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enough to pack but not too much

Báo cáo khoa học: The activation of gelsolin by low pH The calcium latch is sensitive to calcium but not pH docx

Báo cáo khoa học: The activation of gelsolin by low pH The calcium latch is sensitive to calcium but not pH docx

Báo cáo khoa học

... to increase pH to a value of 6.25 (A) Log of fluorescence intensities corresponding to tryptophan emission (j) or Oregon green emission (h) is plotted vs pH (B) The maximum wavelength of tryptophan ... chromatography on a PD10 column (Pharmacia) in 0.1 M NaHCO3 buffer pH 8.6 Immunological techniques The ELISA technique [32], was used to monitor interaction of gelsolin domains, peptides to gelsolin ... disrupts interdomain bonds but not those formed through the G2–6 interface Methods Proteins and peptides Rabbit skeletal muscle actin was isolated from acetone powder [23] and stored in buffer G (2...
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báo cáo hóa học:

báo cáo hóa học:" Reduced renal function is associated with progression to AIDS but not with overall mortality in HIV-infected kenyan adults not initially requiring combination antiretroviral therapy" potx

Hóa học - Dầu khí

... of Tanzania] Ideally, countries with resources too limited to expand care to all patients with CD4 counts of less than 350 cells/mm3 would be able to identify and target other atrisk populations ... chose not to include weight in these initial models as previous studies suggested that the inclusion of weight in the Cockcroft-Gault formula, but not in the simplified MDRD formula, led to significant ... disease): and (2) time to overall mortality We specifically chose to use times to meeting criteria for starting cART, rather than actual times to starting cART, as treatment may not have been initiated...
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Báo cáo y học:

Báo cáo y học: " A Leu to Ile but not Leu to Val change at HIV-1 reverse transcriptase codon 74 in the background of K65R mutation leads to an increased processivity of K65R+L74I enzyme and a replication competent virus" pptx

Báo cáo khoa học

... is not well understood Specifically, the rare combinations of mutations have not been analyzed in depth As novel nucleoside reverse transcriptase inhibitors (NRTI) continue to evolve and be employed ... was calculated according to our previously published protocols [14] To confirm the ratios of peak heights observed, we performed population cloning in Topo TA cloning vector PCRR2.1 (Carlsbad, ... background of K65R leads to an RT which is much more stable as compared to RT with the K65R+L74V mutations In order to validate the reversion observed in sequence-chromatograms, we performed population...
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Báo cáo y học:

Báo cáo y học: " Hyperresponsiveness to inhaled but not intravenous methacholine during acute respiratory syncytial virus infection in mice" pot

Báo cáo khoa học

... makes little contribution to Newtonian resistance in mice and thus R ≈ Raw [33] Page of 18 (page number not for citation purposes) Respiratory Research 2005, 6:142 http://respiratory-research.com/content/6/1/142 ... order to characterise the primary inflammatory and cytokine response to RSV infection, we chose the appropriate kit to measure innate immune responses This included tumour necrosis factor alpha ... significant in adult mice at d (p < 0.05), but did not reach significance in weanling mice Cytokines and mediators in BALF Cytometric bead assay IL-12 p70 was not detectable in BALF from adult mice...
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Báo cáo y học:

Báo cáo y học: " Epigenetic regulation: DNA confers identity but is not enough to maintain it" pps

Báo cáo khoa học

... histones with variant histones Steve Henikoff (Fred Hutchinson Cancer Center, Seattle, USA) used chromatin-affinity purification of histone variant H3.3 in combination with tiling microarrays to ... factors share about 20% of their respective sets of target genes, including many Hox genes Genes bound by all three factors can be active or repressed Jaenisch suggested that an autoregulatory ... factor and epidermal growth factor these precursors can be expanded into neural stem cells that no longer express Sox1 and that can be propagated indefinitely without losing their potential to...
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Báo cáo y học:

Báo cáo y học: "Genetic polymorphism of p53, but not GSTP1, is association with susceptibility to esophageal cancer risk – A Meta-Analysis"

Y học thưởng thức

... genotype seems to induce apoptosis with faster kinetics and to suppress transformation more efficiently than the Pro/Pro genotype.[15] It was shown that p53 Pro/Pro exhibits a lower ability to ... were not enough report support us to make meta-analysis in current research Studies with a larger sample size, especially including smoking or another environment factors will be helpful to confirm ... susceptibility factor The p53 tumor suppressor pathway is well-known to be crucial in maintaining genomic integrity and preventing cells from oncogenic transformation When a cell is exposed to genotoxic...
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Bt viết lại câu so...that, too...to, enough...to

Bt viết lại câu so...that, too...to, enough...to

Ngữ văn

... were more polite than today  …………………………………………………………………… It is colder today than it was yesterday …………………………………………………………………… Our hotel was cheaper than all the others in the town ………………………………………………………………………...
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Báo cáo khoa học: Protein crystallography for non-crystallographers, or how to get the best (but not more) from published macromolecular structures potx

Báo cáo khoa học: Protein crystallography for non-crystallographers, or how to get the best (but not more) from published macromolecular structures potx

Báo cáo khoa học

... symmetryequivalent contributors) is not the most useful indicator, because it does not take into account the multiplicity of measurements More elaborate versions of Rmerge have been proposed [32,33], but they ... is not unusual to see R-factors of 1–2% An important parameter that was introduced into crystallographic practice in 1992 is free R [41] Rfree is calculated analogously to normal R-factor, but ... percent Moreover, if H atoms are not included, their contribution is represented completely by the parent atom and its position tends to refine to the ‘center of gravity’ of both atoms As a result the...
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báo cáo hóa học:

báo cáo hóa học: " Boosting with intranasal dendrimeric Aβ1–15 but not Aβ1–15 peptide leads to an effective immune response following a single injection of Aβ1–40/42 in APP-tg mice" ppt

Hóa học - Dầu khí

... epitope but not the T cell epitopes may avoid a deleterious cellular immune response Prior reports have suggest that this may be true as shorter Aβ fragments conjugated to T cell helper epitopes ... and applied to Aβ1–40-coated ELISA plates Immunohistochemistry and image analysis Immunohistochemistry was performed on 12 µm paraffin sections using the ELITE ABC method (Vector Laboratories, Burlingame, ... peptide in a novel manner The use of the adjuvant LT(R192G) was not enough to overcome tolerance as seen with the lack of a immune response to Aβ1–15 peptide Therefore, we constructed a novel immunogen,...
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Báo cáo y học:

Báo cáo y học: "α Anti-α-fodrin antibodies do not add much to the diagnosis of Sjögren’s syndrome" pot

Báo cáo khoa học

... NP40, 100 mM KCl, mM dithioerythritol, mM EDTA) containing a mixture of protease inhibitors IgG antibodies from sera to be analyzed (SjS and controls) were coupled to protein A-agarose beads (Biozym, ... of apoptotic extracts (to increase the amount of antigenic fodrin cleavage product) did not improve the suitability of these techniques for the detection of anti-α-fodrin antibodies (data not shown) ... and anti-La autoantibodies have been reported to be 60–75% and 30–50%, respectively [6–9], while the specificity of particularly anti-La autoantibodies is generally considered to be reasonably...
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Báo cáo y học:

Báo cáo y học: " HIV-1 reverse transcriptase mutations that confer decreased in vitro susceptibility to anti-RT DNA aptamer RT1t49 confer cross resistance to other anti-RT aptamers but not to standard RT inhibitors" docx

Báo cáo khoa học

... inhibitors (NRTIs) being a staple of most regimens [3,4] In addition to NRTIs, which are both competitive inhibitors and chain-terminators, the nonnucleoside reverse transcriptase inhibitors (NNRTIs) ... HIV-1 RT shown to confer resistance to AZT (T215Y/M41L) and ddI and ddC (L74V) were sensitive to inhibition by RT1t49 (Table 3) In contrast, mutations shown to confer resistance to multiple NRTIs, ... The observed defect in Figure appears to be due to a loss in substrate affinity and not due to defect in the RNase H catalytic activity of these mutant RTs To determine whether these mutant RTs...
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Báo cáo y học:

Báo cáo y học: "CCR5 signalling, but not DARC or D6 regulatory, chemokine receptors are targeted by herpesvirus U83A chemokine which delays receptor internalisation via diversion to a caveolin-linked pathway" pdf

Báo cáo khoa học

... number not for citation purposes) Results U83A efficiently displaces human chemokines from CCR5 signalling chemokine receptor in model system to compare to regulatory receptors In order to investigate ... activities on regulatory receptors and to compare them to those on signalling receptors, U83A binding competition was screened against chemokines also relevant for regulatory receptor specificity ... cascades leading to cell polarisation, cytoskeletal changes, and chemotaxis We have shown previously that U83A is able to block signalling receptor function by stopping their endocytosis via clathrin...
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Báo cáo y học:

Báo cáo y học: " Recovery from depressive symptoms, state anxiety and post-traumatic stress disorder in women exposed to physical and psychological, but not to psychological intimate partner violence alone: A longitudinal study" doc

Báo cáo khoa học

... possible Variables contributing to the recovery of mental health To determine the variables that contributed to the recovery from depression, anxiety and PTSD symptomatology for the physically/psychologically ... primary factors In contrast, cessation of physical IPV was not a significant predictor of recovery from anxiety Finally, the variables that contributed significantly to the change in PTSD symptoms ... understanding the factors that contribute to women’s responses to IPV that allow them to become free of the violence is of relevant importance Some studies have started to assess this issue [33,67,68],...
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báo cáo khoa học:

báo cáo khoa học: " Safe using messages may not be enough to promote behaviour change amongst injecting drug users who are ambivalent or indifferent towards death" ppsx

Báo cáo khoa học

... throw myself into an area where it's impossible to get heroin The best I can is one day without There use an element of control I suppose, but it's not enough to break free I don't want to die Either ... want to die, but it doesn't make me not want to use If it did I wouldn't use any more, because I've dropped a few times It hasn't frightened me off enough I know if I die, I'll just go to sleep ... to talk freely of their experiences and opinions General discussion topics of interest were listed on a checklist to ensure all interviewees views were sought on each topic Discussions were not...
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báo cáo khoa học:

báo cáo khoa học: " Sgt1, but not Rar1, is essential for the RB-mediated broad-spectrum resistance to potato late blight" pptx

Báo cáo khoa học

... from the tomato Sgt1 gene (TC85297) identified a potato EST, TC112395 (1461 bp), which showed 98% sequence similarity to the tobacco and tomato Sgt1 genes and 90% sequence similarity to the Arabidopsis ... (TIGR) potato database [26] using a sequence from the tobacco Rar1 gene (AF480487) identified a potato EST, TC121848 (1187 bp), which showed 96% sequence similarity to the tobacco and tomato Rar1 ... particle" tool in the ImageJ software [49] This tool scans the image selection until it finds the edge of an object, corresponding to fluorescing sporangia or mycelium on the leaf surface The tool...
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Báo cáo y học:

Báo cáo y học: "Cystatin C influences the autoimmune but not inflammatory response to cartilage type II collagen leading to chronic arthritis development" ppsx

Báo cáo khoa học

... the autoimmune but not inflammatory response to cartilage type II collagen leading to chronic arthritis development Arthritis Research & Therapy 2011 13:R54 Submit your next manuscript to BioMed ... synthetic cysteine protease inhibitors are believed to have a protease inhibitory spectrum similar to that of cystatin C These studies, however, were not able to directly assess the physiological ... development of an autoimmune B and T cell response to type II collagen, which in turn leads to the early development of a chronic CIA, rather than having an effect on the inflammatory effector phase Our...
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Báo cáo y học:

Báo cáo y học: "Response to ‘Pain persists in DAS28 rheumatoid arthritis remission but not in ACR/EULAR remission: a longitudinal observational study’" potx

Báo cáo khoa học

... in DAS28 rheumatoid arthritis remission but doi:10.1186/ar3393 Cite this article as: Yoshida K, et al.: Response to ‘Pain persists in DAS28 rheumatoid arthritis remission but not in ACR/EULAR ... Tokyo, 104-8560, Japan 3Division of Allergy and Rheumatology, St Luke’s International Hospital, 9-1 Akashicho, Chuo-ku, Tokyo, 104-8560, Japan not in ACR/EULAR remission: a longitudinal observational ... in patients with rheumatoid arthritis, and comparison with the DAS28 based on erythrocyte sedimentation rate Ann Rheum Dis 2009, 68:954-960 Inoue E, Yamanaka H, Hara M, Tomatsu T, Kamatani N:...
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Báo cáo y học:

Báo cáo y học: " The formation of cysteine-linked dimers of BST-2/tetherin is important for inhibition of HIV-1 virus release but not for sensitivity to Vpu" potx

Báo cáo khoa học

... affinity to ConA or DS lectin due to the lack of oligosaccharide modification of this BST-2 mutant Glycosylation of BST-2 is not required for inhibition of virus release and sensitivity to Vpu To assess ... sensitive to Vpu to varying degrees (Fig 6) In particular the C13 and C3A mutants were highly sensitive to Vpu similar to wt BST-2 while expression of the C12 and C23 mutants appeared to be less ... bifunctional crosslinker to physically link otherwise fully detached virions to the cell surface or to each other [24] Such a mechanism is very attractive but would be difficult to explain without...
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Báo cáo y học:

Báo cáo y học: " Incorporation of podoplanin into HIV released from HEK-293T cells, but not PBMC, is required for efficient binding to the attachment factor CLEC-2" ppsx

Báo cáo khoa học

... does not bind to the viral Env protein, but to a cellular factor incorporated into the viral envelope For viruses produced in the kidney-derived cell line 293T, this factor was Page of 18 found to ... that CLEC-2, in contrast to DC-SIGN, does not capture HIV-1 Env Instead, CLEC-2 seemed to recognize a cellular factor expressed on 293T cells, and binding to this factor did not depend on recognition ... interaction was not inhibited by mannan and was not enhanced by expression of the viral Env protein In agreement with these results, soluble HIV-1 Env protein bound specifically to DC-SIGN but not to CLEC-2...
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Báo cáo y học:

Báo cáo y học: "Variation in HIV-1 R5 macrophage-tropism correlates with sensitivity to reagents that block envelope: CD4 interactions but not with sensitivity to other entry inhibitors" pps

Báo cáo khoa học

... with an increased sensitivity to PRO 542 but decreased sensitivity to Q4120 and BMS378806 HIV-1 R5 macrophage-tropism also correlated with sensitivity to 2G12 but not with b12, TAK779, SCH350581 ... was reported to inhibit gp120 binding to CD4 [39-41] and subsequent conformational changes [42] BMS378806 is believed to bind into a deep hydrophobic channel of unliganded gp120 close to and underneath ... sensitivity to 2G12 Summary of correlations between macrophage-tropism and sensitivity to inhibitors Table and Figure show that R5 macrophage-tropism correlates with sensitivity to inhibitors that...
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