feedback inhibitors in normal and tumor tissues
Báo cáo y học: " Successful treatment of severe sinusoidal obstruction syndrome despite multiple organ failure with defibrotide after allogeneic stem cell transplantation: a case report" ppsx
Ngày tải lên :
11/08/2014, 17:21
... abdomen with hepathomegaly and ascites; (b) liver tissue obtained through transjugular liver biopsy, haematoxylin eosin stained with necrosis and inflammatory round-cell infiltration through transjugular ... according to the modified Seattle criteria [1] with 1) jaundice and bilirubin >34.2 µmol/l; 2) hepatomegaly or right upper quadrant pain; and 3) fluid retention >2% of the initial body mass We initiated ... prophylaxis during conditioning and female gender Both, donor and patient were cytomegalovirus immunoglobulin g-positive The patient had no history of abdominal irradiation or pre-existing liver disease...
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Báo cáo khoa học: "Year in review 2006: Critical Care – multiple organ failure, sepsis, and shock" doc
Ngày tải lên :
13/08/2014, 03:21
... markedly increased ERK1 and ERK2 expression and attenuated reperfusion lung injury and apoptosis, thus presenting a promising approach for moderating lung injury and supporting recovery after clinical ... hand, but protecting lung epithelial cells and inducing cell recovery on the other hand Mura and colleagues [20] estimated the VEGF expression in lung tissue and its concentration in plasma and ... the c-Jun amino-terminal protein kinases (JNKs), and p38 kinases Notably, whereas ERK1 and ERK2 exert a cytoprotective effect and are involved in cell proliferation, transformation, and differentiation,...
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Báo cáo khoa học: "Bench-to-bedside review: Thrombocytopenia-associated multiple organ failure – a newly appreciated syndrome in the critically ill" pdf
Ngày tải lên :
13/08/2014, 03:20
... continues at 28 days use vincristine DIC Thrombocytopenia Decreased factors V and X, and fibrinogen Decreased antithrombin III and protein C Increased D-dimers Prolonged PT/aPTT Reverse shock and ... heparin, protein C, activated protein C, antithrombin III, or prostacyclin Use fibrinolytics for life or limb threatening thrombosis Remember to keep PT/aPTT and platelets normal when giving fibrinolytics ... include protein C concentrate (prot C), activated protein C (APC), tissue factor pathway inhibitor (TFPI), antithrombin III, heparin, and thrombin inhibitors such as argatroban and hyarudin Therapies...
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Báo cáo y học: "Role of PPAR-δ in the development of zymosaninduced multiple organ failure: an experiment mice study" pot
Ngày tải lên :
11/08/2014, 08:22
... nitrotyrosine in pancreas, lung and gut 18 h following zymosan injection, a positive nitrotyrosine staining was found in the pancreas (A), lung (B) and gut (C) There was no detectable immunostaining ... following zymosan injection, a positive PSelectin staining was found in pancreas (A), lung (B) and gut (C) There was no detectable immunostaining for P-Selectin in pancreas (D), lung (E) and gut (F) ... zymosan-induced mice exhibited positive staining for nitrotyrosine in pancreas (Figure 12A), lung (Figure 12B) and gut (Figure 12C) tissues (see arrows) A marked reduction in nitrotyrosine staining...
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Báo cáo y học: " Successful treatment of HIV-associated multicentric Castleman’s disease and multiple organ failure with rituximab and supportive care: a case report" potx
Ngày tải lên :
11/08/2014, 14:21
... of a “cytokine storm” associated with MCD; increased expression of IL-6 is typical of MCD Vasopressor and inotropic support with noradrenaline and dobutamine was required to maintain an adequate ... was made following lymph node biopsy The decision to biopsy an inguinal lymph mode, rather than a cervical node was based on the clinical findings of a large and easily palpable inguinal lymph node ... association of MCD In addition she had elevated prothrombin (PT) and activated partial thromboplastin times (APTT), reduced platelets and reduced serum fibrinogen consistent with disseminated intravascular...
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Báo cáo khoa học: "Early veno-venous haemodiafiltration for sepsis-related multiple organ failure" ppt
Ngày tải lên :
12/08/2014, 23:20
... catecholamines (noradrenaline [norepinephrine] or adrenaline [epinephrine]), with dobutamine being given at µg/kg per minute *Statistically significant finding BE, base excess; CI, cardiac index; ... support involved noradrenaline infusion alone in 28 patients, noradrenaline combined with dobutamine in 11 patients, and adrenaline in 21 patients Average dosages of major catecholamines (for ... fluid challenge and required continuous noradrenaline (norepinephrine) infusion Fluid resuscitation was performed by administering 10–20 ml/kg plasma expanders (6% Hetastarch) over 30 minutes, followed...
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Báo cáo y học: " Decompressive laparotomy for abdominal compartment syndrome – a critical analysis" pps
Ngày tải lên :
12/08/2014, 23:23
... definitions of intraabdominal hypertension, and abdominal compartment syndrome (primary, secondary and recurrent) according to WSACS Term Definition IAH IAH is defined by a sustained increase in ... determining outcome in these patients Mortality in patients undergoing DL remains high and deserves further investigation Several factors may explain the fact that half of the patients in the included ... John R, Stahl WM: Intraabdominal hypertension after life-threatening penetrating abdominal trauma: prophylaxis, incidence, and clinical relevance to gastric mucosal pH and abdominal compartment...
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Báo cáo y học: "Early venovenous haemodiafiltration for sepsis-related multiple organ failure" pptx
Ngày tải lên :
12/08/2014, 23:23
... epidemiology and outcome of severe sepsis in French intensive care units Intensive Care Med 2004, 30:580-588 Abid O, Akça S, Haji-Michael P, Vincent JL: Strong vasopressor support may be futile in the intensive ... but also renal acidosis However, in our opinion, this is better for evaluating the severity of illness in such patients because it takes into account two of the main parameters that have been reported ... 40 ml/kg per hour Finally, Drs Jacobs and Brivet suggest that the lack of improvement in base excess in nonresponders may have been linked to persistent lactate production Indeed, it was caused...
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Báo cáo khoa học: "Visualizing multiple organ failure: a method for analyzing temporal and dynamic relations between failing systems and interventions" pptx
Ngày tải lên :
13/08/2014, 03:21
... relations quantitatively Competing interests YAK is the author and director of the Muavenet Intensive Care Information System, which is an open access, online academic information system The other ... failing organ systems and related interventions We also suggest that this approach could be used as a basis for constructing statistical methods to analyze these relations quantitatively Competing ... competing interests References Kilic YA, Dogrul AB, Karakoc D, Yildiz B, Yorganci K, Sayek I: Impact of organ failure on mortality prediction in a Turkish surgical intensive care unit Intensive...
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Báo cáo y học: " Multiple organ failure after trauma affects even long-term survival and functional status" pdf
Ngày tải lên :
13/08/2014, 08:20
... During the ICU stay, each organ system was evaluated daily at 08.00 am using the most abnormal data from the preceding 24 h, and given a score from (normal function) to (most abnormal) according ... database Missing values were filled in from the patients' records as required The SOFA score was completed in retrospect for the years 1998 and 1999, since SOFA scoring did not become a routine in our ... validated in trauma patients [9] In a recent study of patients with brain injury, the SOFA scoring system had superior discriminative ability and stronger association with hospital mortality and unfavourable...
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Báo cáo y học: "Post-injury multiple organ failure and late outcome. Is it just an association" docx
Ngày tải lên :
13/08/2014, 08:20
... in favour of sequential organ failure assessment (SOFA) in trauma patients SOFA was initially presented for assessing morbidity in septic patients, but has been validated also in trauma and in ... developing MOF, are at major risk of poor longterm survival and impaired functional status Is this a suggestion for a standardisation of scoring MOF in trauma? This question remains unanswered and ... Max, and the changes in SOFA over the first 48 hours are correlated with mortality [9] Ulvik shows that measuring SOFA score on admission and SOFA max may categorise trauma patients, enabling...
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Báo cáo y học: " Year in review 2007: Critical Care – multiple organ failure and sepsi" pdf
Ngày tải lên :
13/08/2014, 11:22
... group-box protein 1, lipopolysaccharide-binding protein and procalcitonin levels were higher in patients than in healthy control individuals None of the biomarkers of interest discriminated between ... finding of greatest interest in McIntyre and colleagues’ study [28] was the infrequent use of central venous saturation monitoring and higher triggers for red cell transfusion than utilized in ... through increased expression of heat shock protein 70 with glutamine administration [40] Heat shock proteins are a group of proteins that are induced by a wide range of stimuli and serve to maintain...
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Báo cáo y học: " Long-term survival of chronic dialysis patients following survival from an episode of multiple-organ failure" pdf
Ngày tải lên :
13/08/2014, 16:20
... required Setting This was a retrospective study using the databases of the general intensive care unit (ICU) and renal unit of the participating hospitals (Hammersmith, Charing Cross and St Mary's ... Hutchison and colleagues [13] found that 1.3% of all ICU admissions (for ICUs participating in the Intensive Care National Audit & Research Centre (ICNARC) case mix programme in England, Wales and ... to intensive care Having said that, one striking observation is that of the 120 'medical' patients originally admitted to intensive care, only 46 were discharge from ICU alive and only 19 remained...
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Báo cáo y học: " Abdominal Compartment Syndrome: pathophysiology and definitions" ppt
Ngày tải lên :
13/08/2014, 23:20
... Competing interests Financial competing interests • Dr Cheatham has served as a consultant for Kinetic Concepts, Inc., Wolfe-Tory Medical, Inc., and Bard Medical, Inc Non-financial competing interests ... the acute increases in ICP characteristic of both traumatic injury and acute illness commonly result in rapidly escalating intracranial pressures Elevations in intra-abdominal and intrathoracic ... compresses thin walled mesenteric veins promoting venous hypertension and intestinal edema Visceral swelling further increases IAP initiating a vicious cycle which results in worsening malperfusion,...
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Báo cáo y học: " Surgical management of abdominal compartment syndrome; indications and techniques" potx
Ngày tải lên :
13/08/2014, 23:20
... and inexpensive, and maintain the abdominal domain In addition, the preservation of the accessibility to the abdominal cavity and the feasibility of gradual closure of the abdominal wall are important ... enough original skin for skin closure Figure Vacuum-dressing with temporary mesh being changed Vacuum-dressing with temporary mesh being changed Conclusion IAH is a recently popularized clinical ... Competing interests The author declares that they have no competing interests Consent section Written informed consents were obtained from the patients for publication of this review and accompanying...
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Báo cáo y học: "Close relationship of tissue plasminogen activator–plasminogen activator inhibitor-1 complex with multiple organ dysfunction syndrome investigated by means of the artificial pancreas" doc
Ngày tải lên :
12/08/2014, 18:20
... fibrin monomer (2) Increase of D-dimer (3) Increase of thrombin–antithrombin complex (4) Increase of plasmin-a2–plasmin inhibitor complex (5) Exacerbation of FDP, platelet, fibrinogen within several ... antithrombin-III; DIC, disseminated intravascular coagulation; FDP, fibrin and fibrinogen degradation products; PAI-1, plasminogen activator inhibitor-1; PIC, α2 plasmin inhibitor–plasmin complex; ... fibrin and fibrinogen degradation products, fibrinogen, prothrombin time (PT) ratio (PT of the patient divided by control PT), D-dimer, α2 plasmin inhibitor–plasmin complex, thrombin–antithrombin...
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Báo cáo khoa học: "Cutaneous vascular reactivity and flow motion response to vasopressin in advanced vasodilatory shock and severe postoperative multiple organ dysfunction syndrome" pot
Ngày tải lên :
12/08/2014, 23:22
... norepinephrine infusion alone At least in these patients, this finding may indicate that AVP/ norepinephrine does not result in further deterioration in microcirculatory oxygen supply in skin These ... administered Norepinephrine infusion was adjusted to maintain MAP above 65 mmHg In patients in the norepinephrine group, a MAP above 65 mmHg was achieved by adjusting the norepinephrine dosage Age, ... response to a combined infusion of AVP and norepinephrine when compared with infusion of norepinephrine alone, using laser Doppler flowmetry in patients with advanced vasodilatory shock and severe postoperative...
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