capital Project Delivery Process pptx

Danh mục: Kế toán - Kiểm toán

... Procedures for the Capital Project Delivery Process • Project Initiation • Procedures for Design and Construction • Other Accounting Procedures • UCONN 2000 Project Audits Procedures for Design ... evaluation committee Procedures for Design and Construction There are two main forms used to initiate a purchase order: Contract Approval Request (CAR) This form is used for any new contract Approval ... Tammie Corioso Accountant Financial Policies and Procedures for the Capital Project Delivery Process • Project Initiation • Procedures for Design and Construction • Other Accounting Procedures...

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creationism's trojan horse the wedge of intelligent design

Danh mục: Sinh học

... Creationism’s Trojan Horse This page intentionally left blank Creationism’s Trojan Horse THE WEDGE OF INTELLIGENT DESIGN Barbara Forrest & Paul R Gross 2004 Oxford New York Auckland ... Copyright © 2004 by Oxford University Press, Inc Published by Oxford University Press Inc., 198 Madison Avenue, New York, New York 10016 www.oup.com Oxford is a registered trademark of Oxford University ... Library of Congress Cataloging-in-Publication Data Forrest, Barbara, 1952– Creationism’s Trojan horse : the wedge of intelligent design / by Barbara Forrest, Paul R Gross p cm Includes bibliographical...

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Báo cáo sinh học: " An immunocompromised BALB/c mouse model for respiratory syncytial virus infection" potx

Danh mục: Điện - Điện tử

... β-actin forward: 5'-GAC ATG GAG AAG ATC TGG CAC-3'; reverse: 5'-TCC AGA CGC AGG ATG GCG TGA -3' All PCRs were denatured at 95°C for min, annealed at 56°C for 30 sec, and extended at 72°C for for ... incubated at 37°C for 72 hours, after which the overlay was removed Following incubation, the cells were fixed in cold 80% methanol for hours, blocked with % horse serum in PBS at 37°C for 30 min, ... diluted 1:400 for hour at 37°C Secondary antibody staining and substrate reactions were performed using the Vectastain ABC Kit (Vector Laboratories) and diaminobenzidine in H2O2 (Pierce, Rockford, IL)...

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Báo cáo sinh học: " Comparison of amplification enzymes for Hepatitis C Virus quasispecies analysis" docx

Danh mục: Điện - Điện tử

... for increased HMR for Taq amplified HALT-C samples as well as for HMR and complexity scores for HCV/HIV coinfected samples Based on the current results, it would Page of 11 (page number not for ... 0.4113, p < 0.0001 for diversity, and R-squared: 0.311, p < 0.001 for complexity; Spearman's rank correlation test: r= 0.68, p < 0.0001 for diversity, and r = 0.47, p < 0.01 for complexity) Figure ... the complexity scores for the 20 HALT-C patients analyzed by both enzymes The average HMR for Taq amplified samples was 0.9845 (range 0.9047–0.9993), while the average HMR for the HF-2 enzyme was...

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Báo cáo sinh học: " Development of an improved microneutralization assay for respiratory syncytial virus by automated plaque counting using imaging analysis" pdf

Danh mục: Điện - Điện tử

... at 100 µl/well Plates were incubated at 37°C, 5% CO2 for days to allow for plaque formation Conventional staining and plaque determination for RSV neutralization Cells infected on transparent ... white opaque tissue culture plates (BD Falcon, Bedford, MA) for automated counting and on transparent 96-well plates (Corning-Costar, Corning, NY) for manual plaque counting 1–3 days prior to infection ... inoculum The serum /virus mixtures were incubated at 37°C, 5% CO2 for h Vero cell monolayers, prepared in 96 well plates, were infected with 50 µl/well (in duplicate) of the serum /virus mixture Plates...

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báo cáo hóa học:" An immunocompromised BALB/c mouse model for respiratory syncytial virus infection" pdf

Danh mục: Hóa học - Dầu khí

... β-actin forward: 5'-GAC ATG GAG AAG ATC TGG CAC-3'; reverse: 5'-TCC AGA CGC AGG ATG GCG TGA -3' All PCRs were denatured at 95°C for min, annealed at 56°C for 30 sec, and extended at 72°C for for ... incubated at 37°C for 72 hours, after which the overlay was removed Following incubation, the cells were fixed in cold 80% methanol for hours, blocked with % horse serum in PBS at 37°C for 30 min, ... diluted 1:400 for hour at 37°C Secondary antibody staining and substrate reactions were performed using the Vectastain ABC Kit (Vector Laboratories) and diaminobenzidine in H2O2 (Pierce, Rockford, IL)...

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báo cáo hóa học:" Development of an improved microneutralization assay for respiratory syncytial virus by automated plaque counting using imaging analysis" pptx

Danh mục: Hóa học - Dầu khí

... at 100 µl/well Plates were incubated at 37°C, 5% CO2 for days to allow for plaque formation Conventional staining and plaque determination for RSV neutralization Cells infected on transparent ... white opaque tissue culture plates (BD Falcon, Bedford, MA) for automated counting and on transparent 96-well plates (Corning-Costar, Corning, NY) for manual plaque counting 1–3 days prior to infection ... inoculum The serum /virus mixtures were incubated at 37°C, 5% CO2 for h Vero cell monolayers, prepared in 96 well plates, were infected with 50 µl/well (in duplicate) of the serum /virus mixture Plates...

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Báo cáo khoa học: "Comparative efficacy of standard AGID, CCIE and competitive ELISA for detecting bluetongue virus antibodies in indigenous breeds of sheep and goats in Rajasthan, India" potx

Danh mục: Báo cáo khoa học

... compared the relative performance of cELISA Comparative efficacy of standard AGID, CCIE and cELISA for bluetongue Table Comparative efficacy of serological tests used for detection of antibodies ... bluetongue virus Am J Vet Res 1969, 30, 33-41 Lunt RA, White JR, Blacksell SD Evaluation of a monoclonal antibody blocking ELISA for the detection of group-specific antibodies to bluetongue virus ... Shringi Table Details of local breeds of sheep screened for presence of antibodies against BTV using standard AGID test Breed accounting for 20 per cent of the total global livestock (3) The Rajasthan...

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Trojan horse Con ngựa thành Troia phần mềm ác tính ppt

Danh mục: An ninh - Bảo mật

... Agobot Trojan AHC Trojan AHomePCSafety Aibolit Trojan Aid Trojan AIDS Information Trojan Ailati Trojan AIM Robber AIM Thief AimFrame Ajan Trojan Ajax Trojan Akuan Trojan Aladino Trojan Alarm Trojan ... Amanda Trojan Ambush Trojan AMG Trojan Amri Trojan AmysHorse Anakha Trojan Anaphylaxis Trojan Andromeda Trojan Androv Trojan Angelfire Anger Anime Trojan Animoo Anits Annihilation Trojan Annoyer Trojan ... truyền Trojan horse LIST OF TROJANS PARASITES : "Warning! Fatal error:" wallpaper 007 Shell 1440 Trojan 1648 Trojan 1840 trojan 1999 Trojan 3B Trojan 3DStars Trojan 3Trojans 3x Backdoor 4112 Trojan...

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Báo cáo y học: "Hematopoietic stem cell transplantation for systemic lupus erythematosus" ppsx

Danh mục: Báo cáo khoa học

... transplantation for severe systemic lupus erythematosus of long duration Lupus 1997, 6:545-548 Burt RK, Traynor A, Ramsey-Goldman R: Hematopoietic stemcell transplantation for systemic lupus erythematosus ... and susceptible to opportunistic infections Patients should be screened for cardiac symptoms, for avascular necrosis and for occult infection prior to registration In addition, aggressive antiviral, ... such as renal or pulmonary insufficiency, is considered a contraindication for HSCT among patients with malignancies For patients with SLE, in contrast, since organ compromise is due to lupus,...

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Báo cáo y học: " Biomarkers for systemic lupus erythematosus: has the right time finally arrived" pdf

Danh mục: Báo cáo khoa học

... tools in informatics are making it possible to fuel the search for biomarkers for SLE (for example) rapidly and with nuance Rather than looking for articles using the same key words, or for bibliographic ... probed for the co-occurrence of terms of interest in an iterative and indirect fashion By such strategies, it is now possible to make links that might not be intutitively obvious, links for which ... not communicated [2] Potentially informative biomarkers in SLE have been identified by using the traditional methods by Illei and colleagues, but current efforts are seeking to reproduce and...

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Báo cáo khoa học: "The "Win-Win" initiative: a global, scientifically based approach to resource sparing treatment for systemic breast cancer therapy" pdf

Danh mục: Báo cáo khoa học

... availability of resource sparing Breast Cancer Systemic Therapy (BCST) and hope that such strategy may meet the demand for effective, affordable breast cancer care for patients who would otherwise be left ... not for citation purposes) World Journal of Surgical Oncology 2009, 7:44 http://www.wjso.com/content/7/1/44 • Formation of a collaborative task force group that aims at more availability and affordability ... opened for innovative scientific thoughts and ideas that could lead to cost effective systemic treatment for more breast cancer patients in LMCS • To develop a strategy to coordinate ongoing efforts...

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