erk mapk pathway activation in cancer
Báo cáo y học: "Genetic polymorphisms in the nucleotide excision repair pathway and lung cancer risk: A meta-analysis"
... binding protein heterodimer in damage recognition, because the complex binds damaged DNA with high affinity [43] and can dramatically increase the repair rate of certain DNA adducts, including ... activated carcinogens can bind to DNA and form DNA adducts that are capable of inducing mutations and initiating carcinogenesis The capacity to repair DNA damage induced by activated carcinogens 61 ... skin tumors at an extremely high frequency (1000 fold increased incidence as compared to normal individuals) because of their inability to repair UV-induced DNA lesions These clinical findings...
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Báo cáo y học: "Eotaxin and FGF enhance signaling through an Extracellular signal-related kinase (ERK)-dependent pathway in the pathogenesis of Eosinophilic Esophagitis" doc
... interferon-inducible protein 10 (IP10); leptin; monocyte chemotactic protein-3 (MCP3); monokine induced by gamma interferon (MIG); macrophage inflammatory protein alpha (MIP-1a); macrophage inflammatory ... pathogenesis of EoE by enhancing activation of eosinophils through synergy with eotaxin via the ERK signaling pathway The data may be used in the possible diagnosis and prognosis of EoE In addition, our ... abnormalities during endoscopy, showing eosinophil infiltration in the esophagus EoE is currently defined as the presence of more than 15 intraepithelial eosinophils per highpowered field (eos/HPF) in both...
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báo cáo khoa học: "CCR9-CCL25 interactions promote cisplatin resistance in breast cancer cell through Akt activation in a PI3K-dependent and FAK-independent fashion" pptx
... tumors originating from the interstitial cells of Cajal, which are pacemaker cells regulating autonomic motor activity in the gastrointestinal tract The majority of the GISTs arise in the stomach ... present with abdominal pain, satiety, obstruction, or GI bleeding However, Figure Pre-operative CT scan showed gastric mass with curvilinear calcification penetrating into surrounding soft tissue ... penetrating into the gastric lumen and pericolic soft tissue Other gastrointestinal tumors may also contain calcification At least three types of calcification have been reported in gastric cancer: ...
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Báo cáo y học: "Signalling pathway involved in nitric oxide synthase type II activation in chondrocytes: synergistic effect of leptin with interleukin-1" pdf
... and protein In this modulation, an intracellular signalling pathway that involves JAK2 tyrosine kinase, PI3K and two members or the MAPK pathway (ERK and p38) is at play The functional interplay ... the specific signalling pathways inhibitors LY294002, PD098059 and SB203580 on leptin/IL-1 costimulation In order to define the signalling pathway involved in the synergistic induction of NOS type ... is in agreement with recent evidence indicating that PI3K/protein kinase B is involved in NF-κB activation [34,35] In addition, PI3K homologues (mammalian target of rapamycin/FKBP12– rapamycin...
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Signaling pathway inhibitor library screening reveals b catenin TCF4 as a novel telomerase regulator in cancer cell lines
... Chromatin immunoprecipitation (ChIP) assays Results Inhibitors screening Verification of screening platform using STAT III and IV inhibitors Wnt pathway inhibitor library screening EGFR pathway inhibitors ... regulation in cancer cell lines 3.3.5.2 β-catenin/TCF4 regulate hTERT promoter in cancer cell lines 3.3.5.3 Characterization of the distal TCF4 binding site (TBE) in the human hTERT promoter 3.3.5.4 In ... accessible to 53BP1 in intact chromatin Therefore inferring form the finding, shelterin is believed to play a role in maintenance of T-loop nucleosomal organization by concealing chromosome end...
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The regulatory role of mixed lineage kinase 4 beta in MAPK signaling and ovarian cancer cell invasion
... ras MAPK Mitogen activated protein kinase MAPKAP-K .MAPK- activated protein kinase MAP2K MAPK kinase MAP3K MAPK kinase kinase MEK MAPK /ERK kinase MEKK MEK kinase Met .Methionine ... BSA Bovine serum albumin CBD Collagen binding domain CR Conserved region CRIB Cdc42/Rac interactive binding protein DTT Dithiothreitol DLK Dual leucine zipper-bearing kinase DNA ... signal peptide domain (SPD), the propeptide domain (Pro), the catalytic domain containing the Zn2+-binding region and the collagen-binding domain (CBD), a hemopexin-like C-terminus connected to...
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Báo cáo y học: "Gain of a 500-fold sensitivity on an intravital MR Contrast Agent based on an endohedral Gadolinium-Cluster-Fullerene-Conjugate: A new chance in cancer diagnostics"
... outw ward-facing o orbital ellipso oid 144 increas in size, w ses while the inw ward facing decreases This re esults in a co oupling of th electron sp he pins with the nuclear spin of the rare ... N-1.3.-diamino propane linker substituted glycine with the GdxSc3-xN@C80 The product 11 acts as the dienophile reaction partner with diene tetrazine-NLS-S∩S-CPP conjugate 13 in the final DARinv as pointed ... acetonitrile in water (B) as eluent The conjugate was eluted with a successive linear gradient, increasing from 25% to 60% B-eluent in 49 at a flow rate of 10 ml/min The fractions corresponding to...
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Báo cáo y học: "yrosine kinase – Role and significance in Cancer"
... ATP binding site serves as a docking site for specific binding of cytoplasmic signaling proteins containing Src homology-2 (SH2) and protein tyrosine binding (PTB) domains These proteins in turn ... tyrosine kinase inhibitors Inhibiting the activity of tyrosine kinases by low molecular weight compounds capable of interfering with either ligand binding (in the case of receptor tyrosine kinases) ... the minor difference in the kinase domain The minor difference leads to changes in hydrogen bonding and hydrophobic interactions resulting in differences of affinity [38] Of all the tyrosine kinase...
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Tài liệu Area Socioeconomic Variations in Cancer Incidence and Stage at Diagnosis in New Jersey, 1996-2002 pdf
... http://nj.gov/health/ces/reports.shtml, including: • Cancer Incidence and Mortality in New Jersey 2000-2004; • Cancer Incidence Rates in New Jersey’s Ten Most Populated Municipalities 1998-2002; • Trends in Cancer Incidence ... pharynx) cancer, ovarian cancer, pancreas cancer, prostate cancer, stomach cancer, thyroid cancer, and urinary bladder cancer To compare incidence rates in the poverty area groups, incidence rate ratios ... of smoking reported among persons living in poverty in the U.S.13 may be one of the main reasons for the increased incidence of oral cancer in the areas with high poverty See Tables 2-9 in Appendix...
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Tài liệu Biomarkers in Cancer: An Introductory Guide for Advocates pdf
... of invasive tumor cells show uniform, intense membrane staining IHC (Herceptest®) Scoring Breast Cancer Cell Staining pattern Score Interpretation No staining Negative Faint incomplete staining ... an initial step that is followed by validation in cancer cells and eventually cancer patients Increasing the Number of Biomarkers in Clinical Use In Chapter 1, we described the expanding interest ... my cancer responding to this treatment? Will my cancer come back? After Cancer Diagnosis Post Treatment Uses of Biomarkers in Cancer Drug Discovery In addition to their uses in cancer medicine,...
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Tài liệu StrategieS for SucceSS: How to Write a Grant in Cancer CAM docx
... Research Multidisciplinary Approaches in Cancer Treatment Investigators are often interested in investigating multidisciplinary approaches in cancer care The advantages of studying the entire approach ... consolidating and focusing cancer- related activities, increasing research productivity, promoting shared use of research resources and improved quality control, stimulating and promoting interdisciplinary ... newly trained basic or clinical investigators to develop their independent research skills through a two-phase program – an initial period involving an 31 intramural appointment at NIH and a final...
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Tài liệu Psychotherapy and Survival in Cancer: The Conflict Between Hope and Evidence pptx
... combining intervention groups may have been to increase power, this post hoc combining of heterogeneous groups likely resulted in increased within-subject error, decreasing the likelihood of finding ... reported In medicine, recognition that many randomized clinical trials were not being reported in a manner that allowed independent evaluation led to calls for reform, culminating in the original ... care Cointervention confound The authors distinguish their trial from studies examining psychosocial interventions, stating, “this is the first [trial] to examine the impact of nursing interventions...
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Tài liệu Nanotechnology in Cancer Treatment and Detection doc
... smaller than most human cells Cancer Nanotechnology research is interdisciplinary and incorporates Biology, Chemistry, Engineering, Medicine, and Physics Properties of Cancer Cells • Epidermal Growth ... trials reveal that a single intravenous nanoparticle injection eradicated 100 percent of tumors in mice when exposed to near-infrared light Most work is being done with near-infrared light, which ... at absorbing light near the infrared than solid gold nanoparticles Nanoparticles can be tuned to be excited only by certain ranges of light Uses in Treatment In another study, pre-clinical trials...
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Tài liệu Báo cáo khoa học: Collagen I regulates matrix metalloproteinase-2 activation in osteosarcoma cells independent of S100A4 pdf
... as inactive proenzymes and latency is maintained by an interaction between a cystein residue in the prodomain and Zn2+ in the active site of the catalytic domain Two major types of endogenous inhibitors ... regarding the role of the aVb3 integrin, because it is also reported to suppress collagen I-induced activation of proMMP-2 [8] Another MMP inhibitor, reversion-inducing cysteinerich protein with ... inhibitors in several cell lines [10] The protein itself has no known enzymatic activity, but binds to distinct intracellular target proteins and regulates specific functions involved in tumour...
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Tài liệu Báo cáo khóa học: Suppression of b1,3galactosyltransferase b3Gal-T5 in cancer cells reduces sialyl-Lewis a and enhances poly N-acetyllactosamines and sialyl-Lewis x on O-glycans Lydia Mare and Marco Trinchera pdf
... according to published procedures [9,16,22], with some modifications Total lysates were obtained by boiling 10 in phosphate-buffered saline containing 0.5% SDS and 1.0% 2-mercaptoethanol, and spinning ... cultured in Dulbecco’s modified Eagle’s medium containing 10% foetal bovine serum, 100 UÆmL)1 penicillin, 1.0 mgÆmL)1 streptomycin and mM L-Glu For treating BxPC3 cells and clones with drugs affecting ... plated in 12-well plates, incubated for 30 h with regular medium that was replaced with medium containing 1.0 lgÆmL)1 swainsonine (Sigma) or mM benzyl-a-GalNAc (Sigma) After growing for 60 h in the...
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Tài liệu Báo cáo khoa học: Enhanced expression of Mcm proteins in cancer cells derived from uterine cervix docx
... examined in five cases of human uterine cervical cancer by immunohistochemical techniques, and the results were compared with the findings obtained by hematoxylin and eosin staining We examined ... In both cells, clear nuclear staining was observed with anti-Mcm4 Ig Although the staining intensity was relatively constant within BrdU-positive and -negative HeLa cells, more intense staining ... diluted in NaCl/Pi containing 2% normal swine serum (DAKO) The slides were washed in NaCl/Pi, and the subsequent immunostaining was performed by the labeled streptavidin biotin-peroxidase method using...
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Tài liệu Báo cáo Y học: Inhibition of the MEK/ERK signaling pathway by the novel antimetastatic agent NAMI-A down regulates c-myc gene expression and endothelial cell proliferation ppt
... role of protein kinases A and C pathways in the regulation of mitogen-activated protein kinase activation in response to gonadotropin-releasing hormone receptor activation Endocrinology 5, 2241–2251 ... concentration in down regulating ERK1 /2 activity (Fig 4B,C) NAMI-A-induced ERK1 /2 inhibition down regulates c-myc gene expression To investigate whether NAMI-A-induced inhibition of ERK1 /2 signaling could ... Stefanelli, C (2001) Signaling pathways leading to the induction of ornithine decarboxylase: opposite effects of p44/42 mitogen-activated protein kinase (MAPK) and p38 MAPK inhibitors Biochem Pharmacol...
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The Use of Mushroom Glucans and Proteoglycans in Cancer Treatment potx
... Trials in Stomach Cancer PSK and Stomach Cancer Stomach cancer continues to inflict major mortality in Japan and has been the object of more clinical trials with PSK than any other cancer Beginning ... predict anticancer efficacy in humans Maitake D-Fraction has been used in a few exploratory studies in cancer patients.17 In 1994, a group from China published in abstract form their findings from ... 1-6 main chains and 1-4 branchings, and the more common 1-3 main chains and 1-6 branchings.18 This fraction also is highly active in vitro and in animal models of cancer, although activity in these...
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Báo cáo khoa học: The dipeptidyl peptidase IV family in cancer and cell biology pot
... chemokines in vitro (Table 2) DPIV in cell biology A number of DPIV-binding proteins have been identified, including adenosine deaminase [78,79], CD45 (protein tyrosine phosphatase) [80], caveolin-1 ... ability to inactivate the incretin hormones glucagon-like peptide-1 and glucose insulinotropic peptide In the treatment of type diabetes, DPIV inhibitors extend incretin action, resulting in improved ... DP9-overexpressing cells of the ECM-interacting molecules discoidin domain receptor 1, a kinase activated by collagen binding, and the MMP inhibitor, tissue inhibitor of matrix metalloproteinase-2,...
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Báo cáo khoa học: Small-molecule modulators of zymogen activation in the fibrinolytic and coagulation systems pptx
... Lys-plasminogen is highly sensitive to activation even in the absence of fibrin or cells PAN–K5 binding is mediated via the aminohexyl (AH) site in K5 [28,29] (Fig 3) Unlike lysine-binding sites in ... plasminogen, the AH site can bind an internal lysine residue in addition to the C-terminal lysine [30], which is a preferred ligand for the lysine-binding site in K1, K2 and K4 Thus, aminohexyl ... efficient binding sites for plasminogen The high-affinity lysine-binding sites in K1 and K4 may be involved in this propagation process Thus, plasminogen binding is essential for the fibrinolytic process...
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