flow binding transporters and enzymes on organ and totalbody clearances
Tài liệu Freedom of Expression on the Internet - A study of legal provisions and practices related to freedom of expression, the free flow of information and media pluralism on the Internet in OSCE participating States ppt
... online content has led to challenging restrictions on the free flow of information and the right to freely impart and receive information on and through the Internet Definitional problems and inconsistencies ... European Convention on Human Rights and other internationally applicable standards, including OSCE commitments E Conclusions and Recommendations The analysis of the data and information provided ... 2002/21/EC on a common regulatory framework for electronic communications networks and services, 2002/19/EC on access to, and interconnection of, electronic communications networks and associated...
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Báo cáo khoa học: Ribonuclease H: molecular diversities, substrate binding domains, and catalytic mechanism of the prokaryotic enzymes ppt
... strand recognition is conserved among various type RNases H The DNAbinding groove contains two DNA -binding sites The major site is a phosphate -binding pocket, which is formed by Arg179, Thr181 and ... Journal compilation ª 2009 FEBS T Tadokoro and S Kanaya Liang R, Liu X, Pei D & Liu J (2007) Biochemical characterization and functional complementation of ribonuclease HII and ribonuclease HIII ... well conserved in the StoRNase HI structure The weak conservation of the DNA -binding groove may account for the ability of Sto-RNase HI to cleave double-stranded (ds)RNA Weaker conservation of...
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Báo cáo khoa học: Effects of sphingomyelin, cholesterol and zinc ions on the binding, insertion and aggregation of the amyloid Ab1)40 peptide in solid-supported lipid bilayers ppt
... distribution (i.e the internal organization of the membrane, including molecular anisotropy and the long range molecular order of the bilayer), and in protein ⁄ lipid conformation occurring as a consequence ... structure ⁄ conformation changes that occur upon peptide insertion into the bilayer and subsequent aggregation The resonator surfaces used in these studies were of two designs – low resolution and high ... layer before and after binding of peptide and subsequent aggregation, and of the layer composed of peptide (or a portion of the peptide) that extends beyond the lipid surface Both p- and s-polarized...
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Báo cáo y học: "Differential clinical efficacy of anti-CD4 monoclonal antibodies in rat adjuvant arthritis is paralleled by differential influence on κ α NF-κB binding activity and TNF-α secretion of T cell" pot
... Increased expression of IL-4 and IL-10 and decreased expression of IL-2 and interferon-gamma in long-surviving mouse heart allografts after brief CD4-monoclonal antibody therapy Transplantation 1995, ... intraperitoneally (corresponding to 17.1 and 11.4 mg/kg, respectively, on the basis of a mean body weight of 175 g) on days 1, 0, 3, and 6, i.e day before AA induction, on the day of induction (day ... applicable only to the onset of AA) and the mAbs W3/25 and OX35 as ameliorating Affinity of the monoclonal antibodies Calculation of the affinity constant (KA) resulted in comparable values for OX35 and...
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Báo cáo y học: "Tetra-O-methyl nordihydroguaiaretic acid (Terameprocol) inhibits the NF-B-dependent transcription of TNF-a and MCP-1/CCL2 genes by preventing RelA from binding its cognate sites on DNA" ppsx
... role in the activation of these genes The results of reporter and ChIP assays confirmed this hypothesis We found strong inhibition of NF-Bdependent transcriptional activation and loading of RelA ... Werner T, Nelson EL, Schlondorff D, Nelson PJ: Molecular and in silico characterization of a promoter module and C/EBP element that mediate LPS-induced RANTES/CCL5 expression in monocytic cells ... advantage of: • Convenient online submission • Thorough peer review • No space constraints or color figure charges • Immediate publication on acceptance • Inclusion in PubMed, CAS, Scopus and Google...
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Tài liệu Báo cáo khoa học: Verprolin function in endocytosis and actin organization Roles of the Las17p (yeast WASP)-binding domain and a novel C-terminal actin-binding domain doc
... polarization is further evidence that the functions of Vrp1p in endocytosis, cytokinesis, and growth at elevated temperature, on the one hand, and in cortical actin-patch polarization, on the other hand, ... polarization because this deletion removes critical residues K485 and R486 Substitution of K485 and R486 with alanine is alone sufficient to abolish C-Vrp1p364)817 function in actin-patch polarization and ... of this interaction is conserved [30,52] Interactions of Vrp1p and Las17p in yeast and WIP and WASP-family proteins in mammalian cells are direct and result in constitutive and apparently stable...
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Tài liệu Báo cáo khoa học: Inhibition of pneumococcal choline-binding proteins and cell growth by esters of bicyclic amines pptx
... analysis of ligand binding to C-LytA (A) Conformational changes induced by ligands on C-LytA monitored by near-UV CD with no ligand added (—) and upon addition of ligands: s, d, 2.5 and 20 mM choline; ... in the elution profile, corresponding to partial accumulation of dimers in these conditions [21] On the other hand, addition of 1.5 mm ipratropium generated a new peak with an elution volume close ... daughter cell separation at the end of cell division, causing the formation of long chains of cells with only small effects on cell growth and viability, even at high concentrations of the compound...
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Tài liệu Báo cáo Y học: Interaction of decorin with CNBr peptides from collagens I and II Evidence for multiple binding sites and essential lysyl residues in collagen pot
... helical conformation in our assay conditions [CB2, CB2,4 and CB3 from a1(I), CB12, CB8 and CB10 from a1(II)] (b) All peptides able to bind decorin contain a region corresponding to the d and e bands ... clusters of charged residues responsible of the banding pattern but on specific sequences that contain ionic residues (c) The action on platelet adhesion and activation by only two peptides from type ... by additions of aliquots of M NaOH These additions, however, introduce local strong basic conditions whose consequence is the breakdown of some peptide bonds and the formation of new bonds leading...
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Tài liệu Báo cáo Y học: NMR-based determination of the binding epitope and conformational analysis of MUC-1 glycopeptides and peptides bound to the breast cancer-selective monoclonal antibody SM3 pptx
... glycopeptides In contrast to conventional methods only one substrate is necessary to obtain that information Here, we present the STD NMR epitope mapping and trNOE-based conformational analysis of ... constrained MD simulation and minimization over 200 steps Both the ligand and the binding site were kept flexible during the simulation (C) Superposition of PDTRP (red) with the ligand of the X-ray ... used for the nonbonded interactions The initial velocities for the atoms were taken from a Boltzmann distribution at 300 K and the step size for the integration of Newton’s equation was fs The...
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Báo cáo khoa học: Inactivating pentapeptide insertions in the fission yeast replication factor C subunit Rfc2 cluster near the ATP-binding site and arginine finger motif docx
... origins, corresponded to only 31 different alleles (insertions indicated in bold type in Table 1) In addition to these insertions, generated by straightforward Tn4430 transposition and excision, seven ... K33 and K27 insertion sites were deleted (Table 1) Similar alleles were constructed using rfc2-K33 and rfc2-K22 (rfc2K33D22) and using rfc2-K23 and rfc2-K14 (rfc2K23D14) Note that construction ... discussion, the mutations are considered in three groups dependent on their location in the 3D structure of the Rfc2 protein Mapping the insertions onto the structure of Rfc2: insertions into...
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Báo cáo khoa học: Caenorhabditis elegans metallothionein isoform specificity – metal binding abilities and the role of histidine in CeMT1 and CeMT2 potx
... involved in metal coordination in the Zn– and Cd–CeMT1 and Zn– and Cd–CeMT2 complexes Diethyl pyrocarbonate (DEPC) modification allows the identification and quantification of the histidine residues ... the one responsible for the second DEPC binding, and thus that this histidine is free (non-metal coordinating) in the corresponding metal complex Consequently, regarding the CeMT1 isoform, and ... two DEPC modifications, one is attributable to its N-terminal amino group (i.e with the conclusion being drawn from a comparison with the NtCeMT1 negative control) and only one is attributable...
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Báo cáo khoa học: Characterization of HbpR binding by site-directed mutagenesis of its DNA-binding site and by deletion of the effector domain pot
... affected the binding of one particular set of contacts only, although still allowing overall binding The combination of mutation types and (operator type 45), on the other hand, not only totally ... that a loss of binding affinity correlated to a deterioration of binding contacts in only those regions with new mutations, not throughout the whole operator region For example, HbpR binding to the ... region was concerned (Fig 4) Binding to the UAS C-2 region (in which the mutations had been placed), was impaired both at the 3¢ end of the central regions R22 and R23, whereas the region R21 and...
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Báo cáo Y học: SMAP-29 has two LPS-binding sites and a central hinge docx
... backbone and B, gray backbone), calculated from simulated annealing and geometry optimization (B) A ribbon representation of SMAP-29 in conformation A (left side) and another in conformation B ... (Fig 6) and NH exchange protection are consistent with considerable helicity in this region Representations of the backbone and important side chains of the lowest energy conformers of the L and ... proportional to the strength of the NOE Symbols represent secondary structure as follows: m, helix; , beta strand; w, helical and beta strand conformations present in ensemble; d, conformations are...
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Báo cáo khoa học: ABCG transporters and disease pdf
... studies will continue to uncover additional novel physiological substrates and functions for ABC transporters and define additional roles in human disease The powerful combination of genetic and physiological ... Harrison AA, Highton J, Jones PB, Stamp LK et al (2010) A strong role for the ABCG2 gene in susceptibility to gout in New Zealand Pacific Island and Caucasian, but not Maori, case and control ... ABCG2-mediated urate secretion in several non-renal tissues is conceivable and needs to be investigated in more detail Pharmacological modulation of ABCG2, both inhibition and activation, has been proposed...
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Báo cáo khóa học: Metal-binding stoichiometry and selectivity of the copper chaperone CopZ from Enterococcus hirae pot
... metal binding and selectivity (Eur J Biochem 271) 995 Construction of the synthetic gene Ehcopz and expression vector PQE-cop Protein and metal quantication for titration experiments The six oligonucleotides ... chaperone was found to depend on the experimental conditions used, especially the concentration of the protein and the presence of an exogenous coordinating molecule The dissociation constants ... addition Corrected spectra were obtained after baseline subtraction Sample preparation for electrospray ionization (ESI)-MS analysis For functional ESI-MS analysis under nondenaturing conditions,...
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fluid flow, heat transfer and boiling in micro-channels
... Introduction 1.2 Scope and Contents of Part I The first part of this book deals with the characteristics of flow and heat transfer in the channels and comparison between conventional size and micro-channels, ... in kg/s The 95% confidence uncertainty UQ in the experimental result Q, is given by the following combination of the precision (random) contribution PQ , and the bias contribution BQ : UQ = PQ ... exception of Peng et al (1994b) and Peng and Peterson (1996) fell below the conventional channel values In particular, those of Adams et al (1998, 1999) and Wu and Little (1984) lay in one group...
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Two Phase Flow Phase Change and Numerical Modeling Part 1 pot
... Constantinescu, Constantin Strimbu, Marius Benta and Catalin Mihai Chapter Numerical Modeling and Experimentation on Evaporator Coils for Refrigeration in Dry and Frosting Operational Conditions ... initial conditions and the conditions on D pattern boundaries, one can have the solution of heat equation, T(x,y,z,t) for a certain substantial 2.1 Temperature source modeling The destruction of ... distribution in material is governed by the full temperature source and results by solving the heat equation 2.2 Boundary and initial conditions for heat equation a Dirichlet conditions Let S...
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Two Phase Flow Phase Change and Numerical Modeling Part 3 doc
... second with its original indexing and parameterization method of flow directions, circuits and other relevant information offers extended capabilities for complex configurations and frosting conditions ... circuiting and its effects on coil operation and performance for different configurations of evaporation paths with CO2 as the working fluid The basic unit had only one circuit forming the whole coil and ... International Conference, Design and Operation of Environmentally Friendly Refrigeration and AC Systems, October 15-17, Poznan, Poland Rich D.G., 1973, The effect of fin spacing on the heat transfer and...
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