epsilon neurofibromin and the ras mapk pathway in neuroblastoma differentiation
Báo cáo khoa học: Insulin induces heme oxygenase-1 through the phosphatidylinositol 3-kinase/Akt pathway and the Nrf2 transcription factor in renal cells pptx
Ngày tải lên :
07/03/2014, 12:20
... growth and differentiation On ligand binding, the insulin receptor tyrosine kinase initiates multiple signaling cascades, including activation of the phosphatidylinositol 3-kinase (PI3K) pathway and ... administered to establish the role of protein synthesis in insulin-induced HO-1 expression (Fig 2B,C) CHX abrogated HO-1 protein induction following insulin treatment but, in agreement with other ... silencing The fold-increase in both HO-1 protein and mRNA in response to insulin was consistent, as well as being time and concentration dependent The role of the PI3K ⁄ Akt pathway in the regulation...
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Báo cáo lâm nghiệp: " Assessment of the contributions of glycolysis and the pentose phosphate pathway to glucose respiration in ectomycorrhizas and non-mycorrhizal roots of spruce (Picea abies L. Karsten)" docx
Ngày tải lên :
09/08/2014, 04:20
... Assuming that the same chitin/protein ratio in the mycelial cords of Hebeloma sp and the fungal component of the ectomycorrhizas, then approximately 50% of the protein in the ectomycorrhizas ... ml-min- was maintained and 14 was collected for 90 CO Effluent air was passed directly into a C0 -trap2 ping scintillation fluid containing an organic amine (Carbomax, Kontron) in 10 ml vials and ... streptomycin and 0.008% (w/v) aureomycin Soluble compounds were then extracted according to A[-Abras et aL (1988) and radioactivity determined by counting 100 ul aliquots Chitin was determined by...
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Báo cáo khoa học:" A role for the JAK-STAT1 pathway in blocking replication of HSV-1 in dendritic cells and macrophages" docx
Ngày tải lên :
12/08/2014, 04:21
... of the STAT1 gene in mice revealed a role for STAT1 in the JAK-STAT signaling pathway [40] The JAK-STAT signaling pathway is involved in mediating biologic responses induced by many cytokines ... here for the first time that STAT1 (likely via the JAK-STAT1 pathway) is involved in suppressing HSV-1 replication in murine DCs and macrophages In addition, the lack of virus replication in wild-type ... infected with HSV-1 McKrae The kinetics of virus replication were quantitated by determining the amount of infectious virus at various times post infection using a plaque assay as described in...
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Báo cáo khoa học: " A role for the JAK-STAT1 pathway in blocking replication of HSV-1 in dendritic cells and macrophages" pps
Ngày tải lên :
12/08/2014, 04:21
... of the STAT1 gene in mice revealed a role for STAT1 in the JAK-STAT signaling pathway [40] The JAK-STAT signaling pathway is involved in mediating biologic responses induced by many cytokines ... here for the first time that STAT1 (likely via the JAK-STAT1 pathway) is involved in suppressing HSV-1 replication in murine DCs and macrophages In addition, the lack of virus replication in wild-type ... infected with HSV-1 McKrae The kinetics of virus replication were quantitated by determining the amount of infectious virus at various times post infection using a plaque assay as described in...
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Circuit theory of finance and the role of incentives in financial sector reform
Ngày tải lên :
24/10/2012, 09:33
... declining The internalization of information within the same institution may thus enhance intra-circuit and inter-circuit stability by reducing the incentive to overfinancing The demand and supply ... capital of others, and that sound financial infrastructures that strengthen 21 trust and prudence increase the return to all participants Thus, producing and maintaining financial infrastructures ... placing money with investment financial institutions in the capital market, and hold the remaining share in noninterest bearing, short-term bank deposits (eq 7) The share of savings going to the...
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The ubiquitin-proteasome pathway in cell cycle control
Ngày tải lên :
25/10/2013, 21:20
... contain an F-box motif near their amino termini and one of several protein-protein interaction motifs carboxy ter- The ubiquitin-proteasome pathway in cell cycle control 157 minal to the F-box In ... C-terminal carboxylate of ubiquitin and a lysine epsilon amino group is carried out through a collaboration between ubiquitin conjugating enzymes (E2) and protein-ubiquitin ligases (E3) The processive ... ubiquitin addition, the predominant linkage for protein turnover is through lysine 48 (Chen and Pickart 1990) Once chains of significant length have been produced, the Fig The ubiquitin proteasome pathway...
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Tài liệu Security Essentials Day 2 Threat and the Need for Defense in Depth docx
Ngày tải lên :
09/12/2013, 17:15
... We can think of these as the “primary colors” of information assurance By mixing and matching these and we mix and match, because they are interrelated we are able to develop either a very ... it’s just “finger” on steroids The attacker “logs in to the Windows NT or Windows 2000 system using the “net use” command listed on your slide After logging in, it is possible to gather a great ... is trusted Instead of questioning why they were getting a certain email or even blocking the attachments, most users opened the attachment and infected their system - 23 Code Red II • Integrity...
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Tài liệu COMMUNICATION FROM THE COMMISSION TO THE COUNCIL AND THE EUROPEAN PARLIAMENT Innovation in a knowledge-driven economy ppt
Ngày tải lên :
16/01/2014, 16:33
... objectives, and by taking innovation into account in the Community-level rules for doing business, in particular the rules for competition, intellectual property rights, and the internal market In spite ... start-ups and for starting up and developing innovative businesses in general Such firms invigorate the economy by being the “first movers” who introduce new ideas, and from their number will emerge the ... expanding businesses of the future But the obstacles to their creation and growth continue to be more severe in Europe than in Europe’s competitors Objective 4: Improving key interfaces in the innovation...
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Slide an investigation into some approaches to vocabulary teaching and learning and the application of games in teaching and learning vocabulary at pre – intermediate level at foreign language center – haiphong university
Ngày tải lên :
29/01/2014, 14:36
... progress and expectation 1.What you think of the games your teachers used in your vocabulary lesson? a b c d Very interesting and useful Rather interesting and useful Interesting and useful Uninteresting ... with one another Games can motivate learners by bringing fun to classes Games are highly motivating because they are amusing and interesting (Ersoz, 2000) By bringing fun to the language ... 1.2.3 The status of vocabulary in current language teaching and learning 1.3 Approaches to language teaching and their relevance to vocabulary 1.4 Recent research about teaching and learning second...
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Tài liệu Egypt''''s Water Warriors : Water Pollution in Egypt and the Role of NGOs in Reaching Integrated Management ppt
Ngày tải lên :
18/02/2014, 04:20
... microbiological properties of groundwater in Saint Katherine, South Sinai, Egypt and exploring the diversity, occurrence and distribution of fungal taxa in groundwater in South Sainai, samples of groundwater ... of a few Media reported the progress in increasing interest.[19],[20].to investigate the amount and seriousness of pollution caused by factories dumping their waste in the Egyptian waters as a ... get the school student involved in protection of the Egyptian environment in general and Egypt's waters in particular On the 3rd of June 2010, among other NGOs, we went out on the protest against...
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Tài liệu Báo cáo khoa học: Activation loop 3 and the 170 loop interact in the active conformation of coagulation factor VIIa pdf
Ngày tải lên :
18/02/2014, 08:20
... located in the vicinity of the active site and sensed by the peptidyl substrate are inuenced, in contrast to the remote exosites, e.g in the vicinity of the activation pocket, that affect FX binding, ... conned to the substrate binding cleft (the 170 loop) in the active site region and the S1 pocket, whereas the intramolecular connections, for instance between the TF-binding region and the active ... as interesting as those involved in the TF-induced allostery Amino acid residues in FVIIa that are involved in the conformational balance that governs the equilibrium between zymogen-like and...
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Tài liệu THE VICTORIAN TAXPAYER AND THE LAW A Study in Constitutional Confl ict doc
Ngày tải lên :
18/02/2014, 11:20
... the land tax and then the income tax, constituted a heavy burden on the wealthier classes at the dawn of the nineteenth century.47 The income tax had been in suspension since 1816 and its reintroduction ... the rights of the individual by ensuring the true meaning of the legislation was adhered to, and by having disputes determined by expert and trained individuals of high calibre Furthermore, the ... Commissioners and complaints by the government official, the surveyor Addington abolished them in 1803 and transferred their powers to the General Commissioners, making them both the supreme assessing...
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Tài liệu Báo cáo khoa học: Characterization of human deoxyribonuclease I gene (DNASE1) promoters reveals the utilization of two transcription-starting exons and the involvement of Sp1 in its transcriptional regulation ppt
Ngày tải lên :
19/02/2014, 06:20
... bp in fragments B and C, 3¢ portion of 35 bp in intron in fragments C and D, and 3¢ portion of 25 bp in intron in fragments F and I The number at the right of each RT-PCR product represents the ... factor and related proteins, as shown in Fig 1B To evaluate whether the Sp1-binding site in the DNASE1 distal promoter is crucial for expression, a mutated binding site was introduced into the )197H ... transcription of the DNASE1 messages containing exons or 1a To examine promoter activity in the 5¢-flanking region of exon in DNASE1, we first obtained the )1386M construct by introducing the )1386 to...
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Tài liệu NATURAL ENDOWMENTS, PRODUCTION TECHNOLOGIES AND THE QUALITY OF WINES IN BORDEAUX. IS IT POSSIBLE TO PRODUCE WINE ON PAVED ROADS? pot
Ngày tải lên :
22/02/2014, 09:20
... picking (and selecting), (2) destemming and crushing, (3) pumping into fermentation tanks, (4) fermenting of grape sugar into alcohol, (5) macerating or keeping the grape skins and pips in contact ... to be completed, (7) putting the wine in oak barrels and letting it age and (8) bottling the wine (1) Picking and selecting Harvesting usually starts after September 15 and may take as long as ... influence quality We are interested in trying to quantify the impact of each of the many inputs and steps used in producing wine in one of the most renowned wine producing regions of France, Haut-Médoc...
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Báo cáo khoa học: Caenorhabditis elegans metallothionein isoform specificity – metal binding abilities and the role of histidine in CeMT1 and CeMT2 potx
Ngày tải lên :
07/03/2014, 02:20
... coordinating and putative coordinating residues are highlighted (Cys in grey shadow, His and Tyr in bold) and the total content in each peptide is indicated The initial GS residues derive from the ... that the coordination of the Zn(II) ion bound at the C-terminal moiety of CeMT1 is contributed to by histidines, and the number of these involved in metal binding is analyzed below Thus, the overall ... present in our preparations The role of histidine in metal ion coordination in MTs is a subject that has gathered increasing importance in the field, especially because the 3D structure of the Zn and...
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Democratic Accountability and the Use of Force in International Law docx
Ngày tải lên :
07/03/2014, 11:20
... the newly independent Congo Its mandate was later modified to include maintaining the territorial integrity and political independence of the Congo by preventing the secession of Katanga province ... www.state.gov/www/global Introduction: broaching the issues and practice Determining whether individual, institutional, and state behavior is in accord with international law is no more problematic than determining ... clearing land mines and training Cambodians to clear land mines, civil administration, restoration of essential infrastructure, repatriation and resettlement of refugees and displaced persons, maintenance...
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Báo cáo khoa học: Increased NADPH concentration obtained by metabolic engineering of the pentose phosphate pathway in Aspergillus niger docx
Ngày tải lên :
07/03/2014, 17:20
... Enzymes in boxes were subjected to metabolic engineering in this study Metabolites and enzymes in italics were measured in wild-type and engineered strains Enzymes involved in polyol formation and ... resulted in an increase of synthesis of pyridine nucleotide cofactors, as the total pool of these increased Whether the synthesis is regulated by the NADPH concentration remains speculation The G6PDH ... of the PLS regression than the data from the Gnd20 strain, in which the G6PDH activity and NADPH concentration were generally increased Therefore the correlations shown in Fig 4B should be interpreted...
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Báo cáo khoa học: Regulation of arginase II by interferon regulatory factor 3 and the involvement of polyamines in the antiviral response potx
Ngày tải lên :
07/03/2014, 21:20
... converting l-arginine into l-ornithine and urea, a critical step in the polyamine biosynthesis pathway Subcellular localization of the two isoforms differs, with ArgI located in the cytoplasm and ... in the biosynthesis of natural polyamines (putrescine, spermidine and spermine) through conversion of l-arginine into l-ornithine [16] The latter is in turn used by ODC to produce putrescine, the ... mitochondrial enzyme involved in the polyamine synthesis pathway through the catalysis of l-ornithine production from l-arginine Of the natural polyamines, spermine and to a lesser extent spermidine, possess...
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Comparing HIV prevalence estimates from prevention of mother-to-child HIV transmission programme and the antenatal HIV surveillance in Addis Ababa docx
Ngày tải lên :
15/03/2014, 10:20
... was involved in supervising the data collection and reviewing the manuscript KMM was involved in developing the study proposal and reviewing the manuscript All authors read and approved the final ... manuscript OM was involved in developing the study proposal, supervising the data collection and reviewing the manuscript SGH was involved in developing the study proposal and reviewing the manuscript ... marked increases in the rate of HIV testing following the introduction of routine opt-out HIV testing approach Paralleling these increases, the HIV prevalence showed a steady decline from 10.0% in...
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