essential macromolecules of the tumor microenvironment
Báo cáo khoa học: Essential role of the C-terminus in Melanocarpus albomyces laccase for enzyme production, catalytic properties and structure pdf
Ngày tải lên :
16/03/2014, 00:20
... present in the mutant structure (Fig. 5B).
Owing to the lower steric limitations of the side chain
of the Ala than of the Leu, water may occupy the
space. Furthermore, the side chain of His140, ... similarities
between the far-UV CD spectra of the mutants and
that of the wild-type ScMaL do not support any major
conformational changes of the deletion mutant. The
reduced thermostability of the Sc(L559A) ... chloride ion
and probably also the T2 copper, as the B-value of the
T2 copper was rather high. On the basis of the anoma-
lous signal, the estimated occupancy of the T2 copper
was about 0.5. T2...
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Báo cáo y học: "Anticancer Activity of the PR Domain of Tumor Suppressor RIZ1"
Ngày tải lên :
25/10/2012, 11:15
... have not yet been addressed.
The first question is whether the expression level for
RIZ1 varies over the progression of cancer; and the
second question is whether the PR domain alone
possesses ... types of PRDMs have
been identified in humans [15, 18]. Most of them are
located near the N-terminal portion of the proteins
followed by zinc-fingers, and are involved in the reg-
ulation of ... quan-
titatively analyzed the mRNA expression level of
RIZ1 over the disease progression in eight different
types of cancer, and evaluated the anticancer activity
of the PR domain against human...
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Báo cáo y học: "Clinical Strategy for the Management of Solid Pseudopapillary Tumor of the Pancreas: Aggressive or Less"
Ngày tải lên :
25/10/2012, 11:40
... in the uncertainty of the
strategy for its treatment. While further delineati n g
the clinicopathological and radiological features, and
summarizing the surgical therapy strategy of this
tumor, ...
Pseudopapillary Neoplasm of the pancreas (SPN) is
the correct description regarding the terminology.
4,5,6
Despite the increases in recognition of characteristics
of this tumor, which include ... (SPN),
the experience with the management of disseminated
disease is very limited in the literature
6
, therefore,
attention to the therapy strategy of this neoplasm in
the future may allow a...
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Báo cáo y học: " A Novel Variable Number of Tandem Repeat of the Natriuretic Peptide Precursor B gene’s 5’-Flanking Region is Associated with Essential Hypertension among Japanese Females"
Ngày tải lên :
26/10/2012, 10:04
...
possible that the plasma BNP level is not an accurate
reflection of the function of the NPPB gene.
In the present study, the overall distribution of
the VNTR genotype and the allele frequency ... for EH [9].
The aim of the present study was to identify mu-
tations or polymorphisms in the 5’-flanking region of
the NPPB gene and to assess the relationship between
variants of the gene and ... underscores the clinical relevance of
the relationship of age, gender, and BNP. In both
studies that used different assays, the effect of gender
on BNP was substantial and independent of other
factors...
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Essential Elements of Sanitation in the Beverage Industry
Ngày tải lên :
25/10/2013, 21:20
... cannot ignore the special needs of the
beverage industry. The production of most types of beverages involves
Þlters of some type. These must be checked regularly to be sure that the
Þlters, and ... a
mushroom farm — because of the amount of yeast growth on it. The intensity
of the yeast and dirt substrate growing in the duct had, in some places, almost
Þlled the diameter of 12 to 16 in. Keep ... environments. The members of the sanitation crew are truly the
unsung heroes of the food safety system.
WHAT ARE THE CURRENT AND FUTURE
REGULATORY COMPONENTS
OF A SANITATION PROGRAM?
The basic sanitation...
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Tài liệu THE ESSENTIAL HANDBOOK OF INTERNAL AUDITING pptx
Ngày tải lên :
26/02/2014, 04:20
... understanding of the company’s finance
The contribution of NEDs can help to raise the level of discussion and improve the quality of
decision-making on the board, thus increasing the chances of the company ... Stakeholder control of the business.
2 THE ESSENTIAL HANDBOOK OF INTERNAL AUDITING
1.3 How to Navigate around the Book
A brief synopsis of the Handbook should help the reader work through the material.
Chapter ... board. They check that these accounts show a true and fair view of the financial
performance of the company and its assets and liabilities at the end of the accounting year.
The corporate governance...
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Báo cáo khoa học: The essential tyrosine-containing loop conformation and the role of the C-terminal multi-helix region in eukaryotic phenylalanine ammonia-lyases docx
Ngày tải lên :
07/03/2014, 12:20
... study
the behavior of the Tyr110-loop in PAL in more
detail.
Results and discussion
Modeling the active conformation of the
essential Tyr110-loop of parsley PAL
Because of the uncertainty of the ... subtilis [34], respectively. On the basis of the
functional similarity of HAL and PAL, of the same
electrophilic prosthetic group at the active sites, and of
the sequence conservation over a ... the biosynthesis of the photoactive yellow protein
chromophore of these bacteria.
The two recently discovered aminomutases, the phe-
nylalanine 2,3-aminomutase (PAM) involved in taxol
biosynthesis...
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Báo cáo khoa học: Two separate regions essential for nuclear import of the hnRNP D nucleocytoplasmic shuttling sequence ppt
Ngày tải lên :
07/03/2014, 21:20
... 2005 FEBS 3985
of D02 was 4.0 nm and the K
D
of DNS 9.2 nm, that is
double that of D02. This larger K
D
was accounted for
by the twofold larger k
d
of DNS than that of D02 and
their nearly similar ... 3975–3987 ª 2005 FEBS
essential for the nuclear import. Results on mt9
suggested that phosphorylation of the tyrosine residue
is not related to the nuclear import. Then, the role
of these two residues ... Trn-1.
Results
Determination of hnRNP D NLS
The exon 8 of hnRNP D encodes the 21 amino acids
sequence common to all the isoforms D01, D02, D1,
and D2 (Fig. 1A) [23]. To examine whether the exon-8
encoding...
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Báo cáo Y học: Solution structure of the Alzheimer amyloid b-peptide (1–42) in an apolar microenvironment Similarity with a virus fusion domain potx
Ngày tải lên :
08/03/2014, 09:20
... b-turn. The surprising similarity of this structure, as
well as the sequence of the C-terminal moiety, with those
of the fusion domain of influenza hemagglutinin suggests a
direct mechanism of neurotoxicity.
Keywords: ... generally agreed
whether toxicity is generically linked to the occupation of a
large area of the cell surface or there is a direct action upon
the cell membrane. A possible explanation of the peptide
neurotoxicity ... those of
the lipid phase of the membrane, which promotes the
formation of short-range H-bonds inducing helical struc-
tures.
The structural characterization of a monomeric, soluble
form of Ab-(1–42)...
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Báo cáo khoa học: Enzymatic features of the glucose metabolism in tumor cells ppt
Ngày tải lên :
14/03/2014, 23:20
... is
capable of reducing the level of fructose 2,6-P
2
inde-
pendent of the phosphorylation state of iPFK-2.
Reducing the level of fructose 2,6-P
2
and thus the
activity of PFK-1 improves the supply of ... Ca
2+
concentration leads to
detachment of PFK from the cytoskeleton and thus
diminishes the provision of local ATP in the vicinity of
the cytoskeleton [71]. The expression of PFK in tumor
cells can be enhanced ... liver tumor tissue there is no evidence for
a significant tumor- related change of the protein level
of this enzyme [188]. On the other hand, enzymatic
assays showed – with the exception of melanoma...
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Báo cáo khoa học: Biochemical properties of the human guanylate binding protein 5 and a tumor-specific truncated splice variant Mark Wehner and Christian Herrmann doc
Ngày tải lên :
15/03/2014, 10:20
... con-
served in the primary structure of the GTPase domain
of hGBP5, so the formation of GMP must be impaired
in an as yet unknown manner. Sequence alignments of
the large GTP-binding domains of hGBP1, ... for the lack of GMP formation
(see Fig. S2). The similar hydrolytic activities of the
a ⁄ b and C-terminally truncated forms of hGBP5 are in
contrast to that of the analogous deletion mutant of
hGBP1 ... account). The size of the protein complex is only
slightly increased when nucleotide-free or in the
presence of GTP. As with hGBP5ta, the complex is
increased to the size of a tetramer after binding of
GppNHp,...
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Báo cáo khoa học: ATP-binding domain of heat shock protein 70 is essential for its effects on the inhibition of the release of the second mitochondria-derived activator of caspase and apoptosis in C2C12 cells potx
Ngày tải lên :
16/03/2014, 01:20
... release of Smac and apoptosis.
The role of the ATP-binding domain of HSP70
in the prevention of the release of Smac and
apoptosis after exposure to H
2
O
2
To determine which region of HSP70 ... that the ATP-binding domain of HSP70,
rather than the peptide-binding domain, was essential for these observed
HSP functions. Taken together, our results provide evidence supporting the
role of ... domain of HSP70 is essential for the inhibition
of H
2
O
2
-induced activation of caspases-9 and -3 and apoptosis. (A)
The effects of HSP70 and its deletion mutant proteins on the acti-
vation of...
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Báo cáo khoa học: Characterization of recombinant forms of the yeast Gas1 protein and identification of residues essential for glucanosyltransferase activity and folding pot
Ngày tải lên :
16/03/2014, 18:20
... followed by the transfer of the new reducing
end t o t he nonreducing end of an acceptor molecule,
with the formation of another b(1,3)-glycosidic bond [3].
As the anomeric configuration of the linkage ... study on the effects
of reducing conditions on the transport of Gas1p from the
ER to the G olgi, w hich had indirectly revealed the
requirement of at least one disulphide bond for the exit of
Gas1p ... m
M
reduced
laminarioligosaccharide of size G
13
,and
HPAEC analysis from samples taken at the
indicated time-points are shown. The size of
some of the major products is indica ted.
Fig. 7. C74 is essential for maturation of the...
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Báo cáo khoa học: Essential roles of lipoyl domains in the activated function and control of pyruvate dehydrogenase kinases and phosphatase isoform 1 pot
Ngày tải lên :
17/03/2014, 09:20
... form the outside
of the wedges. The wedge pockets have an extended seam
that extends the length of the interface between these
domains with the c-phosphate of bound ATP exposed at
one end. On the ... PDK3 and PDP1 with
L2, the inner lipoyl domain of E2, are shown to engage
extensive regions of the surface of L2 and to require the lipoyl
prosthetic group and, in thecase of the PDKs, to be markedly
modified ... the full set of the prototypical regulatory
responses of mammalian PDKs described above. The E2
component transforms the efficiency of PDK2 catalysis and
intervenes to create or alter all of these...
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Báo cáo khoa học: Targeting mechanism of the retinoblastoma tumor suppressor by a prototypical viral oncoprotein Structural modularity, intrinsic disorder and phosphorylation of human papillomavirus E7 doc
Ngày tải lên :
22/03/2014, 21:20
... and thermodynamic understanding of the mecha-
nisms of action of the Rb protein is far behind that of
p53, the keeper of the genome, mutated in most can-
cers and targeted by the same DNA tumor ... of the
Rb protein is underscored by its mutation in a broad
range of human tumors [4]. The most extensively
studied function of the Rb protein is in the control
of cell cycle progression at the ... evidence for the tumor suppressor role of the
Rb protein came from the mechanism of action of the
human papillomavirus (HPV) E7 major transforming
protein [19]. The interaction between E7 and the Rb
protein...
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