food and drug administration and the regulation of small molecules for orphan diseases
Báo cáo khoa học: MicroRNAs and the regulation of fibrosis potx
Ngày tải lên :
15/03/2014, 11:20
... treatments typically target the inflammatory response, the mechanism of fibrosis is poorly understood and there are few effective therapies For these reasons, and knowing the multitude of pathways that miRNAs ... to the development of multiple diseases Fibrosis is characterized by the excess deposition of extracellular matrix (ECM) components, which is the end result of an imbalance of metabolism of the ... downregulation of the miR-29 family members (miR-29a, miR-29b and miR-29c) in the border zone of murine and human hearts during myocardial infarction [25] This study also showed down -regulation of...
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Báo cáo khoa học: Galanin-like peptide and the regulation of feeding behavior and energy metabolism pptx
Ngày tải lên :
29/03/2014, 21:20
... neurons project from the ARC to the PVN, and the other in which they project to the MPA, bed nucleus of the stria terminalis and lateral septal nucleus Central administration of GALP activates neurons ... known about the role of alarin, which was discovered as an alternate transcript of the GALP gene Further elucidation of the function of GALP and alarin will provide the necessary basis for the treatment ... and stimulates thermogenesis in rodents The short-term orexigenic actions of GALP are mediated via NPY and the orexinergic pathway in the rat The long-term anorectic and thermogenic actions of...
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báo cáo khoa học: " Trust and the regulation of pharmaceuticals: South Asia in a globalised world" ppt
Ngày tải lên :
11/08/2014, 14:21
... withdrawn, otherwise retailers and wholesalers would no longer make profits, leaving the companies unscathed The NCDA argued that the volume of drugs being sold would remain the same, and that the drug ... widespread dissemination of information on political and other violations of public trust, the restructuring of the economy, and the increase in health care provision by for- profit institutions, which ... with other patients; and prescriptions may have a life of their own, generating further drug purchases either for the original patient or for someone else entirely [25,26] India and Nepal’s drugs...
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Báo cáo y học: "Influence of HLA DRB1 alleles in the susceptibility of rheumatoid arthritis and the regulation of antibodies against citrullinated proteins and rheumatoid factor" ppsx
Ngày tải lên :
12/08/2014, 12:20
... to study the effect of the presence of HLA-DR3 or DERAA-encoding alleles on susceptibility, we combined homozygous and heterozygous patients and controls for these alleles and compared them with ... draft the manuscript TC and EM-C participated in data collection and helped draft the manuscript GO helped in the statistical analysis and participated in the design of the study MAL-N and JLV ... stratification for the presence of the SE As these same alleles have been associated with a reduced risk of RA [17,18], it is possible that these results are due to the low number of patients remaining...
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Báo cáo y học: "Oxygen-sensing mechanisms and the regulation of redox-responsive transcription factors in development and pathophysiology" ppsx
Ngày tải lên :
12/08/2014, 18:20
... on the other hand, is relatively quick and violent, characterized by the swelling of the cytoplasm, the rupturing of cell membranes, the dilation of the mitochondria and the disintegration of ... enlarge at the beginning of the fifth week to form the main bronchi The embryonic stage is marked by the formation of the lobular and segmental sections of the respiratory tree as columnarepithelium-lined ... in the thickness of the interstitium, thinning of the epithelium and separation of the terminal air units This stage also marks the terminal differentiation stages of alveolar ATI and ATII epithelial...
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Báo cáo y học: "Global nucleosome distribution and the regulation of transcription in yeas" doc
Ngày tải lên :
14/08/2014, 14:21
... transcription factors and the cofactors they recruit to the regulatory regions of the genes are strong candidates Recent studies show that the relationship between transcription-factor binding and nucleosome ... When the cells are heat shocked, these genes are rapidly repressed and their nucleosome occupancy increases [8] This suggests that nucleosome occupancy is either the cause or the result of the ... histones In either case, the physical fractionation of yeast chromatin suggests that the chromatin is organized differently between coding and noncoding regions of the genome, and the heterogeneous...
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Rice Land Designation Policy in Vietnam and the Implications of Policy Reform for Food Security and Economic Welfare
Ngày tải lên :
08/08/2015, 19:23
... However, the law also stipulates the formulation and enforcement of regular land use plans by different levels of government These plans explicitly specify the areas for rice land and for other crops ... The purpose of the phantom taxes is to give effect to both the government’s policy of land designation, and the economic cost of this policy expressed in terms of the land rent foregone by the ... Region-specific land use modeling Within each of the seven agro-ecological regions of our model, we distinguish modeling of the demand- and supply-sides of the land market Beginning with the demand side,...
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Tài liệu Báo cáo khoa học: The effect of small molecules in modulating the chaperone activity of aB-crystallin against ordered and disordered protein aggregation pdf
Ngày tải lên :
18/02/2014, 16:20
... decrease in the amount of precipitation in the presence of high concentrations of Arg-HCl in the absence of the chaperone precluded analysis of the effect of this concentration on the protective ... analysis of the effect of these concentrations on the chaperone activity of aB-crystallin (Fig 4B,C) None of the compounds had an effect on the morphol- A C 940 B ogy of the amyloid fibrils formed ... 7.4, for days either in (A) the absence or (B) the presence of aB-crystallin (0.4 mgÆmL)1) and either 250 mM of Gly (d), 250 mM of Lys-HCl ()), 250 mM of Arg-HCl ( ) or 100 mM of GdnHCl (h) The...
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Báo cáo hóa học: " Research Article Coorbit Theory, Multi-α-Modulation Frames, and the Concept of Joint Sparsity for Medical " ppt
Ngày tải lên :
22/06/2014, 01:20
... device with 151 sensors (coils) The color encodes the Gaussian weighting, that is, the influence of the synthetic background signal The center of appearance of the synthetic signal is marked by a ... to a mixed form of the wavelet and the Gabor transform, and it also provides some kind of homotopy between both cases Indeed, for α = 0, we are in the classical Gabor setting, whereas the case ... sinusoidal signal) forms the data basis to be analyzed In order to evaluate advantages and/ or disadvantages of the two methods, the maximum amplitude at the center of appearance of the synthetic data...
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báo cáo khoa học: " Systems medicine and the integration of bioinformatic tools for the diagnosis of Alzheimer’s disease" doc
Ngày tải lên :
11/08/2014, 12:21
... encompass only informatics and statistics; for example, it includes the development of tools not only for storing and mining the data, but also modeling of the data in the context of disease pathophysiology ... http://genomemedicine.com/content/2/11/83 Page of folding and thus formation and stabilization of protein secondary structure [36] The importance of understanding the structural and spatial context of AD-associated proteins and peptides ... conceived and wrote the manuscript JL and HS critically reviewed the manuscript and contributed to its writing Page of Author information MO is a Research Professor of systems biology and bioinformatics...
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Báo cáo y học: "HLA-DR regulation and the influence of GM-CSF on transcription, surface expression and shedding
Ngày tải lên :
03/11/2012, 09:57
... than the level of HLA-DR in the cell lysates (5ul of a in 10 dilution, from x 106 PBMC) The shed HLA-DR therefore seemed to represent a small fraction of the total HLA-DR of the cell, however the ... Gratton and Andrea Fazakerley for recruiting patients into the study We would also like to acknowledge Dr S Jurcevic for the kind gift of the purified HLA-DR, Drs B Flanagan and D Newton for their ... antibody for 30 minutes at 4˚C in the dark, washed and resuspended in 0.5 ml of PBS For intracellular measurement of HLA-DR the PBMC were fixed for 10 minutes in 1% paraformaldhyde, washed in PBS and...
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Tài liệu Báo cáo khoa học: Roles of AP-2 transcription factors in the regulation of cartilage and skeletal development doc
Ngày tải lên :
16/02/2014, 09:20
... tumorigenesis and genetic diseases [47] Most analyses of the regulation of AP-2 and the interactions of the transcription factor with binding partners, as well as of the regulation of target gene ... increase in apoptosis [73] The authors of this study ascribe the regulation of outgrowth of limb buds and patterning of the digits to the chicken AP-2 The role of AP-2a was further studied in zebrafish ... expression, have been performed for AP-2a Up to now, there have been no similar studies for the other AP-2 isoforms Chondrogenesis and skeletal development Most elements of the vertebrate skeleton...
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Tài liệu Báo cáo khoa học: Osmosensing and signaling in the regulation of mammalian cell function docx
Ngày tải lên :
18/02/2014, 16:20
... activation of the protein kinase B survival pathway [31], p53 activation [32], induction of the serum- and glucocorticoidinducible kinase Sgk [33], expression of the heat shock protein Hsp70 [34] and ... trafficking of the CD95 from inside the hepatocyte to the plasma membrane [39], which depends on a ROS-mediated tyrosine phosphorylation of the epidermal growth factor (EGF)-receptor, the association of ... association of CD95 with the EGF-receptor, and phosphorylation of CD95 on Tyr232 and Tyr291 by the EGF-receptor tyrosine kinase activity [15] Although the appearance of CD95 at the plasma membrane...
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Tài liệu Báo cáo khoa học: Characterization of human deoxyribonuclease I gene (DNASE1) promoters reveals the utilization of two transcription-starting exons and the involvement of Sp1 in its transcriptional regulation ppt
Ngày tải lên :
19/02/2014, 06:20
... and quantitative real-time RT-PCR, the locations of the primers DN)105 and DN)9 used in ChIP assays, the locations of the primers DN+232 and DN+254 utilized in 5¢-RACE, and the locations of the ... in fragments F and I The number at the right of each RT-PCR product represents the length of the product The scheme also shows the location of the reverse primer DN+89 used in another starting ... numbers over the diagrams indicate the position of the corresponding nucleotides relative to the translation start site, and the numbers in parentheses below the diagram show the position of the corresponding...
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Báo cáo khoa học: Roles of the SH2 and SH3 domains in the regulation of neuronal Src kinase functions pptx
Ngày tải lên :
06/03/2014, 01:20
... dysfunction SH3 and SH2 domain dysfunction Deletion of N-terminal, SH3 and SH2 domain of active n-Src Deletion of N-terminal, SH3 and SH2 domain of kinase-dead n-Src of PP3, the inactive form of PP2, ... c-Src forms a salt bridge with an arginine located three residues upstream of the conserved PXXP motif of the SH3 ligand The D99N mutation prevents formation of this salt bridge and disrupts the ... R175K mutations therefore inhibit interactions with ligands of the SH3 and SH2 domains, respectively, both intra- and intermolecularly, and thereby disrupt the overall functions of Src kinase [3,18–21]...
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Governing Electronically E-Government and the Reconfiguration of Public Administration, Policy and Power potx
Ngày tải lên :
06/03/2014, 06:21
... (for example, the administration and management of policy, the delivery of services, the development, analysis and evaluation of policy, the involvement of political and democratic processes and ... intention in the use of tools and reflect on the way in which instruments can transform the way in which we understand and see the world In a very literal way, the invention of the telescope and microscope ... 1990s as part of the popularisation of the internet and the World Wide Web This technological event stimulated intense academic and political interest in the use of ICTs for the conduct of government...
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Báo cáo khoa học: Nuclear actin and actin-binding proteins in the regulation of transcription and gene expression docx
Ngày tải lên :
07/03/2014, 01:20
... domain and then to the nascent RNP, where actin in complex with the hnRNP U can facilitate recruitment of PCAF or P2D10 to the active gene Formation of actin filaments in the proximity of the Pol ... RPABC-2 and -3, are present in all three RNA polymerases, and the solution of the crystal structure of Pol II shows that these two subunits are located close to each other at the surface of the polymerase ... genes and has an essential role in the activation of transcription In addition, actin is required for the initiation of transcription through participation in the formation of PICs [17] These...
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INTERNATIONAL STANDARD Microbiology of food and animal feeding stuffs — Horizontal method for the detection of Salmonella spp docx
Ngày tải lên :
07/03/2014, 16:20
... drops of the creatine solution, three drops of the ethanolic solution of 1-naphthol and then two drops of the potassium hydroxide solution; shake after the addition of each reagent The formation of ... at 37 °C and leave for several minutes (approximately min) Add 0,25 ml of the reagent for detection of β -galactosidase and mix Replace the tube in the water bath set at 37 °C and leave for 24 ... carefully (preferably with the lids off and the agar surface downwards) in the oven (6.2) set between 37 °C and 55 °C until the surface of the agar is dry Store the poured plates for up to days at °C...
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Báo cáo khoa học: Regulation of arginase II by interferon regulatory factor 3 and the involvement of polyamines in the antiviral response potx
Ngày tải lên :
07/03/2014, 21:20
... including the gene encoding arginase II (ArgII) ArgII is the extrahepatic isoform of the arginase type enzymes, and ArgI is the hepatic-specific counterpart [16] The two isoforms possess the same ... response to virus infection As the two isoforms of arginase, I (hepatic isoform) and II (extrahepatic isoform), may contribute to the arginase activity measured in the previous experiment, ArgII ... activity for converting l-arginine into l-ornithine and urea, a critical step in the polyamine biosynthesis pathway Subcellular localization of the two isoforms differs, with ArgI located in the cytoplasm...
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Báo cáo khoa học: Use of lithium and SB-415286 to explore the role of glycogen synthase kinase-3 in the regulation of glucose transport and glycogen synthase pdf
Ngày tải lên :
08/03/2014, 08:20
... establish the importance of GSK3 in the acute regulation of glucose transport in terms of its regulatory control of GS in muscle and fat cells we have investigated the effects of Li and the anilinomaleimide, ... and myotubes with antibodies against GSK3a and b Fig 1B shows that whilst preadipocytes express both GSK3 isoforms, the abundance of the b isoform declines by 85%, whereas that of the a isoform ... elements implicated in the regulation of GSK3 and GS To further understand the effects of Li and SB-415286 on cell signalling events we assessed their effects and that of insulin on p70S6K, PKB,...
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