functional and structural implications
Tài liệu Báo cáo khoa học: Functional and structural analyses of N-acylsulfonamidelinked dinucleoside inhibitors of RNase A ppt
Ngày tải lên :
14/02/2014, 22:20
... The functional and structural studies presented herein demonstrate the attributes of N-acylsulfonamidyl and sulfonimidyl groups as surrogates for the phosphoryl groups of nucleic acids The structural ... interactions: binding and cleavage by ribonuclease A and variants at Lys7, Arg10, and Lys66 Biochemistry 37, 1212112132 31 Anderson DG, Hammes GG & Walz FG Jr (1968) Binding of phosphate ligands to ribonuclease ... RiIi(h), where Ii(h) and I(h) are the ith and the mean measurements of the intensity of reection h, respectively Rcryst = Rh |Fo ) Fc| RhFo, where Fo and Fc are the observed and calculated structure...
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Báo cáo khoa học: Functional and structural characterization of novel mutations and genotype–phenotype correlation in 51 phenylalanine hydroxylase deficient families from Southern Italy docx
Ngày tải lên :
16/03/2014, 01:20
... varies in distinct populations and geographic areas [79] and a number of them have been analyzed and characterized in vitro [10,11] Identication of the mutations and subsequent in vitro expression ... HPA II patients and seven HPA III patients 2050 Characterization and functional analysis of novel mutations Among the mutations identied in our HPA population, two (i.e p.Q301P and c.707-2delA) ... homozygosity for p.R261Q (patients 10 and 11) was associated with different phenotypic classes, namely HPA I and HPA II, respectively (Table 2) Among the functional hemizygotes and compound heterozygotes,...
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Báo cáo khoa học: Two novel Mesocestoides vogae fatty acid binding proteins – functional and evolutionary implications doc
Ngày tải lên :
23/03/2014, 07:20
... Caenorhabditis elegans and Manduca sexta FABPs are good examples [24] The observed high expression of MvFABPs at the tegumental level has interesting implications in platyhelminth biology and parasite ... mica, Facultad de Ciencias, UdelaR, Montevideo, Uruguay) and Dr I Noguera (Department of Cell Biology and Kaplan Cancer Center, and the Raymond and Beverly Sackler Foundation Laboratory, New York ... (1993) Structural relationship of streptavidin to the calycin protein superfamily FEBS Lett 333, 99–102 Veerkamp JH, van Kuppevelt THMSM, Maatman RGHJ & Prinsen CFM (1993) Structural and functional...
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Báo cáo khoa học: Correlation between functional and structural changes of reduced and oxidized trout hemoglobins I and IV at different pHs doc
Ngày tải lên :
23/03/2014, 12:20
... the Soret band is a consequence of R fi Ttransitionanditreflectstheinteractionbetweena1 and b1 subunits It may be due to tertiary structural changes in regions including aromatic residues and it may ... HbI and HbIV: iron(II)-HbI and met-HbI induce a 23.2 and 50.1% reduction of the peak intensity, respectively, when compared with the peak of the buffer Iron(II)-HbIV and metHbIV induce a 35.8 and ... Antonini, E & Brunori, M (1971) Hemoglobin and Myoglobin in Their Reactions with Ligands, p 10–11 North-Holland, Amsterdam, the Netherlands 14 Perutz, M.F., Sanders, J.K., Chenery, D.H., Noble, R.W.,...
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Báo cáo khoa học: The CRIPTO/FRL-1/CRYPTIC (CFC) domain of human Cripto Functional and structural insights through disulfide structure analysis docx
Ngày tải lên :
23/03/2014, 21:20
... VWFC (von Willebrand Factor C)-like domain in human and chicken a-1 collagen, mouse and human NELL 2, and chicken NEL, with low homology (e-value > 0.1), in addition to other Cripto and Cripto-like ... both EGFlike and VWFC domains, but, only in human Jagged and Jagged 2, Drosophila Serrate, and NELL were both domains adjacent to and in the same order as the putative EGF-like and CFC regions ... Cys128-Cys149, and Cys131-Cys140 are indicated by DS1, DS2 and DS3, respectively Residues H120 and W123 have been implicated in Alk4 binding and are shown in purple Residues N79 and T88 (shown...
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Báo cáo Y học: Azidothymidine causes functional and structural destruction of mitochondria, glutathione deficiency and HIV-1 promoter sensitization pptx
Ngày tải lên :
24/03/2014, 04:21
... incubation) and H2O2-treated cells (after 25-day incubation) are marked by +, and their control cells by –, in a bracketed sections for AZT and H2O2 experiments Error bands indicate standard deviation ... AZT, and reached 38% of the normal level in U937CD and 35% in MOLT4CD cells on day 15 In H2O2-treated cells, the level of ATP declined similarly On day 25, U937CD and MOLT4CD contained 45 and ... lanes and 18) However, after 12-day incubation with AZT, shorter fragments of 2.0-, 1.5- and 1.0-kb were also detectable (lane 10) On day 20 of the H2O2 treatment, 1.7-, 1.3- and 1.2-kb new bands...
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Báo cáo khoa học: Phosphatidylserine induces functional and structural alterations of the membrane-associated pleckstrin homology domain of phospholipase C-d1 docx
Ngày tải lên :
30/03/2014, 10:20
... structure and dynamics of individual alanine residues in the domain [3] PLC-d1 is comprised of five domains; PH, EF-hand, X, Y, and C2 [4–6] The PH domain is located at the N-terminus and is known ... active site (X and Y domain) and its substrate, PIP2 [11,12] A study using chimeric proteins of PLC-d1 and PLC-b1 led to the proposal that the interactions between the PH domain and the active ... be PS and >90% of PS is located at the inner leaflet [17–19] The ratio of the PH domain partitioned into supernatant and pellet was determined from the densities of the SDS ⁄ PAGE bands and is...
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math - functional and structural tensor analysis for engineers - brannon
Ngày tải lên :
31/03/2014, 16:19
... his lectures, and I have adopted his notation in this document Later taking Buck’s beginning and advanced finite element classes further improved my command of matrix analysis and partial differential ... violate commonly adopted “standards.” By “standards,” we are referring to those everyday bread -and- butter structures that come implicitly endowed with certain definitions and manipulation rules For ... order for ij to equal mn , you must have i=m and j=n Therefore, we can assert that ∂A ij = δ im δ jn ∂A mn , where i and m range from to N and j and n range from to M (3.35) Later on, when...
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Báo cáo y học: "PhyloFacts: an online structural phylogenomic encyclopedia for protein functional and structural classification" doc
Ngày tải lên :
14/08/2014, 17:22
... active sites and other types of key functional residues HMMs for each family and subfamily provide functional classification of user-submitted sequences at different levels of a functional hierarchy ... the functionalities provided by PhyloFacts with those of standard functional classification resources for structural phylogenomic analysis PhyloFacts is the only online resource that enables structural ... experimental data and bioinformatics predictions for a protein family, and to quickly and accurately infer the function of a protein in an evolutionary context Annotation accuracy requires data and method...
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Functional and structural genomics study of singapore grouper iridovirus
Ngày tải lên :
11/09/2015, 16:04
... major groups, i.e DNA viruses and RNA viruses Viruses are further classified into single-stranded DNA (ssDNA), single-stranded RNA (ssRNA) viruses and double-stranded DNA (dsDNA) viruses The ... and h p.i., most of the E genes commenced expression at h p.i and most of the L genes commenced expression between and h p.i The expression of three of the E genes (ORFs 83R, 099R and 111R) and ... genes of the iridoviruse are transcripted and translated The genomes and structural proteins of the iridoviruse begin to assemble to form new iridoviruses, and are released from the host cells The...
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Functional and structural properties of molecular soy protein fractions
Ngày tải lên :
16/09/2015, 08:30
... developed understanding of the various interaction processes, physicochemical and structural /functional properties of the soy protein fractions (2S, 7S and 11S) The protein-protein and the protein-coagulant ... protein to improve the nutritional and functional properties of the major protein fraction was mapped out Finally, the functional and structural properties of the 11S and 7S were contrasted with those ... fraction (%) (thousands) 2S 15.0 18-33 7S 34.0 11S 15S pI The 11S and 7S fraction contents have been found to vary with soybean variety and environment (Cai and Chang, 1999) Cai and Chang (1999)...
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Functional and structural study of singapore grouper iridovirus ORF086R
Ngày tải lên :
13/10/2015, 16:41
... purification and crystal screening I would like to thank Dr Fan Jingsong and Dr Yang Daiwen for the data collection and discussion on NMR work I would like to thank all other members and ex-members of Functional ... role in virus infection and replication Both full length and truncated ORF086R were cloned and expressed in E coli to get soluble and stable protein for raising antibody and crystal screening Gene ... is between 100 and 210 kbp and composed of double-stranded linear DNA The two genera-Ranavirus and Lymphocystivirus only infect cold blooded animals, such as fish, amphibians, and reptiles while...
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Báo cáo khoa học: NMR and molecular dynamics studies of an autoimmune myelin basic protein peptide and its antagonist Structural implications for the MHC II (I-Au)–peptide complex from docking calculations ppt
Ngày tải lên :
07/03/2014, 16:20
... various systems comprised 3899 and 4516 SPC molecules for the agonist and the antagonist in water, respectively, and 817 and 927 Me2SO molecules for the agonist and the antagonist, respectively, ... agonist analogue) and Glu82 MD simulations of MBP(74–85), and Ala81MBP(74–85) in water and Me2SO To further assess the structural origin of the difference in activity between the agonist and antagonist, ... [82] and (B) sequence alignment of the Vb chain TCR(79–83), MBP(74–85) and MBP(95–103) P5 and P8 are prominent, solvent-exposed TCR contact residues of the MBP(86–105) peptide, and P4, P6 and...
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Significant substitutive figures of speech – linguistic functions and pedagogical implications part 2
Ngày tải lên :
07/11/2012, 14:24
... More importantly, unlike love and people and even more so than looks and hugs, eyes and arms are concrete, visible and touchable, and therefore seem closer to buyable and sellable items Although ... hire some more hands” or “She’s got new wheels,” which not literally refer to a hand or a set of wheels Instead, they stand for the whole person or object – hand for the whole person and wheels for ... instance, Sherwood Anderson may have well omitted the “ands” in italics in the following sentences in the short story “The Corn Planting.” “He made drawings of fish and pigs and cows and they looked...
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Module 2: Architecture and Structural Design Patterns
Ngày tải lên :
19/10/2013, 02:15
... creational and structural design patterns can be used to define an architectural template This section discusses creational and structural design patterns and their uses Module 2: Architecture and Structural ... services facade and the business facade The Web services facade exposes features and functionality to external users and applications The business facade exposes features and functionality to ... Architecture and Structural Design Patterns Structural Topic Objective To provide a background about structural design patterns Lead-in Recordset In this topic, you will learn about the structural...
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DEBT SUSTAINABILITY FRAMEWORK FOR LOW INCOME COUNTRIES : POLICY AND RESOURCE IMPLICATIONS - Part 1
Ngày tải lên :
28/10/2013, 08:15
... of public and publicly guaranteed external debt to gross domestic product and to exports, and debt service on the same debt to exports to judge debt sustainability Country policies and institutional ... countries based on the performance of their institutions and policies and determine thresholds for selected debt indicators for each country grouping and then estimate the level of debt distress as measured ... Allocation System that uses the Country Policy and Institutional Assessment and governance rating of the country concerned The increase in grants has implications for the future of IDA funding which...
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DEBT SUSTAINABILITY FRAMEWORK FOR LOW INCOME COUNTRIES : POLICY AND RESOURCE IMPLICATIONS - Part 2
Ngày tải lên :
06/11/2013, 23:15
... balance and payments and budgets, the mix of loans and grants in its future financing arrangements, and the build-up of its repayment capacity relative to Gross Domestic Product (GDP) and export and ... Countries: Proposal for an Operational Framework and Policy Implications by Mark Allen and Gobind Nankani, IMF and IDA, February 3, 2004 Debt Sustainability and Financing Terms in IDA 14, IDA, June 2004 ... discussed above and in Annex These were the PV of public and publicly guaranteed external debt to GDP, exports, and government revenue, and debt service on the same debt to exports, and government...
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DEBT SUSTAINABILITY FRAMEWORK FOR LOW INCOME COUNTRIES : POLICY AND RESOURCE IMPLICATIONS - Part 3
Ngày tải lên :
06/11/2013, 23:15
... policies and institutional capability and vulnerability to shocks are other factors identified as being important for assessing a country’s debt sustainability In particular, country policies and ... chosen indicators of countries with poor, medium and strong institutional capabilities and quality of policies with the cut offs at the 25th, 50th and 75th percentiles of the CPIA index ranked in ... the external debt outstanding; (b) an application to the Paris Club for debt restructuring of official debt when a breakdown in the payments system is judged to be imminent; and (c) the country...
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DEBT SUSTAINABILITY FRAMEWORK FOR LOW INCOME COUNTRIES : POLICY AND RESOURCE IMPLICATIONS - Part 4
Ngày tải lên :
06/11/2013, 23:15
... resources, safety nets; and poverty monitoring and analysis; and • Public sector management and institutions, including property rights and rule-based governance; quality of budgetary and financial management; ... of the development program; • Structural policies, including trade policy and foreign exchange regime; financial stability and depth; banking sector efficiency and resource mobilization; competitive ... the private sector; factor and product markets; and policies and institutions for environmental sustainability; • Policies for social inclusion, including gender equity and equality of economic...
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