... deciphering the structural andfunctionalorganizationofthe synapse We have assembled leaders in the field of synapse biology to describe and distill the wonders and mysteries ofthe synapse ... STRUCTURAL ANDFUNCTIONALORGANIZATIONOFTHE SYNAPSE STRUCTURAL ANDFUNCTIONALORGANIZATIONOFTHE SYNAPSE Edited by Johannes W Hell University of Iowa Iowa City, IA, USA and Michael D Ehlers ... must occur within the tiny space ofthe synapse, the precise molecular organizationof proteins, lipids, and membranes at the synapse is paramount Given the central role ofthe synapse in neuronal...
... substitute or theenvironment changes in ways that nullify the value ofthe resources) Exploitable? For each step ofthe preceding steps Resources and capabilities that ofthe VRINE test, can the firm ... Valuable resources and capabilities convey the potential to achieve “normal profits” (i.e., profits which cover the cost of all inputs including the cost of capital) Rare? Assuming the resource or ... create goods and services The combination of procedures and expertise that the firm relies on to engage in distinct activities in the process of producing goods and services TRUST AS AN ORGANIZATIONAL...
... that sow the seeds of organizational inertia and prevent the firm from responding appropriately to changes in the external environment Strategic myopia and inflexibility can strangle the firm’s ... causes shaping a firm’s environments and perceptions ofthe environments Intraorganizational Conflicts among people making managerial decisions and those affected by them Ch3 Discovering Core ... including its people andthe value of its brand name Ch3 Resources What a firm Has What a firm has to work with: its assets, including its people andthe value of its brand name Resources represent...
... This leads to a better understanding of how these chemotherapeutic agents work and change the face of drug development The success of chemotherapy in the treatment of some malignant diseases was ... 2(G2), the interval between the end of S andthe initiation of mitosis; and (4) mitosis, the period during which the chromosomes condense, and cytokinesis is completed (Howard and Pelc, 1953) The ... of cell cycle and growth controlThe mammalian cell cycle is the focus of a large number of studies at both genetic and molecular level The cell cycle can be described as the period between the...
... humanbodyThe position of proverbs referring to part ofthehumanbody Parts ofthehumanbody 21 21 21 The classification of parts ofthehumanbody according to position Graduation thesis ... diversified (multiple form) The classification of parts ofthehumanbody according to the position In the system ofthe proverbs, the system of words referring to parts ofthehumanbody is divided into ... referring to parts ofthehumanbody contribute to expression of peoples thoughts, feelings etc Parts ofthehumanbodyThe parts ofthehumanbody used in proverbs are diversified They are more variously...
... earth The hand of a child - The hand of a lock The heart of a man - The heart of a matter 37 The tongue of a man - The tongue of a shoe The tooth of a person - The tooth of a comb The head of a ... hands of a farm 13 The heel of a person - The heel ofthe hand 14 One's leg - The leg of a trip 15 One's brain - The brains of a family 16 The bosom of a person - The bosom ofthe church 17 The ... The head ofthe page The scar left on one's kin - The scars of war The arm of a person - The arm of jacket 10 One's breast - The chest 11 One's foot - The foot of sock 12 One's hands - The hands...
... II The hood domain is mainly built up by residues from the C-terminus and consists of a two-stranded anti-parallel b-sheet composed of b2 and b9 and an a-helix from the C-terminus (Fig 1A) The ... Lys173 interacts with both O6 and N7 (Fig 1C) The 2¢OH ofthe ribose is hydrogen bonded to the main chain andthe side chain of Asp142 (Fig 1C) Both hydroxyl groups ofthe ribose are involved in ... Asp142, 2¢ and 3¢OH ofthe ribose and three water molecules with ˚ coordination distances of approximately 2.4 A The phosphate ofthe GMP is hydrogen bonded to main chain and side chain atoms of amino...
... the C-terminal domain of apoCII interacts with the interface ofthe N- and C-terminal domains of LPL and part ofthe lid surface [32] Because thefunctional importance of LPL’s C-terminal domain ... illustrates the overall saddle shape ofthe dimeric structure andthe key heparin-binding residues in the N-terminal domain held coordinately by the two subunits on the top ofthe hollow (Fig 1A) The ... Model structure ofhuman LPL All model structures of dimeric human LPL were constructed using the INSIGHT II program and were based on the crystal structures ofthe human, porcine, and horse PLs...
... similar Ga in mammals The amino acid sequence of GOA-1 is 82.2% identical to that of Gao Although the similarity ofthe aA–aE region andthe region upstream of a4 was relatively low, the N-terminal ... expressed only in the pharynx and controls pharyngeal pumping [40], indicating that the side effect ofthe activation of GAR-3 is limited Furthermore, the phenotype of gar-3 loss -of- function mutants is ... carbamylcholine) [25] These results indicate that M2 in the GOA-1 fusion protein is functional, andthe ligand-binding properties agree with that ofthe Gai1 fusion protein Activation of GOA-1 by muscarinic...
... significantly in the presence or absence ofthe b1B subunit, whereas, under the same conditions, the rate of inactivation was increased in the presence ofthe b1 subunit The effects of b1B were further assessed ... low level Fig Northern blot analysis ofthe gene expression ofhuman b1B (A,B) and b1 (C,D) subunits, using human b-actin mRNA level as thecontrol (E,F) (A), (C) and (E) are human multiple tissue ... Functional expression ofthehuman b1B subunit with NaV1.2 in Xenopus oocytes To explore the regulatory function ofthehuman b1B subunit, we injected cRNA ofhuman b1B, as well as cRNA ofthe sodium channel...
... bias, there will be no significant difference between the set of spliced exons and that of highly expressed exons Calculating the strength of exon splice sites The sum ofthe scores ofthe splice ... expressed genes It is the density of nucleosomes that differs between exons and introns Therefore, the absolute level of H3K36me3, the product ofthe nucleosome level andthe relative modification ... exons ofthe transcript in question The difference between the read count of each exon andthe average read count of all exons can indicate how inclusive or exclusive the mature transcript is of the...
... of candidate regions High-throughput assays in human cells and model organisms for validating and functionally characterizing these candidates are critical to the overall goal of cataloging functional ... 312 Bernstein and Kellis polyadenylation signals in the transposon are rejected if they occur early in the coding strand but can be tolerated on the reverse strand Taken together, the four tests ... for the systematic identification of regions of open chromatin in thehuman genome The methods involve mapping DNase I hypersensitive sites, which are known to correlate with many types of functional...
... mDCs and moDCs [12] and moDCs and KG-1 cells [13], but no studies have compared the proteomes of all three cell types In this study we compare the proteomes of mDCs, moDCs and KG-1 cells, and then ... analysis of surface marker expression, cytokine profile, endocytic and T cell activation abilities ofthe cells, again suggesting differences in the maturation status between mDCs andthe DC models These ... spectrometric analysis; Table shows the corresponding protein data The factor of difference was calculated by dividing the intensity ofthe protein spot in mDCs by that ofthe corresponding spot in moDCs...
... depending on the growth pattern and synthesis activity ofthe parent cell of origin There is a functional resemblance to the parent tissue The neoplastic cell population is embedded in and supported ... survives in the microenvironment of distant tissues, and finally adapts to the foreign microenvironment of these tissues in ways that facilitate cell proliferation andthe formation of a macroscopic ... number of acini, or glands, embedded within loose connective tissue and connecting to the intralobule duct Each acinus is composed of two types of cells, namely epithelial and myoepithelial cells The...
... where the consequences of infection can be very severe, while the risk of living with one’s beloved cat is practically nill References Angulo FJ, Glaser CA, Juranek DD et al Caring for pets of immunocompromised ... with thehuman immunodeficiency virus Clin Infect Dis.1994;18:14-24 Han K, Shin DW, Lee TY, et al Seroprevalence of Toxoplasma gondii infection and risk factors associated with seropositivity of ... women in Korea J Parasitol 2008; 94: 963-965 Grant S and Olsen CW Preventing zoonotic diseases in immunocompromised persons: the role of physicians and veterinarians Emerg Infect Dis 1999; 5: 159-163...
... the French Declaration ofthe Rights of Man and Citizen As apprehended by Friedrich Tenbruck, they build on the Creation, the universality ofthe Children of God andof brotherhood with the ... facilitate the expansion and balanced growth of international trade, and to contribute thereby to the promotion and maintenance of high levels of employment and real income and to the development ofthe ... in the Middle Ages ofthe salvation ofthe Kingdom of God on earth ’ The ‘secular remnants of this Christian theology of history’ facilitated ideas of an equal and common development of humanity...
... COMPOSITION. The Coordinating Com- 14 mittee shall be composed ofthe Directors ofthe 15 Centers and Offices 16 ‘‘(3) CHAIRPERSON. The Director ofthe Of- 17 fice shall serve as the chairperson ofthe ... DISEASE CONTROLAND PREVENTION OFFICE OF WOMEN’S HEALTH ‘‘SEC 310A (a) ESTABLISHMENT.—There is estab- 19 lished within the Office ofthe Director ofthe Centers for 20 Disease Controland Prevention ... COMPOSITION. The Coordinating Com- mittee shall be composed ofthe Directors ofthe Na- tional Centers ‘‘(3) CHAIRPERSON. The Director ofthe Of- fice shall serve as the chairperson ofthe Coordi-...
... was in the lung Seventy-three percent ofthe dose to the lung was cleared during the first 72 hours, indicating that absorption of DIDP or its metabolites from the lung into the rest ofthebody ... retained in the carcass at the end of 72 hours, and were 56, 46, and 17% for the low, medium, and high doses, respectively The remainder ofthe radiolabeled activity was excreted in the feces with ... oxidative derivative ofthe monoester andof MIDP at the same doses were, respectively, 25 and 30%, 14 and 26%, and 13 and 13% The data suggest a metabolic scheme comparable to the one reported for...
... Disease Controland Prevention The role of BCG vaccine in the prevention andcontrolof tuberculosis in the United States: a joint statement by the Advisory Council for the Elimination of Tuberculosis ... variable and equivocal The concern ofthe public health community about the resurgence and changing nature of TB in the United States prompted a re-evaluation ofthe role of BCG vaccination in the ... vaccination These developments have prompted a re-evaluation ofthe role of BCG vaccination in the prevention andcontrolof TB in the United States CDC, the Advisory Council for the Elimination of Tuberculosis...