from molecular signatures to clinical oncology translation
Tài liệu Báo cáo khoa học: Multisite protein phosphorylation – from molecular mechanisms to kinetic models pdf
... Prototypical examples of multisite phosphorylation in signal transduction and cell-cycle regulation (A) Receptor proteins Binding of a high-affinity ligand to the T-cell receptor (TCR) leads to ... strategy, ATP is added to the enzyme–substrate complex, together with an inhibitor that can trap the free enzyme [27] In a distributive mechanism, the inhibitor traps the free enzyme, stopping the reaction ... phosphoinositol-3-kinase ⁄ Akt pathway and the cAMP pathway Any phosphorylation is enough to trigger dissociation of BAD from the anti-apoptotic protein Bcl-XL, inhibiting the pro-apoptotic activity...
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TEXTBOOK OF Hepatology From Basic Science to Clinical Practice doc
... TTOA01_vol1 3/9/07 10:46 AM Page i TEXTBOOK OF Hepatology From Basic Science to Clinical Practice TTOA01_vol1 3/9/07 10:46 AM Page ii Textbook of Hepatology Third Edition ... highlighted in the text TTOA01_vol1 3/12/07 4:44 PM Page iii TEXTBOOK OF Hepatology From Basic Science to Clinical Practice THIRD EDITION SECTIONS 110 AND INDEX EDITORS ASSOCIATE EDITORS Juan Rodộs MD ... Consultant Hepatologist Beth Israel Deaconess Medical Center Boston, MA, USA Nazia Selzner MD PhD Transplant Hepatology Fellow Multiorgan Transplant Program Toronto General Hospital Toronto, ON, Canada...
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Progestins and the Mammary Gland From Basic Science to Clinical Applications pdf
... 2007-1 Progestins and the Mammary Gland From Basic Science to Clinical Applications O Conneely, C Otto Editors With 43 Figures 123 Series Editors: G Stock and M Lessl Library of Congress Control ... hormone receptors to regulate distinct gene expression profiles in different tissues has been exploited in recent years in the clinical development of novel hormone receptor modulators that have ... the molecular mechanisms by which steroid receptors elicit distinct transcriptional responses in different tissues is critical to the development of optimal tissue-selective receptor modulators...
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Authentication Methods: From Digital Signatures to Hashes doc
... Public Key Cryptosystem One way functions are often used to construct public key cryptosystems We saw one in RSA, we now show an example using the DLOG problem Alice wants to send m to Bob Bob ... seismic waves when detonated) How can A monitor B by using seismic sensors? The sensors need to be in country B, but A needs to access them There is a conflict here Country B wants to make sure that ... like a ciphertext and y1 like a plaintext In order for Eve to make a fake y1 she needs to be able to decrypt m1 to get y1!!! She can’t due to hardness of RSA Existential Forgery: Eve could choose...
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An Introduction to Vascular Biology From basic science to clinical practice SECOND EDITION pdf
... estimated to bind to proteins or to be taken up into stores (Kamishima and McCarron, 1996) Despite this, opening of Ca2+ channels causes [Ca2+]i to rise to micromolar levels This is suYcient to activate ... Growth factors Vascular growth factors are potent chemoattractants and mitogens Factors such as platelet-derived growth factor (PDGF) and basic Wbroblast growth factor (bFGF) are thought to play ... diastole and adds little to systolic pressure but tends to increase early diastolic pressure The former eVect keeps pulse pressure to a minimum and the latter may be important with regard to coronary...
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The Serotonin Receptors From Molecular Pharmacology to Human Therapeutics ppt
... THE SEROTONIN RECEPTORS THE RECEPTORS KIM A NEVE, SERIES EDITOR The Serotonin Receptors: From Molecular Pharmacology to Human Therapeutics, EDITED BY Bryan L Roth, 2006 The Adrenergic Receptors: ... extracellular amino-terminus, and From: The Receptors: The Serotonin Receptors: From Molecular Pharmacology to Human Therapeutics Edited by: B L Roth © Humana Press Inc., Totowa, NJ Kroeze and Roth an ... encoding the serotonin 1c receptor Science 1988;241:558–564 Kroeze WK, Kristiansen K, and Roth BL Molecular biology of serotonin receptors structure and function at the molecular level Curr Top Med Chem...
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Tissue Regeneration – From Basic Biology to Clinical Application Edited by Jamie Davies doc
... osteoclastic markers Receptor Activator of Nuclear Factor Kappa-B (RANK) and Receptor Activator of Nuclear Factor Kappa-B Ligand (RANKL) strongly increased and cells showed the ability to resorb bone (Fig ... transition from inflammatory to the remodelling phase in tissue repair Advanced laser systems allow to apply more complex treatment protocols, to try to potentiate or to exploit synergistically ... Regeneration – From Basic Biology to Clinical Application not required when the cell disassembles microtubules in the cell body to give rise to the formation of neurites, while TAU is required to add...
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chemical kinetics from molecular structure to chemical reactivity
... Chemical Kinetics From Molecular Structure to Chemical Reactivity This page intentionally left blank Prelims.qxd 12/22/2006 10:42 AM Page iii Chemical Kinetics From Molecular Structure to Chemical ... the term molecularity for what we would call today reaction order (the power to which a concentration of a component enters into the rate equation) When referring to the actual concept of molecularity, ... determines the energy necessary to convert from one structure into another, that is, for a chemical reaction to occur In the passage from a reactant well, or valley, to that of products, there is...
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TISSUE REGENERATION – FROM BASIC BIOLOGY TO CLINICAL APPLICATION ppt
... osteoclastic markers Receptor Activator of Nuclear Factor Kappa-B (RANK) and Receptor Activator of Nuclear Factor Kappa-B Ligand (RANKL) strongly increased and cells showed the ability to resorb bone (Fig ... transition from inflammatory to the remodelling phase in tissue repair Advanced laser systems allow to apply more complex treatment protocols, to try to potentiate or to exploit synergistically ... Regeneration – From Basic Biology to Clinical Application not required when the cell disassembles microtubules in the cell body to give rise to the formation of neurites, while TAU is required to add...
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PULMONARY HYPERTENSION – FROM BENCH RESEARCH TO CLINICAL CHALLENGES pot
... functions as high affinity receptor 10 Pulmonary Hypertension – From Bench Research to Clinical Challenges and a cofactor for plasma factors VII/VIIa, the initiator of blood coagulation TF is ... leukocyte apoptosis IL-6-driven STAT3 activation is thought to limit the recruitment of neutrophils as well as pro-inflammatory cytokine However, IL-6 also rescues cells from apoptosis via the ... as inositol triphosphate receptor (IP3R), heterodimeric GTP binding protein, Ca2+ Pulmonary Hypertension – From Bench Research to Clinical Challenges ATPase and several transient receptor potential...
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PROGRESS IN HEMODIALYSIS – FROM EMERGENT BIOTECHNOLOGY TO CLINICAL PRACTICE potx
... coefficient was derived from fitting to clinical data 12 Progress in Hemodialysis – From Emergent Biotechnology to Clinical Practice 3.2 Urea KT/V and creatinine clearance for the kidneys To assess the ... of total solute mass removal from the body, dMR/dt, during hemodialysis is: dM R = K ( Ce − Cd ) + K rCe dt (9) Progress in Hemodialysis – From Emergent Biotechnology to Clinical Practice The total ... patient less prone to IDH in this vulnerable period 30 Progress in Hemodialysis – From Emergent Biotechnology to Clinical Practice Biofeedback system While monitoring may help to understand how...
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báo cáo khoa học: "From basic research to clinical development of MEK1/2 inhibitors for cancer therapy" pot
... activated in response to virtually all mitogenic factors Second, several studies have reported that the mitogenic response to growth factors is correlated with their ability to induce sustained ... Frémin and Meloche: From basic research to clinical development of MEK1/2 inhibitors for cancer therapy Journal of Hematology & Oncology 2010 3:8 Submit your next manuscript to BioMed Central and ... proven to be invaluable academic research tools to investigate the role of the ERK1/2 MAP kinase pathway in normal cell physiology and disease To date, eleven MEK1/2 inhibitors have been tested clinically...
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From Cancer Patient to Cancer Survivor - Lost in Transition: An American Society of Clinical Oncology and Institute of Medicine Symposium pot
... the editors of this wonderful report that we are here today to celebrate I want to begin by thanking the American Society of Clinical Oncology (ASCO) for sponsoring this wonderful symposium today.1 ... delighted to introduce them both here to you today INTRODUCTORY REMARKS Sandra Horning, President, American Society of Clinical Oncology Thank you It is a distinct pleasure for me to be here ... Total mastectomy Positive nodes m Radical mastectomy m Total mastectomy + irradiation N O AT RISK Probability (%) A 27 32 59 56 59 25 21 22 FROM CANCER PATIENT TO CANCER SURVIVOR * Lumpectomy + Chemotherapy...
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Tài liệu Báo cáo khoa học: A single amino acid substitution of Leu130Ile in snake DNases I contributes to the acquisition of thermal stability A clue to the molecular evolutionary mechanism from cold-blooded to warm-blooded vertebrates docx
... corresponding to the nt sequences of the cDNA from positions 28–48 and 867–885, respectively The amplified fragment was ligated into the pcDNA3.1 (+) vector (Invitrogen) to construct the expression vector ... 14657111 to K K and 12357003 to T Y.) and grants from the Japan Science Society 2001 to K M (JSS-12-153), Uehara Memorial Foundation 2002 to H T and Daiwa Securities Health Foundation to K K References ... evolutionary stage from reptiles to birds after deletion of Ser205 from the enzymes of amphibians as they evolved into reptiles Thermal stability of the enzyme might be evaluated as one of the factors that...
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Steroids - From Physiology to Clinical Medicine Edited by Sergej M. Ostojic potx
... the cytoskeleton Many of these regulatory actions related to cell morphol‐ ogy are achieved through rapid, non-classical signaling of sex steroid receptors to kinase cascades, independently from ... produce estradiol from androgens Testosterone contributes to the production of estradiol, while the estrogen estrone is made from androstenedione Phytoes‐ trogens have analogous effects to those of ... P4 13 14 Steroids - From Physiology to Clinical Medicine production, in structural regression to forma corpus albicans and into a follicular develop‐ ment and entrance into a new follicular phase...
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Skeletal Muscle – From Myogenesis to Clinical Relations pdf
... development FGF from the myotome induces epithelial to mesenchymal transition and translocation of dermomytomal cells into the central region of the myotome [57], a process known to contribute to the ... M, Uramoto I, Totsuka T (2000) Differential adaptation of growth and differentiation factor 8/myostatin, fibroblast growth factor and leukemia 22 Skeletal Muscle – From Myogenesis to Clinical ... receptor, either activin receptor-like kinase (ALK4 or ActRIB) or ALK5 to stimulate the phosphorylation of receptor Smad and the Smad2/3 transcription factors in the cytoplasm This leads to the...
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CLINICAL EPIDEMIOLOGY OF ACUTE LYMPHOBLASTIC LEUKEMIA - FROM THE MOLECULES TO THE CLINIC docx
... these children would have to be exposed to Clinical Epidemiology of Acute Lymphoblastic Leukemia - From the Molecules to the Clinic some environmental factor in order to develop ALL, as has been ... section where the review of different topics we want to work with in the future is showed to detail Finally where reference is specially made to the participation of molecular rearrangements in the ... many risk factors that act at the same time to provoke the development of the illness [1] Ac‐ cording to the multicausal theory, illnesses must have at least two risk factors that lead to the development...
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The Evolution from Protein Chemistry to Proteomics Basic Science to Clinical Application potx
... Evolution from Protein Chemistry to Proteomics Basic Science to Clinical Application The Evolution from Protein Chemistry to Proteomics Basic Science to Clinical Application Roger L Lundblad Boca Raton ... breast cancer: From molecular portraits to clinical utility, in Oncogenomics: Molecular Approaches to Cancer, C Brenner and D Duggan, Eds., John Wiley & Sons, Ch 5, 77–100, 2004 TRANSCRIPTOMICS Kellner, ... separate from translational processing as such modifications are of major interest to investigators using proteomics to study toxicology and environmental health The reader is directed to several...
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Báo cáo khoa học: Molecular basis for substrate recognition and drug ˚ resistance from 1.1 to 1.6 A resolution crystal structures of HIV-1 protease mutants with substrate analogs pptx
... peptides, extending from P3 to P4¢ and from P3 to P3¢, respectively The analogs NC-p1 and p1-p6 extended from P5 to P5¢, while p6pol-PR extended from P5 to P6¢ because lysine was added to provide greater ... average B-factors ranged from 8.0 A2 at the higher res˚ at the lower resolutions for protein olutions to 22.4 A ˚ main chain atoms, and 10.6–29.9 A2 for protein side chain and inhibitor atoms Alternate ... interactions with substrate analogs compared to those with clinical inhibitors Substrate analogs showed more flexibility than clinical inhibitors in binding to the mutant PRs The highresolution crystal...
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báo cáo hóa học:" Translating molecular medicine into clinical tools: doomed to fail by neglecting basic preanalytical principles" pptx
... a biomarker in clinical trials [25,26] This principle should be considered already in an early stage to transfer basic science discoveries into new clinical tools In addition, molecular medicine ... of one of the significant "obstacles" to effective translational medicine contributing to the "lost of translation" as well documented in JTM journal [14] To highlight the role and effects of ... Journal of Translational Medicine 2009, 7:87 The study of Diekmann et al [1] deals with an interesting topic and shows the potential of basic science discovery to improve clinical medicine...
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