epstein barr viral load testing role in the prevention diagnosis and management of posttransplant lymphoproliferative disorders

Báo cáo khoa học: Kinetic studies and molecular modelling attribute a crucial role in the speciﬁcity and stereoselectivity of penicillin acylase to the pair ArgA145-ArgB263 pdf

Ngày tải lên : 16/03/2014, 16:20

... ArgA145 and ArgB263, on the negatively charged COO– in the aminic part determines the position of the substrate within the S1¢-binding subsite O atoms of the main chain CO groups of LeuB387 and TrpB240, ... atoms of the side chain d-guanidino group of this residue are involved in H-bonding as follows: Ne with the O atom of the main chain CO group of the TrpB240; Ng1 shares H bonding with O atom of the ... subsite Substrate binding induces conformational changes involving the ArgA145PheA146 fragment of the protein chain, acting as a ﬂap, ﬁrst opening and then closing the groove [45] The catalytic reaction...

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The NINCH Guide to Good Practice in the Digital Representation and Management of Cultural Heritage Materials pptx

Ngày tải lên : 08/03/2014, 14:20

... This involves only keeping one copy of master files and offering thumbnails and access online The cost of this basic maintenance is in the region of 14-38% of the initial imaging cost • The second ... pressure But an investment in this kind of planning will be amply repaid over the life of the project: in the quality of the products, in smooth workflow, in staff morale, and not least in the total ... through the material, or juxtapositions of the works according to themes or particular interests; • by bringing the collections to new audiences and allowing new ways of exploring and enjoying them;...

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Recent Advances in the Biology, Therapy and Management of Melanoma Edited by Lester M. Davids ppt

Ngày tải lên : 23/03/2014, 14:20

... Advances in the Biology, Therapy and Management of Melanoma factor containing multiple enzymes including XPA, XPB and XPD then unwind the DNA in the vicinity of the damaged bases, and then two ... brings both of these together in an easy, readable way The fact that there is so much ongoing scientific and clini‐ cal research in the field of melanoma is an indicator of the importance and ... regions of the genome by involvement of the Cockayne syndrome proteins A and B As a result of the inability of the skin to recover after UV exposure, intense sun sensitivity is one of the first...

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TOPICS IN THE PREVENTION, TREATMENT AND COMPLICATIONS OF TYPE 2 DIABETES pptx

Ngày tải lên : 27/06/2014, 18:20

... characterized by insulin resistance, hyperinsulinemia and impaired insulin signaling Insulin resistance is the common link of the components of the much invoked metabolic syndrome (a cluster of high adiposity, ... which are intermediates in the AGE pathway and the predominant source of endogenous AGEs AGEs may exist as protein cross-links or as modification of the side chains of a single protein, and significantly ... imidazolium cross-link (GODIC), dimers of arginine and lysine residues Examples of AGEs resulting from the single protein modification are pyrraline and Nε -(carboxymethyl)lysine (CML), the lysine-residue...

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Tài liệu Báo cáo khoa học: Interaction between very-KIND Ras guanine exchange factor and microtubule-associated protein 2, and its role in dendrite growth – structure and function of the second kinase noncatalytic C-lobe domain docx

Ngày tải lên : 14/02/2014, 19:20

... in the KIND2 domain of v-KIND contain the core MAP2 binding module To identify the core MAP2-binding site within the KIND2 domain (amino acids 456–620), we analyzed ﬁve EGFP-fused KIND2 domain ... in the central domain of MAP2 contain the v-KIND binding core module MAP2 consists of three main structural domains: the cAMP-dependent protein kinase regulatory subunit RII binding domain, the ... 1B) The results obtained indicate that the KIND2 domain is necessary and sufﬁcient for the targeting of v-KIND to dendrites of neurons To investigate the MAP2-binding characteristics of the KIND...

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Báo cáo khoa học: "Examining the Role of Linguistic Knowledge Sources in the Automatic Identification and Classification of Reviews" doc

Ngày tải lên : 17/03/2014, 04:20

... (particularly the short ones) have all zeroes in them In other words, none of the bigrams from the training set appears in these reviews This suggests that the main problem with the bigram model ... and E Hovy 2004 Determining the sentiment of opinions In Proc of COLING, pages 1367–1373 M Koppel and J Schler 2005 Using neutral examples for learning polarity In Proc of IJCAI (poster) D Lin ... relation is capturing two different situations, one in which the author himself likes the movie, and in the other, the author’s cousin likes the movie The overgeneralization resulting from these “stemmed”...

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Báo cáo hóa học: " Targeting the inflammation in HCV-associated hepatocellular carcinoma: a role in the prevention and treatment" pptx

Ngày tải lên : 18/06/2014, 16:20

... (TIRdomain-containing adapter-inducing interferon-b) joining the RIG-I/MDA5 pathway In the other pathway, TLR7 senses single-strand HCV RNA and via the MyD88 adaptor protein activates IRAK4/IRAK1 These kinases stimulate ... 0.0001) and had a better 5-year survival experience [10] The action of some viral proteins (mainly the HCV core protein and the HBV X protein) [11] or insertional mutagenesis in the case of HBV ... synergistically inhibited the growth of HepG2 cells without affecting the growth of normal human hepatocytes and increased the expression of RARb and p21(CIP1), while inhibiting the phosphorylation of RXRa...

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Báo cáo khoa học: "Does the surgeon still have a role to play in the diagnosis and management of lymphomas?" docx

Ngày tải lên : 09/08/2014, 07:21

... baseline against which the effects of chemotherapy may be judged The aim of this study was to examine whether the 21st century surgeon still has a role to play in the diagnosis and management of ... University in the late 1960s which showed that the performance of a staging laparotomy altered the stage of disease in 42% of cases, up regulating in 28% and down regulating in 14% of cases [2] The ... perihepatic and perisplenic in addition to retroperioneal lymphadenopathy Thus upper gastrointestinal surgeons with training in these techniques may have an increasing role in the diagnosis of lymphomas...

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Báo cáo y học: "Clinical review: The role of biomarkers in the diagnosis and management of communityacquired pneumonia" potx

Ngày tải lên : 13/08/2014, 19:20

... copeptin increased with increasing severity of the PSI and was an independent predictor of outcome, in contrast to other clinical symptoms and ﬁndings [49] In a study of 302 patients admitted to the ... standard of care in the next few years Indicators of prognosis CAP is the leading cause of death from infection in western countries [43] Ideally, the management strategy and nature of the intervention ... of these assays are likely to assume an increasingly important role in clinical management of CAP in the future Search strategy A Medline and PubMed search of relevant medical literature in the...

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Spanishness in the Spanish Novel and Cinema of the 20th – 21st Century docx

Ngày tải lên : 07/03/2014, 15:20

... making their way to the southern shore of Spain during the 1990s On the other hand, the stories told about these people also depend on the social and political context of the present for their ... compelling challenges to the cinema of the action-image and the “sensory-motor schema”, according to Deleuze, occur mainly in four waves: in the cinema of Yasushiro Ozu, in the emergence of Italian ... that in the second half of the 1960s, during the comparatively liberal interlude which started in 1966—with the promulgation of the new “Ley de Prensa” and finished in 1971 the year in which the...

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Báo cáo khoa học: Essential roles of lipoyl domains in the activated function and control of pyruvate dehydrogenase kinases and phosphatase isoform 1 pot

Ngày tải lên : 17/03/2014, 09:20

... acetyl-transferase-catalyzing inner domain E3BP domains: L3, N-terminal lipoyl domain; B, E3 binding domain; I, inner domain which associates with the inner domain of E2 Dotted connections indicate binding interactions ... E2 and E3 are included in Fig Apart from E2, the three domain E3-binding protein (E3BP, Fig 1) also has an anchoring C-terminal domain, an E3-binding domain and a mobile lipoyl domain Again, the ... running in opposite directions The monomer association involves the ATP-using C-terminal domains interacting near the base of that side of the wedge outside; the N-terminal domains form the outside...

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Guidelines for the Diagnosis and Management of Food Allergy in the United States docx

Ngày tải lên : 31/03/2014, 13:20

... disease of the skin Symptoms include scaly, itchy rashes and blistering, weeping, or peeling of the skin The causes of the disease are unclear There may be a problem in the skin’s ability to maintain ... How were the Guidelines developed? The Guidelines are the culmination of a 2-year effort in which the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of ... reactions indicate the presence of sIgE antibodies, but there must be other clinical signs to support the diagnosis NIAID I GUIDELINES FOR ThE DIAGNOSIS AND MANAGEMENT OF FOOD ALLERGY IN ThE UNITED...

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ADVANCES IN THE ETIOLOGY, PATHOGENESIS AND PATHOLOGY OF VASCULITIS potx

Ngày tải lên : 27/06/2014, 19:20

... vaccination and tuberculin skin tests in Takayasus arteritis Mantoux screening test is the main tuberculin reaction used in the world It consists of an intradermal injection of a standard dose of ... perspective, the activation of interleukin-8 by M pneumoniae is one of the key steps in inducing the vasculitic disorders which are the main subject of this chapter As regards the presence of pneumonia in ... presentation, Integrin signaling, Protein Ubiquitination and Nicotinate and Nicotinamide Metabolism pathways Finally, IPA allowed us to demonstrate the existence of network of genes involved in the pathway...

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Báo cáo y học: "Analysis of immunoglobulin light chain rearrangements in the salivary gland and blood of a patient with Sjögren’s syndrome" pptx

Ngày tải lên : 09/08/2014, 03:24

... parotid gland and the peripheral blood of the patient, there was no significant difference in the R/S ratios Comparison of the R/S ratio in the peripheral blood of the patient and of normal donors ... assumption that plasma and memory B cells accumulate in the parotid gland but cannot clarify the origin of these cells Whatever the primary aberration in the induction of the salivary inflammation, one ... characterize the pattern of somatic hypermutation of the VL gene rearrangements of B cells from the patient’s peripheral blood and the parotid gland in more detail, the contribution of mutations within the...

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Curcumin modulates dopaminergic receptor, CREB and phospholipase c gene expression in the cerebral cortex and cerebellum of streptozotocin induced diabetic rats potx

Ngày tải lên : 10/08/2014, 05:21

... guidelines All efforts were made to minimize the number of animals used and their suffering Diabetes was induced in rats by single intra femoral vein injection of STZ freshly dissolved in 0.1 ... consisted of 6-8 animals The insulin-treated diabetic group received subcutaneous injections (1 Unit/kg body weight) of Lente and Plain insulin (Boots India) daily during the entire period of the experiment ... receptor binding parameters were determined using Scatchard analysis [32] The specific binding was deter- Page of 11 mined by subtracting non-specific binding from the total The binding parameters,...

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Báo cáo y học: " An integrated approach to diagnosis and management of severe haemoptysis in patients admitted to the intensive care unit: a case series from a referral centre" ppsx

Ngày tải lên : 12/08/2014, 15:20

... and CT scan findings when performed, severity of haemoptysis, and pre-ICU and in- ICU management The persistence or recurrence of bleeding, the patients' ICU and hospital lengths of stay and their ... describe the characteristics of the patients managed using one of the three main initial therapeutic options (conservative measures, BAE or surgery) and to help better define the role of BAE, according ... discharge, when the procedure was completed Using a strategy including a routine assessment of the amount of bleeding with a standardized scale, and promoting BAE over surgery, the outcomes of patients...

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BS 5588 4 1998 fire precautions in the design, construction and use of buildings

Ngày tải lên : 28/09/2014, 23:27

... around the side walls and over the roof, creating an eddy on the leeward side of the building and a consequent reduction in pressure, i.e suction in these areas The greater the speed of the wind, the ... that, in the event of fire anywhere in the building, the circuits continue to operate and the cables maintain circuit integrity Wiring systems should either: a) consist of one of the following: ... immediate assessment of the situation, including the integrity and operation of the pressure differential system protecting the firefighting access and the means of escape from the building To assist...

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BS 5588 4 1998 fire precautions in the design, construction and use of buildings MVAC

Ngày tải lên : 28/09/2014, 23:27

... around the side walls and over the roof, creating an eddy on the leeward side of the building and a consequent reduction in pressure, i.e suction in these areas The greater the speed of the wind, the ... that, in the event of fire anywhere in the building, the circuits continue to operate and the cables maintain circuit integrity Wiring systems should either: a) consist of one of the following: ... immediate assessment of the situation, including the integrity and operation of the pressure differential system protecting the firefighting access and the means of escape from the building To assist...

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Opportunities to improve the sustainable utilisation and management of water and soil resources for coastal agriculture in Vietnam and Australia

Ngày tải lên : 08/08/2015, 19:23

... Quang Nam province Binh Dinh province: The La Tinh river basin originates in Quang Ngai and central Binh Dinh and discharges into the sea near Hoai Huong in the north of Binh Dinh The Con (also ... Delta, the Dong Nai basin and the SCC VN provinces of Binh Thuan and Ninh Thuan The national level IWRP employs around 300 personnel Of these 234 hold engineering degrees The capabilities of IWRP include ... basin lies to the north of the province and originates near the border with Phu Yen province The Cai Nha Trang river basin is the major river basin of Khanh Hoa It originates from an elevation of...

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Guideline for the diagnosis and management of hypertension in adults

Ngày tải lên : 15/11/2016, 12:08

... Guideline for the diagnosis and management of hypertension in adults 2016 Guideline for the diagnosis and management of hypertension in adults 2016 National Heart Foundation of Australia Introduction ... monitoring Out -of- clinic measures, in particular ABPM, are now of considerable scientiic interest and there is a large body of evidence supporting the beneits of using them to conirm diagnosis of ... for the diagnosis and management of hypertension in adults 2016 National Heart Foundation of Australia Initiating treatment with combination therapy Combination therapy, deined by the use of at...

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