... drag at laminar, transient and turbulent single-phase flows; (2) heat transfer of liquids and gas flows; and (3) two-phase flows in adiabatic and heated micro-channels As indicated by Kandlikar and ... Drop and Heat Transfer in a Single-Phase Flow 33 2.3 Pressure Drop and Heat Transfer in a Single-Phase Flow Many correlations have been proposed in literature for the friction factor and heat transfer, ... pressure drop In recent years spray cooling has received increasing attention as a means of supporting higher heat fluxes In it the liquid is disintegrated into fine droplets that impinge individually...
... known that the activation of these two matrix metalloproteinases is involved in cellular invasion and migration Recent studies also detected BA as an inhibitor of migration, invasion and angiogenesis ... is the finding that in head and neck cancer cells, BA -induced cytotoxic effects were linked to a decreased level of Bax, an inducer of apoptosis [33] In prostate cancer cells, the combination of ... h after incubation with BA Irradiation was accomplished with MV photons and adequate bolus material on a SIEMENS ONCOR (Erlangen, Germany) linear accelerator at a dose rate of Gy/min At 1, 24...
... without looking at the options This makes the purpose of the question clear - Put all relevant material in the stem Do not repeat in each of the alternatives information that can be included in the ... to read and understand, and makes it easier for students to answer the question quickly - Eliminate excessive wording and irrelevant information from the stem Irrelevant information in the stem ... frustrating and often ineffective Writing test questions will always be demanding, even for experienced instructors, but it will be less frustrating for those who know the techniques for writing...
... corresponding to peaks in glass-forming ability and amorphous packing efficiency, indicating that the packing efficiency may not play a dominant role in determining the elastic moduli and CTE of ... packing efficiency in the glassy state and the glass-forming ability for metallic glasses, and the crystallization -induced stresses in phase-change materials, will be critically examined, since ... minimum cooling rate for glass formation, which is the fundamental indicator that reflects the actual kinetic constraint of crystallization However, since it is difficult to measure cooling rates...
... levels in men and we show in this work that similar associations are operating in women, we also looked for a potential gene-to-gene interaction between PPARδ and apoE Allelic variation in apoE ... staining on polyacrylamid gel Statistical Analysis Allele frequencies were determined by gene counting and compared using the ²אtest The data was analysed using SPSS 12.0 software The association ... triglycerides, and insulin [5] In addition, transgenic expression of an activated PPARδ in mice conferred resistance to obesity and hyperlipidaemia [6] Considering that the C allele is linked to a...
... of information from the other participating States”, “make it their aim to facilitate the freer and wider dissemination of information of all kinds” and “encourage cooperation in the field of information ... and other internationally applicable standards, including OSCE commitments E Conclusions and Recommendations The analysis of the data and information provided by the participating States on Internet ... participating States Equally, 13 participating States have private hotlines and 11 have both public and private hotlines to which illegal Internet content can be reported to 91 92 93 This includes INHOPE,...
... dithiothreitol and lgÆmL)1 each of aprotinin, leupeptin, antipain, and pepstatin A), and incubated on ice for 20 The nuclear fractions were isolated by centrifugation at 11 000 g at °C for 10 s The obtained ... fluoride and lgÆmL)1 each of antipain, leupeptin, aprotinin, and pepstatin A) and then incubated for 20 on ice with occasional mixing The nuclear debris was removed by centrifugation at 12 000 ... lanes and 5) Phosphorylation of IKK-b and IjB-a was slightly reduced at 2.5 lm of apocynin and eradicated at 12.5 lm (Fig 4) The ROS level in the SP increased atand reached its peak level at 12...
... at 30 °C with stirring in the ITC cell; the data obtained at this temperature was not included in the analysis The raw data were integrated and normalized for molar concentration The dissociation ... chain of K22 participates in fosfomycin binding, thus providing a rationale for the loss of fosfomycin binding to the K22V and K22E mutant proteins However, two other positively charged amino ... adduct formation with fosfomycin and enzymatic activity of wild-type MurA and the protein mutants investigated in this study Proteins were incubated with fosfomycin alone (10 mM final concentration)...
... plasmin formation, to a decrease in plasmin binding or to a combination of the two We demonstrate that both mAb 34D3 and mAb A10.2 inhibit plasmin binding to cells (Fig 5A) and fibrin (Fig 5B) in a concentration-dependent ... Plasminogen transitions and proteolysis tion into plasmin in situ However, data linking plasminogen conformations and LBS accessibility to its functional properties such as binding to fibrin and ... reinforce plasmin(ogen) anchorage In contrast, in Lys-Pg as in plasmin, K1- and K4-LBS act as independent and complementary domains both able to support plasminogen binding and activation, and both...
... present in their brains [17] In Xenopus laevis, the mammalian form of LHRH appears to be the functional form controlling the reproductive pathway and leutinizing hormone (LH) and follicle stimulating ... has indicated that a form indistinguishable from mammalian LHRH appears to control reproductive behaviors in Xenopus [18], and mammalian LHRH has also been shown to induce ovulation in Rana catesbeiana ... modifications that have been shown to both increase the receptor binding affinity and the pharmacological half-life of the compound [19] This results in high activity in ovulation assays in mammals...
... MDP in inducing mitochondrial proton leak MDP decreases mitochondrial RCR by increasing state respiration (non-phosphorylation state), without affecting state (succinate-link respiration) or state ... °C) Respiration was initiated with mm succinate as substrate State respiration was measured in the presence of 200 lm ADP and state respiration by adding lgÆmL)1 oligomycin Electrode linearity ... electrons through the respiratory chain, increasing the time of interaction between these electrons and molecular oxygen and facilitating the formation of ROS Activation of innate immune cells by MDP...
... dietary curcumin, capsaicin and their combination on iron -induced LDL oxidation in vivo and copper -induced LDL oxidation in vitro Oxidation of LDL observed in iron(II) sulfate-injected rats as measured ... Effect of dietary curcumin and capsaicin on iron(II) -induced (in vivo) and copper -induced (in vitro) LDL oxidation in rats Rats were injected with mL saline or FeSO4 in mL saline (30 mg per kg body ... Manjunatha and K Srinivasan Protective effect of dietary curcumin, capsaicin and their combination on iron -induced LDL oxidation in vivo and copper -induced LDL oxidation in vitro Male Wistar rats...
... in regulating the rate of protein synthesis and cell hypertrophy in skeletal muscle [3–6] mTOR is a serine ⁄ threonine kinase of the phosphatidylinositol kinase-related kinase family and is highly ... obtained in skeletal muscle cells demonstrating how growth factor -induced PI3K ⁄ Akt activation regulates mTOR activity by modulating the interaction between TSC1 ⁄ TSC2 protein complex and Rheb ... Effects of inhibitor treatment (wortmannin and U0126) on insulin ⁄ IGF-1 -induced phosphorylation of PI3K ⁄ Akt ⁄ mTOR-dependent signaling in C2C12 myotubes Fig S2 Complex formation of TSC1 and TSC2...
... EGCG -induced PLC activation and subsequent Ins(1,4,5)P3 production Indeed, as CaM kinase II is activated via the PLC pathway in many cell types [36], and the inhibitor attenuated EGCG -induced increases ... toxin and the phosphoinositide-specific PLC inhibitor, U-73122 Pretreatment with pertussis toxin (100 ngÆmL)1 for 24 h) inhibited sphingosine 1-phosphate -induced PLD activation, suggesting that ... by modulating the redox state of the cell We also found that EGCG induced translocation and activation of PKC-a (a calciumdependent PKC), and PKC was involved in EGCG -induced PLD activation Furthermore,...
... are shown in (A) and (B) Silver staining is shown in (C) and (D) in blue superimposed with the spots of oxidized proteins shown in red Protein labels: 1, a-tubulin; 2, b-tubulin; 3, actin; 4, PDI; ... calciuminduced microtubule depolymerization [36] In this paper, we show that PDT with Hypocrellin A results in direct oxidative modification of tubulin, and we hypothesize that this modification ... protein oxidation and cell death were dramatically different For instance, treatment with 200 lM H2O2 resulted in profound protein oxidation, but caused no cell death PDT with lM Hypocrellin A and...
... stressing that it is these estimates which inject global information into our theory, and exploit the fact that the domain is S rather than some higher genus surface in our main theorems In contrast, ... work in terms of local isothermal coordinates x and y on the domain, and calculate ∇ and ∆ with respect to these, as if we were working on a portion of R2 (in contrast to (1.1) and (1.2)) In this ... Ω Indeed, here, as in Step 2, we are injecting global information using the Hopf differential and the fact that the domain is S Step Armed with the energy estimates on dyadic annuli surrounding...
... phosphorylation of STAT5B induced by Ang II was dramatically inhibited by pretreating VSMCs with AG490 (a specific inhibitor of the JAK-STAT pathway) for 16 h [24], indicating that the activation of STAT5B ... activation of STAT5B in the liver, and of STAT3 and STAT5A in the heart, participates in transcription activation of the AGT gene to modulate the autocrine Ang II loop, and that Ang II-mediated ... antibodies to c-Jun and STAT5B Previous studies have demonstrated that administration of Ang II stimulates the interaction between p300 and STAT5B in the liver, and with STAT3 and STAT5A in the heart,...
... the melting/resolidification velocity and the interface superheating and undercooling, during which the RDF was tried to be applied in determining the interface Tint DT Vint Dz melt-solid interface ... difficulties in measuring the interface temperature during rapid resolidification, however, in order to analyze interface kinetics, the interface location and the interface temperature need to be determined ... is small, Vint, and DT at the interface can be approximated by a linear relation: DT ¼ C V int ðT int Þ ð3Þ The constant C1 is material dependent DT and Vint can be obtained by analyzing the MD...
... between static platelet adhesion andflow cytomCorrelation between static platelet adhesion andflow cytometry Correlation between ADP -induced platelet adhesion (Factor 1) and ADP -induced platelet ... http://www.translational-medicine.com/content/7/1/42 Effects of platelet inhibiting treatment in coronary artery disease When investigating possible effects of platelet-inhibiting treatment with Repeated ... percentage platelet adhesion was calculated Flow cytometry Platelet expression of P-selectin and binding of fibrinogen were measured by flow cytometry as indicators of platelet activation [29-32]...
... representative experiment aimed at quantifying Treg-cell frequency by flow cytometry both at baseline andin expanded CIK cultures is illustrated in Figure 4B and 4C Based on the above data and to ... repeated additions of IL-2 for a maximum of 21-28 days [3,11,12,33] Our interest in TG as a candidate drug to expand CIK cells in preparation for clinical trials originated from reports indicating ... culturing is shown in Figure 1B When used at intermediate (intTG) and high concentration (hiTG), TG induced a greater expansion of PBMC compared with equal concentrations of aCD3 mAb, and the...