epigenetic epidemiology of cancer
báo cáo khoa học: "New clinical developments in histone deacetylase inhibitors for epigenetic therapy of cancer" doc
... hypomethylating agents for epigenetic therapy of cancer Current Cancer Drug Targets submitted and under review 2009 Marks PA: Discovery and development of SAHA as an anticancer agent Oncogene 2007, ... section of azacitidine) 11 Yoo CB, Jones PA: Epigenetic therapy of cancer: past, present and future Nat Rev Drug Discov 2006, 5:37-50 Hashimshony T, Zhang J, Keshet I, Bustin M, Cedar H: The role of ... results of a phase III randomized study Cancer 2006, 106:1794-1803 Kantarjian H, Oki Y, Garcia-Manero G, Huang X, O'brien S, Cortes J, et al.: Results of a randomized study of schedules of lowdose...
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Genetics and Testicular Cancer: Division of Cancer Epidemiology and Genetics Clinical Genetics Branch doc
... testicular cancer to: Develop gene mutation tests for testicular cancer Determine who is at higher risk of testicular cancer Determine the risk of developing testicular and/or other cancers based ... family ~2% of men with testicular cancer also have a relative with testicular cancer Brothers of men with testicular cancer are 8-10 times more likely to develop the disease Sons of men with ... “Hereditary Cancer Parent Parent has mutation present in all cells of the body Offspring Offspring inherits first mutation from parent and may get second “hit” leading to testicular cancer All...
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Báo cáo y học: "The epidemiology of medical emergency contacts outside hospitals in Norway - a prospective population based study"
... have of a large variety of medical problems, where the majority of the patients have a non life-threatening situation The large variation of medical symptoms stands in contrast to a narrow use of ... Herlitz J: The epidemiology of out -of- hospital ‘sudden’ cardiac arrest Resuscitation 2002, 52:235-45 Page of 10 Hansen KS, Morild I, Engesaeter LB, Viste A: Epidemiology of severely and fatally injured ... total number of patients was 180 which corresponds to a rate of 25.5 (24.7-26.1) patients per 000 inhabitants per year Of the 256 extra patients from the accidents, 98% had a NACA score of or lower,...
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Báo cáo y học: "The epidemiology of intensive care unit-acquired hyponatraemia and hypernatraemia in medical-surgical intensive care unit"
... of the city of Calgary and surrounding areas (population 1.2 million) in the province of Alberta, Canada [14] All critically ill adult patients in the CHR are managed in ICUs under the care of ... episode of hyponatraemia compared with 19% (n = 413) of patients with ICU-acquired hypernatraemia who experienced more than one episode of hypernatraemia (p = 0.067) Distinct episodes of both ... median number of days of hyponatraemia (IQR = one to three days) and hypernatraemia (IQR = one to five days) was two Multivariable analysis of patient characteristics The incidence of ICU-acquired...
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Báo cáo y học: "Epidemiology of Hepatitis C Virus (HCV) Infection"
... al-Rashed RS, al-Jeffry M, Hossain A, el-Hazmi M Profile of hepatitis C virus and the possible modes of transmission of the virus in the Gizan area of Saudi Arabia: a community-based study Ann Trop ... Romano L, Tisminetzky S, De Palma M, Stroffolini T, Ventura E, Zanetti A Lack of evidence of sexual transmission of hepatitis C among monogamous couples: results of a 10-year prospective follow-up ... Medhat A, Strickland GT Estimation of the risk of transmission of hepatitis C between spouses in Egypt based on seroprevalence data International Journal of Epidemiology 2005; 34:160-165 54 Alary...
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The Use of Selected Medicinal Herbs for Chemoprevention and Treatment of Cancer, Parkinson’s Disease, Heart Disease, and Depression
... damage of DNA; (2) oxidations of unsaturated fatty acids in lipids; (3) oxidations of amino acids in proteins; and (4) inactivation of specific enzymes through oxidation of catalytic cofactors ... distribution of conjugated forms of phenolic compounds among berry species of the same family were confirmed, but differences in chromatographic profiles of conjugates and compositions of aglycones ... severity of diseases based on inflammatory processes including atherosclerosis and ischemic stroke, neurodegenerative diseases of aging, and certain cancers The first report of the anticancer properties...
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Tài liệu Environmental and Occupational Causes of Cancer doc
... Identification of carcinogenic agents and primary prevention of cancer, Annals of the New York Academy of Sciences 2006; 1076:1-14 145 Doll R, Peto R The causes of cancer: quantitative estimates of avoidable ... types of cancers such as lung cancer among men and colorectal cancer among both sexes However, rates of the following cancers have increased: among both sexes, the last decade has seen rises in cancers ... review of the state of the science regarding environmental and occupational causes of cancer, we conducted a review of the peer-reviewed literature, ENVIRONMENTAL & OCCUPATIONAL CAUSES OF CANCER: ...
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Tài liệu Misconceptions about the Causes of Cancer pptx
... Collacott Prof Barry Cooper Prof Steve Easton Prof Herb Emery Prof Tom Flanagan Gordon Gibson Dr Herbert Grubel Prof Ron Kneebone Prof Rainer Knopff Dr Owen Lippert Prof Ken McKenzie Prof Jean-Luc ... about the causes of cancer Summary The major avoidable causes of cancer are: (1) smoking, which accounts for 27% of cancer deaths in Canada and 80% to 90% of deaths from lung cancer; (2) dietary ... of California, Berkeley He is a member of the National Academy of Sciences and was on their Commission on Life Sciences He was a Member of the National Cancer Advisory Board of the National Cancer...
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Tài liệu The Electrical Properties of Cancer Cells pptx
... properties of cancer cells part • Some of the characteristic features of cancerous cells that affect their electrical activity are: Cancer cells are less efficient in their production of cellular ... more depth • One of the characteristic features of injured and cancerous cells is that they are less efficient in their production of cellular energy (ATP) One of the mysteries of cancer is whether ... potential of cancer cells, the concentration of sodium and potassium inside of cancer cells, and the mechanisms that cancer cells use to produce energy Cure has proposed that the accumulation of an...
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Tài liệu PREVENTION AND TREATMENT OF CANCER-RELATED INFECTIONS docx
... and Treatment of Cancer- Related Infections See Suggested Duration of Therapy for Documented Infection (FEV-10) Fever of unknown origin See Suggested Duration of Therapy for Fever of Unknown Origin ... Earl King, MD X Fox Chase Cancer Center Ken Rolston, MD The University of Texas M.D Anderson Cancer Center Emily Mackler, PharmD å University of Michigan Comprehensive Cancer Center Susan K Seo, ... 2.2009 version of the Prevention and Treatment of Cancer- Related Infections Guidelines from the 1.2009 version include: · The addition of the updated Discussion section Summary of the changes...
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Tài liệu The Burden of Cancer in American Adults ppt
... percentage of the population with a history of cancer, is a function of both new cases of cancer and the survivability of cancer Over 5% of American adults—10.6 million people—report ever having had cancer, ... with a history of cancer is greatest for breast cancer, followed by prostate cancer, colorectal cancer, cervical cancer, and melanoma The Burden of Cancer in American Adults Number of adults with ... respectively, of older men The Burden of Cancer in American Adults Two percent of middle-aged and 7% of older women have a history of breast cancer, the most common cancer among women Sixteen percent of...
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Tài liệu Regulation of cancer cell metabolism docx
... samples of various cancer types, leading to the proposal that PKM2 might be a useful biomarker for the early detection of tumours65,72–74 However, further study of the prevalence of PKM2 in cancers ... Sabatini, D M Defining the role of mTOR in cancer Cancer Cell 12, 9–22 (2007) 30 Bertout, J A., Patel, S A & Simon, M C The impact of O2 availability on human cancer Nature Rev Cancer 8, 967–975 (2008) ... the Warburg effect Only on closer examination of the full metabolic requirements of a cancer cell was the advantage of PKM2 expression revealed A cancer cell, like any normal cell, must obtain...
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Tài liệu The role of cancer registries docx
... registries in cancer control The cancer registry is an essential part of any rational programme of cancer control Its data can be used in a wide variety of areas of cancer control ranging from etiological ... ratios (i.e., the frequency of cancers of a particular site in relation to the total number of cancer cases—see Sections 4.3.5 and 11.1.6 for a discussion of this type of measure) They may also ... results The collection of information on cancer cases and the production of cancer statistics are only justified if use is made of the data collected A population-based cancer registry should...
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Tài liệu MULTICOLOR QUANTUM DOTS FOR MOLECULAR DIAGNOSTICS OF CANCER doc
... progress of Q as clinical labels Ds References Papers of special note have been highlighted as: • of interest • of considerable interest • Jemal A, Murray T, Ward E et al Cancer statistics, 2005 CA Cancer ... Prostate-specific antigen: a review of the validation of the most commonly used cancer biomarker Cancer 101(5), 894–904 (2004) 30 Goessl C Noninvasive molecular detection of cancer – the bench and the ... Screening of blood, urine and other bodily fluids for the presence of cancer markers has become a commonly used diagnostic technique for cancer; however, it has been impeded by the lack of specific...
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Tài liệu PROTEOMIC APPLICATIONS FOR THE EARLY DETECTION OF CANCER doc
... online to: Cancer. gov: http://www .cancer. gov /cancer_ information/ bladder cancer | breast cancer | colon cancer | liver cancer | lung cancer | oesophageal cancer | ovarian cancer | prostate cancer ... 70% (107 of 153) of sera from patients with benign disease and PSA levels of >4 ng/ml, and could accurately predict the presence of cancer in 95% of the patients tested, including 18 of 21 men ... this type of technology to the clinic detection and to the problem of ovarian cancer diagnosis53 More than two-thirds of ovarian cancer cases are detected at advanced stages, when the cancer cells...
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Tài liệu FACTS AND FIGURES CAUSES OF CANCER PREVENTION EARLY DETECTION CURE AND CARE CONTACTS docx
... oesophagus, and kidney cancers The incidence of stomach cancer has gone down because of reduced intake of salt and improved living conditions Source: IARC 2000 CAUSES OF CANCER 12 WHO P.Virot ... Eastern Europe 903,400 Types of cancer Lung cancer kills more people than any other cancer Prostate Lung Colorectal Western Europe 873,700 More men than women get cancer of the lung, stomach, throat, ... most avoidable cause of cancer In most developed countries, smoking is responsible for up to 30% of all cancer deaths Worldwide, it is responsible for more than 80% of lung cancer cases in men,...
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Tài liệu Báo cáo khoa học: A strategy for discovery of cancer glyco-biomarkers in serum using newly developed technologies for glycoproteomics ppt
... previously demonstrated the application of this method to the determination of the glycan structure of a form of AFP [10] However, identification of the details of a glycan structural change on a glycoprotein ... Effective incorporation of biomarkers into phase II trials Clin Cancer Res 15, 1898–1905 Discovery of cancer glyco-biomarkers 38 Hanahan D & Weinberg R (2000) The hallmarks of cancer Cell 100, 57–70 ... Discovery of cancer glyco-biomarkers H Narimatsu et al pathways [1] Knowledge of the substrate specificities of these gene products allowed us to better understand the molecular basis of human...
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Tài liệu Báo cáo khoa học: EGF receptor in relation to tumor development: molecular basis of responsiveness of cancer cells to EGFR-targeting tyrosine kinase inhibitors docx
... associated with stimulation of ERK1 ⁄ and Pak1 pathways, gefitinib might lead to inhibition of invasiveness of human cancer cells through the inhibition of ERK1 ⁄ and Pak1 The use of gefitinib in cells ... level of Bcl-2 family genes and the phosphorylation state of their proteins, thereby changing the amount and localization of Bcl-2 family members However, each type of cancer has its own way of ... [23] Regulation of Bcl-2 family members can occur by a number of mechanisms, including up-regulation of synthesis, enhancement of degradation and phosphorylation In the event that cancer cells undergo...
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Tài liệu Misconceptions About Environmental Pollution, Pesticides and the Causes of Cancer doc
... major causes of cancer are: a) Smoking: About a third of U.S cancer (90 percent of lung cancer) ; b) Dietary imbalances, e.g., lack of dietary fruits and vegetables: The quarter of the population ... plausibly increase the risk of birth defects and childhood cancer in offspring.18 A new epidemiological study suggests that the rate of childhood cancers is increased in offspring of male smokers, e.g., ... Cause of Cancer APPENDIX TABLE I Review of Epidemiological Studies on Cancer Showing Protection by Consumption of Fruits and Vegetables86 Cancer site Fraction of Studies Showing Significant Cancer...
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- epidemiology of prostate cancer
- the epidemiology of diet and cancer
- epigenetic therapy of cancer
- epidemiology of the association between bacterial infections and cancer
- epigenetic epidemiology for cancer risk harnessing germline epigenetic variation
- epigenetic biomarkers in cancer epidemiology
- the epidemiology of cancer
- considerations in the design conduct and interpretation of studies in epigenetic epidemiology
- epigenetic epidemiology of infectious diseases
- epigenetic epidemiology of inflammation and rheumatoid arthritis
- epigenetic epidemiology of autism and other neurodevelopmental disorders
- epigenetic epidemiology of psychiatric disorders
- epigenetic epidemiology of type 1 diabetes
- epigenetic epidemiology of obesity type 2 diabetes and metabolic disorders
- epigenetic epidemiology of atherosclerosis
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