... expression of CD4 and CD25 and the lack of expression of CD127 We also characterized the number of monocytes and NK cells based upon the expression of the usual markers (CD45, CD14, HLA-DR, CD16, and ... (PE)-labelled anti- HLA-DR (clone IM 1639), FITC-labelled anti- CD3, PC5-labeled anti- CD56, PC5-labelled anti- natural killer (NK) G2D, PC5-labeled anti- CD4, FITC-labelled anti- CD25 and PElabelled anti- CD127; ... sex; severityof underlying medical condition according to the criteria of McCabe and Jackson [16]; Simplified Acute Physiology Score (SAPS) II [17]; Sepsis-related OrganFailure Assessment (SOFA)...
... Elisabet Mo and Mrs Monika Strand for instruction and support in the analytical work, to Prof Stig Larsen for help in the planning of the study, and to Prof Eystein Skjerve and Prof Aage Tverdal ... recommendations of Moreira & Mahan [8] and others On the other hand, the use of additional supplements with vitamins or minerals is uncommon [12] In the present investigation we have examined the ... regression model and the xtgee procedure, and by examining predictions and residuals by x-y plots and normal quantile plots In addition, the statistical differences between the average Vit E and Se concentrations...
... et al [10] and by other authors [1,9] None of these authors, however, analyzed the severityof multiple organ dysfunction rather than the severityof sepsis and systemic inflammation and there ... different groups of patients, eg for purposes of differential diagnosis, assessment of the severityof the disease andof systemic inflammation, including the severityof MODS, is mandatory When ... relation of PCT concentrations and the severityof multiple organ dysfunction during systemic inflammation By using the SOFA score, we thus focused particularly on the extent of multiorgan dysfunction...
... of the antibody were 16% with 15keto-PGF2α, and 4% with 13,14-dihydro-PGF2α The intraassay coefficients of variation ranged between 13.1 and 13.0% for different ranges of the standard curve and ... effects of inhibition of prostaglandin biosynthesis with flunixin meglumine and later administration of prostaglandin-F2-alpha on the intraluminal pressure variations in the isthmus of the oviduct ... AM, Kindahl H, Einarsson S: Effect of ACTH and CRH on plasma levels of cortisol and prostaglandin F2α metabolite in cycling gilts and castrated boars Acta Vet Scand 2005, 46:249-256 Montgomery A,...
... 2100 mg/kg of vitamin PP, 2100 mg/kg of choline, 800 mg/kg of Fe, 700 mg/kg of Mn, 175 mg/kg of Cu, 1750 mg/kg of Zn, 35 mg/kg of I, mg/kg of Co, 11.5 mg/kg of Se content evaluation and net energy ... IU/kg of vitamin A, 14,000 IU/kg of vitamin D3, 1880 mg/kg of vitamin E, 31.50 mg/kg of vitamin B1, 21 mg/ kg of vitamin B2, 11 mg/kg of vitamin B6, 0.21 mg/kg of vitamin B12, 0.21 mg/kg of biotin, ... sensitivity of leptin assay was 0.37 ± 0.01 ng/ml; the intra- and inter-assay coefficients of variation were 4.2 and 8%, respectively Parallelism with standard curves and scalar dilution of bovine...
... procalcitonin and number of failing organs sAxl correlated to bilirubin, Gas6, number of organs in failureand inversely to C-reactive protein (Table 2) Gas6 was higher in patients with organ failure, ... analysis of the data and wrote parts of the manuscript AL participated in the design of the clinical study, included and followed patients, assisted in analysis of the data and wrote parts of the ... infectious disease, at least two SIRS criteria, and the presence or development of hypotension and/ or organfailure within 24 h of the collection of the blood samples Sepsis was defined as an infectious...
... over production of O2-• by the xanthine oxidase enzyme during ischemia, and release of redox active transition metals such as iron and copper [3] The presence of various biomarkers of oxidative ... assessing the degree of oxidative stress, inflammation, severityof injury, and efficacy of antioxidant treatment in critically ill patients More importantly, the simplicity and rapidity of measurement ... the clinical situation Finally, and perhaps most important, is the issue of timing of antioxidant administration Lovat and Preiser suggest that the repletion of antioxidants would probably achieve...
... the interest in and necessity of a comprehensive documentation of the disease severityand progression The clinical and genetic heterogeneity of the non-classic or late-onset forms of Pompe disease ... history and current status of children and adults with Pompe disease by means of self-report questionnaires The recruitment of patients, collection of informed consent forms, and the distribution and ... prevention of antibody formation against the viral vector and/ or α-glucosidase, and safety of the vector are still important issues to be addressed Dietary treatment Another approach in the treatment of...
... 4.3 and 7.3 mgÆdL)1) This indicates that the genetic basis of APA is complex andother genetic and/ or biological factors are involved in the occurrence of APA The structural organization of the ... measure of linkage disequilibrium between markers in the b2GPI gene was estimated by ID’I calculation [37] Comparison of genotype and allele frequencies between antibody positive and antibody ... The size of the DNA insert and fidelity of DNA polymerase was confirmed by restriction analysis and DNA sequencing The wild ()1C) and mutant ()1A) type fragments were then inserted upstream of the...
... dimers of four different chains IL-4 is the ligand of two receptors: A high-affinity heterodimer of IL-4Rα and the IL-2R common γ-chain and another heterodimeric receptor composed of IL-4Rα and ... position of NF-κB in the induction of iNOS and production of NO is also indicated by experiments showing that antibodies to TNF inhibit activation of NF-κB and production of NO in HSVinfected cells and ... progression and evaluation of final outcome of infection is more unclear, in that many other viral and host factors are of importance in these more complicated models with several stages of infection and...
... Denmark,3Division of Clinical and Experimental Neuroimmunology, Department of Neurology, University of Pecs, Pecs, Hungary, 4Institute of Anaesthesia and Intensive Therapy, Faculty of Medicine, University of ... these assays is ng/ml of ficolin-2 and ng/ml of ficolin-3 The inter-assay coefficient of variation (CV) is 7.1% and 4.7% and the intra-assay CV 4.3% and 3.9% for the ficolin-2 and ficolin-3 assay, ... ficolin-3 on the one hand and the severityof ischemic stroke and the infarct size on the other hand, as discussed above It is well known that both the high baseline NIHSS score and the high serum...
... dimers of four different chains IL-4 is the ligand of two receptors: A high-affinity heterodimer of IL-4Rα and the IL-2R common γ-chain and another heterodimeric receptor composed of IL-4Rα and ... position of NF-κB in the induction of iNOS and production of NO is also indicated by experiments showing that antibodies to TNF inhibit activation of NF-κB and production of NO in HSVinfected cells and ... progression and evaluation of final outcome of infection is more unclear, in that many other viral and host factors are of importance in these more complicated models with several stages of infection and...
... Health and Quality of Life Outcomes 2011, 9:17 http://www.hqlo.com/content/9/1/17 quantified and expressed Therefore, characterizing and quantifying the relationship between pain severityand corresponding ... purpose of the current study is to use the pain NRS to characterize and quantify in a clinical and meaningful way the extent of the relationship between pain severity scores and scores on other ... relationship between change in pain severityand mean change in severityof patient-reported sleep disruption Relationship between change in pain severityand change in severityof patient-reported sleep...
... TNF-α, IL-6 and IL-1β [20], whereas VIP inhibits the production of the proinflammatory cytokines TNF-α, IL-6 and IL-12, and stimulates the production of the anti- inflammatory cytokines IL-10 and IL-1Ra ... levels of soluble TNF receptor (which binds to and neutralizes TNF-α) Furthermore, there was an inter-relationship between levels of SP, TNF-α and MCP-1, as well as levels of SP, BN/GRP and IL-6 ... further analysis of the data revealed that in longstanding RA but not in early RA the synovial levels of BN/GRP were tightly correlated with the synovial levels of both IL-6 and TNF-α, as well...
... chemoradiotherapy One course of treatment consisted of protracted venous infusions of 5-fluorouracil (400 mg/m2/day for days 1-5 and 8-12) and cisplatin (40 mg/m2/day on days and 8), and radiation ... 5-FU exerts its anticancer effects through inhibition of thymidylate synthase and incorporation of its metabolites into RNA and DNA, and has been used widely for the treatment of solid tumors ... dose-modification of these regimens, incorporation of a novel anticancer drug, pharmacokinetically guided administration of 5-FU or CDDP, and identification of responders via patient genetic profiling...
... coefficient of variation was below 10% for concentrations between 5.6 and 180 pmol l-1 The inter-assay coefficient of variation, calculated from the precision profiles of five standard curves, ... gathered and analyzed the data, and drafted the manuscript CPB contributed in carrying out the experiment and with contents of the manuscript MAA as the director of the doctoral project of MVC ... Veterinaria Scandinavica 2010, 52:13 http://www.actavetscand.com/content/52/1/13 with the analysis of the data and revising critically the contents of the manuscript All authors have read and approved...
... encourage hemostatic disturbances andorgan dysfunction [23] Low F XIII activity in sepsis is associated with the severityof illness andorgan damage [19] In the treatment of sepsis, F XIII may have ... leukocytes was defined as the count of white cells moving at a velocity of less than twofifths of that of erythrocytes in the centerline of the microvessels [27] and is quoted as non-adherent leukocytes ... effect of F XIII on permeability in guinea pig endothelial cells, enhanced by intradermal injection of anti- endothelial cell antiserum administered into the dorsal skin Antiserum or a mixture of antiserum...
... Funds of these sources were used for assay material and salaries of technical personnel involved in laboratory work and for shipping and handling of data and specimens and presentation of data ... analyzing and writing of the report DS, RB, CM, SH and MT had substantial contributions in planning of the study, data collection, interpretation of data and/ or writing of the manuscript JS and AB ... and depends on many variables, including estimates of the severityof illness It often relies on the clinician's judgment; however, the interpretation of clinical signs and symptoms lacks standardization...
... Funds of these sources were used for assay material and salaries of technical personnel involved in laboratory work and for shipping and handling of data and specimens and presentation of data ... analyzing and writing of the report DS, RB, CM, SH and MT had substantial contributions in planning of the study, data collection, interpretation of data and/ or writing of the manuscript JS and AB ... and depends on many variables, including estimates of the severityof illness It often relies on the clinician's judgment; however, the interpretation of clinical signs and symptoms lacks standardization...
... the degree oforgan injury, its use as part of a panel ofseveritymarkers is interesting and could be further tested Conclusion Gas6 plasma concentrations correlate with severity, and especially ... recorded: age, sex, severityof underlying medical condition stratified according to the criteria of McCabe and Jackson, SAPSII, Sepsis-related OrganFailure Assessment (SOFA) score, vital signs, ... coefficients of variation were 6.3% and 7.8%, respectively Page of (page number not for citation purposes) Repeated determinations of sTREM-1 and Gas6 plasma concentrations were performed on days 1, 3, and...