... solving problems The book is also a must-have for instructors wishing to enrich their teaching with some carefully chosen problems and for individuals who are interested in solving difficult problems ... chosen lying in the interval (A− n , A n ) Since a is a limit point, such an xn can √ √ be found, and since A n →∞ and A− n →0, we deduce that every xn eventually is √ √ included in an interval ... are useful in many applications (see, e.g., Carleman’s inequality in the next section) We illustrate here this result to deduce an interesting inequality involving positive numbers We point out...
... 42 43 inadvancedcancer patients of a diversified prime-and-boost vaccination protocol using recombinant vaccinia virus and recombinant nonreplicating avipox virus to elicit anti-carcinoembryonic ... cancer patients Many clinical trials have been conducted using active specific immunotherapy (ASI) in CRC, including autologous tumor cell vaccines, define-tumor protein vaccines, monoclonal antibodies ... suspected minimal residual colorectal cancer (suspected minimal residual CRC), and reviewed the objective clinical outcomes of ASI inadvanced colorectal cancer (advanced CRC) during the past...
... probably could introduce new insight into clinical practice to assure better clinical outcomes By comparing the gene expression patterns of gefitinib sensitive and gefitinib resistant lung cancer, Balko ... lung cancer Ann Oncol 2007; 18(1): 99-103 Sequist LV, Martins RG, Spigel D, et al First-Line Gefitinib in Patients With Advanced Non-Small-Cell Lung Cancer Harboring Somatic EGFR Mutations J Clin ... factor receptor and in KRAS are predictive and prognostic indicators in patients with non-small-cell lung cancer treated with chemotherapy alone and in combination with erlotinib J Clin Oncol 2005;...
... debulking in patients with advanced epithelial ovarian cancer has been compared with chemotherapy and interval debulking in different studies Equal survival has been reported in patients undergoing ... with advanced epithelial ovarian cancerIn America 95% of patients with advanced epithelial ovarian cancer are treated with primary surgery [15] Regarding that residual tumor is more than cm in ... indications have not yet determined A critical point in order to define indications of neoadjuvant chemotherapy for advanced ovarian cancer is determination of uniform selection criteria that can...
... detailed investigation Our results showed that there was a single route leading to a single SN in 68% of the patients, multiple routes leading to a single SN in 4%, a single route leading to multiple ... Vries J: Lymphatic mapping with intralesional tracer administration in breast carcinoma patients Cancer 2000, 88:2546-2552 Leong SPL: Selective sentinel lymph node mapping and dissection for ... report our findings to date regarding the clinical efficacy and problems associated with SN identification by the combination of CTLG and a dye-guided method Patients and methods All studies in this...
... approach in patients with advanced hypopharyngeal cancer Concerning the radiotherapy technique in the treatment of hypopharyngeal cancer, we recommend the adoption of IMRT in the routine clinical ... routine laboratory studies Patients were staged according to the 2002 criteria of the American Joint Committee on Cancer [26] Written informed consent was obtained from the patients for including ... structures by using IMRT are reasonably expected to enable improvement in locoregional control inadvanced hypopharyngeal cancer The improvement of locoregional control inadvanced head and neck cancer...
... using a mouse model [62] Preclinical application of RNAi therapy against PLK-1 in a murine advanced lung cancer model Here we introduce an application of PLK-1 siRNA against an advanced lung cancer ... damage [19,39-41] PLK-1 has an N-terminal serine/threonine protein kinase domain and two polo box domains at the C-terminal region Polo box domains regulate the kinase activity of PLK-1 [21,42] PLK-1 ... an N-terminal helicase domain, an RNA-binding Piwi/Argonaute/Zwille (PAZ) domain, two tandem RNAse III domains, and a dsRNA-binding domain [26,27] Mammals and nematodes have only a single Dicer,...
... positive staining of p53 in a representative case of high-grade (G3) ductal carcinoma Immunostaining shows a clear and wide nuclear staining in an high grade (G3) invasive ductal carcinoma Original ... categories: no staining, or weak staining in fewer than 10% of the tumor cells (0); weak staining in part of the membrane in more than 10% of the tumor cells (1+); complete staining of the membrane ... of cancer and the second leading cause of cancer death in women in the USA [1] and its incidence is increasing in many countries, including Italy [2] thus representing a major health problem To...
... hemoglobin (Hgb) ≥9.0 g/dL, and platelets ≥100,000/mm ; bilirubin ≤1.5 mg/dL, aspartate aminotransferase ≤40 IU/L; creatinine clearance >55 mL/minute The written informed consent was obtained from ... prime vaccine and a single boost were given fifteen days apart For each dose of vaccine, two aliquots were prepared in separated syringes with saline solution (500 μl/dose) containing × 107 cells ... lung cancer vaccine therapy: a concise review J Clin Oncol 2005, 23:9022-9028 Estimativa 2010 - Incidência de Câncer no Brasil - 2010 - INCA [http:// www.inca.gov.br/estimativa/2010/index.asp?link=tabelaestados.asp&UF=BR]...
... months [49] Paclitaxel-carboplatin-gemcitabine triplet was investigated in two phase II trials involving patients in the first line in one trial, and in 1st/2nd lines in another trial ORRs and CR ... cell carcinoma and in the second line treatment of GIST (gastrointestinal stromal tumors) after failure of imatinib Sunitinib has been tested in bladder cancer as single agent, in combination ... treatment in first line and second line in different metastatic tumors In bladder TCC, bevacizumab (15 mg/kg on day 1) was evaluated in first line treatment in combination with GC protocol (gemcitabine...
... sites in terms of immunogenicity, safety and preliminary efficacy of CimaVax-EGF inadvanced NSCLC patients In both clinical trials, patients started vaccination month after finishing first line ... decrease of circulating EGF after vaccinating with higher dose at multiple sites Previously, in mice, an EGF vaccine dose resulting suboptimal when administered at a single site, induced a robust ... for each vaccine in the clinical setting Even though we have preliminary evidences of improved immunogenicity and clinical benefit of the new vaccination approach, the definitive information will...
... and GGT activity TCE administration TCE administration significantly increased urea (P < 0.001) and creatinine (P < 0.01) levels in rats (Table 1) Administration of TCE induced a marked oxidative ... were inserted into the EPR of quartz tubes and measured at suitable instrument parameters The peak height of the radiation-induced EPR signals was determined for each sample The reading intensities ... utilization of protein thereby increasing the urea level that is accompanied by an increased creatinine level suggested by Mostafa [33] Table 1: Effects of KT and TCE administration on serum...
... determine the initial velocity of DMPO-OH generation precisely The amount of DMPO-OH increased gradually with time after mixing, and the initial velocities of DMPO-OH generation increased in both ... radical generation in water containing humic acid during ozonation 20-60 µM of aqueous ozone was rapidly mixed with DMPO solution containing humic acid at room temperature After mixing aqueous ozone ... rapid data acquisition systems in order to analyze the initial velocity of OH radical generation more precisely The DMPO solution containing 3-chlorophenol or resorcinol in phosphate buffer (0.1 M,...
... rephrasing, improvising, discarding, avoiding, foreignizing, paraphrasing, mining of a word, and clarifyingin order to express oneself and comprehend others In short, speakers are required to incorporate ... analyzed in terms of routines, which are conventional ways of presenting information In Bygates opinion, there are two kinds of routines They are information routines and interaction ones Information ... Interaction routines are routines based not so much on sequences of kinds of terms occurring in typical kinds of interactions These routines, thus, can be characterized in broad terms including...