experimental psychiatric illness and drug abuse models from human to animal an overview
Báo cáo khoa học: Recent insights into cerebral cavernous malformations: animal models of CCM and the human phenotype pptx
... denoted (a) and (b) C elegans, Caenorhabditis elegans CCM animal models genes are found not only in mammals, fish and other vertebrates, but are also found in much more simple and primitive organisms ... into CCM is to understand the basic processes that have been disrupted, resulting in the vascular malformation Between observational and genetic studies in humans and biochemical and cellular ... help us further understand the human phenotype Recent investigations have further refined our understanding of this phenotype, and bear reviewing in this manuscript In human CCM disease, the lesions...
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Báo cáo y học: " Characterization of protein tyrosine phosphatase H1 knockout mice in animal models of local and systemic inflammation" docx
... light phase and animals were allowed 1-hour habituation to the test room, if different from the holding room, before testing Testing sequence was randomized between KO and WT animals, and all apparatus ... challenge on PTPH1-KO and WT mice aimed to understand the possible role of this phosphatase in the inflammatory process and in particular in cytokine expression and release Thus, CBA analysis was performed ... on PTPH1-WT and KO animals VM, BG and RH have been deeply involved in the first editing of the manuscript and all the authors contributed to modifications in subsequent drafts PFZ and RH have...
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Báo cáo khoa học: "Tree-ring characteristics of subalpine fir (Abies lasiocarpa (Hook.) Nutt.) in relation to elevation and climatic fluctuations" docx
... elevation and LW% and RD deserve a further explanation Firstly, there is a strong association between LW% and RD The mean RD depends more on LW% than on ED and LD because variation in ED and LD ... mean, maximum, and minimum temperature and monthly total precipitation data for the same period from climate stations in Prince George and Revelstoke, respectively (Environment Canada, Historical ... were standardized and combined to residual chronologies [14, 46] using the ARSTAN program − for two data sets (low- and high-elevation trees) and four tree-ring variables (RW, LW, LW%, and MXD)...
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Báo cáo y học: " Dimensional and hierarchical models of depression using the Beck Depression Inventory-II in an Arab college student sample" pot
... conceived the study and supervised collection of data FAA and JUO designed the study and analyzed the data FAA and JUO drafted the manuscript All authors read and approved the manuscript Competing ... that, in exploratory factor analysis by principal axis factoring and oblique rotation for our data, four factors emerged, accounting for 41.8% of variance explained, and that these factors were effectively ... a standard manner, using a large sample size and with a broad variety of indices to judge the fitness of hierarchical and dimensional models to the data However, our sample is different from...
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Báo cáo khoa học: "Acute renal failure – definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group" doc
... limitations, animal models remain fundamental to improving our understanding of human ARF [28-30] There are three basic types of animal models in use for study of ARF: ischemia; toxins and sepsis models; ... Piper and colleagues [27], in planning, conducting and critically evaluating studies utilizing animal models Table summarizes these principles and other guidelines for the use of animal models ... and acute dialysis The goals of information technology in its application to acute dialysis therapy are to improve our understanding of current practice and to improve patient care In order to...
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Tài liệu Báo cáo khoa học: Animal models of amyloid-b-related pathologies in Alzheimer’s disease docx
... FEBS 1391 Animal models of Alzheimer’s disease O Philipson et al Transgenic animal models Models devoid of any disease-causing APP mutations Animal models expressing wild-type (wt) human APP are ... with animal models of AD Concluding remarks and future perspectives Transgenic techniques have revolutionized our ability to develop animal models of AD, and also contributed significantly to the ... understanding of molecular pathogenesis Today a wide range of animal models are available for mechanistic, therapeutic and functional studies They offer an appealing means to rapidly move from...
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Tài liệu Báo cáo Y học: Short peptides are not reliable models of thermodynamic and kinetic properties of the N-terminal metal binding site in serum albumin doc
... Tables and thus present only the novel data: protonation constants for DAHKam and VIHN, and stability constants (log a values) of Cu(II)-VIHN, Cu-DAHKam and Ni-DAHKam systems The parameters of CD and ... Characterization of the copper (II) and nickel (II)-transport site of human serum albumin Studies of copper (II) and nickel (II) binding to peptide 124 of human serum albumin by 13C and 1H NMR spectroscopy ... studies MATERIALS AND METHODS Materials NiCl2 and CuCl2 were purchased from Fluka HNO3, KNO3, EDTA, dimethylglyoxime and ethanediol were obtained from Aldrich Tris/HCl, mono- and disodium phosphates...
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Báo cáo khoa học: "Corpus-Based Induction of Syntactic Structure: Models of Dependency and Constituency" pdf
... Solan, Eytan Ruppin, David Horn, and Shimon Edelman 2003 Automatic acquisition and efficient representation of syntactic structures In Suzanna Becker, Sebastian Thrun, and Klaus Obermayer, editors, ... Dan Klein and Christopher D Manning 2003 Fast exact inference with a factored model for natural language parsing In Suzanna Becker, Sebastian Thrun, and Klaus Obermayer, editors, Advances in Neural ... S Becker, and Z Ghahramani, editors, Advances in Neural Information Processing Systems 14, Cambridge, MA MIT Press Fernando Pereira and Yves Schabes 1992 Inside-outside reestimation from partially...
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báo cáo hóa học:" Immunological considerations of modern animal models of malignant primary brain tumors" doc
... using viral vectors can create a localized tumor genetically similar to human cancer in an immune competent animal [74] While these and other similar models [83-85] certainly represent an improvement ... authors read and approved this manuscript MS provided the manuscript idea, and prepared the manuscript IY also provided the manuscript idea, and helped prepared the manuscript AK, MR, and SF helped ... searches and manuscript preparation and editing DJ helped edit the manuscript and contributed insight from his experience in the field AP helped generate the manuscript idea and contributed significantly...
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báo cáo hóa học:" General anxiety, depression, and physical health in relation to symptoms of heart-focused anxietya cross sectional study among patients living with the risk of serious arrhythmias and sudden cardiac death" doc
... variables, and measuring general anxiety and depression, physical health, and symptoms of heart-focused anxiety (avoidance, attention, and fear), whereas information about diagnosis was obtained from ... between a given predictor and an outcome in a standardized form It is the change in the outcome (in standard deviations) associated with a one standard deviation change in the predictor, thus it is ... Hospital Anxiety and Depression Scale; PCS: SF-36 Physical Component Summary; HADS, and Cardiac Anxiety Questionnaire; CAQ are presented as mean (standard deviation) and number of participants Hamang...
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Báo cáo y học: " In vivo imaging approaches in animal models of rheumatoid arthritis" pot
... signal over time and to obtain a usable signal To apply this approach, the luciferase gene can be introduced into an animal using transgenic or homologous recombination technology to place luciferase ... luminescence methodology to humans would be problematic due to the greater thickness of human skin as a barrier to photon escape and detection Shifting the luminescent emission to the red end of the ... owing to the greater background from autofluorescence and scattered excitation light [6] Radioactive tracer imaging in intact animals Radioactive tracer studies offer greater penetration and quantitative...
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Báo cáo y học: " Gene therapy in animal models of rheumatoid arthritis: are we ready for the patients" pdf
... factor (TGF)-β, and these cytokines mediate the suppression of antigen-activated T cells to induce tolerance These modulating cytokines or their antagonists can be used to restore cytokine balance, ... transforming growth factor The strategy to protect cartilage and chondrocytes in arthritis given in this illustration are reviewed in detail by van der Kraan and coworkers [111] and by Evans and ... animal models of RA, as summarized in Figs and Restoring the cytokine balance 184 In animal models of arthritis it has long been recognized that proinflammatory cytokines, particularly TNF-α and...
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Báo cáo y học: "Role of fibroblast growth factor 8 (FGF8) in animal models of osteoarthritis" doc
... affinities FGF8 can bind to three receptors – FGFR2IIIc, FGFR3IIIc, and FGFR4 [15] – and has an important role in embryogenesis and morphogenesis [16] FGF8 is expressed during gastrulation and is involved ... cartilage from the lateral femoral condyle and from the lateral tibial plateau of meniscectomized animals showed degenerative changes that were similar to those observed in human OA In the meniscectomized ... degradation and pain in OA An anti-FGF8 antibody is expected to attenuate the symptoms of rheumatoid arthritis We are studying the effects of anti-FGF8 antibody on collagen-induced arthritis and on...
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Báo cáo y học: "Colony variability under the spotlight in animal models of arthritis" pps
... susceptible to PGIA The goal of the research was to compare the incidence and severity of PGIA and proteoglycan-induced spondylitis and to determine expression patterns of a panel of relevant genes ... not reveal any differences in incidence and severity, the sub-lines of BALB/c mice showed modest but significant differences in immune parameters such as cytokine and antibody responses and clinical ... for human- disease models Nat Cell Biol 2007, 9:993-999 Brand DD, Kang AH, Rosloniec EF: Immunopathogenesis of collagen arthritis Springer Semin Immunopathol 2003, 25:3-18 Glant TT, Finnegan A and...
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Báo cáo y học: "Lessons from animal models of arthritis over the past decade" pot
... Conclusion Models are tools that mimic aspects of human disease It is clear that animal models have contributed considerably to further our understanding of arthritic processes and concomitant cartilage ... using any of the classic arthritis models and this holds as well for the more novel models such as KRN and SKG arthritis and passive GPI/KRN arthritis In fact, both T cell- and IC-driven murine models ... [24,25] Immune complex arthritis Autoantibodies like rheumatoid factor and ACPAs are a key feature of RA and the recent success of treatment with an anti-B cell drug (Rituximab) supports the belief...
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Báo cáo sinh học: "Estimating variances and covariances for bivariate animal models using scaling and transformation" pot
... l and var(e I and e and e are uncorrelated, and the ) e Q ’;1 fixed effects #i and (3 have no elements in common, and the random effects u , i 2 l , l u e and e normally distributed The vectors ... !2, and so a scaled vector of x can be found to satisfy [Al] function of x and Aj z Hence vectors S can be calculated to satisfy [11] Each vector can be i substituted into !11! in order to find ... L can be written as a function of terms of M, using and C with the ratio with r = Qe2 i/ Qe satisfying the equation df* = 1/df /df 2i - and so and hence ufli and CT can be found from [4] and...
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Báo cáo y học: " General and Specific Components of Depression and Anxiety in an Adolescent Population" pdf
... Depressive and anxiety symptoms often co-occur resulting in a debate about common and distinct features of depression and anxiety Methods An exploratory factor analysis (EFA) and a bifactor modelling ... statistical analysis and drafted the manuscript RAA contributed to the statistical analysis and the manuscript IMG conceived and designed the study and contributed at all stages of both the study and manuscript ... affectivity factor as an explanation for the overlap of depressive and anxious symptoms the role of physiological arousal is less clear and has to date been more significantly related to panic than to other...
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Báo cáo y học: " The development of a knowledge test of depression and its treatment for patients suffering from non-psychotic depression: a psychometric assessment" ppt
... of antidepressants Ability to act appropriately to failed response to antidepressants Q17 Q21 Ability to act and respond appropriately to positive response to antidepressants Q23 Ability to understand ... standard treatment and standard psycho-education as a part of standard clinical care prior to recruitment Patients with chronic or recent alcohol and illicit drug abuse, patients suffering from ... therapy, and admission to a psychiatric ward) were more often rated as harmful than helpful, and some nonstandard treatments (increased physical or social activity, relaxation and stress management,...
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báo cáo khoa học: " Psychosocial and contextual correlates of opioid overdose risk among drug users in St. Petersburg, Russia" pot
... clinical and research settings to evaluate and monitor potential problems salient to mental health and substance abuse treatment The ASI assesses the perceived severity of problems and need to seek ... were collected and therefore are open to the vulnerabilities of social desirability bias, interviewer bias, and recall bias We made every effort to be empathic and non-judgmental and to provide specific ... symptoms, risk factors, and prevention strategies, (3) self-reported history of having witnessed overdoses and details about the most recently witnessed overdose, and (4) self-reported history...
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Báo cáo y học: " First Siena International Conference on Animal Models of " pptx
... important to determine the antiprotease and antioxidant status of the chosen model That investigator showed that C57Bl/6J and DBA/2J mice (reduced antielastase and increased sensitivity to oxidants) ... stressed the need to look for improved methodologies and protocols, and end-points other than pathology with biomarkers and lung function being the desired goal Transgenic models Dr J Hogg (McDonald ... emphysema that are both predictive of the human condition and userfriendly to the experimentalist Animal models that may be of great benefit to the study of the mechanisms involved in the development...
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