experimental models of oxidative stress protection by melatonin
Tài liệu Báo cáo khoa học: Enhancement of oxidative stress-induced apoptosis by Hsp105a in mouse embryonal F9 cells pptx
... activation of p38 is an essential step for induction of apoptosis by hydrogen peroxide, and Hsp105a is suggested to enhance the oxida- Fig Effects of Hsp105a on activation of JNK and p38 by oxidative stress ... rate and differentiation of F9 cells were not affected by the over-expression of Hsp105a, the sensitivity of cells to oxidative stress was enhanced by the over-expression of Hsp105a, and these findings ... the Ó FEBS 2002 Hsp105 enhances oxidative stress- induced apoptosis (Eur J Biochem 269) 4147 Fig Enhancement of oxidative stress- induced apoptosis by over-expression of Hsp105a (A) F9, V1, S3 and...
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Tài liệu Báo cáo khoa học: Attenuation of cardiac mitochondrial dysfunction by melatonin in septic mice ppt
... mitochondrial damage induced by oxidative and ⁄ or nitrosative stress [23] Several reports have shown that melatonin (aMT) protects against 2136 mitochondrial oxidative stress, due to its antioxidant ... presence of this enzyme in different tissues with properties of endothelial NOS, nNOS, and ⁄ or iNOS [14,31,32] In different models of sepsis and tissues, the existence of both mtNOS and i-mtNOS isoforms ... found in heart mitochondria of iNOS– ⁄ – mice under any experimental conditions (Fig 4A–D) Fig Effects of aMT treatment on CLP-induced mRNA levels of iNOS Ten nanograms of RNA extracted from mouse...
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Tài liệu Báo cáo khoa học: Analysis of oxidative events induced by expanded polyglutamine huntingtin exon 1 that are differentially restored by expression of heat shock proteins or treatment with an antioxidant ppt
... rather than a cause of the deleterious effect generated by the oxidative stress Another important parameter of oxidative stress is nitric oxide (NO•) Indeed, elevated levels of NO• have been observed ... the effects of oxidative stressors on mitochondrial membrane potential and increase cell vulnerability to oxidative injury [32] Moreover, Hsps can confer resistance to oxidative stress by preserving ... inhibition of proteasome activities generated by httEx1-polyQ expression does appear to be a consequence of the oxidative stress induced by this mutant protein The effects induced by Hsps in...
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The effects of oxidative stress on female reproduction: a review ppt
... culmination of these effects in spontaneous abortion [321] The generation of ROS [322-324] is often associated with DNA strand breaks induced by THC [315] Epoxidation of the 9, 10-alkene linkage by THC ... (Figure 2) Oxidative stress contributes to oocyte quality, and its degree can be assessed by biomarkers of TAC and lipid peroxidation [387] The effects of OS may be may be further altered by environmental ... indicating DNA damage by OS However, Tamura et al (2008) found that the administration of melatonin led to a reduction of intrafollicular oxidative damage and a net increase of fertilization and...
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Báo cáo khoa học: Effect of oxidative stress and involvement of poly(ADP-ribose) polymerase (PARP) in Dictyostelium discoideum development doc
... role during oxidative stress is further confirmed by the use of low concentrations of benzamide Preincubation of cells with benzamide prevented the peak activity observed during oxidative stress (Fig ... effect of oxidative stress Thus, our results demonstrate that partial PARP inhibition under mild or severe oxidative stress did not affect repair of the damage incurred due to oxidative stress, ... under oxidative stress To study the effect of oxidative stress on differentiation, developmental studies were performed The dose-dependent effect of HA on D discoideum development was studied by...
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recursive models of dynamic linear economies by hansen and sargent 2005 (526 pages)
... would like to be able to analyze The purpose of this book is to display the versatility and tractability of our class of models Versions of a wide range of models from modern capital theory and asset ... stochastic difference equation, and shows how special cases of it are formed by a variety of models of time series processes that have been studied by economists This difference equation will be used to ... t of D or, equivalently, according to the distinct eigenvalues of A In the law of motion ( 2.4.3 ), partition j of x∗ is linked only to partition j of x∗ In this t t+1 sense, the dynamics of...
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báo cáo hóa học: " The microglial NADPH oxidase complex as a source of oxidative stress in Alzheimer''''s disease" ppt
... disruption of oxidative damage through the sustained inhibition of the NADPH oxidase could possibly lead to an attenuation of the neuronal cell loss induced by fibrillar Aβ peptides Page of 12 (page ... [116] Both of these interactions rely on the isoprenylation of Rac Therefore, reduction in ROS is likely a consequence of statin inhibition of Rac prenylation resulting in the inability of Rac to ... however, it is believed that the primary source of ROS and the source of widespread oxidative damage found in both AD brains and mouse models of AD is the microglial NADPH oxidase [26-30] Despite...
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báo cáo hóa học: " Biomarkers of oxidative stress and its association with the urinary reducing capacity in bus maintenance workers" pptx
... concentrations of the particle-related variables OC, NO x , and possibly the particulate copper content The increase of the oxidative stress marker was accompanied by an increase of urinary levels of water ... suggests that low levels of oxidative stress induce protective effects (tier-1) by the activation of antioxidant enzymes If these responses fail to provide adequate protection, then a further ... urinary excretion of 8OHdG can be considered as a measure of the whole-body oxidative stress [20-22] The presence of 8OHdG in urine seems to originate mostly from the oxidation of the deoxynucleotide...
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Báo cáo khoa học: " Induction of oxidative stress and lipid peroxidation in rats chronically exposed to cypermethrin through dermal application" pps
... 15 16 17 18 19 20 21 22 Exacerbated responses to oxidative stress by an Na+ load in isolated nerve terminals: the role of ATP depletion and rise of [Ca2+]i J Neurosci 2000, 20, 2094-2103 Chow CK, ... production of free radicals [24] Similarly, GST catalyzes the conjugation of the reduced glutathione to electrophiles and protects cellular components from oxidative damage [16] Increased activity of ... inhibition of GSH synthesis or increased utilization of GSH for detoxification of toxicant induced free radicals [33] The decrease in SOD, blood GSH and GSH-Px suggests that the dermal exposure of cypermethrin...
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Báo cáo y học: "The role and clinical implications of G6PI in experimental models of rheumatoid arthritis" pptx
... (1:50) in the serum of 64% of RA patients but not in control individuals However, a number of other investigators did not find increased levels of α-G6PI antibodies in the serum of patients with ... one of 55 RA patients who did not have systemic manifestations of the disease produced antibodies against G6PI, seven of 22 patients with systemic manifestations (nodules or vasculitis) and 12 of ... unlike the CIA and K/B×N models, both CD4+ T cells and antibodies are necessary for the development of G6PI-induced arthritis, and neither transfer of T cells nor transfer of antibodies alone can...
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Báo cáo y học: "Potential involvement of oxidative stress in cartilage senescence and development of osteoarthritis: oxidative stress induces chondrocyte telomere instability and downregulation of chondrocyte function" pptx
... the role of oxidative damage in the pathogenesis of OA, we looked for the presence of oxidative damage in degenerated cartilage from OA patients and examined whether chemical oxidative stress (ROS) ... the analysis of cellular activity, telomere length and telomerase activity was conducted Oxidative stress in human articular cartilage We compared the degree of oxidative stress (antioxidative potential) ... different oxidative conditions To clarify the effect of oxidative stress on the telomeric instability in chondrocytes, we analyzed the telomere length of chondrocytes in the presence of an antioxidative...
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Báo cáo y học: " Resveratrol retards progression of diabetic nephropathy through modulations of oxidative stress, proinflammatory cytokines, and AMP-activated protein kinase" potx
... quantified with the aid of Image J software (NIH, Bethesda, MD, USA) Oxidative stress and proinflammatory cytokines analysis The renal production of superoxide anion was measured by modified lucigenin-enhanced ... tissues (Figure 1C, D) RSV ameliorated oxidative stress in the STZ-induced type diabetic kidneys The indicators of oxidative stress including the contents of superoxide anion, malondialdehyde, ... Castellino P: Oxidative stress and cellular stress response in diabetic nephropathy Cell Stress Chaperones 2007, 12(4):299-306 31 Schmitz A, Gundersen HJ, Osterby R: Glomerular morphology by light...
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Báo cáo khoa học: " The effect of methyl sulphonyl methane supplementation on biomarkers of oxidative stress in sport horses following jumping exercise" doc
... mechanism by which MSM may exert its protective effect against exercise-induced oxidative stress in horses The purpose of the present study was to determine whether exercise-induced oxidative stress ... hypothesis of augmented oxidative stress with exercise The exercise-induced increase in LPO content was reverted by supplementation with MSM, pointing to an improvement in the oxidative status of the ... stress There may be a number of sources of this oxidative stress, including mitochondrial superoxide production, ischemia-reperfusion mechanisms and auto-oxidation of catecholamines Severe or...
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Gamma glutamyltransferase is it a biomarker of oxidative stress
... mechanism, i.e induction of cellular GGT under oxidative stress1 65 Oxidative stress was introduced in vitro using menadione by Kugelman et al.170 on rat lung alveolar cells Exposure of cells to menadione ... death by 24h time point 20µM of menadione shows a more drastic decrease in cell viability with 30% cell death by 6h, 40% cell death by 9h and 60% cell death by 24h Acute addition of 50µM of menadione ... convert activity measured at 25oC to that at 37oC by multiplying by 1.78 and of 30oC at 37oC by multiplying by 1.31106 1.8 Normal Function The activity of GGT was initially observed to be greatest...
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Hydrogen peroxide as a potential biomarker of oxidative stress is there a reliable assay
... Biomarkers of oxidative stress/ damage associated with some human diseases 14 1.3 Data of urinary hydrogen peroxide analyzed by different ways 16 3.1 Accuracy of determination of PBS solutions of H2O2 by ... DCF by ROS and RNS 121 4.2 Schematic representation of DCFH oxidation by HRP initiated by H2O2 123 4.3 Chemical structure of scopoletin 126 4.4 Comparison of structures of HFLUOR (dihydrofluorescein) ... Formation 1.3 The Good Side Of Reactive Oxygen Species 1.4 Antioxidant Defences 1.5 Oxidative Stress: The Bad Side Of Reactive Oxygen Species 1.6 Use Of Biomarkers In Oxidative Stress Measurement 10...
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Báo cáo y học: " Protection of pulmonary epithelial cells from oxidative stress by hMYH adenine glycosylase" pptx
... repair genes by individually overexpressing each in lung cells and determining which of these provides the greatest degree of protection under conditions of increased oxidative stress Methods ... over-expression of any of these genes This is an important finding for interpretation of survival data; protection of cells is due to the overexpression of the specific gene and not due to enhancement of ... leading to increased cell survival following oxidative stress Discussion Oxidative stress to the lung leads to cellular DNA damage as evidenced by the release of specific gene products known to regulate...
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Báo cáo khoa học: Increased expression of c-Fos by extracellular signal-regulated kinase activation under sustained oxidative stress elicits BimEL upregulation and hepatocyte apoptosis pot
... to oxidative stress affects c-Fos stability and BimEL expression by changing the duration of the ERK signal Therefore, the duration of oxidative stress might be a fundamental determinant of cellular ... AP-1-dependent gene expression occurred under the conditions of sustained oxidative stress This idea is supported by data showing that transient oxidative stress for or h did not induce apoptosis [38] In ... Ishihara et al Regulation of BimEL expression by c-Fos A (a) (b) B C (c) (a) (b) Fig Suppression of BimEL expression by knockdown of c-Fos or c-Jun After transfection of c-Fos or c-Jun siRNA or...
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Báo cáo y học: "Anti-cancer and potential chemopreventive actions of ginseng by activating Nrf2 (NFE2L2) anti-oxidative stress/anti-inflammatory pathways" ppt
... transformation when subject to oxidative stress and carcinogens is performed by enhancing the expression of detoxifying metabolizing enzymes and maintaining oxidative stress homeostasis by producing antioxidant ... School of Pharmacy, Rutgers, the State University of New Jersey, USA 2Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, the State University of New Jersey, USA 3Department of ... neoplastic cells Inflammation and oxidative stress, together with the accumulation of genetic alterations over a lifetime of patients, will result in the formation of cancer It is important to take...
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Regulation of na+ h+ exchanger 1 (NHE 1) gene expression by mild oxidative stress
... 222 4.2 ROLE OF CASPASES AND IN THE INHIBITION OF NHE-1 EXPRESSION BY MILD OXIDATIVE STRESS 225 4.3 IRON AND THE ACTIVATION OF CASPASES AND BY MILD OXIDATIVE STRESS .232 ... Chelating of iron by DFO inhibits the repression of NHE-1 promoter mediated by H2O2 145 Figure 31: Chelating of iron by DFO prevent the increase of caspases and activities mediated by H2O2 ... ACTIVATION OF CASPASES AND MEDIATED BY MILD OXIDATIVE STRESS INVOLVES IRON .140 3.3.1 Sustained repression of NHE‐1 mediated by H2O2 is iron‐dependent140 3.4 DOWN-REGULATION OF NHE-1...
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Tài liệu Báo cáo khoa học: Nucleolin/C23 mediates the antiapoptotic effect of heat shock protein 70 during oxidative stress pptx
... effect of Hsp70 B Jiang et al After 24 h of H2O2 exposure, 44% of untransfected control cells and 45% of cells transfected with the empty vector (pcDNA3.1) exhibited similar features of apoptotic ... size However, only 22% of the cells transfected with Hsp70 underwent apoptosis (Fig 1B) We also investigated the effects of Hsp70 on caspase-3 activation induced by oxidative stress Using an in vitro ... important role in preconditioning, a phenomenon of protection of a heart from strong ischaemic insult by prior exposure to mild ischaemia or other mild stresses In the present study, we have shown...
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