enzymes and the binding of ligands to receptors from improvements in packing
Báo cáo khoa học: The binding of IMP to Ribonuclease A pptx
Ngày tải lên :
07/03/2014, 21:20
... that the phosphoryl group that binds at P1 in a manner similar to other nucleotides is the anchoring point for the binding of IMP mol I The rest of the inhibitor molecule binds outside of the ... in contrast to the binding of IMP mol I, the anchoring point of IMP mol II seems to be the inosine ring, which is involved in polar interactions with Thr45, the primary functional component of ... protonated and therefore they cannot form hydrogen bond interactions with the carbonyl O6 group of the inosine base to favour binding in this subsite Thus, the IMP base binds in the outskirts of the...
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Credit Unions and the Supply of Insurance to Low Income Households pdf
Ngày tải lên :
15/03/2014, 07:20
... If the result of the income draw in the second period is negative then the agent will be in receipt of the minimum income guarantee and desires to increase consumption then on the expectation of ... credit union is gained from dividing the expected utility from membership into two parts, depending on the result of the income draw in period two The expected utility from not joining the credit union ... function to be either the maximisation of interest income of savers or the minimisation of the rate of interest to borrowers (see, for example, Overstreet and Rubin,1990; Smith 1984, 1986; and Srinivasan...
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Đề tài "Invariant measures and the set of exceptions to Littlewood’s conjecture " doc
Ngày tải lên :
15/03/2014, 09:20
... the hospitality of the Newton Institute for Mathematical Sciences in Cambridge in the spring of 2000 and ETH Zurich in which some of the seeds of this work have been sown We would also like to ... key ingredient of the proof of Lemma 3.3 in [3] is the translation produced along Uik when going along Uij and Ujk and returning to the same leaf Uik x Proof of Theorem 2.2 For = a, b we define the ... consisting of rational vectors) Since Vg is rational, there is an integer vector m ∈ Zn ∩ (Vg )⊥ In particular, the last k − k entries in the vector gm (which is a vector in the lattice in Rk...
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Báo cáo khoa học: Transcriptional regulation of the desferrioxamine gene cluster of Streptomyces coelicolor is mediated by binding of DmdR1 to an iron box in the promoter of the desA gene doc
Ngày tải lên :
16/03/2014, 11:20
... explaining the regulation of desA expression by binding of DmdR1 to the iron box The same overlapping was found in S pilosus DmdR1 binds to the promoter region of desABCD in both S coelicolor and ... start point is indicated as +1 (bent arrow) The1 9-bp palindromic region, which contains the repressor -binding site, is boxed, and the ribosome -binding site is underlined The ATG is shown in bold ... desferrioxamine cluster Indeed, binding of the pure DmdR1 protein to the S coelicolor desA promoter region was shown for the first time in this work As described previously, binding of DmdR1 to the iron box...
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Gradual phase and morphology transformation of Fe3O4nanoparticles to a - FeOOH nanorods in alcohol/water mediain the presence of surfactant F127
Ngày tải lên :
19/03/2014, 16:48
... color change from black to yellow was observed, starting from the interface between solution and air This could be attributed to the oxidation of Fe(II)Fe(III) intermediate to a-FeOOH The whole ... ratios of alcohol/water is consistent with XRD results well The magnetism of the samples prepared in pure water and in alcohol/water media is also investigated, as shown in Fig The value of saturation ... alcohol to water is set to 1:1 (sample b), peaks of both Fe3O4 and a-FeOOH appear in XRD pattern, as shown in Fig 1b It reveals the coexistence of two phases in the product From the above results,...
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summary of dissertation delimitation of the jurisdiction to deal with administrative complaints and the jurisdiction of courts to deal with administrative cases in vietnam
Ngày tải lên :
17/07/2014, 11:06
... on the objectives of complaint and the transfere of authority in handling with administrative complaint in public management The scope of administrative complaint objectives and the transfere of ... amending and adding regulations on concept of complainantpetitioner in order to distinguish the subjects having the right to complain initiate with the subjects exercising this right Third, the ... current in order to decentralize the 21 competence in resolving administrative complaint and adjudicating administrative lawsuit Eleventh, defining principles for determining jurisdicion of the first...
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Báo cáo sinh học: "RNAi and the shape of things to come" ppsx
Ngày tải lên :
06/08/2014, 18:20
... genes thought to be involved in regulating the cytoskeleton, such as putative GTPases and kinases The library of dsRNAs was introduced into cells in 384-well optical-bottom plates, to allow image-based ... Several of the genes identified are thought to limit the rate of formation of filamentous (F) actin and encode proteins with F-actin capping functions Some of these regulators seemed to play ... targeting specific gene families to investigate cytoskeletal function in Drosophila S2 cells They targeted dynein and all 25 Drosophila kinesins to investigate the role of molecular motors during...
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Báo cáo y học: " Eotaxin and the attraction of eosinophils to the asthmatic lung" ppt
Ngày tải lên :
12/08/2014, 18:20
... in the BAL fluid, and increased expression of eotaxin mRNA and protein in the epithelium and submucosa of their airways as compared with normal control individuals In the BAL cells the eotaxin ... recruitment of all of these cell types in the context of allergic inflammation reports Guinea pig eotaxin was shown to be potent in inducing a calcium flux in human eosinophils [4], indicating the existence ... [20] The promotor region of the C-C chemokines contain consensus -binding sites for the transcription factors nuclear factor-κB and AP-1, which are known to be important in regulating inflammatory...
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Tài liệu Investigating the Role of Poultry in Livelihoods and the Impact of Avian Flu on Livelihoods Outcomes in Africa docx
Ngày tải lên :
21/02/2014, 01:20
... affected the poultry sectors The countries also differ in various other factors, including the size and structure of the poultry sector, reliance of the poor on poultry, and the levels of diversification ... culled No information is available on the costs of culling, diagnostic testing of samples, cleaning and disinfection, and other administrative costs (Obi, Oparinde, and Maina 2008) Regarding the impacts ... et al 2008; Aning, Turkson, and Asuming-Brempong 2008; Obi, Oparinde, and Maina 2008; Omiti and Okuthe 2008) Therefore, information regarding the role of poultry in the livelihoods of small-scale...
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Human Capital and the Development of Financial Institutions: Evidence from Thailand docx
Ngày tải lên :
06/03/2014, 10:20
... percent of the banks in the Northeast and 81% of the banks in the Central region make loans, while only 35% of the banks in the Northeast and 53% of the banks in the Central region offer savings ... banks to provide both savings and lending services In the Northeast, only 17% of the banks offer savings and lending In the Central region, 40% of the banks offer both savings and lending services ... non-linearities in the education variables, only the direct effects of the years of schooling of the head of the household, the years of schooling of the money manager and the average schooling of...
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Báo cáo khoa học: Local stability identification and the role of key acidic amino acid residues in staphylococcal nuclease unfolding ppt
Ngày tải lên :
07/03/2014, 21:20
... near the flexible C terminus of SNase Changes in the fluorescence intensity of W140 reflect a change in the surrounding hydrophobic environment of the tryptophan and thus indicate a change in the ... we hypothesize that pH unfolding SNase is mainly processed by the addition of 2.5 protons and both E75 and E129 are the targets of protonation It is of interest to determine which other amino acids ... (E129G) and 43.43% (E75G) lower than that of the wild-type protein, suggesting that Glu residues at positions 75 and 129 play key roles in maintaining the native structure of the protein Furthermore,...
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Promoting the Use of End-to-End Congestion Control in the Internet pptx
Ngày tải lên :
15/03/2014, 22:20
... routers using either FCFS or WRR set to 128 Kbps, 9% of the bandwidth of the R1-R2 link Be- scheduling In these scenarios, there is one TCP connection cause the final link in the path for the UDP ... available bandwidth on the R1-R2 link (Because there is no congestion on the first link, the UDP arrival rate at the first router is the same as the UDP sending rate.) The bold line (at the top of the ... connections, one TCP and the other UDP, from node S1 to node S4 For each simulation set the sending rate of the UDP flow ranges from zero up to the available bandwidth of the congested link The router uses...
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Internet Banking and the question of Bank Run: lesson from the Northern Rock Bank case pdf
Ngày tải lên :
29/03/2014, 09:20
... signs of the crisis, the only alternative left to those banks was to borrow from the Bank of England Surprisingly the first reaction of the Bank of England has been from being prompt On the contrary ... bank is to turn to the central bank in order to get the liquidity unavailable in the market In that context the action of the central bank has to be prompt in order to stop the run on the targeted ... limited to Northern Rock and started only when the leak from the BBC alarmed the public about the state of the bank This shows despite the easiness of transferring accounts to another bank by internet...
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Báo cáo sinh học: " Irreducibility and efficiency of ESIP to sample marker genotypes in large pedigrees with loops" pot
Ngày tải lên :
14/08/2014, 13:21
... alleles and 4, and the Aa offspring of family inherited founder alleles and 4; the AA offspring of family inherited founder alleles and 4, and the Aa offspring of family inherited founder alleles and ... AA offspring of family inherited founder alleles and 4, and the Aa offspring of family inherited founder alleles and or and 4; the AA offspring of family inherited founder alleles and 4, and the ... sampling m from the cut pedigree conditional on y, where m is the vector of missing genotypes of the original individuals and y is the vector of observed genotypes of the original and introduced individuals...
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Financial crisis and the resolution of financial distress evidence from malaysia and thailand
Ngày tải lên :
12/09/2015, 08:18
... Malaysia and Thailand to find evidence of the existence of credit crunch in the early years of the crisis Section reviews the road to recovery in Malaysia and Thailand and explains the recovery in the ... financial crisis focuses on the transmission and not the resolution of the crisis Therefore, the main contribution of the thesis is to offer new theoretical and empirical insight on the role of ... involve the capital market imperfections and associate the decline in inventory to a ‘cut-off’ in the flow of bank credit The authors go one step further in their effort to distinguish these two...
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the use of pictures to engage young learners in speaking activities at new oriental english school
Ngày tải lên :
27/04/2016, 11:29
... to review theories relating to the understanding of communicative competence and the understanding of oral communicative competence in language teaching and learning Stages and ways of teaching ... Then minutes they are going to receive a set of eight pictures After watching the trailer, they have to name the cartoon and main characters Discuss the orders of the pictures, and then try to ... learners to combining listening and speaking in real time and in natural interaction Davies and Pearse emphasized that the best chance for them to so is to get learner in the general use of English in...
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Báo cáo khoa học: The binding of foot-and-mouth disease virus leader proteinase to eIF4GI involves conserved ionic interactions ppt
Ngày tải lên :
23/03/2014, 13:20
... presence of eIF4E binding sequences on the eIF4G fragment and the presence of eIF4E in the binding assay are required for more efficient Lbpro binding As a control, we examined the binding of radiolabelled ... is included in the binding assay Although these two parameters increase Lbpro binding, Lbpro is still capable of binding to eIF4GI fragments in their absence Thus, the two picornaviral proteinases ... contain the eIF4E binding site and eIF4E is present in the binding assay Once again, the versatility of viral proteins is amply illustrated Although viral proteins must remain small in order to...
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Báo cáo khoa học: Catalytic activation of human glucokinase by substrate binding – residue contacts involved in the binding of D-glucose to the super-open form and conformational transitions ppt
Ngày tải lên :
30/03/2014, 04:20
... E256 and E290) and the S-domain (residues T168 and K169) (Fig 1B) To identify the contact residues involved in the initial binding of Glc to the super-open state (Fig 1C) of this two domain hinge-bending ... involved in the binding of Glc to the super-open state (Fig 1C) of this two domain [large (L) and small (S)] enzyme, and thus the site of initiation of the global conformational transition; and (c) to ... demonstrating that the binding of Glc at the active site indeed induces a large-scale domain movement that closes the active site cleft and creates the stereochemical environment for binding of the...
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Báo cáo khoa học: Aromatic amino-acid residues at the active and peripheral anionic sites control the binding of E2020 (AriceptÒ) to cholinesterases doc
Ngày tải lên :
30/03/2014, 20:20
... gorge, the piperidine ring interacts with Tyr70, Asp72, Tyr121 and Tyr334 in the middle of the gorge, and the indanone ring interacts with Trp279 at the lip of the gorge The calculated modes of binding ... of these residues to the binding of E2020, we analyzed single and triple mutants of Mo AChE for their activity toward E2020, and estimated the binding forces by partitioning the free energy of ... studies The mutation of Tyr337 to Phe or Ala in Mo AChE resulted in a gain of binding energy suggesting that the bulky Tyr residue was sterically hindering the binding of E2020 to AChE The two...
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