from growth regulatory factors to cell cycle genes
Báo cáo y học: " From transcription start site to cell biology" ppt
... factor binding sites were identified and this information was linked to changes in expression levels of the downstream transcript to infer the activity of the relevant transcription factors From ... abundantly clear by the study from the FANTOM Consortium and the Riken Omics Science Center [11], which modeled the transcriptional regulatory networks of a differentiating human cell The authors used ... differentiation, as opposed to the model in which the process is controlled by a small number of ‘master regulators’ A similar strategy could be applied to identify transcription factors involved in regulation...
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Báo cáo khoa học: Injection of poly(b-L-malate) into the plasmodium of Physarum polycephalum shortens the cell cycle and increases the growth rate pot
... linker histone H1 in the cytoplasm during S-phase and G2-phase of the cell cycle but not in G1-phase have been reported for HeLa cells [26] In some other mammalian cells, examples of cytoplasmic ... strains, which Ó FEBS 2004 Polymalate effects growth and cell cycle (Eur J Biochem 271) 3809 Fig Effects of polymalate injection on growth and duration of the cell cycle Variable amounts of PMLA (A–D) ... the increase in the growth rate and the shortening of the cell cycle might be related to the ability of PMLA to form complexes with nucleic acid binding proteins and thus to compete with nucleic...
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Báo cáo khoa học: A transcription factor of lipid synthesis, sterol regulatory element-binding protein (SREBP)-1a causes G1 cell-cycle arrest after accumulation of cyclin-dependent kinase (cdk) inhibitors pdf
... ubiquitin pathways in a cellcycle-dependent manner and could thereby regulate the cell cycle and growth It is important to investigate endogenous Fbw7 activity in relation to the cell cycle and lipid ... regulate the cell cycle and growth Thus, lipid synthesis in proliferating cells is not simply a secondary event under the regulation of cell growth [24], but rather, actively controls cell growth This ... SREBP-1a (A) Expression of genes involved in lipid synthesis and cdk inhibitors in relation to cell- cycle progression Total RNAs (10 lg) were prepared from each CHO stable cell line (CHO-BP1a, CHO-BP-2...
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Báo cáo khoa học: Analysis of the contribution of changes in mRNA stability to the changes in steady-state levels of cyclin mRNA in the mammalian cell cycle doc
... RNA from elutriated cells The cell cycle distribution of the cell fractions is shown in Fig 5219 Cell cycle regulation of mouse cyclin mRNAs A Penelova et al Fig Cell cultures of mouse EL4 cell ... enriched cell cycle fractions of mouse EL4 cells Cells were separated either by elutriation or by cell sorting into G1, S and G2 ⁄ M phase fractions (A) Cells were separated by elutriation into about ... fraction of cells (sometimes up to 30%) were unable to resume growth It was reassuring that cell sorting gave results similar to elutriation, as transcription inhibitor is added to unperturbed...
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Báo cáo khoa học: The inhibition of Ras farnesylation leads to an increase in p27Kip1 and G1 cell cycle arrest pdf
... commonly observed during the progression from normal cells to benign and malignant tumors p27Kip1 appears to play a role in the switch from cell proliferation to differentiation, and loss of p27Kip1 ... Rat1/ras cell growth at the G1 phase of the cell cycle Experimental procedures Rat1/ras or Rat1/myr-ras cells was plated in agar at a density of 000 cells per well in a 96-well plate in growth ... HR12 induces arrest of Rat1/ras cells at the G1 phase of the cell cycle We next examined the effect of HR12 on the distribution of Rat1/ras cells in the cell cycle To resolve the G1, S and G2/M...
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Báo cáo sinh học: "Differences in the way a mammalian cell and yeast cells coordinate cell growth and cell-cycle progression" ppt
... yeasts, cellsize checkpoints apparently operate to coordinate cell growth and cell- cycle progression For Schwann cells, by contrast, extracellular signals that stimulate cell growth, cellcycle ... and Raff Cell growth occurs in all phases of the cell cycle except M phase [1,3] Yeast cells are thought to coordinate cell- cycle progression with cell growth through the action of cell- size ... can depend on extracellular signals [19] The rate of Schwann cell growth is limited by extracellular growth factors We showed previously that Schwann cell growth depends on extracellular signals,...
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Báo cáo khoa học: "Sensitivity of seedlings from different oak species to waterlogging: effects on root growth and mineral nutrition" pdf
... of tolerances to waterlogging Their degree of tolerance is often estimated from either duration of survival or measured growth and productivity in forest stands or young plantations submitted to ... species known to differ in their waterlogging toler- (Q robur, Q rubra and Q palustris) and tested their ability to produce adventitious roots in response to a 7-wk flooding We tried to assess the ... connected to the bottom of these pots, allowing a RESULTS Effects of flooding and root growth on shoot Flooding was imposed after complete growth cessation in Q rubra and Q palustris as shown by growth...
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Báo cáo y học: "Susceptibility of rheumatoid arthritis synovial fibroblasts to FasLand TRAIL-induced apoptosis is cell cycle-dependent" ppsx
... is a well-known apoptosis-signalling cell surface receptor belonging to the TNF receptor family [36] To investigate the susceptibility of RASFs to FasL-mediated apoptosis, cell surface expression ... several important cellular functions (including cell growth, cell cycle entry, migration, and cell survival), is an endogenous inhibitor of the TRAIL-mediated synovial cell apoptotic pathway Furthermore, ... spindle assembly and impedes re-entry into the cell cycle [32,33], was used to arrest RASFs at G2/M phase (~4 n DNA) Cell cycle analysis of earlycultured RASFs (104 cells) treated with nocodazol for...
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Báo cáo khoa học: "Malignant mixed Mullerian tumors of the uterus: histopathological evaluation of cell cycle and apoptotic regulatory proteins" ppt
... The aim of this study is to evaluate the role of cell cycle and apoptotic regulatory proteins in the carcinomatous and sarcomatous components of uterine MMMT in relation to clinicopathological ... protocols were not standardized across all cases studied Cell cycle and apoptotic regulatory proteins were analyzed for statistical significance as possible prognostic indicators Two cell cycle ... adhesion, cell death and apoptosis [2] Cell survival and apoptotic regulatory proteins such as the Bcl-2 family of genes, PCNA, p16, p21, p27, and cyclin D1 are of vital importance to malignant...
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Báo cáo y học: " Classic swine fever virus NS2 protein leads to the induction of cell cycle arrest at S-phase and endoplasmic reticulum stress" potx
... induces cell cycle arrest at S-phase To determine whether the growth inhibition of CSFV NS2-expressing cells was due to the arrest of the cell cycle at a certain phase(s) of cell division, flow cytometric ... intervals Cell cycle analysis by flow cytometry Since DNA fragmentation suggests apoptotic DNA damage and indicated by a distinct sub-G0/G1 peak in flow cytometry assay [14], the cell cycle and apoptosis ... subcellular localization of CSFV NS2 protein and its effects on cell growth and cell cycle progression The swine endothelial vascular cell is one of the CSFV target cells, vascular endothelial cells...
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báo cáo khoa học: " Berry and phenology-related traits in grapevine (Vitis vinifera L.): From Quantitative Trait Loci to underlying genes" ppt
... average size of linkage groups was 71 cM, ranging from 26 to 125 cM; for the Big Perlon map the average size was 60 cM, ranging from to 11 to 99 cM The total number of positioned markers per linkage ... cM distance of the local LOD maximum from the top of the linkage group, with 't' for top and 'b' for bottom of linkage group; Nearest marker = marker nearest to the QTL position; Interval = 1-LOD ... addition to the major QTL on LG18, we identified QTLs on LG (3.5–21.4% of total variance), LG10 (7.7–36.3% of total variance), LG13 (7.2–15.7% of total variance) and finally LG15 (6.7– 13.0% of total...
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Báo cáo khoa học: " Resistance to penicillin of Staphylococcus aureus isolates from cows with high somatic cell counts in organic and conventional dairy herds in Denmark" potx
... resistance was found in 14% to 22% of the SA isolates from milk samples examined at the Danish Veterinary Institute (DVI) from 1994 to 2001 [6,20] From 1963 to 1983 isolates from different surveys ... changed from none to 32% of the tested cows within one year In another herd the prevalence of SAr changed from 23% to 0% over two years while the overall prevalence of SA only decreased from 80% to ... penicillin resistance between 3.1% and 7.2%, from 1983 to 1988 the prevalence varied from 7.0 to 11.4% The prevalence of penicillin resistance found at DVI from 1994 to 2001 was higher than the results...
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Báo cáo y học: " Human T-lymphotropic virus type-1 p30 alters cell cycle G2 regulation of T lymphocytes to enhance cell survival" pptx
... Camptothecin effectively induces apoptosis in cells in the S phase of the cell cycle This increased susceptibility to camptothecin-induced apoptosis in the ACH.30.1 cell line is likely due to ... of ACH.30.1 cells were induced into apoptosis compared to ACH.1 cells (nonparametric Wilcoxon rank sum test, p-value 0.03) ACH.30.1 cells and ACH.1 cells were induced into apoptosis to an equal ... sensitivity to apoptotic stimuli, we tested the cell lines following treatment with various apoptosis inducing agents, camptothecin, etoposide, and TRAIL Camptothecin is a topoisomerase I inhibitor,...
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Báo cáo y học: "Comment on and reply to "Analysis of variation of amplitudes in cell cycle gene expression" by Liu, Gaido and Wolfinger: On the analysis of gene expression during the normal, eukaryotic, cell cycle" docx
... G1-control of the mammalian cell cycle Prog Cell Cycle Res 2000, 4:27-39 Cooper S, Shayman JA: Revisiting retinoblastoma protein phosphorylation during the mammalian cell cycle Cell Mol Life Sci 2001, ... synchronized cells should be narrower than the size distribution of the original population, cell size should increase as the cells move through the cell cycle, and during the period of cell division ... distribution, or does not have the starting cells mimic a particular cell (with respect to DNA content, cell size and cell composition) of a particular age, then the cells are not synchronized A complete...
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Báo cáo y học: " Distinguishing between linear and exponential cell growth during the division cycle: Single-cell studies, cell-culture studies, and the object of cell-cycle research" ppsx
... include mitochondria as part of the cytoplasm During cell growth this cytoplasm produces more cytoplasm As there is no expectation that cytoplasm produced by a cell cannot immediately enter into biosynthesis, ... of cell cycle growth is whether specific mechanisms exist that need to be looked for and understood to produce linear growth, or whether there are no further specific mechanisms to regulate cell ... regulate cell growth If growth is exponential, no further search for growth control is needed as exponential cytoplasm growth can explain the total cellular growth If, however, growth is linear...
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Báo cáo y học: "Metabolic cycle, cell cycle, and the finishing kick to Start" potx
... Respiratory quotient Budding of cells G1 S,M Start G1 Start Cell- cycle progression Figure The metabolic cycle in slowly growing yeast cells (a) The cycle of stored carbohydrate In slowly growing cells, ... spontaneously synchronized with respect to the cell cycle: all the cells in the culture align at the same place in the cell cycle and then progress through the cycle together, an effect first seen more ... course, some of these are typical cell- cycle- linked genes such as the histone genes, as noted in previous studies [16] But there were many strongly oscillating genes that are intimately associated...
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Báo cáo y học: " Building bridges from ‘omics’ to cell biology" ppt
... Lunenfeld Research Institute, Toronto, Canada) discused an ethylnitrosourea-based mutagenesis screen in mice that uncovered genes conferring differential sensitivity to serotonin, a neurotransmitter ... cryo-electron tomography to generate three-dimensional topological structures of macromolecules He then identifies different macromolecular complexes in fixed cells, based on a library of topological ... work using the immobilized tyrosinekinase inhibitors imatinib mesylate (Gleevec), bosutinib and dasatinib as affinity reagents to isolate kinases from cell lysates Although bosutinib and dasatinib...
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cell cycle regulation - Ebook USA ( biotechnology)
... Cell Cycle Regulatory Genes Required for Initiation and Maintenance of Meiosis Transcriptional and Translational Factors Cell Signaling Cytoplasmic and Apoptotic Factors ... exciting areas of cell cycle regulation The chapters of this book have been written by experts in the cell cycle field and cover topics ranging from yeast to mouse and from Rb to sterility In the ... Contributions to the knowledge of the cell and its vital processes J Cell Biol 25:1–69 Follette PJ, O’Farrell PH (1997) Connecting cell behavior to patterning: lessons from the cell cycle Cell 88:309–314...
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Báo cáo y học: "BRCA1 May Modulate Neuronal Cell Cycle Re-Entry in Alzheimer Disease"
... than succumbing to apoptosis immediately, neurons may attempt to survive by initiating cell cycle progression, and attempting to control the deregulated cell cycle and concurrent apoptotic signaling ... Elevations in BRCA1 in neurons in AD may represent an attempt towards homeostasis by the cell, working with other factors to halt the cell cycle and mediate DNA repair Interestingly, a much higher ... cases, the number of tau-positive NFT ranged from to 260, and in AD cases, from 39 to 321 NFT Figure Monoclonal antibody to BRCA1 recognizes intracellular NFT in all cases of AD (A), yet in many...
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Báo cáo y học: "Cell Cycle Arrest by a Natural Product via G2/M Checkpoint"
... pro-apoptotic effect of CKBM is further investigated in AGS, a gastric cancer cell line CKBM is found to inhibit cell proliferation through the induction of apoptosis and G2/M cell cycle arrest To ... 66:233-238 Gillio Tos A, Cignetti A, Rovera G, Foa R Retroviral vector-mediated transfer of the tumour necrosis factor alpha gene into human cancer cells restores an apoptotic cell death program ... genistein is found to induce G2/M cell cycle arrest in MCF-7 cells [2] Whereas anti-carcinogenic compounds like lunasin and lectins in soybean were shown to induce apoptosis in malignant cells [3] Schisandra...
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