expression regulation and the role of slc26 c1 hco exchangers in kidney and gastrointestinal tract

Báo cáo khoa học: Use of lithium and SB-415286 to explore the role of glycogen synthase kinase-3 in the regulation of glucose transport and glycogen synthase pdf

Ngày tải lên : 08/03/2014, 08:20

... of GSK3 (using Li or SB-415286) appears to be sufﬁcient for inducing activation of GS in muscle and fat cells, and that inhibition of the kinase potentiates insulin action in muscle of insulin-resistant ... by insulin Regulation of GS activity To establish the importance of GSK3 inhibition on GS activity we monitored the effects of insulin, Li, SB-415286 and wortmannin (a PI3K inhibitor) on the incorporation ... greater than that by insulin Since the activity of GS depends on the relative activities of GS kinases and PP1G, inhibiting GSK3 (one of the principal GS kinases) will shift the balance towards...

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Báo cáo Y học: Elucidation of the role of fructose 2,6-bisphosphate in the regulation of glucose fluxes in mice usingin vivo 13 C NMR measurements of hepatic carbohydrate metabolism docx

Ngày tải lên : 17/03/2014, 17:20

... up -regulation of glucokinase and a down -regulation of glucose-6-phosphatase gene expression, suggesting that this biofactor may also be involved in balancing the uptake and release of glucose from the ... 3, and > h from the start of glucose infusion For the calculation of glycogen C6 changes, data acquired within h of the start of the glucose infusion was not included to avoid any in uence of ... the initial rate of label incorporation into glycogen C6 relative to the rate of label incorporation into glycogen C1 reﬂects the relative isotopic enrichment of Glc6P in the C6 relative to the...

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Báo cáo Y học: The role of hydrophobic active-site residues in substrate speciﬁcity and acyl transfer activity of penicillin acylase pdf

Ngày tải lên : 17/03/2014, 23:20

... Tyr These mutations may in uence the shape and volume of the acyl binding pocket and thereby alter the binding mode and afﬁnity of the enzyme for PAA and derivatives thereof, while maintaining the ... maintaining the structure of the binding site given the short distances of ˚ ˚ 3.5 A and 3.9 A between bF57(CZ) and the substrate binding residues bP22(CB) and bF24(CE2), respectively Changing ... residues and interactions in uence the performance of PA in the formation of semisynthetic b-lactam antibiotics The X-ray structure of the complex of PA with PAA shows that the acyl binding site of...

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báo cáo khoa học: "The role of 18F-FDG-PET/CT in the preoperative staging and posttherapy follow up of gastriccancer:Comparison with spiral CT" docx

Ngày tải lên : 09/08/2014, 02:20

... the decision of continuing the ongoing therapy or stopping and redirecting the patient to other salvage therapies Our study also supports the idea of routine use of PET or preferably PET/CT in ... Kim and colleagues accepted the cut off SUVmax value as 2.5 in their study at which the role of PET/CT was investigated, and they found out the Page of sensitivity of the technique 40% [12] In ... uptake in our study It is an important limitation that the number of patients is small especially in the first group, the number of studies in the literature investigating the role of PET in the...

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Báo cáo y học: "Chronic whiplash and central sensitization; an evaluation of the role of a myofascial trigger points in pain modulation" docx

Ngày tải lên : 10/08/2014, 10:20

... at the same three sites as the symptomatic subjects prior to an injection of cc of1 % lidocaine in the left thigh, and then re-evaluated for PPT within minute of the injection The purpose of the ... thresholds in uninjured tissues, and explained the finding as the expression of an abnormal processing of nociceptive information in the brain and spinal cord [2-7] Others have postulated that chronicposttraumatic ... contrast, the increase in cervical range -of- motion observed in the symptomatic cohort following the injections suggests that the initial finding of reduced motion was either a result of peripherally...

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The Role of Genetically Modified Organisms (GMOs) in Beverage Production

Ngày tải lên : 25/10/2013, 21:20

... throughout the world bears little resemblance to teosinte, the original ancestor of corn The newer techniques involving genetic engineering, on the other hand, allow for the transfer of a few genes in ... create signiÞcant changes in the genetic makeup of plants and animals due to the random recombination and sorting of thousands of genes As a result of intervention by people, the hybrid seed corn ... commercially introduced in the U.S in 1996 and have been rapidly adopted by farmers It has been estimated that 24% of the corn and almost 70% of the soybeans and cotton grown in the U.S in 2001 were...

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Báo cáo khoa học: The role of evolutionarily conserved hydrophobic contacts in the quaternary structure stability of Escherichia coli serine hydroxymethyltransferase pptx

Ngày tải lên : 07/03/2014, 03:20

... helix of the third cluster of CHCs is part of the inter-domain segment and the other helix lines the boundary between the major domain and the N-terminus (Fig 1) Therefore, the formation of the ... located in the cores of the large and small domains, respectively, and appear to stabilize their protein scaffolds, allowing the proper positioning of the residues involved in PLP binding, substrate ... Y55¢ interacts with the phosphate moiety of PLP; E57¢ is crucial in the binding of the l-serine hydroxyl group [15] and in the catalysis of the hydroxymethyltransferase reaction [16]; and Y65¢ interacts...

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The role of floating-rate bank loans in institutional portfolios pdf

Ngày tải lên : 22/03/2014, 17:20

... for the other asset classes listed on the chart Indexes are unmanaged and cannot be invested in directly Data is historical and is not indicative of future results Russell Investments // Role of ... upon market or other conditions and are current as of the date at the beginning of the document The opinions expressed in this material are not necessarily those held by Russell Investments, its ... surprise The duration of the Credit Suisse Leveraged Loan Index is significantly lower than durations in the traditional fixed income asset classes, reflecting the prevalence of floating rate instruments...

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Báo cáo khoa học: The role of Ureaplasma nucleoside monophosphate kinases in the synthesis of nucleoside triphosphates potx

Ngày tải lên : 30/03/2014, 08:20

... monophosphate kinases, i.e adenylate kinase, thymidylate kinase, cytidylate kinase, and uridylate kinase, were cloned and expressed in E coli The recombinant enzymes were affinity purified and their role in ... [16–18] Interestingly, the sum of ATP and UTP was two-fold higher than that of CTP and GTP, and the ratio of dATP and dTTP to dCTP and dGTP was also : [16,17] This fact is in accordance with the ... a maximum after and then declined, while the formation of [3H]ATP was increased linearly with time within the first 15 After 30 min, the reaction reached equilibrium (Fig 4A) Further experiments...

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the role of u s engineering schools in development assistance doc

Ngày tải lên : 31/03/2014, 14:20

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báo cáo hóa học: " The role of cumulative physical work load in symptomatic knee osteoarthritis – a case-control study in Germany" potx

Ngày tải lên : 20/06/2014, 00:20

... confounders were included in the final logistic regression model if they changed the odds ratio of kneeling and squatting by more than 10% in at least one category In the final model, the following confounders ... number of squatting and the duration of kneeling work D'Souza et al [20] examine the relationship between the daily amount of kneeling and knee osteoarthritis in the subset of participants at the ... draft the manuscript, NA participated in the design of the study and performed the re-assessment of all X-rays, GE coordinated the study and helped to draft the manuscript The members of the knee...

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Báo cáo y học: "The role of T cell interleukin-17 in conducting destructive arthritis: lessons from animal models" pps

Ngày tải lên : 09/08/2014, 06:22

... Beer Y: Interleukin-17 enhances tumor necrosis factor alpha-induced synthesis of interleukin 1, 6, and in skin and synovial fibroblasts: a possible role as a ‘fine-tuning cytokine’ in inflammation ... between the innate and adaptive parts of the immune system that might be an interesting target for the immunotherapy of inflammatory autoimmune diseases [26,27] Role of IL-17 in the pathogenesis of ... resulted in elevated levels of IL-1β protein in the synovium [41] Intriguingly, blocking of IL-1α/β with neutralizing antibodies had no effect on the IL-17-induced synovial inflammation and joint...

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Báo cáo y học: "The role of tumor necrosis factor-alpha in systemic lupus erythematosus" pdf

Ngày tải lên : 09/08/2014, 10:22

... However, in view of the autoimmunogenic potential of inhibiting TNF, we tested TNF inhibition as a means to interfere with the inflammatory response in SLE by administering only an induction regime of ... suggests that the reciprocal negative regulation of the two cytokines is not functional in active SLE Rather, the combined increase of both TNF and IFN-α might contribute to the pathogenesis of systemic ... pneumonitis, and skin disease of moth-eaten mice [18] and nephritis and leukopenia in the C3H.SW mouse [19], two additional lupus models Of particular interest, administration of low-dose TNF later in the...

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báo cáo khoa học: " Multiple evidence for the role of an Ovate-like gene in determining fruit shape in pepper" pptx

Ngày tải lên : 11/08/2014, 11:21

... increase in the expression of the gene in the DAA fruit of the infiltrated plant compared to the expression in the DAA fruit of the WT The analysis of the CaOvate genomic sequences obtained from the ... contains asparagine) In subf the corresponding amino-acid in position 23 is mainly asparagine while in subf is arginine The amino-acid in this position in subf is mainly histidine Tsaballa et ... As shown in Figure 7, our results suggest that there is an increase in the expression of CaGA20ox1 in the DAA fruit of the infiltrated plant comparing to the DAA fruit of the WT, implying that...

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Báo cáo khoa học: "The role of high-frequency oscillatory ventilation in paediatric intensive care" pot

Ngày tải lên : 12/08/2014, 22:21

... higher range of OI values in the DAD group, in which the mortality was higher than in the SAD group Another significant finding of the study conducted by Arnold and coworkers was that, in a post ... receiving HFOV remained dependent on supplementary oxygen therapy at 30 days In that study the OI was shown to discriminate between survivors and nonsurvivors in the first 24 hours of therapy, and ... largest randomized clinical trial examining the effects of HFOV in children was the cross-over study reported by Arnold and colleagues [5], in which 70 patients with DAD and/ or air leaks were randomly...

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Báo cáo y học: " The role of poly (ADP-ribose) polymerase in ventilator-induced lung injury" ppsx

Ngày tải lên : 13/08/2014, 11:23

... ventilation in healthy mice induces reversible pulmonary and systemic cytokine elevation with preserved alveolar integrity: an in vivo model using clinical relevant ventilation settings Anesthesiology ... Kang EH, Lee SY, Suh IB, Shin C, Shim JJ, In KH, Yoo SH, Kang KH: Inflammatory and transcriptional roles of poly (ADP-ribose) polymerase in ventilator-induced lung injury Crit Care 2008, 12:R108 ... volume, which might not be clinically relevant, is frequently necessary to induce appropriate lung injury Competing interests The authors declare that they have no competing interests References Kim...

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Báo cáo y học: "The role of RNA folding free energy in the evolution of the polymerase genes of the influenza A virus" potx

Ngày tải lên : 14/08/2014, 21:20

... plots of folding energies (referenced in the main text) and one table listing the folding energies of vaccine strains WHO and CDC use against H5 influenza 19 20 Click of folding file against H5 influenza ... -0.97) The effect of the folding energy on the evolution of the virus appears to be independent of the concurrent amino acid changes in the polymerase and NP genes, and independent of the codon ... NA, and PB1) in the case of the 1957 pandemic, and two avian segments (HA, PB1) in the case of the 1968 pandemic [10] The other segments are believed to have been circulating in humans since the...

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The role of serum amyloid A1(SAA1) in coronary artery disease

Ngày tải lên : 10/09/2015, 15:51

... facilitating its growth and hence angiogenesis is pro-atherogenic The final stage in the development of an atheroma involves the rupturing of a plaque Plaque rupturing involves the erosion of the ... elucidate the surface receptors of SAA1 and the study the genetic expression induce by SAA1 in the macrophages 1.3 Thesis Organisation The thesis is organized into other chapters The thesis begins ... the endothelial cells and the fracture of the fibrous cap which exposes the blood to the content in the plaque Rupturing of the plaque occurs as a result of the proteolysis of collagen in the extracellular...

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The role of BLNK, DOK 3 DIP in BCR signaling 2

Ngày tải lên : 16/09/2015, 17:12

... protein SLP-76 that is expressed in T cells (12) and intimately involved in TCR signaling In general, the order of the signaling events from the TCR and BCR is quite similar, with the engagement of ... cavity and bone marrow cells were obtained by injecting staining medium (PBS containing 3% FCS and 0.1% NaN3) into the peritoneal cavity and femur and tibia respectively using a 10 and ml syringe ... difference in the timing of assessment of the activation of BLNK–/– B cells In our study, we examine the up -regulation of the activation markers after an overnight stimulation of Ͻ18 h Since BLNK...

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The role of BLNK, DOK 3 DIP in BCR signaling 1

Ngày tải lên : 16/09/2015, 17:12

... PI(3,4)P2 interacts with the PH domain of serine/threonine protein kinase Akt/PKB and recruit it to the membrane In doing so, this leads to the activation of Akt by the serine/threonine protein kinase ... activating most of the isoforms of the protein kinase C (PKC) in B cells, including PKCα, β, δ, ε, and 31 CHAPTER 1♦INTRODUCTION θ (DeFranco, 1997) PKC is a family of serine-threonine kinases ... that the SH2 domain of Src PTKs can bind to phosphorylated ITAM sequences and this binding stimulates the catalytic activity of the Src-family PTKs, probably by competing off the binding of negative...

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