genetic variation in inflammatory responses to luminal antigens
Is Lactobacillus GG Helpful in Children With Crohn’s Disease? Results of a Preliminary, Open-Label Study docx
... multi-item index including subjective reporting of abdominal pain, general well-being, and diarrhea and physical findings, including linear growth and laboratory parameters (hematocrit, serum albumin, ... function could allow luminal bacterial antigens to initiate a chronic relapsing inflammation Several studies have shown an increased intestinal permeability for various sugar molecules in patients with ... intestinal inflammatory response is the result of an exaggerated intestinal host immune response to commensal enteric bacteria or their components in genetically predisposed individuals A defect in mucosal...
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Infliximab therapy in pediatric Crohn’s disease: a review docx
... proinflammatory cytokine, TNF-α must be firmly regulated; and failure to so, allows for an unmediated inflammatory response.20 In patients with CD, TNF-α is highly localized to the intestinal ... animal models Indeed, the proinflammatory cytokine TNF-α is known to play an important role in CD,19 and has led to the development of several novel treatment strategies, including infliximab TNF-α ... drugs, including methotrexate, azathioprine (AZA, and 6-mercaptopurine (6-MP) are all effective in maintain disease remission in 40% to 65% of patients with corticosteroid-dependent moderate to severe...
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Báo cáo Y học: Structural study on lipid A and the O-specific polysaccharide of the lipopolysaccharide from a clinical isolate of Bacteroides vulgatus from a patient with Crohn’s disease ppt
... coupling from H1-a to C3-b showed that residue a was linked to O3 of residue b Coupling from H1-b to C4-a indicated that residue b was linked to O4 of residue a Interresidual cross-peaks in ROESY ... observed in the methylation analysis, OPS had a linear structure Thus, the nonsubstituted Rha was estimated to be located at the nonreducing terminus of the OPS chain Taking these observations into ... LPS in the induction of cytokines, including tumor necrosis factor, and the phosphate residue at the 4¢-position is a critical site for the activity [24] Therefore, the monophosphoryl lipid A in...
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CROHN''''S DISEASE pdf
... intestinal mucosal fibroblasts to profibrogenic cytokines in inflammatory bowel disease Inflamm Bowel Dis, Vol.7, No.3, (pp 226-236, Lohi J (2001) Laminin-5 in the progression of carcinomas Int ... Considering that changes in BM composition under inflammatory conditions are mainly observed in the lower part of the crypt (Fig 3), our laboratory investigated the effect of proinflammatory cytokines ... TNF/IFN combination in human intestinal crypt cells on laminin production suggesting a TGF-independent mechanism (Francoeur et al 2004) In summary, the two proinflammatory cytokines TNF and...
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Báo cáo sinh học: "Mycobacterium avium subsp. paratuberculosis linked to Crohn''''s Disease and Paratuberculosis" pot
... of >2 μg/ml for bovine and animal isolate Rifabutin MIC was very similar to rifampin Also ethambutol generated a MIC of 2–8 μg/ml in human strains and 4–16 μg/ml in animal strains The highest MIC ... 4 16 32 16 STR: Streptomycin, CPX: Ciprofloxacin, EMB: Ethambutol, DPS: Dapsone, RIF: Rifampin, RIB: Rifabutin, CLA: Clarithromycin Source of isolation of strains is also indicated Numbers represent ... μg/ml in both animal and human strains, for ciprofloxacin it was at 0.5–16 μg/ml, independently of the source of isolation, while rifampin produced a MIC of 0.5–1 μg/ml in human and bovine strains...
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Báo cáo y học: "Adalimumab - an effective and promising treatment for patients with fistulizing Crohn’s disease: a case series" pdf
... maintenance of remission in adult patients with moderate to severe CD (luminal and/or fistulizing), who are refractory to conventional therapy or intolerant to infliximab [3-5] In the ACCENT II trial, ... for the induction and maintenance of remission in patients with moderate to severe CD, and safe and efficacious in regaining a medical response in patients intolerant or non-responsive to infliximab ... upon oral feeding An endoscopic examination revealed linear, deep ulcers with edematous margins in his ascending colon, cecum, ileocecal valve and terminal ileum A histologic examination revealed...
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Báo cáo y học: "Perforated Meckel’s diverticulum presenting with combined bowel and urinary obstruction and mimicking Crohn’s disease: a case report" pps
... and painful urination, in addition to the presenting complaints He denied having a fever, but did complain of night sweats A physical examination revealed a tall, thin man in no acute distress ... tip, attached to the small intestine Complications in patients with Meckel’s diverticulum are rare; most patients remain asymptomatic for life [3] In both adults and children, intestinal obstruction ... http://www.jmedicalcasereports.com/content/4/1/264 sensitivity without intraluminal opacification [11] In our patient, the CT findings of terminal ileal thickening, an ileocecal fistula, and a pelvic abscess increased the suspicion for...
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Báo cáo y học: "Perforated Meckel’s diverticulum presenting with combined bowel and urinary obstruction and mimicking Crohn’s disease: a case report" doc
... and painful urination, in addition to the presenting complaints He denied having a fever, but did complain of night sweats A physical examination revealed a tall, thin man in no acute distress ... tip, attached to the small intestine Complications in patients with Meckel’s diverticulum are rare; most patients remain asymptomatic for life [3] In both adults and children, intestinal obstruction ... http://www.jmedicalcasereports.com/content/4/1/264 sensitivity without intraluminal opacification [11] In our patient, the CT findings of terminal ileal thickening, an ileocecal fistula, and a pelvic abscess increased the suspicion for...
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Báo cáo y học: "Acute panuveitis with hypopyon in Crohn''''s disease secondary to medical therapy: a case report." pptx
... the case in this subject[9] Previous studies reported pharmacokinetic interactions when combining rifabutin and clarithromycin leading to an increase in rifabutin levels, resulting in an increase ... cyclopentolate 1% twice daily The patient discontinued rifabutin, pending rheumatology review the following week Within three days, the hypopyon had reduced to mm and the vision had improved to 6/9 in ... reducing course of dexamethasone was instituted One week after discontinuing rifabutin and clarithromycin, azathioprine 50 mg twice daily was restarted by his rheumatologist At weeks, the IOP in...
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Báo cáo y học: "Association of the T allele of an intronic single nucleotide polymorphism in the colony stimulating factor 1 receptor with Crohn''''s disease: a case-control study" ppt
... cells being sloughed off into intestinal lumen staining most vividly (Figure 1A,1B,1C) Examination of the intracellular staining pattern revealed a characteristic staining pattern with the terminal ... protein might play in cytoskeletal regulation in either mononuclear cells or in intestinal epithelial cells the intestine as well as its expression pattern and pathogenic role in inflammatory ... that were being sloughed into the lumen Because of this superficial location of staining, it is tempting to hypothesize that the CSF1R protein plays a role in differentiation of intestinal epithelial...
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Báo cáo y học: "Granulomatous cheilitis associated with exacerbations of Crohn''''s disease: a case report" potx
... lips, secondary to an underlying granulomatous inflammatory process Granulomatous cheilitis is the histopathological description of such inflammation occurring in the lips and surrounding tissues ... and includes oral ulceration, labial, buccal and gingival swelling, buccal abscesses, mucosal inflammatory hyperplasia, mucosal tags and fissuring, gingivitis, granulomatous inflammation of minor ... secondary to an underlying granulomatous inflammatory process It is a heterogeneous clinical condition that presents with chronic swelling of the oral or facial tissues due to granulomatous inflammation...
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Báo cáo y học: "Colonic adenocarcinoma revealing Crohn''''s disease: a case report Case report" pdf
... those of the underlying disease, the recognition of cancer arising in an inflamed bowel becomes difficult Thompson et al [12] recognized the occult nature of intestinal cancer in Crohn's disease ... risk of colonic cancer in Crohn's disease is lower compared to that expected in the general population, vigilance is appropriate while watching over patients with inflammatory large bowel disease ... http://www.jmedicalcasereports.com/content/4/1/167 Page of Figure Histological examination of the specimen revealing adenocarcinoma of the colon sigmoid Figure Pre-operative abdominal scan showing the sigmoid process ation or the...
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báo cáo khoa học: " Musings on genome medicine: Crohn’s disease" potx
... detected, including NOD2 (nuclearbinding oligomerization domain containing 2; usually associated with structuring disease), IL23R (receptor for interleukin 23) and PTPN2 (protein tyrosine phosphatase ... residing in the gut In this model, CD is seen as a disorder arising from both the environment (including micro-organisms, smoking and ‘stress’) and one’s individual reactive genotype, including variations ... Steinhart AH, Targan SR, Vermeire S, Warren BF: Toward an integrated clinical, molecular and serological classification of inflammatory bowel disease: Report of a Nathan and Orkin: Genome Medicine...
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Báo cáo y học: "A 47-year-old man with neuro-Sweet syndrome in association with Crohn’s disease: a case report" ppsx
... disease in which in addition to the skin, parts of the central nervous system (CNS) are affected by an aseptic neutrophilic inflammation Again, other organs including liver and kidneys may be involved ... dermatosis (Sweet’s disease.) On days 4-6 of admission, his symptoms started to improve He was still having headaches and spiking temperatures of up to 38.9°C in the evenings but the skin lesions ... first-line systemic treatments are potassium iodide and colchicine Second-line agents include indomethacin, cyclosporine and dapsone Conclusion This is a case of aseptic meningitis secondary to neuroSweet...
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Báo cáo y học: "Sweet''''s syndrome in a patient with Crohn''''s disease: a case report" pot
... criteria are 1) skin lesions preceded by a nonspecific respiratory or gastrointestinal tract infection, vaccination or associated with inflammatory diseases such as autoimmune disorders, infections, ... understood Cytokines, such as granulocyte colony stimulating factor (G-CSF), interleukin (IL)-1, IL-6, or IL-8, if deposited in the dermis, may be responsible for the immunopathologic and clinical ... ovarian, vaginal squamous cell, genitourinary and gastrointestinal malignancies Viral infections Chronic active hepatitis, cytomegalovirus, human immunodeficiency virus Bacterial infections Streptococcus,...
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Báo cáo y học: " Takayasu''''s arteritis associated with Crohn''''s disease: a case report" pot
... showed no lesion in the oesophagus, stomach, or small intestine including the terminal ileum and cecum Abdominal CT scan showed thickening of the abdominal aorta (4 mm) and narrowing of renal arteries ... compromise intestinal vessels Therefore, it may present with gastrointestinal bleeding and exacerbate the clinical course of patients with inflammatory bowel disease Clinical suspicion, proper imaging, ... http://www.jmedicalcasereports.com/content/2/1/87 because TA can compromise intestinal vasculature and may present with gastrointestinal bleeding, complicating the diagnosis and perhaps exacerbating the clinical course of patients with...
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Báo cáo y học: "Chronic cough associated with Crohn’s disease" pdf
... observed in UC, predominates in women and more common in non-smokers Interestingly flare up of bronchiectasis has been observed within a year following colectomy [4,5] This transfer of the inflammatory ... demonstrating infiltrates in both the apices Discussion and conclusion The Inflammatory Bowel Diseases (IBD), Ulcerative Colitis (UC) and Crohn’s disease (CD), are known to have multiple extra intestinal ... prednisolone to which he responded very well However stopping prednisolone resulted in a relapse of his symptoms necessitating a small maintenance dose along with inhaled budesonide He remains well...
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báo cáo hóa học: " Identification of symptom domains in ulcerative colitis that occur frequently during flares and are responsive to changes in disease activity" ppt
... symptom domains Flow diagram of 28 symptom domains in questionnaire and criteria for determining frequent and responsive symptom domains Sixteen symptom domains were included from commonly used indices ... clinical trials, including molecules targeting interleukin 12, interleukin 17, and endothelial integrins The efficacy of UC therapies in clinical trials is assessed with disease activity indices that ... 86.7 tom domain stool mucus are presented in Figure In this symptom domain, 48 of 60 individuals had a VAS rating greater than 50 mm for the first endpoint ("present during flare"), 46 of 53 individuals...
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Báo cáo khoa hoc:" Complicated Crohn''''s-like colitis, associated with Hermansky-Pudlak syndrome, treated with Infliximab: a case report and brief review of the literature" pot
... azathioprine 100 mg/daily Within 72 hours this treatment led to improvement in symptoms The patient had soft tools without blood and only minimal pain and drainage from the fistula She again received ... healing of linear ulcers in sigmoid colon (8 weeks after the initial dose of infliximab) Improvement of edema and healing of linear ulcers in sigmoid colon (8 weeks after the initial dose of infliximab) ... including sulfasalazine, mesalamine, corticosteroids and antibiotics, such metronidazole and ciprofloxacin [3] In some cases surgical intervention is necessary, while subtotal colectomy or total...
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The Use of Selected Medicinal Herbs for Chemoprevention and Treatment of Cancer, Parkinson’s Disease, Heart Disease, and Depression
... kaempferol, myricetin Anthocyanins: cyanidin, delphinidin, malvidin, pelargonidin, petunidin, and peonidin Isoflavones: genistein, genistin, daidzein, daidzin and puerarin Lignans: podophyllotoxin, α- and ... myricetin 3-arabinoside, quercetin 3-glucoside, delphinidin 3-galactoside, delphinidin 3-glucoside, delphinidin 3-arabinoside, petunidin 3-galactoside, petunidin 3glucoside, and malvidin 3-arabinoside ... anthocyanidins, cyanidin, delphinidin, peonidin, malvidin, and petunidin), proanthocyanidins, tannins, catechin (and epicatechin, gallocatechin and epigallocatechin units), flavonols (myricetin, quercetin,...
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