expressional alterations of versican hyaluronan and microfibril associated proteins in the canc
Sterol rich membrane domains and membrane associated proteins in the fission yeast schizosaccharomyces pombe
... targeting to the middle of the cell (Fig 3, 60 to 90 min) Filipin also stained the plasma membrane invaginations that follow the constricting ring (Fig 3, 105 min) After constriction of the ring ... one double bond in its carbon chain This introduces a kink into the otherwise straight molecule Both the introduction of such kinks as well as the length of the acyl chains affect the van-der-Waals ... if the actomyosin ring contracts and actively pulls the plasma membrane inwards, or if the actomyosin ring is pushed by the ongoing deposition of septum material in the plasma membrane invaginations...
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Computational study of therapeutic targets and ADME associated proteins and application in drug design
... one of the limited number of target families; (2) Sequence variation between protein’s drug-binding domain and those of the human proteins in the same family allows differential binding of a ... these target features, some simple rules can be derived for facilitating the search of druggable proteins and for estimating the level of difficulty of their exploration, including (1) Protein ... which proteins are responsible for the metabolism and disposition of a particular drug, and how the polymorphisms, transcriptional and post-transcriptional profiles of these proteins determine the...
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Báo cáo khoa học: Nuclear actin and actin-binding proteins in the regulation of transcription and gene expression docx
... Bundling proteins Coactivator Supervillin NLS F-actin- and membraneassociated scaffolding protein Filamin NLS? Cross-linking proteins Filamin A NLS? Cross-linking proteins Transgelin ()) Cross-linking ... STARS-interacting proteins These novel proteins contain four LIM domains and a C-terminal villin headpiece domain, which mediates actin-binding in several proteins, such as villin and dematin [59] Both ... actin is associated with rDNA genes, and microinjection of anti-actin Ig into the nuclei of HeLa cells inhibits pre-rRNA synthesis in vivo [25,34] The interaction of NM1 with actin in the initiation...
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Use of Alternative Fuels in Cement Manufacture: Analysis of Fuel Characteristics and Feasibility for Use in the Chinese Cement Sector pdf
... stay in the fields to enrich the soil are collected As an example of the magnitude of the CO2 intensity of collecting and transporting biomass residues, according to the Biofuels Emissions and ... capture, end use in cement manufacturing has the key benefits of utilizing pre-existing infrastructure and enabling the incineration ash to be incorporated into clinker, thus providing a completely ... phase and the remaining steel and ash are incorporated into the clinker Tires can be substituted at a rate of 20% or less; higher rates can cause instability and overheating in the kilns, and can...
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Báo cáo khoa học: Co-operation of domain-binding and calcium-binding sites in the activation of gelsolin pptx
... for the binding of calcium to G2 domain Footprint of G2 on gelsolin G4–6 domain Two sites within the G2 domain appear involved in the G2- G4–6 interface in the presence of EGTA (Fig 3) The interaction ... actin-binding sites, is in interaction with the C-terminal a-helix of G6 domain The sequence 159–193, including the second actin interface, appears also in interaction with G6 domain Therefore, ... other domains until the gelsolin is fully ÔopenÕ, then additional calcium ions are required to bind actin to G1 and to G4 for severing and capping The details of the latch helix structure in the...
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Báo cáo khoa học: Mapping of chorismate mutase and prephenate dehydrogenase domains in the Escherichia coli T-protein doc
... domain in the T–protein, the interaction of various fragments with Tyr was investigated to determine whether the Tyr binding site overlapped with one or more catalytic domains in the T-protein ... from the product-binding pocket of the CM site to the substrate-binding pocket of the PDH site, then the weak CM activity of the CM fragments might be due to slow product release or trapping of ... from the CM and PDH domains Initial attempts to pinpoint the C-terminal boundary of the PDH domain established that even minor deletions of C-terminal residues resulted in complete loss of PDH...
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báo cáo hóa học: " Quantification of functional weakness and abnormal synergy patterns in the lower limb of individuals with chronic stroke" pdf
... and extension of the hip, extension of the knee and extension and inversion of the ankle) and the flexion synergy (external rotation, abduction, and flexion of the hip, flexion of the knee, and ... history of seizure, that would inhibit exercise in a standing position Informed consent was obtained before testing and all protocols were approved by the local institutional review boards The clinical ... characteristics of each subject group is shown in Table Instrumentation Each subject was placed in a custom setup that allowed for the study of strength and coordination of the lower extremities in a standing...
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báo cáo hóa học:" Current status of medication adherence and infant follow up in the prevention of mother to child HIV transmission programme in Addis Ababa: a cohort study" potx
... data, interpreted the findings and wrote the manuscript OM was involved in developing the study proposal, supervising the data collection and reviewing the manuscript SGH was involved in developing ... developing the study proposal and reviewing the manuscript MMS was involved in supervising the data collection and reviewing the manuscript KMM was involved in developing the study proposal and reviewing ... two mothers had live birth of twins (Figure 1) Table shows the demographic and obstetric characteristics of the mothers enrolled in the study The median age of the mothers was 25 years and the...
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báo cáo hóa học: " Strong convergence theorems for system of equilibrium problems and asymptotically strict pseudocontractions in the intermediate sense" pot
... out the proof of convergence of the theorems and realization of numerical examples JZ carried out the check of the manuscript All authors read and approved the final manuscript Competing interests ... element of the fixed point set of a finite family of asymptotically li-strict pseudocontractions and the solution set of the problem (1.3) Using the hybrid method, we obtain strong convergence theorems ... Page 11 of 13 Duan and Zhao Fixed Point Theory and Applications 2011, 2011:13 http://www.fixedpointtheoryandapplications.com/content/2011/1/13 Page 12 of 13 In fact, in one dimensional case, the...
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Báo cáo hóa học: " Cross-Layer Quality-of-Service Analysis and Call Admission Control in the Uplink of CDMA Cellular Networks" potx
... mobiles within and outside the reference cell SINR is a function of the received powers, spreading gains and number of active spreading codes, and is an important attribute at the data link layer ... 10/5) − Q (7) σ2 In (7), is variance of the lognormal shadowing, rm and rd denote the distance between a mobile and its own intracell BS, and the distance between the mobile and the intercell BS, ... metrics in CDMA networks are associated with the multiple access interference (MAI) contributed from the interfering mobiles MAI includes both intracell and intercell interference resulting from...
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Báo cáo khoa học: "The role of Bcl-xL and nuclear factor-kB in the effect of taxol on the viability of dendritic cells" ppsx
... viability These findings provide a basic rationale for the use of taxol in DC immunotherapy and insights into the development of combinational DC therapies with other anticancer drugs that not harm the ... survival and maturation of DCs [11,17,20] To investigate further the mechanisms of taxol-induced changes, the viablity of TPCK, an inhibitor of the serine protease that inhibit NF-κB signaling pathway ... major cytokines involved in immune responses Importantly, taxol increased the expression of the anti-apoptotic protein Bcl-xL, and increased the mobilization of p65 subunit molecules into the DC...
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Báo cáo khoa học: " Role of protease inhibitors and acylation stimulating protein in the adipogenesis in 3T3-L1 cells" potx
... and inhibited when co-treated with different doses of PI in comparing with insulin and control (Fig 3) To test that effect, cells were incubated with insulin and as seen in Fig 4, the level of ... (Fig 4) When the cells were incubated in presence of insulin and PI, TG accumulation was decreased When ASP in low, medium and high doses of ASP was added together with insulin and PI, TG accumulation ... round and a marked increase in lipids was recorded (C-F) C; Insulin plus PI (×300), D; Insulin plus PI (×200), E; Insulin plus PI (×150) and F; Insulin plus PI (×100) Oil red O stain, ×400 Fig Inhibitory...
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Báo cáo khoa học: "Evaluation of clinical, laboratory and morphologic prognostic factors in colon cancer" ppsx
... may be indicators of the pT staging of the tumour Considering clinical data, we observed that the presence of mucorrhea and anismus were indicators of pT staging > 2, it was suggested that these ... factor remains the extension of the tumour into the bowel wall as expressed in the Dukes classification or TNM classification [2,4] The main endpoint of the present study was to evaluate the prognostic ... Journal of Surgical Oncology 2008, 6:98 Introduction Advances in the management of colon cancer over the past decades have resulted in an improvement of the prognosis of the disease The proportion of...
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Báo cáo y học: "Correlation of histopathological findings and magnetic resonance imaging in the spine of patients with ankylosing spondylitis" potx
... illustration of the anatomy and detection of inflammation in the bone marrow The entire lumbar spine including the zygapophyseal joints and, if available, the thoracic spine was analyzed for increased ... of osteitis were seen at other sites of the spine: in the vertebral bodies of thoracic vertebrae 11 and 12 of patient and at posterior sites of the vertebral bodies of thoracic vertebrae to including ... signs, superior and inferior articular processes of the zygapophyseal joint; hash sign, processus spinosus) (b) Hematoxylin and eosin staining of the zygapophyseal joint, revealing numerous mononuclear...
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báo cáo khoa học: " High-throughput analysis of chromosome translocations and other genome rearrangements in epithelial cancers" pdf
... small tandem duplications, inversions and deletions were entirely within genes In many cases this affected the exon structure at the transcript level and novel isoforms were observed Some of these ... breast cancer, because these kinds of mutation would not be detected by Sanger sequencing studies on individual coding exons; and secondly, whether there are numerous small rearrange ments of this ... that is, random mutational noise, but some must be selected, ‘driver’ events and, as the number and variety of known mutations increases, estimates for the number of ‘driving’ mutations in cancer...
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Báo cáo y học: "A health economic model for evaluating a vaccine for the prevention of herpes zoster and post-herpetic neuralgia in the UK" ppsx
... testing the applied point estimate and duration of vaccine efficacy The lower and upper limit of the 95% confidence interval of the vaccine efficacy obtained from the Oxman trial were tested in the ... vaccine efficacy input parameter was adjusted in the model in order to best reflect the efficacy in reducing the incidence of PHN As a result, the PHN vaccine efficacy input parameter used in the ... total pain), defined as primary clinical endpoint of the SPS In the base case, the vaccine efficacy is expected to last a lifetime While the efficacy of the vaccine may diminish over time, the lengths...
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Báo cáo y học: "Morphological characterisation of portal myofibroblasts and hepatic stellate cells in the normal dog liver" pptx
... positivity around the bile ducts, in the arterial tunica media, and in the wall of the portal veins There is slightly irregular moderate staining in the perisinusoidal spaces throughout the parenchyma ... consistently in all slides In the portal areas, the terminal and sublobular hepatic veins, and in Glisson's capsule identical staining was observed In the hepatic parenchyma moderate positive staining ... observed in any other location in these sections Despite strong staining for synaptophysin in the adrenal medulla (external positive control), no staining was observed in any of the formalin fixed...
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CHARACTERISATION OF GLUTAMYL TRANSPEPTIDASE AND ELUCIDATING ITS ROLES IN THE PATHOGENESIS OF HELICOBACTER PYLORI
... Cloning of ggt gene (full length and individual large and small subunits) from H pylori and expressing the recombinant proteins in E coli Raising and characterizing specific polyclonal and ... hypothesis Interestingly, nuclear localization of GGT coincided with a decrease in the levels of glutathione in the nucleus, indicative of a role of GGT in causing redox imbalance in host cells ... at the Cterminus of the protein (Selbach et al., 2002; Tammer et al., 2007) Phosphorylated CagA then interacts with the Src homology domains of several eukaryotic signalling proteins including...
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The study of interactions of transmembrane receptors and intracellular signaling proteins in live cells by fluorescence correlation and cross correlation spectroscopy
... C-terminus domain, to expose binding sites for Src-homology-2 (SH2) domain-containing proteins and phosphotyrosine-binding (PTB) domain-containing proteins Adaptor proteins with a SH2-binding domain such ... numerous proteins that bind to a protein of interest, and result in the availability of the cloned genes encoding identified binding proteins The major limitation of Y2H is that target proteins must ... ligands bind to the extracellular domains of two receptor subunits and form a 2:2 complex (42), resulting in activation of the intracellular kinases of the receptors Upon ligand binding, the...
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Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam xác định các mục tiêu của chương trình khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản xác định thời lượng học về mặt lí thuyết và thực tế tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra đối với đối tượng giảng viên và đối tượng quản lí điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ lồng sóc đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến dòng điện stato i1 fi p2 sự cần thiết phải đầu tư xây dựng nhà máy phần 3 giới thiệu nguyên liệu từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008 chỉ tiêu chất lượng 9 tr 25