functions of glycogen in the central nervous system
báo cáo hóa học: " Temporal expression and cellular origin of CC chemokine receptors CCR1, CCR2 and CCR5 in the central nervous system: insight into mechanisms of MOG-induced EAE" pptx
... around inflammatory foci in the spinal cord of rats with EAE, thus identifying potential determinants for trafficking of these cells to the CNS These findings are discussed in relation to therapeutic ... apoptosis of infiltrating cells in the CNS of animals with EAE [80] The limitation of inflammation seen in the CNS could also be the result of a diminished antigen-presenting capability In conclusion, ... marked demyelination in the inflammatory areas (F) The majority of the infiltrating inflammatory cells are macrophages, as evidenced by positive staining for the ED-1 marker (E) During the remission...
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Báo cáo sinh học: "Systemic 5-fluorouracil treatment causes a syndrome of delayed myelin destruction in the central nervous system" doc
... demyelinated axons, including partial or complete loss of myelin sheaths and increases in inter-laminar splitting of the myelin sheaths Analysis of transverse sections (Figure 9) provided further ... point, along with markedly decreased levels of MBP in the CC and in the white-matter tracts of the striatum of treated animals (Figure 10) In agreement with the majority of the cell bodies in the ... treatment, there was a 2.5-fold increase in apoptosis in the subventricular zone (SVZ) and a 4-fold increase in the dentate gyrus of the hippocampus (DG) The increased cell death persisted in the SVZ...
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Báo cáo khoa học: "Immunohistochemical study of constitutive neuronal and inducible nitric oxide synthase in the central nervous system of goat with natural listeriosis" potx
... of nNOS and iNOS in the nonneurological control brain Both nNOS and iNOS immunoreactivity was recognized in the brain of control goats No inflammatory cells were found in the brain sections of ... and iNOS in neurons increased when bacterial encephalitis occurred This is the first study of NOS expression in the goat brain with listeriosis The involvement of iNOS in bovine and caprine listeriosis ... single positive-staining bacteria were found in the neuronal processes Both nNOS and iNOS immunoreactivity were found in a proportion of the neurons in the brainstem and the staining pattern was...
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báo cáo khoa học: "In vivo observation of gold nanoparticles in the central nervous system of Blaberus discoidalis" potx
... by the nAuNPs The XPS was used to verify the presence of nAuNPs embedded in the brain tissue The confocal microscope and TEM were used to gain insights into the interaction of nAuNPs and the insect’s ... no signs of motion were observed (approximately 30 s) The needle was inserted 1.5 to mm into the neck in the location and direction shown in Figure 2, allowing to reach the brain of the insect ... introduction to the CNS The nAuNPs were introduced in the CNS through an injection between the brain and the sub esophageal ganglion (SEG) through the neck in the direction shown in Figure A cc syringe...
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The role of hydrogen sulfide in the central nervous system implications in the treatment of alzheimers disease
... like tau is involved in microtubule assembly It serves as a binding for the tubulin Mutations in α-synuclein lead to loss of this binding ability, resulting in tubulin and α-synuclein aggregation ... enhancing the activity of gamma-glutamylcysteine synthetase and up-regulating cystine transport The upregulation in gammaglutamylcysteine synthetase activity facilitates the redistribution of GSH into ... either inhibit the production of Aβ or escalate its clearance in the brain The most common mechanisms of action of these drugs are the inhibition of the rate limiting steps of Aβ generation i.e β-...
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INVESTIGATION OF MEMBRANE PROPERTIES IN THE CENTRAL NERVOUS SYSTEM OF DROSOPHILA MELANOGASTER STUDIED BY FLUORESCENCE CORRELATION SPECTROSCOPY
... constituent instead of sphingomyelin (PE-cer has phosphoethanolamine as the head group, instead of the phosphocholine head group in SM) [32] Despite having shorter fatty acyl chains (the longest being ... tube The eppendorf tube was kept cold at °C in ice After collecting 10 larval brains, they were washed times with 200 µl of sterile-filtered HL3 containing 10 µg/ml of insulin The brains were then ... be studied using FCS These intensity fluctuations contain information which can be extracted by analysing the rates and the amplitudes of the intensity fluctuations and subjecting them to an autocorrelation...
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Báo cáo sinh học: "The long term effects of chemotherapy on the central nervous system" docx
... with certain brain tumors, especially for the very young Because of the rapid myelinization that occurs in infants, the finding by Noble and colleagues [1] of the adverse effects of chemotherapy ... children treated with chemotherapy alone (methotrexate injected either intrathecally (into the cerebrospinal fluid) or intravenously and intrathecally) This study and many Journal of Biology 2006, 5:21 ... vulnerable, population of patients Chemotherapy-induced cognitive decline in the absence of radiation The best data on the cognitive effects of chemotherapy alone have come from studies of children with...
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Chemical drug assisted gene transfer a sensible approach to improve transgene expression in the central nervous system
... volume of μl of the complexes containing μg DNA was used in each injection The rate of injection was μl/min and the needle was allowed to remain in situ for mins before being slowly retracted at the ... remain at large in terms of choosing appropriate MW PEIs and biodegradable linkages as well as designing the degree of cross-linking, the particle size and the surface charge of the resulting ... IN THE CENTRAL NERVOUS SYSTEM GUO HAIYAN (B.M., PRC) A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY DEPARTMENT OF BIOLOGICAL SCIENCES NATIONAL UNIVERSITY OF SINGAPORE & INSTITUTE OF...
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báo cáo khoa học: "Isolated angiitis of the central nervous system with tumor-like lesion, mimicking brain malignant glioma: a case report and review of the literature" pdf
... provided the pathological diagnosis TJ was the surgeon and gave the final approval of the version to be published Competing interests The authors declare that they have no competing interests ... China Department of Pathology, Beijing Neurosurgical Institute, Beijing 100050, China Authors’ contributions GY wrote the initial draft WY drew the pictures WZ revised the draft SL described the ... viral infections initiate the inflammatory process that somehow becomes self-sustaining [5] It is also speculated that there may be a genetic predisposition in certain individuals leading to...
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Genetic engineering and surface modification of baculovirus derived vectors for improved gene delivery to the central nervous system
... analysed using the integrated software of the instrument 27 2.2.7 Cell Lines and Cell Culture Sf9 insect cells were obtained from Invitrogen and cultured according to the manual’s instructions ... adenovirus, there is virtually no immune response in the brain following direct injection of “gutless” vectors in rats However, the high antigenicity of the Ad virion and toxicity of the virion ... execute functions of the therapeutic genes 1.1.2 Non-viral and Viral Gene Delivery Systems Depending on the usage of vectors, there are two main types of gene delivery systems: non-viral and viral systems...
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A study of the recombination activating gene 1 in the zebrafish nervous system
... brief overview of the nervous system The nervous system is the most complex organ system in animals, and makes them distinguishable from other living organisms Because of the nervous system, animals ... divided into central and peripheral parts The central nervous system (CNS) consists of the brain and the spinal cord (or nerve cord for invertebrates), which contains the main portion of neural ... the expression of Rag1 in the nervous system, and its function remains unknown As a step towards understanding the role of Rag1 in vertebrate nervous system, we have initiated a study using the...
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Development of hybrid promoters and viral vectors for improved gene delivery to the central nervous system
... in the nervous system, carrying out the fundamental tasks of receiving, conducting and transmitting signals Therapeutic protection of these cells is one of the main goals of gene therapy of neurological ... diseases, either inherited or acquired, by enhancing, reducing or altering a particular gene expression in the target cells (Mountain, 2000) The promoter is one of the key issues of gene therapy The ... SUMMARY Gene therapy is a promising approach for the treatment of neurological disorders in the central nervous system (CNS) Because of the complex structure and high vulnerability of the CNS, it...
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Specificity and diversity in the vertebrate nervous system an analysis of two genes
... role of EphrinB2 in vivo EphrinB2 expression has been detected in the visual system in other organisms The aim of this project was to study the expression pattern of EphrinB2 in the visual system ... guidance at the midline, Eph-Ephrins are also involved in creating patterned neuronal connections in the CNS and the peripheral nervous system Similar to the topographic mapping in the visual system, ... target neurons in the tectum The Recombination activating gene-1 (RAG1) is expressed in the vertebrate immune system and in the nervous system, including the zebrafish visual system (Chun et...
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The study of the mediation of ohanin, a king cobra (ophiophagus hannah) toxin through the central nervous system
... 14 Binding Studies of Ohanin and Pro-ohanin The lack of natural abundance of ohanin (~1 mg/g of crude venom) and absence of pro-ohanin in the venom necessitates the use of recombinant proteins ... protein to transverse the BBB, and to study in detail the regions of interaction of the protein with components in the brain, as this might be useful to the understanding of the control of locomotion ... importance of maturation, we compared the hypolocomotory effects of pro-ohanin and ohanin by administering them through i.p and i.c.v routes The specific binding sites of these proteins in mouse brain...
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Báo cáo khoa học: Planarian peptidylglycine-hydroxylating monooxygenase, a neuropeptide processing enzyme, colocalizes with cytochrome b561 along the central nervous system pptx
... animals by the time of the emergence of the Plathelminthes in the evolutionary history The eye of the planarian is one of the most ancestral and primitive types of visual systems in animals and is ... represent the coding region and the noncoding regions of the planarian PHM cDNA, respectively; whereas the two flanking broad lines outside indicate the k ZAP II vector The two gray boxes in the planarian ... observable in the cell body of neurons in the peripheral region of the brain Cytochrome b561 was observable in neuropil (np), composed of axons and dendrites of the neurons, as well as in their cell...
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Section III - Drugs Acting on the Central Nervous System docx
... cells of this class may be attracted to the brain during periods of inflammation following either microbial infection or other postinjury inflammatory reactions The response of the brain to inflammation ... specific pathways of interconnecting nuclei Identifying the location of these receptors in the central nervous system (CNS), the function of pathways that incorporate them, and the behavioral and ... between the major dopamine-containing nuclei in the substantia nigra and ventral tegmentum and their targets in the striatum, in the limbic zones of the cerebral cortex, and in other major regions of...
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Báo cáo sinh học: "How chemotherapy damages the central nervous system Christina A Meyers" ppsx
... response in the mice at various times following treatment Loss of myelin is known to increase the latency between specific peaks in the auditory brainstem response, reflecting slowing of the impulse ... used in other studies The authors then examined the effects of 5-FU on adult mice They found an acute, transient increase in apoptosis in several brain regions, which subsided 56 days after injection ... reported in association with some chemotherapeutic treatments [18-20] However, these findings have not always been replicated, suggesting the need for further investigation [21] The findings of Noble...
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Báo cáo khoa học: "Histochemical Detection of Glycoconjugates in the Male Reproductive System of the Horse" pptx
... types in numerous tissues [11] This is the first study to examine the binding of six different lectins, including DBA, SBA, isolectin B4, WGA, PNA and UEA-I, in thoroughbred horses The lectins ... consistent binding in the sterocilia of seminiferous tubules, while only limited binding to spermatocytes was seen WGA lectin was strongly detected in the reproductive ducts These findings suggest ... Additionally, the heterogeneity of the lectin staining patterns in the reproductive tubules of the adult thoroughbred horse suggests that the Histochemical Detection of Glycoconjugates in the Male...
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the rule of accounting in the germany financial system
... question in evaluating an accounting system is whether it satisfies the needs of the economy’s main contracting parties and, in the context of financial systems, whether the relevant financing parties ... hypotheses about the role and properties of accounting in the German financial system Section describes the key elements of the German accounting system and ties them in with the financial system ... II FINANCIAL ACCOUNTING AND THE INSTITUTIONAL FRAMEWORK In this section, we discuss the link between the accounting system and the institutional framework and, in particular, the financial system...
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Enhancing the protection of the welfare of animals in the malaysian legal system
... views on the scope of law signify the influence of a conflicting stance of naturalism and positivism in shaping the attitude of judges in legal interpretation (ii) Custom In the context of the history ... Malaysia in the west, and the states of Sabah and Sarawak on the island of Borneo, in the east The Peninsular is bordered by Thailand in the north, and the island of Singapore lies to the south ... reviewing the draft of the project, from the early preparation of the candidature proposal through to the final draft of the thesis In addition, I am indebted to Dr Kerry Tarner for her kindness in...
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