genes involved in ion transport and its regulation
Báo cáo y học: "Preferential regulation of duplicated genes by microRNAs in mammals" ppt
... acquisition of microRNA-mediated regulation Considering the pervasive nature of microRNA regulation in mammalian cells, it is intriguing to inquire how the function and evolution of duplicate genes ... diverging function through comparisons of co-conservation of coding regions [7,8], shared transcriptional regulation [9,10], or similarity in protein-protein [11,12] or genetic [13] interaction ... microRNA-mediated regulation plays an important role in the regulatory circuits involving duplicate genes, including adjusting imbalanced dosage effects of gene duplicates, and possibly creating a mechanism...
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Tài liệu Báo cáo khoa học: Characterization of promoter 3 of the human thromboxane A2 receptor gene A functional AP-1 and octamer motif are required for basal promoter activity docx
... results in a strong increase in AP-1 binding to TREs [53] Prm 1and Prm3- reporter gene expression and TPa and TPb mRNA expression are up-regulated by PMA in HEL cells [25] While the site of action ... significantly increase luciferase activity directed by Prm3 subfragments containing the AP-1* mutation Moreover, preincubation of HEL cells with PMA resulted in a 2.3-fold increase in nuclear factor binding ... the preinitiation complex relies on binding of multiple general transcription factors, such as SP-1, in proximity to the transcription initiation site [28] Herein, successive 5¢-deletion of Prm3...
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Báo cáo khoa học: 15-Deoxy D12,14-prostaglandin J2 suppresses transcription by promoter 3 of the human thromboxane A2 receptor gene through peroxisome proliferator-activated receptor c in human erythroleukemia cells ppt
... stimulation Examination of PPARc ⁄ RXRa interactions within the PPRE To further investigate the identity and specificity of the DNA ⁄ protein interactions within the PPRE centred at )159 and )148 ... action on TP gene expression showing no reduction in Prm1 activity or TPa mRNA expression The reduction in TPb mRNA expression in response to 15d-PGJ2 in HEL cells was reflected in a corresponding ... PPARc-mediated inhibition, as opposed to activation, of gene expression are becoming increasingly common [16,56], transcriptional inhibition is mainly documented to involve PPARc-mediated trans-repression...
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Đề tài " Robust transitive singular sets for 3-flows are partially hyperbolic attractors or repellers " ppt
... containing Γ and tans gent to WY (σ(Y )) along Γ This connection is called inclination-flip The existence of inclination-flip connections contradicts the existence of the dominated splitting in ... splitting to all of Λ, obtaining Theorem C Theorems 3.6 and 3.7 are proved in Section The results in this paper were announced in [26] Attractors and isolated sets for C flows In this section we ... Theorem C is proved in Section We start by proposing an invariant splitting over the periodic points lying in Λ and prove two basic facts, Theorems 3.6 and 3.7, establishing uniform estimates...
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Báo cáo toán học: "A calmodulin inhibitor, W-7 influences the effect of cyclic adenosine 3'''', 5''''-monophosphate signaling on ligninolytic enzyme gene expression in Phanerochaete chrysosporium" pot
... suggesting that the increased cAMP concentration affects the transcription of genes encoding LiPs and MnPs via regulation of CaM transcription 14 Discussion Expression of all lip and mnp isozyme genes ... important role in initiating the lignin degrading reaction of the fungus, because they can cleave lignin structures extracellularly in the first step of lignin mineralization (Cullen and Kersten ... ligninolytic system in white-rot fungi could be used as a target for breeding a high lignin-degrading strain and for furthering our understanding of the lignin-degradation system in these fungi Phanerochaete...
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báo cáo hóa học:" A calmodulin inhibitor, W-7 influences the effect of cyclic adenosine 3’, 5’-monophosphate signaling on ligninolytic enzyme gene expression in Phanerochaete chrysosporium" pot
... suggesting that the increased cAMP concentration affects the transcription of genes encoding LiPs and MnPs via regulation of CaM transcription Discussion Expression of all lip and mnp isozyme genes ... important role in initiating the lignin degrading reaction of the fungus, because they can cleave lignin structures extracellularly in the first step of lignin mineralization (Cullen and Kersten ... However, a shortage of cAMP, arising from inhibition of intracellular cAMP production via CaM inhibition, may also possibly result in reducing transcription of the isozyme genes To clarify this ambiguity,...
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Báo cáo hóa học: "A calmodulin inhibitor, W-7 influences the effect of cyclic adenosine 3’, 5’-monophosphate signaling on ligninolytic enzyme gene expression in Phanerochaete chrysosporium" pptx
... suggesting that the increased cAMP concentration affects the transcription of genes encoding LiPs and MnPs via regulation of CaM transcription Discussion Expression of all lip and mnp isozyme genes ... important role in initiating the lignin degrading reaction of the fungus, because they can cleave lignin structures extracellularly in the first step of lignin mineralization (Cullen and Kersten ... However, a shortage of cAMP, arising from inhibition of intracellular cAMP production via CaM inhibition, may also possibly result in reducing transcription of the isozyme genes To clarify this ambiguity,...
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Báo cáo y học: "Community transcriptomics reveals universal patterns of protein sequence conservation in natural microbial communities" pdf
... fraction and toward genes of cell replication and growth in the less expressed fraction Additionally, this finding, in the context of our results demonstrating enhanced sequence conservation among ... acid proportion in RNA) - (Amino acid proportion in DNA))/(Amino acid proportion in DNA) × 100 Soil sample collection and DNA/RNA isolation rRNA subtraction, RNA amplification and cDNA synthesis ... (12 DNA/RNA samples × 20 amino acids), 227 (95%) involved a significant change in amino acid frequency, with 114 involving an increase and 113 involving a decrease in frequency from DNA to RNA...
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báo cáo khoa học: " Identification and characterization of flowering genes in kiwifruit: sequence conservation and role in kiwifruit flower development" ppt
... flowering and sex-determination is very scarce, yet essential to accelerate breeding and aid our understanding of flowering control in kiwifruit and woody perennial species in general Molecular and ... proteins AP3-1 and PI, as well as FUL and SEP4; weaker interactions were detected between AG and SEP4 and SEP3 and SEP4 No interactions were identified with FUL-like and SEP1 (Figure 2H) Expression ... widely observed and questioned in Antirrhinum [52,53], as well as other plants [54] In addition, this model fails to explain floral diversity seen within flowering plants, and additional models...
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Báo cáo y học: "A poxvirus Bcl-2-like gene family involved in regulation of host immune response: sequence similarity and evolutionary history" pptx
... of the C6 binding partners was programmed cell death interacting protein (PDCD6IP/ALIX), which has been involved in apoptosis regulation, cytokinesis and HIV-1 budding VACV C6 also interacted ... other hand a VACV attenuated strain with a C6L gene deletion has shown an enhanced immune response in vivo (manuscript in preparation), indicating that this protein may also be involved in the regulation ... proteins, phospholipid scramblase (PLSCR4), that participates in the regulation of the movements of phospholipids in membranes, and valosin containing protein p97/p47 complex interacting protein...
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báo cáo khoa học: " Conifer R2R3-MYB transcription factors: sequence analyses and gene expression in wood-forming tissues of white spruce (Picea glauca)" pot
... subgroups [18,30,31], including the bHLH-interaction and calmodulin-binding motifs in the DNA-binding domain [28,29], and the repression domain pdLNLD/ELxiG/S in the C-terminus [7] In our study, the ... in gymnosperm lignin biosynthesis and wood formation MYB proteins have two structural regions, an N-terminal DNA-binding domain (DBD or MYB domain) and a Cterminal modulator region that is responsible ... motifs I, K and P found in PgMYB6, and The motifs might be involved in protein or DNA interactions; however, it remains to be seen whether they play a role in protein structure or function Spruce...
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Elucidating the role of dok 3 in b cell receptor signaling using gene knockout mice 2
... (PH) and phosphotyrosine binding (PTB) domains in its amino-terminal portion, followed by many binding sites for SH2 domains The N-terminal region of Dok1 consists of a PH domain, that may be involved ... family kinases, including Lyn, Blk and Fyn, Syk and Btk tyrosine kinases, initiating complex signaling cascades involving multiple adaptors, kinases, phosphatases, G-proteins and transcription factors ... containing an N-terminal module composed of tandem pleckstrin homology (PH)-phosphotyrosine binding (PTB) domains followed by a region rich in binding motifs to Src homology (SH)2 and SH3 domains...
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Elucidating the role of dok 3 in b cell receptor signaling using gene knockout mice
... Dok-6 and Dok-7 These proteins though having different expression profiles, are structurally similar, containing tandem Nterminus Pleckstrin (PH) and Phospho-tyrosine binding (PTB) domains as ... domain binding protein Geneticin Gancyclovir Growth factor receptor-bound protein Haemagglutinin 1,3,4,5-tetrakisphosphates Immunoglobulin Interleukin Inositol 3,4,5-triphosphate Insulin receptor ... Phosphatidylinositol 4,5-bisphosphate Polymerase chain reaction Pleckstrin homology Protein kinase B Protein kinase C Phospholipase C gamma Phospho-tyrosine binding Phosphatase and tensin homolog...
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Characterization of zebrafish vitellogenin gene family for potential development of receptor mediated gene transfer method 3
... induction 86 Chapter Expression of vtgs 3.1 Introduction The major sites for Vtg synthesis in egg-laying animals (oviparous) include the fat body (in insects), intestine (in nematodes and echinoderms) ... (Leica) 3.2.7 Haematoxylin and eosin staining After dewax and rehydration, tissue sections were first stained by Haematoxylin for 8-20 Excessive staining was removed by washing in tap water for 0.5-1 ... expressions of both vtg1 and vtg2 mRNAs were detected in the liver and no vtg expression was detected in the intestine Interestingly, the expression of vtg1 and vtg2 mRNAs was also detected in the...
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The Retinoblastoma Gene Family in Cell Cycle Regulation and Suppression of Tumorigenesis
... regulated genes (Lee et al 2002) Finally, other studies have shown that pRb is involved in preventing chromosome instability by transcriptional regulation of genes involved in G2/M checkpoints such ... inhibits the transcriptional activity of E2F by binding to its carboxy-terminal transactivation domain, thereby preventing the interaction of E2F with the basal transcription machinery (Helin et ... Flemington et al 1993) However, expression of an E2F variant containing the DNA binding motif but not the pRb-binding or transactivation domain or introduction of a competitor plasmid containing...
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Tài liệu Báo cáo khoa học: The miRNA-192 ⁄194 cluster regulates the Period gene family and the circadian clock doc
... single-stranded, nonprotein-coding RNA molecules, approximately 19–25 nucleotides in length By binding to the complementary sites in the 3¢UTRs of their target genes, they can induce translational ... in comparison with the control, indicating that the sequences regulated by miR-192 ⁄ 194 indeed reside in the 3¢UTRs of the Per1–3 genes (Fig 2D) A close examination of the 3¢UTR of the Per genes ... able to maintain circadian rhythms of clock gene expression in the absence of a functional SCN [27] Therefore, it would be interesting 5452 to determine the exact role of miR-192 ⁄ 194 in these...
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Tài liệu Báo cáo khoa học: Globin gene family evolution and functional diversification in annelids ppt
... Globin ⁄ DHP Ar marina A2 Intron Intron Intron Intron Intron Intron Intron Intron Intron Intron Intron Intron Intron Intron Intron Intron Intron Intron Intron Intron Intron Intron Intron Intron ... marina Hb Intra Mb G dibranchiata mIV A ornata DHP CDS Intron Intron CDS Intron Intron Intron Intron Intron Intron Intron Intron Intron Intron CDS Intron Intron CDS Intron Intron Intron Intron Intron ... simultaneously involved the possibility for globins and linkers (proteins involved in the structure of HBL-Hb) to interact and to bind to dimers or other aggregation states while conserving functionality Indeed,...
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Tài liệu Báo cáo Y học: Divergent members of a soybean (Glycine max L.) 4-coumarate:coenzyme A ligase gene family potx
... respectively, and tailing with terminal transferase and dCTP according to the manufacturer’s instructions (Gibco/BRL) The following annealing conditions were used during PCR: increasing from 54.5 ... into the vector pTrcHisB and into pQE-31, yielding upstream in- frame extensions of 45 and 20 codons, respectively, including six histidine codons each In spite of different N-terminal extensions, ... metabolically important ring-substituted cinnamic acids Expression studies in cell cultures and in seedlings revealed differential regulation of the four 4CL genes, supporting earlier notions on different...
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Tài liệu Báo cáo Y học: Analyses of the CYP11B gene family in the guinea pig suggest the existence of a primordial CYP11B gene with aldosterone synthase activity docx
... related genes within intron and intron This could indicate frequent recombination between the genes for which close association has Guinea pig CYP11B genes (Eur J Biochem 269) 3845 been shown in mice ... recombination between the two genes in intron and intron eventually lead to both distinct regiospecificities and/ or differential regulation We next sought to determine when this gene duplication ... the guinea pig as a model The guinea pig is an interesting species because its taxonomical position remains controversial [12,13] These features should provide new insight into the evolution and...
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Báo cáo Y học: Cloning of the manganese lipoxygenase gene reveals homology with the lipoxygenase gene family doc
... A507T, and I586M) Table Translation, transcription and termination sequences of the Mn-LOX-Gga gene and the exon–intron borders Transcription start pointa a1gcaggttc… Intron Intron I a Translation ... Ala16 and Ala17 This tentative signal peptide, MRSRILAIVFAARHVA, thus contains four alanine and three arginine residues, which might explain the low number of alanine and arginine residues in the ... C-terminal isoleucine residue of LOX was not conserved The C-terminal amino acid of Mn-LOX was valine, and there is precedence for the C-terminal valine as a metal ligand in both native and recombinant...
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Tìm thêm: xác định các mục tiêu của chương trình xác định các nguyên tắc biên soạn khảo sát chương trình đào tạo gắn với các giáo trình cụ thể xác định thời lượng học về mặt lí thuyết và thực tế điều tra đối với đối tượng giảng viên và đối tượng quản lí điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu nội dung cụ thể cho từng kĩ năng ở từng cấp độ phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ lồng sóc hệ số công suất cosp fi p2 đặc tuyến hiệu suất h fi p2 đặc tuyến dòng điện stato i1 fi p2 động cơ điện không đồng bộ một pha sự cần thiết phải đầu tư xây dựng nhà máy thông tin liên lạc và các dịch vụ phần 3 giới thiệu nguyên liệu từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008 chỉ tiêu chất lượng 9 tr 25