ex vivo generated dendritic cells for clinical trials versus in vivo targeting to dendritic cells critical issues
Báo cáo khoa học: "Can generic paediatric mortality scores calculated 4 hours after admission be used as inclusion criteria for clinical trials" pot
... clinical trials remains an important problem in PICUs [6] Scoring systems are used to compare or control for severity of illness in clinical trials and have been integrated into guidelines [6] The question ... (PRISM)hoursPRISM and H24 for [1,2] for the length points for which the namely hours Index [1,2] for (a) the time points for which the scores were developed (1 hour [H1] for PIM, 24 hours [H24] for PRISM, and ... Understanding articles describing clinical prediction tools Evidence Based Medicine in Critical Care Group Crit Care Med 1998, 26:1603-1612 Gemke RJ, van Vught J: Scoring systems in pediatric intensive...
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Báo cáo y học: "Protein C as a surrogate end-point for clinical trials of sepsis" docx
... Fleming TR, DeMets DL: Surrogate end points in clinical trials: are we being misled? Ann Intern Med 1996, 125:605-613 The Cardiac Arrhythmia Suppression Trial (CAST) Investigators: Preliminary ... baseline levels of all six biomarkers, including protein C, exhibited poor discriminant function for death, with areas under the receiver operator characteristic curve ranging from 55% to 60% ... likely to benefit from treatment with DrotAA as well as to monitor patient response to therapy The use of protein C as a surrogate end-point may allow tailoring of infusion length or drug dose to...
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Marketing strategy for clinical express service in TNT express in Vietnam market
... Vietrans Express operation in Clinical Express during the last year? Please give your own opinion of TNT in comparison with DHL, FeDex, UPS in term of branding in Clinical Express? What is your forecast ... laws in countries such as Japan, China and India, have led to the burgeoning clinical trials market in Asia Increasing globalization and digitalization of business has brought into prominence ... is expected to grow by up to 12 per cent annually To support the growth of the clinical trials sector in Asia, TNT Vietrans Express launched Clinical Express Service, which started in Vietnam in...
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Dissertation summary for doctoral philosophy program in education: Methods to develop communication skills for children with autism 3 4 years old
... development of CS for CwA Since detection, intervention to how inclusive caring and teaching in inclusive classes, create advantage environment for education organizing for CwA in order to minimize disadvantages ... of practice in order to obtain targeted results There is a cause related to environment factors, for example, watching 1.2.2 Communication skill television too much, hinder children in communication ... immitation, the factor of early intervention cooperating with intervention activities take implementing in the environment of inclusive education turn, listening and performing verbal instruction,...
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báo cáo khoa học: "CyberKnife® enhanced conventionally fractionated chemoradiation for high grade glioma in close proximity to critical structures" pdf
... collimator to generate highly conformal plans (mean new conformity index of 1.62, Table 3) Selected plans were inhomogeneous by design (mean homogeneity index of 1.38, Table 3) to minimize dose to ... cm margin when clinically indicated In this study, there was no limit set on the treatable target volumes Homogeneity Index The homogeneity index (HI) describes the uniformity of dose within a ... margin Critical structures in close proximity to the target volume were not excluded from the treatment volume during conventional radiation treatment Forty to 50.4 Gy was delivered in 1.8 to...
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Báo cáo y học: "The potential of human regulatory T cells generated ex vivo as a treatment for lupus and other chronic inflammatory diseases" pot
... Weiner HL, Hafler DA: Induction of circulating myelin basic protein and proteolipid protein-specific transforming growth factor-beta1secreting Th3 T cells by oral administration of myelin in ... Asano M, Itoh M, Toda M: Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor-chains (CD25) Breakdown of a single mechanism of self-tolerance causes various autoimmune ... numbers in humans for clinical trials Although this will be carried out initially with mitogens as the T-cell activating agent, the ultimate goal is to induce autoantigen-specific regulatory T cells...
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báo cáo khoa học: "Phenotype and functional evaluation of ex vivo generated antigen-specific immune effector cells with potential for therapeutic applications" pps
... memory effector cells (Fig 2), the cultured cells differentiated toward Tem and (Teff) cells after expansion (Fig 3B and 3C) Intracellular staining for effector cytokines showed that the expanded ... immune effector cells after ex vivo expansion Phenotype Phenotype analyses of IFN-γ- or CD137-selected immune effector cells after ex vivo expansion (A) Phenotype analysis after ex vivo expansion ... to in vivo therapeutic efficacy,[7,34,35] clinical studies have proven that ex vivo expanded effector cells can persist many years after infusion [36] Clinical benefits of these different protocols...
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Báo cáo sinh học: " Streamlined design of a self-inactivating feline immunodeficiency virus vector for transducing ex vivo dendritic cells and T lymphocytes" ppsx
... more promising avenues [3,4] Viruses are considered ideal for delivering transgenes due to their inherent ability to bring genetic material into cells but need extensive engineering to overcome ... VSV-G pseudotyping is extremely convenient for vector development and in vitro testing since, being the cell receptor for VSV a ubiquitous phospholipid [44], it allows vector access into virtually ... transducing protocol used We finally examined the efficiency of LAW34 at transducing ex vivo murine DCs and T cells using different transduction protocols The results showed that the vector has...
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báo cáo hóa học:" Regulatory activity of azabisphosphonate-capped dendrimers on human CD4+ T cell proliferation enhances ex-vivo expansion of NK cells from PBMCs for immunotherapy" potx
... expansion of T cells was maintained in the presence or absence of exogenous IL-2 (Fig 3b) Thus, monocytes are involved in the ex- vivo priming of autologous CD4+T cells but 3a-G1 is directly acting on ... regulatory cells [25] Using high doses of IL-2 in our NK cell expansion protocol, we were interested in whether regulatory T cells could persist and even expand in these conditions, thus dampening ... according to manufacturer's recommendations For surface staining, cells were incubated with fluorochrome-conjugated monoclonal antibodies in cold PBS containing 5% of fetal bovine serum at 4°C for...
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Design of artificial microenvironment for cord blood CD34+ cells expansion ex vivo
... population for ex vivo expansion Before determining if a protocol results in the expansion of a stem cell, one must define what a stem cell is Based on transplantation of marked stem cells in murine ... modulators of cell function, many investigators have focused on developing culture systems supplemented with stroma, appropriate combinations of stimulatory factors to maintain and expand HSC ex vivo ... hematopoietic cells Most of these cultures have been performed in well-plates and T-flasks utilizing CD34+ cells For the scale-up of these cultures for clinical trials, most investigators have chosen to...
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SURVEY OF CURRENT GUIDANCE FOR CHILD HEALTH CLINICAL TRIALS pot
... recruitment in clinical trial in pediatrics] Therapie 1991; 46(2):139-142 (8) Karlberg JP Clinical trials in pediatrics In: Machin D, Day S, Green S, editors Textbook of clinical trials John ... considerations for clinical trials on medicinal products conducted 23 with the paediatric population 2009 Guideline 2009/C28/01 on the information concerning paediatric clinical trials to be entered into ... Recommendations for regulatory agencies on ethical issues of pediatric research Critical issues in clinical drug trials in children Good clinical practice and ethics of clinical trials Patient...
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Báo cáo hóa học: " The status of clinical trials: Cause for concern" potx
... report [10] dealing with the tracking of off-shore clinical trials was telling It reported that the number of foreign clinical investigators conducting clinical research under an IND increased 16fold ... absence of attention to creating and maintaining infrastructures for trials and training trialists One way to address the issue would be for the NIH intramural program to initiate an integrated program ... campus to train personnel involved at all levels of the clinical research infrastructure The running of clinical trials demands a concentrated effort by a team, including trialists, information...
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Báo cáo hóa học: " The Reflux Disease Questionnaire: a measure for assessment of treatment response in clinical trials" pdf
... viable instrument for assessing symptom severity, subject selection and response to treatment in clinical trials of GERD Work focusing on the performance of the RDQ for epidemiological survey (or tool) ... viable instrument for assessing symptom severity and response to treatment in clinical trials of patients with GERD 10 11 12 Competing interests The authors declare that they have no competing interests ... worsening on a sevenpoint scale ranging from to In the present analysis worsening was collapsed into one category, a little better was defined as +1 to +4, while much better was defined as +5 to...
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báo cáo khoa học: "Ex vivo hepatic venography for hepatocellular carcinoma in livers explanted for liver transplantation" ppsx
... revealed in cases without demonstrated histopathological invasion to hepatic vein for the first time in the literature The finding suggests that there is direct spillage of HCC cells into the systemic ... extrahepatic recurrence In this study, we performed hepatic venography for HCC in explanted livers for liver transplantation, in order to explore the direct connection between the hepatic vein ... dedifferentiation, resulting in regurgitation of blood to the portal vein with the rising internal pressure of HCC nodule This causes intrahepatic metastasis through the portal vein as well In regard to the outcomes...
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Báo cáo y học: "Role of regulatory T cells in experimental arthritis and implications for clinical use" potx
... because not all autoantigen-specific T cells seem to be effective in treating an ongoing autoimmune disease as described in the T1D model [22] Therefore in humans such a prescreening of effective ... This study therefore suggested that during a chronic autoimmune inflammatory disease CD4+CD25+ Treg are attracted to and accumulate where needed but fail to suppress the autoimmune inflammation ... AM, Huizinga TW, de Vries RR, Toes RE: Functional regulatory immune responses against human cartilage glycoprotein-39 in health vs proinflammatory responses in rheumatoid arthritis Proc Natl Acad...
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Báo cáo y học: " Molecular therapies for systemic lupus erythematosus: clinical trials and future prospects" pptx
... Figure 1) bind to the specific cytosolic binding-protein FKBP12; but while tacrolimus complexed to FKBP12 inhibits the Ca2+-dependent phosphatase calcineurin, rapamycin-FKBP12 binds to and inactivates ... rapamycin; SLE, systemic lupus erythematosus; SLEDAI, Systemic Lupus Erythematosus Disease Activity Index shown to induce apoptosis of lupus T cells ex vivo, leading in co-cultures to the inhibition ... phosphoinoside 3-kinase gamma inhibitors, such as AS605240 (a specific p110γ inhibitor) [37] Promising molecules targeting the phosphoinoside 3-kinase pathway that have entered clinical trials for...
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báo cáo khoa học: "Effect of anti-CD52 antibody alemtuzumab on ex-vivo culture of umbilical cord blood stem cells" doc
... explained the pitfalls in clinical- scale transplantation using ex vivo CB products To overcome this problem, new approaches for ex vivo expansion need to be developed, aiming at expansion of the "stem" ... hematopoietic cells Exp Hematol 2006, 34(8):1060-1068 Hutton JF, D'Andrea RJ, Lewis ID: Potential for clinical ex vivo expansion of cord blood haemopoietic stem cells using nonhaemopoietic factor ... enhanced ex vivo expansion of CB CD34+ cells and TNC In addition, compared to both the initiating cells and cytokines-alone control cultures, total CFU, especially CFU-GEMM and CFUGM were expanded...
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Báo cáo y học: "A novel human ex vivo model for the analysis of molecular events during lung cancer chemotherapy" pptx
... flow cytometry in human Caspase-3 induction determined by flow cytometry in human cancer cell lines in the absence (RPMI) or presence of carboplatin (CARB), vinorelbine (VIN) and gemcitabine (GEM), ... all cytotoxic For means of completeness, the responses of all individual samples in the presence of the cytotoxic drugs carboplatin (CARB), vinorelbine (VIN) or gemcitabine (GEM) as compared to ... same holds true for HEK cells (about 90% positively stained tumor cells in medium controls vs 30 – 40% in the presence of the cytotoxic drugs) In contrast, the Ki-67-index of 90% in the chemo-resistant...
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Báo cáo y học: "Vpu serine 52 dependent counteraction of tetherin is required for HIV-1 replication in macrophages, but not in ex vivo human lymphoid tissue" docx
... tissue removed during routine tonsillectomy was received within hours of excision The tonsils were washed thoroughly with medium containing antibiotics and sectioned into 2- to 3-mm3 blocks These ... cells with interferon-alpha [6,20] Interestingly, interferon-alpha is upregulated by HIV-1 infection [41,42] which may subsequently lead to the induction of tetherin in a feedback mechanism Indeed ... quantified using the Gene-snap software Ex vivo- infected HLT HIV-1 replication and cytopathicity in ex vivo- infected HLTwas determined as described previously [26,27] Briefly, human tonsillar tissue...
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Báo cáo y học: "Determinants in HIV-1 Nef for enhancement of virus replication and depletion of CD4+ T lymphocytes in human lymphoid tissue ex vivo" doc
... Direct staining of CD4 was avoided due to the reduction of CD4 surface exposure in HIV-1 infected cells, but a control staining for mock infected cells reveals that virtually all cells in this ... Direct staining of CD4 was avoided due to the reduction of CD4 surface exposure in HIV-1 infected cells, but a control staining for mock infected cells reveals that virtually all CD3+/CD 8cells in this ... determinants for Nef's activity in HIV-infected HLAC Molecular determinants for Nef's activity in HIV-infected HLAC HLACs were infected with ng p24 of wt HIV-1, Δnef HIV-1 or HIV-1 encoding for...
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Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam xác định các mục tiêu của chương trình khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản xác định thời lượng học về mặt lí thuyết và thực tế tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu nội dung cụ thể cho từng kĩ năng ở từng cấp độ xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ lồng sóc các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 sự cần thiết phải đầu tư xây dựng nhà máy phần 3 giới thiệu nguyên liệu từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng 9 tr 25