... weak ties in situational conversation (Reingen and Kernan 1986; Brown and Reingen 1987) • Individual influence inthe buying systems in a B2B context (Ronchetto, Hutt and Reingen 1989) The Socio-Economic ... in cross channel use – 54% of Gen Yers research online and buy offline – Gen Xers also are more likely to have researched and purchased a product online – Gen Xers also dominate online shopping ... (Balasubramanian and Mahajan 2001; Devaraj, Porter and Sun 2006; Dholakia et al 2004; Kozinets 2002; Muniz and O’Ginn 2001; Porter and Donthu 2004; Schouten and Koenig 2002) Questions for future research...
... role of HIF-1 in chondrocytic energy generation, matrix synthesis and cell survival During hypoxic and normoxic conditions, functional inactivation of HIF-1α inthe presence of interleukin-1β ... resulted in a significantly increased number of apoptotic chondrocytes These in vitro data are in accordance with thein vivo observations described by Schipani and colleagues [15] Loss of HIF-1α in ... that HIF-1 is of pivotal importance in cartilage development and homeostasis Furthermore, given the decreased oxygen levels and presence of inflammatory mediators during the course of OA, a causal...
... Mozambique Int J Epi 1996, 25(2):349-356 Page of 13 Coninx R, Dupuy C: Effects ofthe civil war in Central Mozambique and evaluation ofthe intervention ofthe International Committee ofthe Red ... outside Beira) and absence of a father This indicates that women may have been searching for sanctuary in Beira while men were either fighting or working in neighboring countries So, agreeing with ... returning which could have helped explain some ofthe patterns observed inthe late 1990s-early 2000s Even including the other causes among the 24-49 year olds in Beira, HIV/AIDS was the main cause...
... regard being specially paid, inthe Wrst instance to the contribution of Members ofthe United Nations to the maintenance of international peace and security and to the other purposes ofthe Organization, ... been the mixture of UN and extra-UN activity, with the UN regularly laying down the guiding principles, helping keep the parties to them, and then acting as the rallying-point in gathering political ... Council andthe state leading the coalition about the continuation and interpretation ofan earlier mandate to use force This problem arose inthe Korean War in 1950–3, and was also at the centre of...
... description ofthe statistical methods used, detailing ofthe flow of participants through the study and their baseline characteristics, andan interpretation ofthe results as they fit inthe context of ... content ofthe interventions, the statistical analytic decisions, andthe dates of recruitment and follow-up, and they addressed their findings inthe context ofthe literature Primary weaknesses included ... regarding the intervention itself, the statistical analyses performed, andthe methodology and adequate discussion ofthe generalizability ofthe results and how they fit inthe context of existing...
... alternative splicing inthe 3¢-end (leading to the formation of a, b, c, d, e, f and g isoforms) [8–12]; (b) the use ofan extrinsic promoter (P1) andan alternative, intrinsic promoter (P2) inthe 5¢-end ... lung cancer cell lines (HTB59, HTB58, and SKMES1), inthe adenocarcinoma cell lines (CALU3, CRL5935, A549, and SKLU1), andinthe large cell lung cancer cell line (CORL23) In agreement with the ... noted inthe anaplastic carcinoma cell line (Fig 2C, lane 3), andthe levels ofthe complexes appeared to remain equivalently high inthe small cell lung cancer cell line (Fig 2C, lane 4), the...
... read and approved the final manuscript JV, JRo and AF prepared the design ofthe manuscript; SV made the treatment planning and selected the patients; MS managed the experimental schedule and ... toxicity andthe percentage ofthe urinary bladder receiving 50 Gy, andthe association of late GU toxicity with the percentage ofthe urinary bladder receiving 40 Gy Both types of urinary toxicities ... occurrence andevolutionof acute and late GI and GU toxicities andthe treatment related characteristics in patients entering our hospital Important findings include: (i) a higher proportion of acute...
... Dehydroepiandrosterone inhibits the proliferation of HUVEC by enhancing the expression of p53 and p21, restricting the phosphorylation of RB, and is androgen- and estrogen-receptor independent ... can induce early and late apoptosis and also necrosis Discussion DHEA is an intermediate inthe biosynthesis of androgen and estrogen hormones It was originally isolated from the adrenal gland, ... presence and risk of development ofcancer Oral administration of DHEA to mice inhibits spontaneous breast cancerand chemically induced tumors ofthe lung and colon [7]; however, its effect in cervical...
... the autoimmune process On the basis ofthe previous finding of a differential impact of Th1 and Th2 cells on the function of bone marrow-derived DCs (BMDCs), transcriptional changes induced in ... described the effect of angiogenesis blockade in murine CIA Angiogenesis represents an attractive target for therapy in RA, in that increased synovial vessel density is a feature of RA and several angiogenic ... disease the group has made crosses between susceptible and resistant rat strains Several loci that control the onset of arthritis, the severity and chronicity ofthe disease, and autoantibody...
... toxicity-free Of particular importance is the lack of understanding ofthe fundamental roles and mechanisms of protein quality control in development, organ function, theevolutionand fitness of organism ... cells and normal cells offers an advantage for the agents that target the UPR to achieve the specificity incancer therapy The therapeutic potential of targeting the UPR components incancer mainly ... important mechanism required for cancer cells to maintain malignancy and therapy resistance Identifying the UPR components that are activated or suppressed in malignancy and exploring cancer therapeutic...
... training and leadership behavior modeling to bring about significant cultural change and quality and financial gains In contrast to the number of transformational strategies originating in manufacturing, ... than the other Six Sigma studies in terms of external validity In spite of this strength, they still both share many ofthe same limitations and concerns, as noted above Inthe case ofthe hand ... transforming inputs into outcomes) ofan organization Adopting and routinizing innovations capable of generating fundamental organization-wide change in practices is a necessary condition of...
... training and leadership behavior modeling to bring about significant cultural change and quality and financial gains In contrast to the number of transformational strategies originating in manufacturing, ... than the other Six Sigma studies in terms of external validity In spite of this strength, they still both share many ofthe same limitations and concerns, as noted above Inthe case ofthe hand ... transforming inputs into outcomes) ofan organization Adopting and routinizing innovations capable of generating fundamental organization-wide change in practices is a necessary condition of...
... trend of FDI into Vietnam First, within the manufacturing, while during the early part of 1990s, the majority of FDI inflows were in oil and mining sector, by the end ofthe last century and early ... to the fact that Hanoi and Ho Chi Minh city are the two main economic hubs ofthe country The concentration of FDI in Hanoi and Ho Chi Minh has been attributed to the increased cost of living and ... and modified again to acknowledge the right of foreign investors to merger and acquire companies and branches, andthe right to transfer the form of investment Most recently the Unified Law of...
... in two scales ofthe inventory namely: students’ perceived use of all their mental processes and their satisfaction in their organizing and evaluating their learning ofthe Foreign Language The ... strategies Advance organization Previewing the main ideas and concepts ofthe material to be learned, often by skimming the text for the organizing principles Advance preparation Rehearsing the language ... department basing on their good scores in their entrance exam to university, their results ofthe language proficiency test and their IQ test at the beginning ofthe school year The group of student...
... (given in kb) was determined by kHindIII Size ofthe bands observed in each autoradiogram is indicated at the right side The 6.6 kb band detected in lanes b, c, and d in autoradiogram (B), and lanes ... enhancing activity, as determined by transient transfection, was associated with DHSs inthe Na channel gene andinthe first intron ofthe Ig-b gene Furthermore, the acetylation status of H3 and ... determine the roles of these DHSs on the transcription of Ig-b gene and on the maintenance ofthe active chromatin state Results Generation of DT40/Cre cells with a long deletion in one allele of the...
... All use of animals complied with the ARVO Statement for the Use of Animals in Ophthalmic and Vision Researchandthe Intramural Animal Care and Use program ofthe National Institutes of Health ... other mammals A change inthe ancient role of cN may be one part of a suite of molecular adaptations inthe eye inthe human lineage In addition to theevolutionof cN and cS crystallins, even more ... relative to cS, the protein has insertions (mainly of glycines), inthe c–d loops of motifs I and III andinthe connection between motifs III and IV (Fig 1) This protein was given the name cN,...
... EMSA analysis ofthe function of Octamer motif inthe fgl2 promoter Lanes 2–5 of panel A and lanes 2–5 of panel B, NE were incubated with labelled consensus Oct-1 Lanes 6–12 of panel A and lanes ... probe are indicated inthe top ofthe panel Supershift, ss-Sp1 and ss-Sp3, were shown in presence of anti-Sp1 and anti-Sp3 Ig Cold and mutated competitors are indicated at the top ofthe figure ... endothelial cells were incubated with probes shown in Table and Fig Arrows indicate the bands that are interacting with these probes All the lanes have labelled probes The adding of extracts and...