... factors extrinsic and intrinsic to the left ventricle determine these end-diastolic properties Extrinsic factors are mainly pericardial restraint and ventricular interaction Intrinsic factors include ... evaluation and interpretation of intraventricular filling in clinical practice is complicated by the multitude of variables that determine intraventricular flow Not only driving pressure, inertial forces, ... Its clinical value in distinguishing normal from pseudonormal mitral in ow has diminished since the introduction of tissue Doppler recordings of the mitral annulus to assess the status of LV...
... angiography showing a filling defect in the lumen of the left pulmonary artery (LPA) consistent with LPA thrombosis of a thrombus (Figure 3) In addition, large collateral vessels originated from ... vessels originating from the aorta and supplying the left lung were previously described with LPA thrombosis at birth and clinical evidence of PPHN [4,12] No reported cases were found of infants ... lung maturation in utero and might be the main reason for LPA thrombosis and left pulmonary hypoplasia in this baby Review of the embryology of the pulmonary vessels indicates that, in this patient,...
... angiography showing a filling defect in the lumen of the left pulmonary artery (LPA) consistent with LPA thrombosis of a thrombus (Figure 3) In addition, large collateral vessels originated from ... vessels originating from the aorta and supplying the left lung were previously described with LPA thrombosis at birth and clinical evidence of PPHN [4,12] No reported cases were found of infants ... lung maturation in utero and might be the main reason for LPA thrombosis and left pulmonary hypoplasia in this baby Review of the embryology of the pulmonary vessels indicates that, in this patient,...
... the decrease of Ang I One unit (U) of activity was defined as the amount of enzyme producing ng Ang I decrease per The activity not inhibited in the presence of lisinopril, aprotinin and EDTA ... chymostatin administration significantly reduced the smokeinduced increase in chymase activity but had no effect on ACE activity, suggesting that chymostatin was mainly acting through the inhibition of ... Up-regulation of chymase expression in smoke-exposed lungs To determine whether chymase is involved in cigarette smoking-induced pulmonary artery remodeling and PAH, chymase protein and mRNA levels in the...
... shunts in a porcine model Page of 10 external jugular vein which was surgically dissected; a right side arterial line was inserted under direct vision by a small incision in the groin, and in the left ... concerning the percentage change from baseline to 10 minute of the pCO2 of the left atrium variable (p = 0.016) and the percentage change from baseline to 20 minute of the pCO2 of the left atrium ... pressure (MAP) < 2/3 of the beginning], an initial > 1/3 increase of systolic right ventricular pressure (RVP) and a depressed cardiac output (< 2/3 of the baseline) Additionally, right ventricular function...
... such as feeding or crying, but further increases in myocardial oxygen demand lead to infarction of the anterolateral leftventricular free wall, with resultant compromise ofleftventricular ... normalization of heart rate In our patient, the initial cause was not immediately obvious The occurrence of SVT in infancy is well known, but to the best of our knowledge the combination of ALCAPA ... suspicion of probable ALCAPA was raised after his third echocardiographic examination and was confirmed by a CT scan The left coronary artery originated from the leftward-facing sinus of the pulmonary...
... and seeding of emboli [1,2] Intimal sarcoma is a rare tumor, and the incidence of PA intimal sarcoma is almost twice that of sarcomas of aortic origin It mainly occurs in adults within the age ... discharged Figure spindle cells Pathological findings of surgical specimen show abundant Pathological findings of surgical specimen show abundant spindle cells Hematoxylin and eosin stain ×100 Thirteen ... gender variation in the incidence of aortic intimal sarcoma The mean age of patients diagnosed with PA intimal sarcoma is 48 years, while the mean age of patients at diagnosis of aortic intimal sarcoma...
... leading to endothelial damage Our results indicating overexpression of pro-apoptotic proteins, including Thsp-1 and PAI-1, prompted us to investigate the effects of a nonselective inhibitor of ... (Sigma, Saint-Quentin Fallavier, France) Then, ECs in the proximal and distal PA were counted in a blinded fashion by two investigators working independently from each other, and the proportion of ECs ... values (Figure 5B) Effect of pentoxifylline Injecting pentoxifylline immediately before reperfusion resulted in a significant decrease in the proportion of apoptotic ECs in the distal PA, from 46.4...
... interaction is perhaps not surprising given the critical role of the cAMP-protein kinase A signalling pathway in regulating the expression, activity and intracellular localization of PDE4 isoforms ... min, gels were stained in 0.25% Coomassie blue for 1–2 h and destained in fixing/destain solution until bands of activity were clearly visible The presence of MMP activity was confirmed by inhibition ... attenuated the release of gelatinase activity from PASMCs and this may be significant in the light of recent findings indicating that prednisolone selectively inhibits the proliferation of PASMCs from...
... data is often incorrectly interpreted and utilized The current standard of practice is to insert a PAC in cases of hemodynamic uncertainty As there is no data supporting a beneficial effect of the ... potentially harmful intervention when assessing clinical data in a case study provided Subsequent to insertion of a PAC, the range of treatments and the number of harmful interventions were reduced ... small numbers of heterogeneous patient populations, inappropriate use of the PAC, insufficient evaluation of intensivist expertise and nonprotocol-driven therapeutic strategies in response to...
... idea of mixing SVC and IVC blood as the mechanism for development of Δ[Lac] The finding of greater SO2 and [Lac] in IVC and SVC than in pulmonary artery indicates that further dilution of oxygen ... reflecting the high rate of cerebral glucose uptake In adult humans glucose represents the main, if not the sole, substrate of brain energy metabolism, with the brain utilizing approximately 25% of ... markers of myocardial energy metabolism in hemodynamically stable individuals [6] Further work remains to be done to establish the provenance of these gradients in other clinical conditions, including...
... decreased in none of the fluid challenges resulting in increased SV, and in 44% of those in which SV did not increase (P = 0.0003) EDV increased in 28% of fluid challenges resulting in increased ... concomitant increase in central venous pressure; thin solid line, line of identity of fluid challenges strongly suggests that preload acutely increased in the majority of fluid challenges; in those ... increased SV and in 45% of those in which SV did not increase (P, not significant) Discussion The main finding of this study was the lack of association between PPV and volume responsiveness in patients...
... line, all fluid challenges; dashed line, fluid challenges with concomitant increase in central venous pressure; thin solid line, line of identity during an endotoxemia-induced acute increase in ... preceding hemorrhage Solid line, all fluid challenges; dashed line, fluid challenges with concomitant increase in central venous pressure; thin solid line, line of identity Discussion The main finding ... showing all fluid challenges during endotoxemia Solid line, all fluid challenges; dashed line, fluid challenges with concomitant increase in central venous pressure; thin solid line, line of identity...
... decrease in Pao2 with age was minimal (6 mm Hg) Most of the variance of V/Q mismatch was not a result of aging and remained unexplained; the role of an increase in closing volume with aging was ... consistently find an increase in the average distance between airspace walls (mean linear intercept) and a decrease in the surface area of airspace wall per unit of lung volume beginning in the third ... decrease in Pao2, increase in alveolar-arterial difference in partial pressure of oxygen (Pao2 À Pao2), and decrease in carbon monoxide transfer, measurement of V/Q inequality using the multiple inert...
... facilities of doing cultures are prohibitive in most developing countries Sputum smear microscopy remains the main diagnostic tool for PTB that allows initiation of treatment and monitoring of patient ... history and physical examination was done by a study clinician and the findings were recorded on a clinical record form The investigators did not interfere in the treatment of these patients The ... the results of sputum culture were missed and they received inappropriate treatment, leaving them vulnerable to developing severe disease as well as remaining source of TB infection in the community...
... families of proteins: inhibitor of kinase ⁄ alternative reading frame and CDK inhibitor protein ⁄ kinase inhibitor protein The inhibitor of kinase ⁄ alternative reading frame family includes p16INK4a ... cell cycle in the G1 phase by binding to, and inactivating, cyclin–CDK complexes [29,30] The results of our PPARc inhibition of cell proliferation study reveal that activation of PPARc increases ... Lipofectamine and incubated at room temperature for 20 Then, the complex of siRNA and Lipofectamine was added to cells, and culture was maintained for 72 h at 37 °C and 5% CO2 in a humidified incubator...
... [28] Employing a range of selective inhibitors, we investigated the roles of PtdIns 3-kinase, MEK1/ERK, protein kinase C and pertussis toxin-sensitive G-proteins Only partial inhibition of DNA synthesis ... pertussis toxin, which ADP-ribosylates the a subunit of Gi and Go resulting in blockade of G protein activation, inhibited duodenase-induced [3H]thymidine incorporation by 52 ± 2.5%, suggesting involvement ... localization of duodenase in bovine intestine and lung Representative positively stained mast cells are indicated by large arrows Panels (a–e) show localization of duodenase in bovine jejenum In panel...
... and this is one of the production of host enzymes (Adenosine Deaminase) important limiting factors in determining the directly in clinical samples TSA is present not sensitivity of PCR assays for ... those of us who are carried away by certain reports coming from research DNA PROBES publications Batches of 200 samples containing Recent developments in the field of molecular varying numbers of ... model of history, examination and sputum microscopy has proved itself capable of detecting the majority of infectious cases and, in conjuction with adequate case-finding and 109 treatment, remains...
... mycobacteria Mode of infection The disease is transmitted through inhalation of infected sputum droplets or ingestion of infected milk Primary Tuberculosis Occurs in the body when it is infected for ... regional lymph nodes specially in prim infection Blood born spread: •Early in prim infection bacillemia occurs through lymph-hematogenous spread with seeding of bacilli to all parts of the lungs and ... intima , with subsequent discharge of bacilli into the blood stream leading to miliary spread Usually solitary, caseating and liquefying but can later heal by endothelial covering Can occur in...