gene environment interaction in the expression of allergic phenotype
Tài liệu Báo cáo khoa học: Adaptive changes in the expression of nuclear and mitochondrial encoded subunits of cytochrome c oxidase and the catalytic activity during hypoxia pptx
... alters the expression of the two nuclear genome coded isoforms of CytOX V [10,32] The regulation of genes CytOX5a and CytOX5b, coding for the two isofoms Va and Vb, parallels that of genes CYC1 ... the effects of hypoxia on the steady state levels of nuclear genome encoded CytOX IV and Vb mRNAs There was no change in the levels of these mRNAs in macrophages at h of hypoxia, the time point ... Results As a measure of the hypoxic effect on CytOX gene expression, we measured the steady state CytOX mRNA levels The Northern blot in Fig shows the effect of hypoxia on the levels of mitochondrial...
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báo cáo hóa học:" Decrease in the expression of the type 1 PTH/PTHrP receptor (PTH1R) on chondrocytes in animals with osteoarthritis" potx
... Macroscopic grading of OA PTH1R staining by immunohistochemistry Immunohistochemical staining of PTH1R showed marked staining of the cell membrane in all cases PTH1R was expressed mainly in the middle ... and bone tissue according to the Mankin scale [16] The Mankin score included assessments of the structure, cellularity, Safranin stainability, and integrity of the tidemark The scores for structure ... knee joints were opened using a medial paramedian skin incision of cm in length and a medial parapatellar incision of the capsule In animals of group 1, the ACL was resected using a tapering scalpel...
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Báo cáo y học: "Nature of Regulatory T Cells in the Context of Allergic Disease." ppsx
... inhaled antigen in the lung and present it in an immunogenic or tolerogenic form into the draining lymph nodes.30,31 The essential role of lung pDCs in preventing the cardinal features of asthma has ... Arvidsson M, Oancea I, et al The effect of specific immunotherapy on the expression of costimulatory molecules in late phase reaction of the skin in allergic patients Clin Exp Allergy 2004;34:1862–7 ... in the mucosa, as well as the number of mast cells in the skin27 and the IgE-mediated release of histamine by basophils.3,28 Also, a significant decrease in nasal eosinophils after years of sublingual...
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Báo cáo y học: "Evaluating the Safety of Intranasal Steroids in the Treatment of Allergic Rhinitis" docx
... study in 558 children aged to 11 years.20 Intraocular pressure remained within the normal range (, 21 mm Hg) in $ 98% of the patients in any treatment group in both studies However, in the 12-month ... one of the methods used to determine if steroids have potentially negative effects Reviewing the types of studies and methods used to Sheth, Safety of Intranasal Steroids in Treatment of Allergic ... levels after weeks of therapy with FF in children aged to 12 years with perennial AR.18 The ratio of end of treatment to baseline was 0.98 in the placebo group and 0.94 in the FF-treated group...
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Báo cáo y học: "Treatment of hypertriglyceridemia and HIV: fenofibrate-induced changes in the expression of chemokine genes in circulating leukocytes" ppsx
... (B) The use of fenofibrate was related to significant decreases in the expression in circulating leukocytes of CX3CL1 and CCR2 genes and a significant increase in the expression of SDF-1 Page of ... ligands for these receptors was clearly different We did not find any significant effect of fenofibrate in the MCP-1/CCL2 gene expression However, there was a significant decrease in the gene expression ... documented role in the local accumulation of monocytes [8,9] However, fenofibrate had an intriguing effect in SDF-1 expression neutralizing the significant decrease in its expression observed in untreated...
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báo cáo khoa học: " Field transcriptome revealed critical developmental and physiological transitions involved in the expression of growth potential in japonica rice" potx
... hypothetical protein and hypothetical protein in the RAP-DB We divided the organ/tissue-specific genes into clusters based on the organ/tissue specificity of expression The majority of the genes ... allocation, and the PHR1 binding motif is often found in the upstream regions of Arabidopsis genes induced by Pi-starvation [52] The PHR1 binding motif was enriched in the 1-kb upstream regions of the Sato ... wide range of expression profiling can be very useful as well in elucidating the interactome in cereal crops In comparison with the anther, only a few specific genes were identified in the pistil...
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Báo cáo y học: "B cells from rheumatoid arthritis patients show important alterations in the expression of CD86 and FcgRIIb, which are modulated by anti-tumor necrosis factor therapy" potx
... with a blockage of FcgRIIb is sufficient to induce an increase in the expression of CD86 [38,39], whereas the overexpression of this receptor on murine B cells reverses the induction of CD86 triggered ... participated in the recruitment and clinical evaluations of patients LS participated in the recruitment of patients and clinical data analysis MC participated in the design and coordination of the study ... participated in the conception and design of the study and critically revised the manuscript JCA participated in the conception and design of the study and in the interpretation of data and helped...
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Báo cáo y học: " Role of lysophosphatidic acid receptor LPA2 in the development of allergic airway inflammation in a murine model of asthma" potx
... receptors in linking lung injury in the murine bleomycin model of pulmonary fibrosis Asthma is a chronic inflammatory disease of the airways involving T-lymphocytes and eosinophils infiltration, ... cytokines play a key role in orchestrating inflammatory and structural changes of the airway in asthma by recruiting, activating and promoting inflammatory cells into the airway [38-40] In addition ... LPA2 in influx of eosinophils into alveolar space during allergic inflammatory response Airway goblet cell metaplasia and mucus production, indices of degree of inflammation, are hallmarks of asthma...
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Báo cáo y học: "Changes in the expression of NO synthase isoforms after ozone: the effects of allergen exposure" doc
... (Model 49C; Thermo Environmental Instruments Inc., Franklin, Mass) The air-sampling probes were placed in the breathing zone of the mice The mean chamber ozone concentration ( ± SEM) during the hr ... http://respiratory-research.com/content/5/1/5 Western blot analysis of the expression of nNOS, eNOS, and iNOS in the lung tissue Figure Western blot analysis of the expression of nNOS, eNOS, and iNOS in the lung tissue Mice were categorized ... cycle of the animal A pneumotachograph with defined resistance in the wall of the main chamber acts as a low pass filter and allows thermal compensation The time constant of the box was determined...
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Báo cáo y học: " Alterations in the expression of DEAD-box and other RNA binding proteins during HIV-1 replication" potx
... multiplicity of infection inocula Figure shows the expression patterns for genes encoding DEAD box proteins, and other genes encoding RNA helicases and RNA binding proteins, as assigned by the gene ontology ... involvement in RNA binding, transport or splicing A compilation of latently infected profiles of genes with known or active replication A compilation of the expression profiles of genes with known ... addition, genes encoding other proteins involved in nucleic acidprotein interactions were also upregulated, such as members of the SWI/SNF family of ATP-dependent chromatin remodeling factors involved...
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Báo cáo sinh học: "Changes in the expression of genetic characteristics across cohorts in skeletal deformations of farmed salmonids" potx
... hand, the negative genetic correlations were observed only for the pairs of correlations including generation 2000 The average of the ten genetic correlations of generation 2000 with all the other ... deformations in these generations were determined partly by the same set of genes, or a set of closely linked genes The second major finding of this study is that genetic correlations between generations ... deformations were obtained from the Finnish rainbow trout breeding programme The broodstock fish were held at the fresh water breeding station located in Tervo, Central Finland The lifecycle of the fish is...
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THE STUDY OF THE EFFECTS OF a CHANGE IN THE EXPRESSION OF MIXED LINEAGE LEUKEMIA 5 ON TRANSCRIPTION REGULATION
... structures and there is a continuous shuttling of splicing factors in and out of the speckles In the event of transcription inhibition, either through the use of inhibitors or as a consequence of heat-shock, ... maintain the HOX gene expression (Ziemin-van der Poel et al., 1991) The mechanisms by which these two evolutionally conserved genes maintain the HOX gene expressions occur at the epigenetic level ... tri-methylation and expression of endogenous p53 target genes, in the presence of the DNA-damaging agent, doxorubicin (Kim et al., 2009) The expression of p21, a downstream target gene of p53, was found...
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Báo cáo khoa học: Nuclear actin and actin-binding proteins in the regulation of transcription and gene expression docx
... actin is associated with rDNA genes, and microinjection of anti-actin Ig into the nuclei of HeLa cells inhibits pre-rRNA synthesis in vivo [25,34] The interaction of NM1 with actin in the initiation ... enhances its activity in the presence of androgen The interaction between the N- and C-termini of the AR does not affect gelsolin FXXFF binding to AR LBD, indicating that the gelsolin FXXFF motif has ... regulation of the AR N-terminal domain, and the LBD interaction (N ⁄ C interaction) [78–82] All available data suggest that no single AR-binding protein completely defines the multiple functions of the...
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Báo cáo khoa học: Gene expression silencing with ‘specific’ small interfering RNA goes beyond specificity – a study of key parameters to take into account in the onset of small interfering RNA off-target effects potx
... differences in exposure times during western blotting We also observed a slight increase in SREBF1 protein level triggered in the presence of the NT siRNA, in agreement with the slight increase in SREBF1 ... increase in the abundance of SREBF1 transcript in each cell type The efficiency of SREBF1 ⁄ siRNA1 was also investigated at the protein level by western blotting analysis of SREBF1 abundance in ... cells The numbers of transcripts differentially expressed in the presence of both siRNAs specific for the same target are indicated in diagram intersections allowing the expression analysis, at the...
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Báo cáo khoa học: Sp1 binds to the external promoter of the p73 gene and induces the expression of TAp73c in lung cancer doc
... TAp73 expression in vivo by treating the standard TAp73expressing cell line A549 with either Sp1 small interfering RNA (siRNA) or an Sp1 protein inhibitor The resulting changes in TAp73 expression ... treatment of A549 cells with increasing concentrations of the Sp1 inhibitor mithramycin A (Fig 3B), which not only interferes with the transcription of genes containing GC-rich regions in their promoters, ... difference in the C-terminal domain of TAp73c is that, owing to the excision of exon 11 during alternative splicing, it lacks most of the Glu ⁄ Pro-rich domain and the Pro-rich domain, which are...
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Báo cáo khoa học: Myocyte enhancer factor 2 (MEF2) is a key modulator of the expression of the prothoracicotropic hormone gene in the silkworm, Bombyx mori ppt
... enhancing reporter gene expression These findings suggest that the Bombyx MEF2 homolog binds to the MEF2 consensus binding sequence in the PTTH promoter, enhancing PTTH gene expression Cloning of the ... protein Furthermore, overexpression of the BmMEF2 gene can induce PTTH gene expression Thus, it appears that BmMEF2 plays a role in the enhancement of PTTH gene expression in PTPCs A single MEF2 gene, ... lateral region of the brain in each hemisphere [14] Regulation of PTTH gene expression by controlling BmMEF2 expression To investigate whether the expression of BmMEF2 affects PTTH gene expression, ...
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báo cáo hóa học:" MicroRNA and gene expression patterns in the differentiation of human embryonic stem cells" doc
... instance, miR-373 induces the expression of E-cadherin and CSDC2 by targeting their promoter region and initiate their expression[ 73] Another mechanism is that the engagement of miRNA and their targets ... [21,43], if the function of the miRNA is dominant in leading the mRNA target degradation, however, most animal miRNAs pair to the 3' UTRs of their targets by incomplete base-pairing through their seed ... analysis of these genes also divided the samples into three groups, hES, EB, and adult cells, and divided the genes into major nodes (Figure 4) The node containing 226 genes that were upregulated in...
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Báo cáo hóa học: " Glycerol conversion to 1, 3-Propanediol is enhanced by the expression of a heterologous alcohol dehydrogenase gene in Lactobacillus reuteri" ppt
... (1 min) The amplicon was cloned into TA vector to generate the recombinant plasmid pHR1 Further, the yqhD gene was sub-cloned from pHR1 into NcoI/XhoI site of pSIP411, resulting in recombinant ... reuteri Further engineering of the strain to improve the redox balance and minimize the formation of byproducts like lactate and ethanol could pave the way for maximizing 1, 3-PD biosynthesis Acknowledgements ... in the recombinant cells after induction, which correlates well with the expected size of YqhD Batch fermentation analysis of recombinant L reuteri harbouring yqhD To investigate the impact of...
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Báo cáo y học: "Identification of intra-group, inter-individual, and gene-specific variances in mRNA expression profiles in the rheumatoid arthritis synovial membrane" pot
... individuals In contrast to conventional differential gene expression analyses, the determination of inter-individual gene expression variances, often affecting gene expression of members of the ... (cytokine–cytokine receptor interactions) The mean gene expression (blue line) and the intra-group inter-individual variances in RA and NC synovial membrane (red bar) are indicated, resulting in ... small number of genes (for example, 2.6% in the human retina [20]) To analyze inter-individual mRNA expression variances in RA, the occurrence of gene- specific expression differences in the SM was...
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Cyclic stretch enhances the expression of Toll-like Receptor 4 gene in cultured cardiomyocytes via p38 MAP kinase and NF-B pathway doc
... significantly inhibited the increase of TLR4 protein expression induced by stretch Addition of losartan (100 nM) before TNF-a use significantly inhibited the increase of TLR4 protein expression induced ... kinase pathway because the specific and potent inhibitors of an upstream p38 kinase, SB203580 inhibited the induction of TLR4 protein This signaling pathway of p38 was further confirmed by the ... attenuated the increase of TLR4 induced by stretch (data not shown) This finding indicates that TNF-a may directly mediate the increase of TLR4 by cyclic stretch As shown in Fig 4, addition of losartan...
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