existence uniqueness stability and differentiability properties of the flow associated to weakly differentiable vector fields

Tài liệu Carnivore Ecology and Conservation A Handbook of Techniques pptx

Ngày tải lên : 17/02/2014, 17:20

... level, size and shape of sampling units must depend on the behavior and distribution of the target animals, the attribute to be measured, and the size of the study area Size and shape of sampling ... researcher analyzes to make inferences Choice of an attribute depends on the life history of the target species, on the distribution and density of the target population, on the terrain and the local vegetative ... based on the accessibility and other characteristics of the study area (i.e land cover, topography, climate) At xed costs, the larger the sampling area, the lower the sampling intensity and the resolution...

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Carnivore Ecology and Conservation: A Handbook of Techniques pptx

Ngày tải lên : 06/03/2014, 18:20

... level, size and shape of sampling units must depend on the behavior and distribution of the target animals, the attribute to be measured, and the size of the study area Size and shape of sampling ... researcher analyzes to make inferences Choice of an attribute depends on the life history of the target species, on the distribution and density of the target population, on the terrain and the local vegetative ... based on the accessibility and other characteristics of the study area (i.e land cover, topography, climate) At xed costs, the larger the sampling area, the lower the sampling intensity and the resolution...

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Báo cáo y học: "Pravastatin Provides Antioxidant Activity and Protection of Erythrocytes Loaded Primaqe"

Ngày tải lên : 25/10/2012, 11:40

... oxidative stress [4] Furthermore, the decrease of glutathione can enhance the tendency of sulfhydryl groups to oxidation [5] Oxidation of proteins increases the formation of disulfide as well as ... many drugs to erythrocytes [7] PQ is used for treatment of malarial infections and its loading to erythrocytes is useful The therapeutic use of this drug is restricted due to its toxic side effects ... of pravastatin The erythrocytes were treated with 2mM of primaquine in the third group And in the fourth group the erythrocytes were exposed to pravastatin plus primaquine 2mM After 30 min, the...

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Windows Home Server Protect and Simplify Your Digital Life

Ngày tải lên : 01/01/2014, 16:48

... Server offers a wide variety of tools to help you simplify your digital life, and the availability of these tools should factor in to your organizational strategy, including centralized storage, and ... climb these mountains in v1 and leave the others for another time “These mountains” are: An easy -to- use consumer experience on top of the most powerful operating system on the planet Automatic ... the camera that took the picture, the date and time the picture was taken, and the dimensions of the files Figure 2-2 shows some image metadata in columns in Windows Vista (Note the prompts to...

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Tài liệu Physical Activity and Women’s Health pptx

Ngày tải lên : 13/02/2014, 08:20

... to 30% of cardiovascular deaths, 20 to 60% of cancer deaths, and 30% of diabetes deaths The only more prominent behavioral contributor to mortality than diet and physical inactivity was use of ... training was associated with lower TC, TG, and TC/HDL-C, but not to changes in HDL-C or LDL-C The average age of the subjects was 29.5 years, and the women with the most atherogenic lipid profiles ... appears to reduce the risk of colon cancer and breast cancer in white women, but there is an obvious need to incorporate minority women into future research on these topics PHYSICAL INACTIVITY AND...

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Tài liệu Time trends in leisure time physical activity and physical fitness in elderly people: 20 year followup of the Spanish population national health survey (1987-2006) docx

Ngày tải lên : 14/02/2014, 06:20

... stratified the fully adjusted models by the relevant factor The estimates were made using the “svy” (survey command) functions of the STATA program, which allowed us to incorporate the study design and ... permit to establish a cause and effect relationship due to the lack of longitudinal follow-up of the same individuals Nevertheless, the use of a national populationbased survey permits the inclusion ... 0.01, Figure 3) The results of the multivariate analysis to estimate time trends and associated factors for older women are summarized in the table Further, variables significantly associated with...

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Tài liệu Báo cáo khoa học: Secondary substrate binding strongly affects activity and binding afﬁnity of Bacillus subtilis and Aspergillus niger GH11 xylanases docx

Ngày tải lên : 14/02/2014, 19:20

... to Ala aiming to investigate their importance Several mutations were also combined to assess the importance of the SBS as a whole for the biochemical properties of XBS and XAN In an attempt to ... of CBMs from (or fusion of CBMs to) xylanases was shown to lead to lower activities in the absence of the CBM comparable to those seen for the elimination of the SBS in the present study [26–28] ... investigation of whether the SBS has a similar functionality in different GH11 xylanases and hence whether the occurrence of SBS is a more general strategy of GH11 xylanases to compensate for their lack of...

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Tài liệu Báo cáo khoa học: Processing, catalytic activity and crystal structures of kumamolisin-As with an engineered active site pptx

Ngày tải lên : 19/02/2014, 07:20

... a total of intensities of the 57-kDa, 38-kDa and 19-kDa bands, where the intensity of the 38-kDa protein band was corrected for the amounts of the added proteins with similar sizes The rates of ... Isolation of the 19-kDa propeptide of the E78H/D164N mutant To study the binding and ligation of the 19-kDa propeptide to the 38-kDa mature form of E78H ⁄ D164N (see the Results section and Fig ... surrogate of the c-carboxy group of Glu78 of the wild-type enzyme Moreover, a comparison of log kcat vs pH proﬁles of the E78H and E78H ⁄ D164N mutants provides clues to understanding the importance of...

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Tài liệu Báo cáo khoa học:Symmetric fluoro-substituted diol-based HIV protease inhibitors Ortho-fluorinated and meta-fluorinated P1/P1¢-benzyloxy side groups significantly improve the antiviral activity and preserve binding efficacyy docx

Ngày tải lên : 19/02/2014, 16:20

... groups of Ile50/Ile50¢ to the carbonyls of the inhibitor and is observed in all complexes The difference Fourier maps, 2Fo–Fc and Fo–Fc, unambiguously indicate the conformation of the inhibitors and ... inhibitors 2–6 bind to the active site of the protease with specific accommodations of the residues lining the S1/S1¢ subsites, as compared with the nonsubstituted analog The rmsd of Ca atoms of ... summarizes the binding characteristics of the fluoro inhibitors For the P1/P1¢ mono-substituted inhibitors, and 3, the accessible volume of the subsites is utilized more efficiently in relation to the...

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Tài liệu Báo cáo khoa học: Mutational analysis of plasminogen activator inhibitor-1 Interactions of a-helix F and its neighbouring structural elements regulates the activity and the rate of latency transition pdf

Ngày tải lên : 20/02/2014, 11:20

... orange and parts of b-sheet A in pink Backbone atoms of the s1A/hFloop (residues D127 to E130) and of the top of hF and the hF/s3Aloop (residues T146 to L154) are shown in CPK colours The following ... variant, the speciﬁc inhibitory activity towards uPA was determined in a peptidolytic assay and expressed as percentage of the theoretical maximum The activity was monitored over time and the rate of ... expressed as percentage of the theoretical maximum The activity was monitored over time and the rate of latency transition expressed as the functional half-life, t½ The averages and standard deviations...

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Tài liệu Báo cáo khoa học: Changes in rat liver mitochondria with aging Lon protease-like activity and N e-carboxymethyllysine accumulation in the matrix doc

Ngày tải lên : 20/02/2014, 11:20

... acid [40,41] They are prime target of ROS due to their location near to the site of ROS production [42] and could be the source of carbonyl adducts Other recent reports have shown that there is intracellular ... between the relative rates of glycoxidation/oxidation and proteolysis in the mitochondrial matrix Although the respiratory function of mitochondria is not compromised in spite of the extent of altered ... ng atoms of oxygen consumed per minute and per mg protein The rate of oxygen consumption in state and in state 4, respiratory control ratio (RCR) of oxygen consumptions in states and and the...

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Tài liệu Báo cáo khoa học: Endotoxic activity and chemical structure of lipopolysaccharides from Chlamydia trachomatis serotypes E and L2 and Chlamydophila psittaci 6BC pdf

Ngày tải lên : 20/02/2014, 23:20

... a-Kdo-residues The resonance frequencies and 3J1,2 coupling constants of signals belonging to the anomeric protons of GlcpN-residues revealed that one was a- and the other was b-conﬁgured These residues ... were sharp and proton signals were more dispersed However, the signal of the anomeric carbon of the b-GlcpN was absent from the spectrum under these conditions and could not be assigned The severe ... the equatorial deoxy proton of residue C and proton of the second Kdo residue (D) This ROE is characteristic of an a2–4-linked Kdodisaccharide [19] This substitution also leads to a b-shift of...

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Báo cáo khoa học: Relationship between functional activity and protein stability in the presence of all classes of stabilizing osmolytes ppt

Ngày tải lên : 07/03/2014, 00:20

... osmolyte and the peptide backbone, and (b) the total contribution of side chains to the stability of the native state, which may interact differently with different osmolytes, is very small These ... reactions of the enzyme–substrate, enzyme–intermediate and enzyme–product complexes [29] On the other hand, kcat ⁄ Km is an apparent second-order rate constant that refers to the properties and the ... reaction of the free enzyme and free substrate [29] We have therefore estimated kcat ⁄ Km values of all the reactions in the presence and absence of all classes of osmolytes It can be Fig Effect of...

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Báo cáo khoa học: Haptoglobin binds the antiatherogenic protein apolipoprotein E – impairment of apolipoprotein E stimulation of both lecithin:cholesterol acyltransferase activity and cholesterol uptake by hepatocytes pdf

Ngày tải lên : 07/03/2014, 00:20

... PAGE and densitometric analysis of the Coomassie-stained bands This Hpt preparation contained small amounts of ApoA-I and ApoE, and was free of albumin and other protein contaminants Isolation of ... worsens the onset and the rate of progression of atherosclerosis We evaluated the negative effects of Hpt on LCAT activity and cholesterol uptake by hepatocytes by using molar ratios of Hpt with ... from gel to the PVDF membrane, with HRP-conjugated avidin and ECL Coomassiestained bands of VLDL and LDL proteins are shown in lanes and 2, respectively VLDL and LDL proteins, blotted onto the PVDF...

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Báo cáo khoa học: Simultaneous improvement of catalytic activity and thermal stability of tyrosine phenol-lyase by directed evolution ppt

Ngày tải lên : 07/03/2014, 00:20

... 8.0), the thermal stability of both mutants was conﬁrmed to be up to 10 °C higher than that of the wild-type (Fig 2B) When the pH properties of the puriﬁed enzymes were investigated, the AS4 and ... of activity and stability included the additional T129I or T451A mutation (Table 1) Therefore, to understand the structure and function of the mutated residues, hypothetical structures of S toebii ... tighter binding of the cofactor in C freundii TPL, thereby reducing the decomposition rate of the cofactor by a Pictet–Spengler reaction [9] In the S toebii enzyme, Pro16 occupies the Thr15 position...

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Báo cáo khoa học: Hyperthermophilic enzymes ) stability, activity and implementation strategies for high temperature applications pot

Ngày tải lên : 07/03/2014, 05:20

... correlation of the G-C content of the paired stem regions (Watson–Crick base pairing) of the 16S rRNA genes, with the actual length of the stem, and with their Topt [15] In spite of attempts to correlate ... based on the Topt of the microorganism They compared the crystal structures of proteins from moderate thermophilic microorganisms (Topt ¼ 45–80 °C) and extreme thermophilic microorganisms (Topt ... 75–100% of the activity (cf free enzyme), whereas other combinations lead to full inactivation of the enzyme [74] Moreover, epoxy modiﬁcation of the gel surface leads to the precise control of the...

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Báo cáo khoa học: The Vps4 C-terminal helix is a critical determinant for assembly and ATPase activity and has elements conserved in other members of the meiotic clade of AAA ATPases pdf

Ngày tải lên : 07/03/2014, 05:20

... sheets and 8, the AAA domain helix and the C-terminal helix) However, the majority of these proteins are likely to be other meiotic clade AAA ATPases and have the AAA domain helix and the C-terminal ... by their ﬁrst three amino acids The TRP sequence (TRPTVNEDDLLK) is at the start of the helix, whereas the RDF sequence (RDFGQEGN) is at the end of the helix (Fig 1B,C) To determine whether the ... in transport of endocytosed material, including alpha factor and 1430 both water- and membrane-soluble dyes, to the vacuole [41,42] To assess the importance of the C-terminal helix and b-domain...

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Báo cáo khoa học: Engineering and characterization of human manganese superoxide dismutase mutants with high activity and low product inhibition potx

Ngày tải lên : 07/03/2014, 11:20

... based on the ability of Escherichia coli to grow in the presence of the toxic compound paraquat; and (b) the use of the paraquat-based selection scheme in a directed evolution approach to identify ... part, be due to a loss of the interaction between the side chains of Asn73 and Gln143 The X-ray crystal structure of hMnSOD shows that the side chain amide ˚ of Asn73 is near to (3.1 A) and possibly ... the uncatalyzed dismutation of superoxide [32] A least-square ﬁt of Eqn (1) to the data of Fig yields the constants given in the legend of Fig The values of kcat ⁄ Km and kcat for catalysis by...

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Báo cáo khoa học: Alpha-fetoprotein antagonizes X-linked inhibitor of apoptosis protein anticaspase activity and disrupts XIAP–caspase interaction ppt

Ngày tải lên : 07/03/2014, 12:20

... triggering of the apoptosis machinery Further studies are required to better understand the importance of the role AFP in modulating the level of IAPs in tumor cells Elucidation of the role of AFP ... [16–18,52] The ability of the cell to die at the postmitochondrial level depends mainly on the activity of endogenous inhibitors of apoptosis, such as IAPs, sHSPs, or Bcl-2 [6,7,54,55] There is further ... that they belong to the same XIAP molecule Discussion Recent evidence has broken the main paradigm of apoptosis, stating that the release of cytochrome c is the point of no return in the apoptotic...

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Báo cáo khoa học: Amino acids at the N- and C-termini of human glutamate carboxypeptidase II are required for enzymatic activity and proper folding pptx

Ngày tải lên : 07/03/2014, 15:20

... secretion of the truncated variants into the culture medium, suggesting the importance of the C-terminus for the correct folding and procession of GCPII throughout the secretory pathway These data ... absence of the intracellular and transmembrane domains does not inﬂuence carboxypeptidase activity of GCPII and neither does the attachment of the HisXpress epitope at the N-terminus of the 44/750 ... NAAG-hydrolyzing activity (the 44/736 variant), and the C-terminal extension (addition of the V5-His tag in the case of the 44/750_V5-His variant) reduced the activity by a factor of > 104 Furthermore, C-terminal...

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