enzymatic mechanism of the protein biosynthesis in the developing nervous system
Structural study revealing the unique enzymatic mechanism of the severe acute respiratory syndrome (SARS) coronavirus main protease highly mediated by the extra domain
... the N-finger, are inserted into the cleft between domain II and domain III of the parent protomer, and interact with domain III of the opposite protomer In this thesis, the two β-barrel domains ... protomer In the absence of these two interactions, the active site and the S1 substrate binding region will lose their competent conformations (Lee et al 2005) Interestingly, the binding of a native ... determined by the interactions between Ser1 from the opposite protomer, and Phe140 from the parent protomer These interactions are certainly important in maintaining the catalytic loop in the catalytically...
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báo cáo khoa học: "Isolated angiitis of the central nervous system with tumor-like lesion, mimicking brain malignant glioma: a case report and review of the literature" pdf
... provided the pathological diagnosis TJ was the surgeon and gave the final approval of the version to be published Competing interests The authors declare that they have no competing interests ... China Department of Pathology, Beijing Neurosurgical Institute, Beijing 100050, China Authors’ contributions GY wrote the initial draft WY drew the pictures WZ revised the draft SL described the ... viral infections initiate the inflammatory process that somehow becomes self-sustaining [5] It is also speculated that there may be a genetic predisposition in certain individuals leading to...
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Divisions of the autonomic nervous system
... within the target effectors The cranial component of the parasympathetic system is based in particular nuclei of the brain stem In the midbrain, the Eddinger–Westphal nucleus is part of the oculomotor ... stressors What other organ system gets involved, and what part of the brain coordinates the two systems for the entire response, including epinephrine (adrenaline) and cortisol? The endocrine system is ... gets involved, and what part of the brain coordinates the two systems for the entire response, including epinephrine (adrenaline) and cortisol? Chapter Review The primary responsibilities of the...
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Báo cáo khoa học: The role of Tyr71 in Streptomyces trypsin on the recognition mechanism of structural protein substrates ppt
... of residue 71 in collagen binding The elucidation of the mechanism of structural protein substrate recognition in serine proteases should help advance therapeutic research into the prevention ... 400 nm The spectra of the proteins, an average of four scans, were corrected by subtracting the spectra of the corresponding background media without protein Substrate recognition mechanism of Streptomyces ... equivalent in ninhydrin colour to 1.0 lmol of leucine in h at pH 7.4 at 37 °C in the presence of CaCl2 Data are expressed as the mean ± SD of three independent experiments (C) The ratio of hydrolytic...
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Báo cáo khoa học: Mechanism of the ring contraction process in vitamin B12 biosynthesis by the anaerobe Propionibacterium shermanii under aerobic conditions docx
... contraction mechanism of vitamin B12 Fig The mechanisms of the ring contraction process in the biosynthesis of vitamin B12 postulated on the basis of the isolation of factor IV from the anaerobe ... Iida et al Ring contraction mechanism of vitamin B12 Fig The highlights of previously postulated mechanisms of the ring contraction process in the biosynthesis of vitamin B12 in the anaerobe ... from the migration of ring D followed by cleavage of the carbon–oxygen bond of the c-lactone at C1 of 13C,18O-precorrin3x [8–10] as shown in the lower row of Fig We were interested in the mechanism...
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Báo cáo khoa học: A steady-state modeling approach to validate an in vivo mechanism of the GAL regulatory network in Saccharomyces cerevisiae ppt
... that controls the protein expression in the wild-type is the shuttling of Gal80p Increasing the amount of Gal80p in the cytoplasm by increasing the distribution coefficient (K) causes the switch ... components of the selected model provide insights into the importance of their roles in the overall performance of the network A similar experimental evaluation of the roles of individual elementary mechanisms ... between the various components However, these in vitro experiments may not yield the in vivo mechanism of the regulatory system An experimental determination of the in vivo mechanism in a genetic...
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Báo cáo Y học: Role of conserved residues within helices IV and VIII of the oxaloacetate decarboxylase b subunit in the energy coupling mechanism of the Na+ pump ppt
... binding ligand Sodium ions may still bind to the N373L mutant through coordination to the other ligands of the binding site (center I), but the binding becomes much weaker as emphasized by the ... is the shift of the pH optimum from near neutral in the wild-type to pH 9.2 in the R389A mutant, which is in accord with an increase in the pK of Y229 if the stabilizing R389 residue is lacking ... essential feature in the proposed mechanism is the binding of Na+ ions from the cytoplasm at D203 and S382 including sites and their delivery into the periplasm as a proton enters the channel from...
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Báo cáo khoa học: Enzymatic features of the glucose metabolism in tumor cells ppt
... [115] reported the finding of two potential binding sites for HIF-1 in the first intron of the PK-M gene On the other hand, Yamada and Noguchi [116] reported that there is no HIF-1 binding sequence ... elevation of the cellular Ca2+ concentration leads to detachment of PFK from the cytoskeleton and thus diminishes the provision of local ATP in the vicinity of the cytoskeleton [71] The expression of ... tumor-related change of the protein level of this enzyme [188] On the other hand, enzymatic assays showed – with the exception of melanoma – a significant decrease of activity of about 50% in the several...
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Báo cáo khoa học: Catalytic mechanism of the primary human prostaglandin F2asynthase, aldo-keto reductase 1B1 – prostaglandin D2 synthase activity in the absence of NADP(H) pptx
... catalyzed the reduction of the 9,11-endoperoxide group of PGH2 to produce PGF2a in the presence of NADPH, which was defined as the PGFS activity, and the isomerization of PGH2 to PGD2 in the absence of ... mutants (D) Typical fluorescence quenching curves of wild-type AKR1B1 and its mutants The binding of NADP+ to these proteins was determined by measuring the decrease in fluorescence emission at 338 nm ... significantly the overall three-dimensional structure of the cofactor-binding site within the catalytic pocket Discussion Catalytic mechanism of PGDS and PGFS activities of AKR1B1 Mutational analysis of the...
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Báo cáo khoa học: Untangling the folding mechanism of the 52-knotted protein UCH-L3 potx
... control the recycling of ubiquitin and therefore the cellular balance of free ubiquitin [16,17] Indeed, depletion of these enzymes decreases the overall levels of free ubiquitin in living cells ... Andersson et al The folding mechanism of UCH-L3 A Fig Chevron plot for the unfolding and folding kinetics of UCHL3 Depicted are the rate constants for the only observed unfolding phase in the single-jump ... Correlation of folding kinetics with the number and isomerization states of prolines in three homologous proteins of the RNase family FEBS Lett 580, 5029–5032 The folding mechanism of UCH-L3 34...
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Báo cáo khoa học: The enzymatic activity of SR protein kinases 1 and 1a is negatively affected by interaction with scaffold attachment factors B1 and 2 pot
... domain of the substrate with the catalytic region of the kinase, on the one hand, and of the positive charge of the RS domain with the negatively charged ‘docking groove’ of SRPK1, on the other ... 1) These results confirm the direct interaction of SAFBs with the SRPK1 ⁄ 1a proteins and provide a direct link between the affinity of the SAFB–SRPK1 ⁄ 1a interaction and the extent of the inhibition ... domain RS domains are known to be protein protein and protein RNA interaction surfaces and the phosphorylation of serines affects those interactions as well as interactions between RS domain-containing...
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Báo cáo hóa học: " Experimental investigation on the bi-directional growing mechanism of the foils laminate approach in AAO fabrication" pptx
... from the laminating interface It was intuitively assumed that leakage of etchant from the clamped areas into the laminating interface induced the upward pores However, this leakage hypothesis ... laminate experiment Figure shows the setting up of the triplex laminate foils Under the leakage hypothesis, the etchant should leak into both the interfacing surfaces between foils Therefore, the ... When the rate of alumina dissolution on the electrolyte side equals to the rate of alumina production on the metal side, the thickness of the barrier layer remains constant It can be further inferred...
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Báo cáo y học: "Proposed protective mechanism of the pancreas in the ra" pot
... numbers of macrophages precede neutrophils [26] The shift in time for the onset of the inflammation may be explained by the delay of increasing HS levels in the duct and the fact that the pattern ... up-regulation of MCP-1, but not CINC-1 in ductal cells Invading inflammatory cells stained positive for both cytokines These findings suggest that HS stimulation of the ductal epithelium induce MCP-1 ... transcription of MCP-1 in the epithelial cells, capable of recruiting monocytes and a later expression of CINC-1 of the invading monocytes, which in turn can attract neutrophils The opposite may be true in...
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Báo cáo y học: "Proposed protective mechanism of the pancreas in the rat." ppt
... numbers of macrophages precede neutrophils [26] The shift in time for the onset of the inflammation may be explained by the delay of increasing HS levels in the duct and the fact that the pattern ... up-regulation of MCP-1, but not CINC-1 in ductal cells Invading inflammatory cells stained positive for both cytokines These findings suggest that HS stimulation of the ductal epithelium induce MCP-1 ... transcription of MCP-1 in the epithelial cells, capable of recruiting monocytes and a later expression of CINC-1 of the invading monocytes, which in turn can attract neutrophils The opposite may be true in...
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Báo cáo y học: " The role of surfactant protein D in the colonisation of the respiratory tract and onset of bacteraemia during " doc
... surfactant protein D plays an important role in delaying the appearance of pneumococci in the blood and in limiting their numbers in the bloodstream SP-D binds and agglutinates S pneumoniae in the presence ... currently in the process of investigating these questions In summary, the absence of lung surfactant protein D increases the persistence of pneumococcal colonisation and infection in the upper ... strains, increased recruitment of neutrophils into inflamed areas of lung tissue was detected within the bronchiolar lumen, in the bronchiole wall and also in the perivascular areas within the...
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Báo cáo khoa học: "Bench-to-bedside review: The role of activated protein C in maintaining endothelial tight junction function and its relationship to organ injury" pot
... summarize the in vitro and in vivo evidence and concentrate on potential mechanisms of endothelial barrier preservation Experimental evidence supports a role for APC in maintaining the integrity of the ... concluded that the Available online http://ccforum.com/content/10/6/239 Figure The role of the protein C pathway in the endothelial cell APC modulates endothelial phenotype by inhibiting thrombin production, ... cleaving PAR1 than is APC [31] The concentrations of APC used in the in vitro studies showing endothelial barrier protection were within the pharmacologic range of APC in the PROWESS study in one...
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Báo cáo y học: "Mechanism of the chromosome-induced polar body extrusion in mouse eggs" potx
... position of the spindle relative to the protruding cortex, which may maximize the constriction of the contractile ring at the shoulder region of the cortical protrusion, leading to the final abscission ... cap, which then reorganizes into a myosin II ring surrounding the actin cap Disruption of the actin cap by Lat-A had no effect on the DNA beadinduced myosin II cap formation but prevented the subsequent ... for both the formation and the maintenance of the myosin II ring The oocyte cortex underwent distinct protrusion and invagination which led to polar body extrusion Meiotic spindles in the MII...
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Understanding the functional roles of intrinsic protein disorder in NFkB transcription factors
... using intrinsic protein disorder to identify protein binding sites[101,102] and analyse the functions of chromatin remodeling proteins have been recorded[22] In the context of cell signaling, the ... recognition site The study was focused on the dynamics of the DNA, rather than the dynamics of the C-Rel protein during binding[99] However, the effects of protein dynamics in cell signaling and allosteric ... conformation of the head of the cross-bridge and produces energy for the pulling movement of the actin filament towards the centre of the cell Finally, the release of ADP disrupts binding with the actin...
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