features biological functions of the alpha 1 antitrypsin and contribution to esophageal cancer
Báo cáo y học: " Role of the C-terminal domain of the HIV-1 glycoprotein in cell-to-cell viral transmission between T lymphocytes" potx
... 10 10 10 10 10 10 10 4 10 10 B 10 10 np / Wt, high 10 10 7% 10 np / Tr 712 , low 10 0% 10 10 10 10 10 10 10 10 GFP 10 10 10 10 10 10 10 10 10 10 GFP GFP 10 np / Tr 712 , high Cell number 10 0% 10 10 p24 ... D 10 np / Fus-, high 80% 10 10 10 10 p24 10 np / Wt, low 0% 10 10 10 10 GFP 10 10 10 p24 10 10 np / Tr 712 , low 10 0% 10 10 10 p24 10 15 % 10 10 10 10 p24 np / high p / Tr 712 , low 10 0% 10 10 10 10 ... transmis- 512 A gp120 684 705 gp 41 TMD gp120 856 Wt 15 1 aa gp 41 712 aa Tr 712 B 10 000 10 00 10 00 ng p24 / ml 10 000 10 0 MT-4 (p) 10 0 10 1 0 .1 H9 (np) 10 0 .1 0. 01 0. 01 Days p i Days p i 10 15 Figure...
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Báo cáo y học: " Therapeutic efficacy of alpha-1 antitrypsin augmentation therapy on the loss of lung tissue: an integrated analysis of 2 randomised clinical trials using computed " potx
... FEV1 (L), median 1. 63 ± 0.49 1. 63 1. 72 ± 0.53 1. 61 1.44 ± 0.60 1. 14 1. 35 ± 0.62 1. 14 1. 55 ± 0.56 1. 47 1. 48 ± 0.63 1. 38 0.553 FEV1% predicted, median 47.3 ± 11 .4 48.6 51. 2 ± 14 .5 49.0 46.3 ± 19 .6 ... Phys Ther 2008, 88 :15 6 -17 5, Epub 2007 Dec 11 doi :10 .11 86 /14 65-99 21- 11- 136 Cite this article as: Stockley et al.: Therapeutic efficacy of alpha- 1 antitrypsin augmentation therapy on the loss of ... (n = 59) p value 11 4 ± 14 .7 59.7 ± 16 .0 57.0 11 7 ± 16 .4 60 .1 ± 16 .3 65.0 94 ± 21. 8 50.7 ± 19 .5 47.6 98 ± 23.2 52.2 ± 15 .2 50 .1 103 .1 ± 21. 8 56.3 ± 17 .3 56 .1 104.7 ± 23.9 55.7 ± 15 .9 56.0 0.789...
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Báo cáo y học: " Exploring the optimum approach to the use of CT densitometry in a randomised placebo-controlled study of augmentation therapy in alpha 1-antitrypsin deficiency" pptx
... 0.0 21 0.873 47.98 ± 19 .07 63.36 ± 24.96 51. 48 ± 18 .35 38. 61 ± 18 .90 13 1.57 ± 21. 99 44.43 ± 13 .66 18 .66 ± 10 .97 956.40 ± 14 0.64 7.46 ± 1. 60 45.48 ± 16 .95 62.96 ± 19 .77 48.35 ± 18 .40 34.94 ± 15 .44 ... 0.0001a -4 .12 4 ± 4 .14 7 -4 .11 7 (0.539) < 0.0001a 1. 472 (0.009, 2.935) 0.049 Prolastin (n = 36) Placebo (n = 35) -2 .11 5 ± 7.937 -1. 911 (0.788) 0. 018 1a -3.289 ± 5.949 -3. 313 (0.8 01) 0.0001a 1. 402 ... = 35) 1. 7 61 ± 4. 511 1. 643 (0.508) 0.0 019 a 2.209 ± 3.378 2.254 (0. 517 ) < 0.0001a -0. 611 (-2. 019 , 0.797) 0.389 Prolastin (n = 36) Placebo (n = 35) 1. 994 ± 3.307 1. 924 (0. 411 ) < 0.0001a 2. 315 ± 2.578...
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Tài liệu Báo cáo khoa học: Branched N-glycans regulate the biological functions of integrins and cadherins doc
... compilation ª 2008 FEBS 19 45 Biological functions of branched N-glycans 10 11 12 13 14 15 16 17 18 Y Zhao et al expression of UDP-N-acetylglucosamine: beta-Dmannoside beta -1, 4N-acetylglucosaminyltransferase ... [9 11 ], and a -1, 6-fucosyltransferase (Fut8) [12 – 14 ], are discussed, thereby demonstrating the importance of glycosyltransferase regulation to the function of the adhesion molecules integrin and ... conformation and biological function For example, only N-glycans located on either the b-propeller of a5 [55] or the I-like domain of b1 or b3 [68] contribute to the regulation of integrin function Therefore,...
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Báo cáo y học: " Short-term variability of biomarkers of proteinase activity in patients with emphysema associated with type Z alpha-1-antitrypsin deficiency" pdf
... type of alpha- 1- antitrypsin deficiency (AATD) the burden of PMN and other inflammatory cells in the lung is higher than in those without the deficiency [2,3] The serum levels of alpha- 1- antitrypsin ... 0 .1% (w/v) BSA, and the subsequent conversion of TMB/H2O2 as described [11 ] The CVa of the assay was 10 % http://respiratory-research.com/content/6 /1/ 47 Statistical analysis After the code of ... altered processing of the heparan sulfate molecule in the lungs of patients with emphysema In view of the biological functions of heparan sulfate, this could lead to destabilisation of the extracellular...
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Tài liệu Báo cáo khoa học: The structure and biological characteristics of the Spirochaeta aurantia outer membrane glycolipid LGLB pdf
... O13 O13 K12 C12 C12 G12 O14 B13 G12 C13 G14 C15 K13 K14 ,15 F12 B12 ,14 N12 L14 F24 N13 I13 E12 A12 D12 ,13 E13 B1:K4 B12 I23 D34 F34 N14 I45 I14 E45 E35 D12 A1:G5 N15 N13 K15 I34 O1:I3 4.2 K1:E3 F34 ... I35 D1:N4 M1:D3 I12 E1:F4 F45 E14 E5:F2 G1:A2 A12 I24 I12 N1:Q1 E12 E34 F13 G15 F14 D15 D14 F12 A1:L4 O15 I34 E24 C1:G4 D1:N3 M15 G13 3.7 A1:L3 M14 L13 ,15 F45 I1:D4 D45 F1:I4 4.7 E45 E15 A1:G1 5.6 ... to the Ó FEBS 2004 4692 E Vinogradov et al (Eur J Biochem 2 71) 11 80.25 11 14.29 10 00 10 0 12 00 13 00 14 00 13 00 14 00 11 97.25 11 89.28 11 80.30 11 16.27 11 31. 28 10 00 11 00 12 00 m/z Fig CE-MS spectra of...
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Tài liệu Báo cáo khoa học: Moult cycle-related changes in biological activity of moult-inhibiting hormone (MIH) and crustacean hyperglycaemic hormone (CHH) in the crab, Carcinus maenas From target to transcript ppt
... Bmax ( 10 )9) C4 D0 D2-3 B 3.9 ± 0.3 8 .1 10.3 ± 1. 9 18 .7 ± 10 .0 1. 1 ± 0.2 0.9 2 .1 ± 0.03 15 .3 ± 4.7 27.5 8.3 13 .7 13 .7 0.4 0.3 0.2 0.2 ± ± ± ± 11 .1 4.3 1. 2 0.9 ± ± ± ± 0.06 0.09 0. 01 0 .1 Table ... with the resumption of competence of the YO at stage C1 Thus, it seems that selectivity, with regard to YO responses to MIH or CHH during the moult cycle is not at the receptor level In view of these ... amounts of the molt-inhibiting hormone in sinus glands during the molt cycle of the American crayfish, Procambarus clarkii Zool Sci 17 , 11 29 11 36 Sefiani, M., Le Caer, J.-P & Soyez, D (19 96) Characterization...
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Tài liệu Báo cáo khoa học: Different mechanisms for cellular internalization of the HIV-1 Tat-derived cell penetrating peptide and recombinant proteins fused to Tat docx
... with the GFP-Tat fusion protein to assess the effective inhibition of the receptor mediated endocytosis Despite a 12 .5 molar excess of the Tat peptide, no detectable reduction of the uptake of the ... A (19 96) Cell internalization of the third helix of the Antennapedia homeodomain is receptor-independent J Biol Chem 2 71, 18 188 18 193 Brugidou, J., Legrand, C., Mery, J & Rabie, A (19 95) The ... (CRAC) of the peripheral-type benzodiazepine receptor and inhibition of steroidogenesis by an Ó FEBS 2002 15 16 17 18 19 20 21 22 HIV TAT-CRAC peptide Proc Natl Acad Sci USA 98, 12 67± 12 72 Hughes,...
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Báo cáo khoa học: SAF-3, a novel splice variant of the SAF-1/MAZ/Pur-1 family, is expressed during inflammation pptx
... Shenk T (19 96) The serotonin 1a receptor gene contains a TATA-less promoter that responds to MAZ and Sp1 J Biol Chem 2 71, 4 417 –4430 12 Ray A, Schatten H & Ray BK (19 99) Activation of Sp1 and its ... response to mediators of signal transduction and phosphorylation by a number of protein kinases [13 ,16 ,17 ] The transcript level of SAF -1/ MAZ is also reported to be increased in response to cytokine ... addition, methylation of the cytosines of CpG islands in the promoter or the first exon has been shown to affect the rate of transcription [33], and ever since the clear demonstration of a causal relationship...
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Báo cáo khoa học: Role of different moieties from the lipooligosaccharide molecule in biological activities of the Moraxella catarrhalis outer membrane pot
... lipid-A and two phosphate moieties The ions with m ⁄ z of 15 19.6 and 15 41. 6 are mono- and di-sodiated forms of the de-O-acylated LOS and the ion with m ⁄ z of 14 79.6 is the anhydrous form of the ... of de-O-acylated LOS for the mutant O35Elgt3 showed the presence of ions with m ⁄ z of 14 79.6, 14 97.6, 15 19.6 and 15 41. 6, respectively The ion at m ⁄ z 14 97.6 (M-H)– corresponds to the deprotonated ... moieties The deO-acylated lipid-A unit consists of two GlcNAc and two 3-OH C12:0 groups Among the other ions m ⁄ z of 2654.8, 2694.8 and 2 717 .4 indicates the presence of the anhydro form and mono- and...
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Báo cáo khoa học: Structural mobility of the monomeric C-terminal domain of the HIV-1 capsid protein pptx
... mean of 13 .2 s )1 (range 11 .9 14 .2); the third a-helix presented a mean of 11 .3 s )1 (range 8 .19 – 13 .5); and, finally, amino acids in the loop region presented a mean of 12 .3 s )1 (range 9.2 14 .7) ... l0 is the permeability constant of the free space, cN and cH are the gyromagnetic ratios of 15 N ()2. 71 · 10 7 radÆs )1 T )1) and 1H (2.68 · 10 8 radÆs )1 T )1) , h is the Planck constant, xN is the Larmor ... frequency of the 15 N, xH is the Larmor frequency of the 1H, is the ˚ length of the amide bond vector (1. 02 A), and r|| and r^ are the parallel and perpendicular components of the CSA tensor...
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Báo cáo khoa học: Interactions of HIPPI, a molecular partner of Huntingtin interacting protein HIP1, with the specific motif present at the putative promoter sequence of the caspase-1, caspase-8 and caspase-10 genes pdf
... the upper bands of the middle panel correspond to procaspase -1 (45 kDa), and the lower bands correspond to the 20 kDa activated caspase -1 The lowermost panel shows the level of b-actin (14 .4 kDa) ... Caspase -10 10 1 675 814 8 01 355 315 963 808 418 262 6 51 725 857 caspase -10 gene, four variant motifs were identified Among them, AAACAGATG () 254 to ) 262) is present in the positive strand, and the ... () 254 to ) 262) in the positive strand, and AAAGAAAAG () 6 51 to 643), AAAGAAAAG () 725 to ) 717 ) and GAAGACATT () 849 to ) 857) in the negative strand We were unable to exclude any of the motifs...
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Đề tài " Prescribing symmetric functions of the eigenvalues of the Ricci tensor " pdf
... satisfies (1. 11) λi > − (1 − 2δ) 1 + · · · + λn (n − 2) ∀ ≤ i ≤ n To explain the significance of (1. 11) , suppose the eigenvalues of the Schouten tensor Ag are in Γ at each point of M n Then (M ... C3 (C1 , R ) Lemma 7 .14 Let p2 ∈ N1 with |p2 |0 ≥ R1 , where R1 is as given in R Lemma 7 .13 Let p1 = |p 210 p2 ∈ N1 Then | (7.33) dw (p1 , p2 ) ≤ eC1 + C |p2 − p1 |0 R1 Proof Let γ denote the ... |p2 −p1 |0 C |γ(t)|0 dt ˙ |p1 |0 C |p2 − p1 |0 + R1 ≤ eC1 + = eC1 Since the distance is the infimum of the length of all paths, we obtain dw (p1 , p2 ) ≤ eC1 + C |p2 − p1 |0 R1 520 MATTHEW J...
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Báo cáo khoa học: Kinetic study of the HIV)1 DNA 3¢-end processing Single-turnover property of integrase docx
... allowed to proceed for 15 Both DNA and Mg2+ cofactor protected IN from inactivation (T1 2, IN alone ẳ 11 1 min; T1 2, IN+DNA ẳ 15 4 min; T1 2, IN+Mg ẳ 222 min) FEBS Journal 273 (2006) 11 3 711 51 ê ... preincubation of IN with 11 44 [Product] (nM) 0 .12 0.08 T1/2 = 11 1 15 0.04 0.00 200 400 600 800 10 00 Time (min) B [Product] (nM) Stability of IN during the 3Â-processing reaction A 0 .12 0.08 T1/2 = 222 16 ... 11 3 711 51 ê 2006 The Authors Journal compilation ê 2006 FEBS M Smolov et al 2.5 [Product] (nM ) T S I II III 2.0 1. 5 1. 0 0.5 0.0 P 50 10 0 15 0 200 250 300 Time (min) N S P 15 30 60 90 12 0 15 0 18 0...
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Influences of the si(1 1 3) anisotropy on ge nanowire formation and related island shape transition
... of the side faces of elongated islands are faceted with (1 9)/(5 9) at an angle of 16 ° with respect to the substrate surface, their ½3 ends are faceted with (15 17 ), (1 1) and (3 15 17 ) at the ... characterized by an increase in the island length and the number density The width of the island is $20 nm and the height of the island is $1. 5 nm In comparison, growth of elongated islands mainly proceeds ... islands adopt the facet structure of the elongated islands by simply re- placing the (1 9)/(5 9) facets with the (1 11) / (7 11 ) at an angle of 19 ° with respect to the 98 Z Zhang et al / Surface...
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Báo cáo khoa học: Alizarine derivatives as new dual inhibitors of the HIV-1 reverse transcriptase-associated DNA polymerase and RNase H activities effective also on the RNase H activity of non-nucleoside resistant reverse transcriptases pot
... > 10 0 ( 91% ) 13 > 10 79 82 61 60 52 61 14 12 0.003 0.0 01 > 10 0 (58%) > 10 0 (10 0%) > 10 0 (10 0%) > 10 0 (98%) 21 16 > 10 0 (10 0%) 16 ND 68 10 0 10 0 35 93 92 64 28 0.68 0.2 > 10 0 (10 0%) ... Asn103 Tyr1 81 VAL108A VAL106A LEU234A ASN103A TYR188A Tyr1 81 D H O O O K126 Asp 110 VAL108A O O O TYR188A VAL108A O Asp 110 O O O VAL106A Asp186 TYR188A Trp229 Asp186 PHE227A NNRTIbp Asp185 K126 ... (10 0%) > 10 0 (10 0%) > 10 0 (10 0%) > 10 0 (86%) 22 16 > 10 0 (10 0%) > 10 0 (79%) ND > 10 0 (10 0%) > 10 0 (10 0%) > 10 0 (10 0%) > 10 0 (74%) > 10 0 (92%) > 10 0 (10 0%) > 10 0 (72%) > 10 0 (87%) 0.40 0 .1 NDe...
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Báo cáo khoa học: Peptides that bind the HIV-1 integrase and modulate its enzymatic activity – kinetic studies and mode of action pptx
... 16 217 6 16 618 0 17 018 4 17 418 8 18 219 6 18 6200 210 224 214 228 218 232 222236 238252 242256 246260 HIV IN residues 9 410 7 9 811 6 12 614 5 13 014 9 13 915 3 15 116 5 16 317 7 16 718 1 17 919 3 18 72 01 1 912 05 19 5209 223237 ... 56 71 5678 5679 5680 56 81 5682 5683 5685 5686 5692 5693 5694 5695 5699 5700 57 01 a Sequence NIH no 3852 4256 6276 6680 7084 8296 9 410 8 9 811 2 11 012 4 11 813 2 12 213 6 12 614 0 15 416 8 15 817 2 16 217 6 16 618 0 ... 31, 9 810 5 49 Engelman A, Mizuuchi K & Craigie R (19 91) HIV -1 DNA integration: mechanism of viral DNA cleavage and DNA strand transfer Cell 67, 12 111 2 21 FEBS Journal 278 (2 011 ) 316 330 ê 2 010 The...
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Báo cáo khoa học: Antimicrobial and conformational studies of the active and inactive analogues of the protegrin-1 peptide docx
... the N-terminal fragments and bend structures in the Arg10–Val13 region of IB-367 and the Cys6–Cys 11 region of BM -1 The daa(5 14 ; 7 12 ) of IB-367 and daa(4 13 ; 6 11 ) of BM -1 NOEs strongly suggest ... PG -1 IB-367 BM -1 BM-2 4 8 32 2 12 8 12 8 12 8 256 12 8 8 8 8 64 2 16 12 8 256 256 256 256 16 32 32 16 256 > 256 16 16 16 64 12 8 64 256 > 256 64 32 256 256 12 8 12 8 64 256 256 64 256 256 256 256 12 8 ... BM -1 and BM-2 FEBS Journal 277 (2 010 ) 10 10 10 22 ª 2 010 The Authors Journal compilation ª 2 010 FEBS 10 11 Conformational studies of protegrin -1 analogues S Rodziewicz-Motowidło et al (BM -1 and...
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Báo cáo khoa học: Extraenzymatic functions of the dipeptidyl peptidase IV-related proteins DP8 and DP9 in cell adhesion, migration and apoptosis doc
... 10 4 10 3 10 2 CFP 10 1 Propidium iodide 10 2 10 1 60.6 10 0 Annexin V-PE CFP 1. 2 5.3 60.7 10 0 C 0.9 1. 1 10 3 B 10 4 0h 1h 2h 4h Incubation time with STS 10 0 10 1 10 4 2 .1 1 01 102 DP9 20.5 10 10 10 10 CFP ... dipeptidyl peptidases, DP8 and DP9 60 90 12 0 15 0 D M T Yu et al 10 0 10 1 10 2 10 3 10 4 10 0 Fluorescence intensity 10 4 DP8 15 0 50 0 10 1 10 2 10 3 10 4 10 0 10 2 10 3 10 4 200 16 0 DP9 80 40 0 20 40 60 Events ... 2 .1 1 01 102 DP9 20.5 10 10 10 10 CFP expression 10 4 10 4 10 3 10 2 10 1 10 G 10 3 1. 2 10 Propidium iodide 10 30 .1 10 10 4 10 5.4 3.6 DP9 10 0 19 .7 10 1 10 2 10 3 CFP expression a universal decrease in protein...
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Charity Law & Social Policy National and International Perspectives on the Functions of the Law Relating to Charities pptx
... 10 7 10 8 10 8 10 8 10 9 10 9 11 0 11 0 11 1 11 1 11 1 11 3 11 3 11 3 11 4 11 5 11 5 11 5 11 6 11 9 11 9 12 0 12 0 12 1 12 2 12 2 12 2 12 3 12 3 12 3 12 3 12 4 12 4 12 5 12 5 12 6 12 7 12 7 12 8 12 9 xii Contents Giving Effect to Social ... 15 2 15 3 15 3 15 4 15 4 15 5 15 6 15 6 15 7 15 7 15 8 15 8 15 9 16 0 16 0 16 1 16 1 16 1 16 2 16 2 16 3 16 3 16 3 16 4 16 4 16 4 16 5 16 5 16 6 16 6 16 6 Legal Functions: Mediation and Adjustment 16 7 ... 13 3 13 3 13 4 13 4 13 5 13 5 13 6 13 7 13 7 13 8 13 8 13 9 14 0 14 1 14 1 14 2 14 3 14 3 14 4 14 4 14 5 14 5 14 6 14 6 14 7 14 8 15 0 15 1 15 1 15 2 Contents xiii Commissioners’ Registration...
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