... cells Pro-inflammatory cytokines and chemokines expression are activated in cells of the monocyte/macrophage lineage inthe innate responseto injury or infections Microglia are considered the primary ... contribute only marginally and is limited tothe residual cells inthe vasculature at the time of sectioning Therefore, the extent of the measured pro-inflammatory response is predominantly by resident ... [27,28 ]in vivo Since there were no established foci of inflammation inthe tissue prior to sectioning in our explant model, the influence of the miniscule number of leukocytes inthe vasculature...
... be involved in either eliminating the toxicity of the chemical or repairing the damage caused by the drug It is not known whether any of these plumbagin-responsive genes are directly involved in ... counteracting plumbagin toxicity To examine the importance of the up-regulated genes previously found [12] in counteracting the plumbagin toxicity, we examined the relative sensitivity of mutant strains ... of the ΔsodA and the ΔygfZ strains and the parental strain were tested (Table 3) Therefore, adding a methyl group tothe 3-position of naphthoquinone ring apparently diminishes the plumbagin toxicity...
... infected DCs tothe draining LN (Humphreys et al., 2006) Taken together, these studies suggest that the migratory properties of infected DCs is 18 Chapter 1: General Introduction crucial tothe delivery ... important role inthe initiation of T cell responses during M tuberculosis infection 117 4.3.5 Proposing a role for the lung CD103+ DC subset inthe early transport of bacteria tothe LN after ... Gram staining procedure; instead, the ZiehlNeelson stain is applied in order to confirm the presence of these acid-fast bacilli (Pfyffer, 2007) In addition to M tuberculosis, several other mycobacteria...
... tothe repair processes at the end of the season The total phenol content is reported to increase inresponseto O3 [8, 32] and phenolic compounds such as the precursors of lignin are known to ... ascorbate-glutathione detoxication cycle [14] GR is one of theenzymes of this cycle Inthe present study, GR activity increased two-fold in sugar maple seedlings inresponseto increasing O3 stress This ... grown inthe absence of O3 decreased more than two-fold during the growing season Inthe truncated seedlings there was no change inthe NR activity under O3 (Figs 6A6C) On day 85, the rst ush of the...
... carried out attempting to clarify the influence of various factors on tacrolimus kinetics However, the results remain controversial with regard to pharmacokinetic and clinical effect of the studied ... hospital and informed consent was obtained from all subjects Maintenance treatment scheme consisted of a combination of a calcineurin inhibitor (tacrolimus) with a purine inhibitor (mycophenolate ... immunosuppressive therapy although epigenetic factors must be taken into account [7] The aim of the present study was to 95 determine the impact of CYP3A5*1 and CYP3A5*3 genotype on the kinetics of...
... as a single band on these gels, as the ODN hybridizes tothe center of the input target RNA The asterisk indicates the input target RNA; the arrow indicates the digested product bands The amount ... attributable to their ability to bind a number of heparin-binding proteins [28] In our search for allele-speci®c inhibitors based on singlenucleotide polymorphisms in target mRNA sequences using antisense ... obtained is indicated at the bottom of the lanes as percentage of total signal detected inthe lane (remaining uncut input RNA plus digested product RNA) Fig Northern blot analysis of the cell lines...
... building on national education sector responses to HIV throughout the Caribbean, with the overall goal of strengthening the role of the education sector in preventing HIV inthe region The overall ... building on national education sector responses to HIV throughout the Caribbean The overall goal of this Network is to strengthen the role of the education sector in preventing HIV inthe region The ... Demonstrates the government’s commitment to responding to HIV&AIDS The inclusion of the education sector shows the recognition of the role of the sector intheresponse Addresses sector specific...
... with the practice that has been adopted since 1997 The Government therefore intends to use its powers inthe GRAA to make the C&AG the statutory auditor of the Environment Agency, the Housing ... 2000 In doing this, the C&AG, the bodies involved, their regulators, and other auditors should produce protocols for the exercise of these new statutory powers The protocols should be prepared to ... and measures included inthe guide are tools for analysing and interpreting the raw figures in departments’ accounts, and the results of the calculations are intended to be used to indicate areas...
... contribute tothe pool of activated macrophages inthe injury site To examine whether the increased Ym1 in wild type mice occurs in monocytes before they enter the injured brain, RT-PCR was used to determine ... concentrations of Th1 and Th2 cytokines were assayed to determine if there were systemic differences inthe inflammatory responseto brain injury Unfortunately most of the cytokines tested were not detectable ... cells infiltrating the injury site in wild type and MT-I/II -/- mice Analysis of the numbers of leukocytes in circulation inthe days following brain injury was also conducted to determine if the...
... 6), the similar outcomes from the two analyses reinforce the overall conclusions while providing further insights into the impact of patient characteristics on dose responseThe key finding of the ... included in this analysis The most striking feature of the plot is that theresponseto indacaterol at the plateau exceeds theresponse of all comparators In other words, doses of indacaterol 150 μg ... characterization of the doseresponse relationship of indacaterol and the responses to comparators used in some trials The key metrics of interest were: the minimum effective dose (MED), defined as the lowest...
... following chronic aspiration of either gastric fluid or normal saline are shown The ratio of macrophages inthe left tothe macrophage inthe right lung is shown as a function of time Inthe inset, ... http://respiratory-research.com/content/8/1/87 Figure Cytokine responseto chronic aspiration of gastric fluid Cytokine responseto chronic aspiration of gastric fluid Cytokine levels were evaluated inthe ... from the left lung of rats receiving gastric fluid in their left lung, the left lung of rats receiving normal saline in their left lung, the right lung of rats receiving gastric fluid in their...
... appear to block histamineinduced responses Skin reactions were not influenced by mixing AS with histamine or by injecting histamine into sites previously injected with AS (Fig 3) Its effects on other ... Clinically, the inhibitory effects of AS in vivo can more readily be seen by the photographic evidence presented in Figure Aluminum sulfate does not block histamine effects To determine if the ... the allergeninduced skin prick response without being present inthe test material The reduction in wheal was identical between the sample containing AS and the sample which contained no AS,...
... earthquake area to a specific city, and because of the inability to admit the casualties, they were referred to yet a second city“ according to another interviewee The lack of a coordinated plan ... regarding disaster responseThe preparedness of the Ministry of Health in Pakistan was far from sufficient regarding the earthquake in 2005 [18] Since there was no disaster management plan during the ... tothe extent that evacuating the casualties by road way was impossible.“ “Only a few hours after the arrival of the first response teams, the evacuation by air was stopped“ according to another...
... of the training process in organizations as much as technical training In Chapter 12, Mark Griffiths continues to examine the issue of employee well-being from a different lens by introducing the ... and themes The first two numeric columns show the coordinates of the categories and themes of the dimensions The next two columns provide the contribution tothe inertia of the dimensions The final ... 11% of the sample Coding the Narratives The goal of the coding scheme was to capture the major themes and relationships respondents mentioned in their answers We developed the coding scheme inductively,...
... provided their employees Internet access inthe workplace Forty-six of these companies were inthe service sector, whereas the remaining were inthe manufacturing sector These companies ranged in size ... which determines the importance of the transaction which is then factored into the totality of all other transactions in order to determine the value of the judgment Trust becomes the outcome ... Exploratory Study into the Relevance of Trust inthe Context of Information Systems Technology Doctoral Dissertation, The George Washington University, Washington, DC Lippert, S.K (2002) Contributing...
... monitoring tool, as listed in another section below File-Sharing Monitoring Products File-sharing has a history of waxing and waning between one of the easiest applications to monitor to one of the ... employees loading games onto their desktop PCs which may contain potentially harmful viruses or otherwise disturb the computing atmosphere within the organization Plugging into the Internet was ... monitoring effort Increase Employee Productivity The Internet was introduced into many organizations as a tool to aid employees in completing their jobs more efficiently This was the case with the...
... monitoring to determine whether a legitimate business justification for the monitoring exists Here factors such as whether the employer provided notice tothe employee of the monitoring and whether the ... inthe ordinary course of business” includes anything of interest tothe employer’s business The Court stated that the exclusion does not apply tothe interception of personal calls except to ... indication tothe conversants that their calls were being monitored In ruling for the employee, the Court stated: [The employer] did not inform [the employee] that they were monitoring the phone,...
... workplace is intricately linked tothe world outside the company The sources of the abuse are societal and the challenge to understand them seems insurmountable Taiwan is rather unique inthe adoption ... what they discovered was shocking to them Confirming tothe stereotypical image portrayed inthe public, there were indeed some very abusive behaviors, which, in Freud’s terms, appear to be the ... and likely to become Internet users Finally, these women must behave in a seductive way for any man to be interested in talking to them These negative stereotype beliefs about both the Internet...