examples of combinatorial biosynthesis of anticancer natural products
Investigating the Biosynthetic Pathway of Polyacetylenic Natural Products in Fistulina hepatica and Echinacea purpurea
Ngày tải lên :
24/08/2014, 11:28
... GC/MS Analysis of Yeast Lipids 24 2.2.5 Isolation and NMR Analysis of Fatty Acid Natural Products 25 2.2.5.1 Purification of Natural Products ... could contribute to the large diversity of acetylenic natural products 1.7 Acetylenic Natural Products Acetylenic natural products are metabolites that contain a carbon-‐carbon ... involvement of the crepenynic acid pathway in fungal acetylenic natural product biosynthesis 20 Figure 10: Examples of acetylenic natural products isolated...
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CHEMISTRY OF NATURAL PRODUCTS ppt
Ngày tải lên :
18/03/2014, 20:20
... overview of catabolic pathways Metabolism of fatty acids Metabolism of glucose (glycolysis) Conversion of pyruvate to acetyl coenzyme A Anabolism of fatty acids from CH3COSCoA Anabolism of glucose ... Biogenesis of phenols through shikimic acid Biosynthesis of shikimic acid O COO OH + PO PO O OP COO O HO OH OH OH COO HO COO -H2O O OH OH NADPH shikimic acid OH HO OH Biosynthesis of aromatic ... Condensation of isoprene units Formation of acyclic terpenes -H+ OPP OPP OPP H OPP OPP geranyl OPP OPP farnesyl OPP OPP tail-tail dimerization OPP geranylgeranyl OPP squalene Formation of monoterpenes (examples) ...
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synthetic applications of 1,3 dipolar cycloaddition chemistry toward heterocycles and natural products
Ngày tải lên :
09/05/2014, 17:06
... inhibitors of the biosynthesis of chitin, a major structural component of the cell wall of most fungi (Scheme 1.2) Merino and co-workers (38,39) reported the total synthesis of (þ)-polyoxin J 1b and of ... and asymmetric versions of these dipolar cycloadditions represent an entirely new aspect of the current reference work In recent years, numerous natural and unnatural products have been prepared ... HETEROCYCLES AND NATURAL PRODUCTS This is the fifty-ninth volume in the series THE CHEMISTRY OF HETEROCYCLIC COMPOUNDS The Chemistry of Heterocyclic Compounds, Volume 59: Synthetic Applications of 1,3-Dipolar...
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Activity based chemical proteomics profiling of natural products and drug like small molecules
Ngày tải lên :
09/09/2015, 18:54
... Table of Contents Page Dedication iii Acknowledgements iv Table of Contents vi Summary x List of Publications xii List of Abbreviations xv List of Figures xxi List of Schemes xxv List of Tables ... 16 1.2.4 Application of ABPP for Target ID of Natural Products Natural products, and their derivatives and mimics, have rendered an enormous contribution to the treatment of diseases such as infentions ... 2.5 Determination of absolute configuration of 2-19 36 Scheme 2.6 Synthesis of 2-3 36 Scheme 3.1 Synthesis of 3-1b-j 60 Scheme 3.2 Synthesis of 3-2b-f 61 Scheme 3.3 Synthesis of 3-3b-c 61 Scheme...
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Synthesis and biological evaluation of natural products and their analogs as new cancer chemotherapeutic agents
Ngày tải lên :
10/09/2015, 15:49
... Sources of Antitumor Agents 14 1.2.4 Anticancer Drugs from Marine Sources 16 1.2.5 Synthesis of Natural Products 17 1.2.6 Semisynthesis and Total Synthesis of Natural Products 18 1.2.7 Combinatorial ... years i TABLE OF CONTENTS TABLE OF CONTENTS ii SUMMARY iv LIST OF TABLES vi LIST OF FIGURES vii LIST OF SCHEMES ix LIST OF ABBREVIATIONS x Chapter 1: Introduction 1.1.1 Overview of Cancer 1.1.2 ... countries, of the top 50 selling drugs sold in pharmacies, half of them are based on or derived from natural products. 50,51 Since the 1950s, natural products have attracted the interests of numerous...
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Applications of capillary electrophoresis in the analysis of natural products
Ngày tải lên :
11/09/2015, 14:27
... effective components in natural products Hence, the major aim of this thesis is to expand the analytical applicability of CE in the analysis of natural products The range of natural products is quite ... used for the separation of different groups of alkaloids 1.3 Scope of the research Natural products are interesting to researchers because of their inestimable potential to offer a vast and virtually ... the development of pharmaceutical industry relies closely on the understanding of natural products Plenty of drugs, such as Penicillin, taxal, morphine, were developed from natural products The...
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Chemistry of calophyllum wallichianum, scapania undulata, plagiochila colorans and biotransformation of natural products
Ngày tải lên :
03/10/2015, 20:33
... H N H N H N O HO (42) CNS 2013 1.3 Biosynthesis of Natural Products There are a huge number of natural products in nature, and they differ greatly in terms of their structures, characteristics ... HMBC correlations of compound 125 Figure 3-16 Key HMBC Correlations of compound 126 List of Schemes Scheme 1-1 Biosynthesis of phloracetophenone (43) Scheme 1-2 Biosynthesis of alternariol (44) ... introduction 1.1 Introduction 1.2 Natural Products 1.3 Biosynthesis of Natural Products 1.4 Natural Products in Modern Drug Discovery Chapter Chemistry of Calophyllum wallichianum 12 14 2.1 Introduction...
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SELECTED EXAMPLES OF NEWAPPLICATIONS
Ngày tải lên :
25/10/2013, 16:20
... Dextran esters of ketoprofen, diclofenac, ibuprofen and fenoprofen have been studied, showing that the dextran ester prodrug approach provides selective colon delivery systems of drugs possessing ... development of nanoparticle systems usable for parental injection, the use of hydrogels, and the preparation of hydrolytically instable prodrugs that are of recent importance Because of the fact ... devices is one of the major developments in the field of therapeutics In addition to controlled release mechanisms accom- 188 10 Selected Examples of New Applications Fig 10.4 Percentage of released...
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Tài liệu The Insider’s Guide to PR: Chapter 6 PR IN PRACTICE The following case studies are examples of PR pptx
Ngày tải lên :
13/12/2013, 04:15
... reached two out of five mothers at least twice and just over half of all primary school children at least twice • 83% of coverage included tips on food hygiene, 83% included mentions of the schools ... who would campaign in favour of the amendment and table it on the floor of the House of Commons This included drafting speeches used in the House during the passage of the Bill • Identifying and ... practice • To encourage the teaching of food safety in the classroom • To raise awareness of and encourage basic food hygiene practice within the target group of 7-11 year olds Solution • Commission...
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99 examples of pneumatic applications
Ngày tải lên :
01/01/2014, 00:25
... the development of solution concepts 12 99 Examples of pneumatic applications Examples of pneumatic applications Examples are provided by problem solutions that have been taken out of their complex ... question of the right degree of automation Too much automation can soon prove costly! The degree of automation is the quotient of the sum of the weighted automated functions and the sum of the ... higher Fig 1: Collections of examples are not a modern invention The purpose of examples is above all to stimulate the imagination of engineers and provide suggestions of ways to find high-quality...
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Tài liệu Art of Surface Interpolation-Chapter 5:Solving special tasks In the next sections there are examples of interpolation problems, ppt
Ngày tải lên :
21/01/2014, 07:20
... SurGe software there is an elevation model of mount Shasta in Northern California 74 Fig 5.7: Digital elevation model of mount Shasta in Northern California 5.8 Construction of model grid One of ... layer thickness maps and volume calculations One of the most important applications of SurGe in my profession are projects of geological models of underground gas storages (UGS) in the Czech Republic ... After more than three-years of publication through the medium of Internet WWW pages (see [13]) and through the medium of more than 300 software distributors (see List of selected SurGe distributors...
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Tài liệu Marketing of Indian Organic Products: Status, Issues, and Prospects pptx
Ngày tải lên :
14/02/2014, 08:20
... delisted from the list of approved countries in the EU for import of egg powders, two years ago, for non-submission of Residue Monitoring Plan (RMP) In dairy products export, problems of mastitis in ... growth of organic farming in Latin American countries where it was encouraged by increased opportunity for export of organic products (Naik, 1999) or in Cuba where a crisis (of the fall of the ... partnerships which is an emerging mode of fair trade The main products which have been the focus of fair trade are: tea, coffee, cocoa, spices, and handicrafts and major forms of support have been marketing,...
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Tài liệu Báo cáo khóa học: Non-specific depolymerization of chitosan by pronase and characterization of the resultant products pptx
Ngày tải lên :
19/02/2014, 12:20
... value of LMWC is due to the release of GlcNAc and GlcNAc-rich oligomers as some of the products An examination of DA values indicates that the total DA of the products is equal to that of native ... chito-oligomers as one of the products and a drastic decrease in molecular mass of chitosan indicates an endo-type activity of pronase Addition of hexosaminidase (specific for the release of GlcNAc from ... protonation of the amine groups of samples The number of equivalents of acid groups was calculated using the formula: [NH3+] (mequiÆkg)1) ¼ 1000 · molarity (moles/L) · volume of titrant (mL)/mass of sample...
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Tài liệu Self-Affirmation through the Choice of Highly Aesthetic Products Author(s): Claudia Townsend and Sanjay Sood doc
Ngày tải lên :
19/02/2014, 17:20
... coffee or not for the coffeemaker), or its level on a hedonic attribute (rating by consumers on comfort and ease of use for the mouse and rating by consumers on taste of the coffee for the coffeemaker) ... affirming effects of something can diminish its impact We find it unlikely that consumers are aware of the self-affirming benefits of choice of high design Therefore, discovery of this new form of affirmation ... test the notion that choice of highly aesthetic products is linked to selfaffirmation Study tests this connection by looking at the impact of self-affirmation on choice of products with high design...
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Tài liệu For the Term of His Natural Life pdf
Ngày tải lên :
21/02/2014, 14:20
... attention, the inexpediency of again allowing offenders against the law to be herded to- For the Term of His Natural Life gether in places remote from the wholesome influence of public opinion, and ... Third’s Lords of the Admiralty This contract was the thin end of that wedge which eventually split the mighty oak block of Government patronage into three-deckers For the Term of His Natural Life ... is often a part of such violent natures, proved intractable, and after three years of parental feud, he went off to the Continent, to pursue there the same reckless life which in London had offended...
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Tài liệu Examples of the Standards for Students’ Writing 2009: English Language Arts Grade 9 ppt
Ngày tải lên :
24/02/2014, 18:20
... placement of each postal code on a separate line and the presentation of “EDITOR OF THE WENTWORTH NEWS” on the envelope and the inclusion of “Kim Rogers” in the heading of the letter E Proportion of ... situation of being appreciative of the work of an animal shelter in caring for lost or abandoned pets While nearly all students referenced the “services” offered by the shelter, the role of volunteers, ... length and complexity of response has been considered 23 Student Exemplar – Proficient 24 Student Exemplar – Proficient 25 Student Exemplar – Proficient 26 Student Exemplar – Proficient 27 Rationale...
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Ceylon; an Account of the Island Physical, Historical, and Topographical with Notices of Its Natural History, Antiquities and Productions, Volume doc
Ngày tải lên :
07/03/2014, 14:20
... sketch of Turnour (note) The Mahawanso Recovery of the "tika" on the Mahawanso Outline of the Mahawanso Turnour's epitome of Singhalese history Historical proofs of the Mahawanso Identity of Sandracottus ... late officer of the Ceylon Government, that many years ago, what remained of the Dutch records were removed from the record-room of the Colonial Office to the cutcherry of the government agent of ... traditions of their splendour and profusion; and fabulous as this story of the ruby of the Kandyan kings may be, the abundance of gems in Saffragam has given to the capital of the district the name of...
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