endogenous extracellular hsp72 release is an adaptive feature of the acute stress response
Báo cáo y học: "Shuffling of cis-regulatory elements is a pervasive feature of the vertebrate lineage" ppsx
... for the tissue specificity of the Fugu SCEs tested in our transient transgenic embryo assays The functional analysis of SCEs by enhancer essays carried out in the transient transgenic zebrafish ... dataset of nongenic SCEs between collinear (as discussed above) and noncollinear (all other categories discussed above taken together) elements, and analyzed the distribution of their distances ... Materials and methods, below) This analysis classified 22.7% of the resulting rCNEs as 'genic', refereed research The analysis described herein attempts to tackle the issue of the extent, mobility, and...
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An Adaptive Version of the Immersed
... is performed always when the distance from an immersed boundary point to the border of the finest level is less than an allowed minimal distance This minimal distance depends on the size of the ... that the right-hand side of (12) is the left-hand side of (11) For the particular problem considered, the evaluation of the force F will depend on the unknown value of the velocity un+1 and, ... together in time, with the time step of the finest level In the incompressible case, there is not a finite limit to the speed at which disturbances can propagate in the flow Since each part of the...
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báo cáo khoa học: " The NAC domain-containing protein, GmNAC6, is a downstream component of the ER stress- and osmotic stress-induced NRP-mediated cell-death signaling pathway" pptx
... accumulation of GmNAC6 transcripts The synergistic induction of gene expression by the combination of ER stress and osmotic stress inducers is one of the criteria that link target genes to the ER stress- ... experiments, the statistical analysis of the data and drafted the manuscript MTBR and PABR assisted directly the qRT-PCR assays and the caspase 3-like activity experiment.GLR assisted the Agro-infiltration ... information between these two distinct stress response pathways to potentiate a cell death response Therefore, the integration of the ER stress and osmotic stress signals into a circuit of cell death...
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Báo cáo y học: " Human immunodeficiency virus type 1 Vpr: oligomerization is an essential feature for its incorporation into virus particles" ppsx
... particles is an important event in HIV-1 biology While the structure of Vpr based on X-ray crystallography is not yet available, biochemical analysis and NMR studies suggest that Vpr is composed of ... [29,35] and Rosetta softwares [31] The highly ranked models included both antiparallel and parallel orientations In the majority of models, the interface comprised mainly residues from helices II and ... transfection Next, we assessed the ability of Vpr mutants to form oligomers by BiFC analysis The expression of Vpr molecules was also assessed from the same batch of cells by indirect immunofluorescence...
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Báo cáo khoa học: MBP-1 is efficiently encoded by an alternative transcript of the ENO1 gene but post-translationally regulated by proteasome-dependent protein turnover doc
... Collectively, these data confirm the existence of this transcript in the cells Distribution of the MBP-1 transcript in normal tissues and cancers To determine the distribution of this putative MBP-1 transcript ... transcript is a product of alternative transcriptional initiation of ENO1 and is transcribed from the intron III of the gene The transcript can be exported to the cytoplasm, and can be translated in vitro ... the ENO1 transcript, and the other is transcribed from an alternative transcription start site in the ENO1 gene locus In a comparison of their relative mRNA abundance in the same cell, the RT-qPCR...
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Báo cáo y học: "Natural killer cell dysfunction is a distinguishing feature of systemic onset juvenile rheumatoid arthritis and macrophage activation syndrome" pot
... the basis of our data, the feature that distinguishes systemic onset JRA from other forms of JRA, and is common to the major hemophagocytic syndromes, is NK cell dysfunction The exact mechanisms ... Caucasian, African American, and Latin American patients The ethnic heterogeneity of the patients with JRA included in this study might also underlie the discrepancy between our results and the ... NK cells (observed in of 20 patients with sJRA only) NK dysfunction seems to be a distinguishing feature of sJRA that is intrinsic to the disease itself Further analysis of the flow cytometry data...
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báo cáo khoa học: "Down-regulation of UHRF1, associated with re-expression of tumor suppressor genes, is a common feature of natural compounds exhibiting anti-cancer properties" pot
... [26,47-49] The mechanism of DNA methylation pattern duplication, involves the SRA domain which is able to detect the hemi-methylated state of the DNA that occurs after the synthesis of the new DNA strand ... well studied, the mechanism by which these TSGs are specifically targeted is still unclear One hypothesis is that CpG island hypermethylation of TSGs is driven by a mechanism involving unknown ... belongs to the Ranunculaceae family which grows in the Mediterranean sea and Western Asia countries, including Pakistan, India and China [74] This plant is used in traditional folk medicine for the...
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Báo cáo khoa học: "Intensive care unit delirium is an independent predictor of longer hospital stay: a prospective analysis of 261 non-ventilated patients" ppt
... of this manuscript has: made substantial contributions to conception and design, acquisition of data, and the analysis or interpretation of data; been involved in drafting the article or revising ... delirium is to persist with the status quo in which an estimated 60% to 80% of delirium is missed in the absence of standardized monitoring [37-41] The strengths of this report include the unique patient ... Introduction Delirium is defined as an acute change or fluctuation in mental status plus inattention, and either disorganized thinking or an altered level of consciousness at the time of the evaluation...
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Báo cáo y học: "Urine neutrophil gelatinase-associated lipocalin is an early marker of acute kidney injury in critically ill children: a prospective cohort study" pot
... pRIFLEmax) during admission The data were examined for an association between mean or peak uNGAL and the presence of sepsis, PRISM II scores, and mortality The diagnostic characteristics of uNGAL in predicting ... inflammatory response syndrome were classified as having sepsis The Pediatric Risk of Mortality (PRISM) II score (a measure of severity of illness/mortality risk) was calculated on the day of ICU admission ... samples Before statistical analysis of urine samples, patients were further excluded from this study if fewer than two SCr values were available for the duration of the admission (and not before...
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Báo cáo y học: " Urine interleukin-6 is an early biomarker of acute kidney injury in children undergoing cardiac surgery" pdf
... LDH release and media hIL6 was determined The percent of LDH release is a measure of hypoxiainduced membrane injury and increased percent LDH release is an indicator of proximal tubular necrosis ... not examined the effect of AKI on renal IL-6 handling, our data demonstrating a role of the kidney in the filtration and metabolism of IL-6 are consistent with the known role of the proximal ... future analysis Dennen et al Critical Care 2010, 14:R181 http://ccforum.com/content/14/5/R181 Page of 13 Statistical analysis of murine data Data were analyzed by one-way analysis of variance...
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One leg balance is an important predictor of injurious falls in older persons
... predict the majority of such events We feel this to be a reflection of the complex and interacting nature of falls, injuries, and their etiologies and risk factors It is extremely unlikely that any ... years as the comparison group, controlling for age, sex, and other important variables in the logistic regression model Age was also significantly associated with the risk of incurring an injurious ... number of medications taken at baseline and either all falls or injurious falls, consistent with another recent study of predictors of falls and fall injuries DISCUSSION One-leg standing balance...
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Tài liệu Báo cáo khoa học: The Arabidopsis protein kinase Pto-interacting 1-4 is a common target of the oxidative signal-inducible 1 and mitogen-activated protein kinases docx
... within 0.5–1 h of the treatment and was transient However, the accumulation of the OXI1 transcript in response to oxidative stress was stronger than that of the PTI1-4 transcript If OXI1 and PTI1-4 ... proteins were then detected by western blot analysis with an anti-HIS IgG GST alone was used as a negative control One tenth of the input was loaded on to the gel and represents the amount of HIS-tagged ... glutathione-agarose beads The proteins were then detected by western blot analysis using an anti-HIS or an anti-GST IgG Figure 1C shows HIS-PTI1-4 and HIS-OXI1 bound to GST-OXI1 and GST-PTI1-4, respectively,...
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Tài liệu Báo cáo khoa học: An autoinhibitory effect of the homothorax domain of Meis2 ppt
... the equivalent of exons and from Meis3 Among the three Meis genes, intron is considerably smaller (< 200 bp) in human and mouse Meis3 than in either of the other genes Examination of the 5¢ and ... creating Meis3.2 in humans The intron–exon structure of Meis1, Meis2 and Meis3 is relatively well conserved in this region of the genes – in both mouse and human, the 17 codons removed in human Meis3.2 ... revealed the presence of two isoforms of human Meis3 (termed Meis3.1 and Meis3.2), which were also found in the expressed sequence tag (EST) database Although only a single mouse Meis3 isoform is listed...
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Tài liệu Báo cáo khoa học: Regulation of dCTP deaminase from Escherichia coli by nonallosteric dTTP binding to an inactive form of the enzyme ppt
... The theoretical analysis of kinetic behaviour of ‘hysteretic’ allosteric enzymes I The kinetic manifestations of slow conformational change of an oligomeric enzyme in the Monod, Wyman and Changeux ... inhibition of dCTP deaminase E Johansson et al rates) prior to and after the transition of the enzyme to a more active form, respectively, t is the time and s is the lagtime The rate constant, k, for the ... ½Sn Þ 0:5 where rate is the initial turnover of the enzyme with a maximum of kcat, S0.5 is the concentration of substrate S at half-maximal saturation of the enzyme and n is the Hill coefficient...
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Tài liệu Báo cáo khoa học: Endogenous expression and protein kinase A-dependent phosphorylation of the guanine nucleotide exchange factor Ras-GRF1 in human embryonic kidney 293 cells pptx
... increased the phosphorylation of the endogenous 140 kDa and 60 kDa isoforms of Ras-GRF1 (Fig 2A, left panel) and of recombinant HA-Ras-GRF1 (Fig 2B, upper panel) Phosphorylation of ERK1 ⁄ in the ... receptors The mechanism of Ras activation through Gs-coupled receptors is not fully understood In the present study, we show endogenous expression of the Ca2+-dependent 140 kDa and shorter isoforms of ... [17,19] The smaller isoforms correspond to N-terminal deletions of the fulllength 140 kDa protein The physiological role of the guanine nucleotide exchange activity of the truncated forms is not...
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Tài liệu Instant Galleria How-to Recipes to make you an expert user of the Galleria JavaScript framework ppt
... the size of the gallery If the image is drastically larger than the gallery, a visitor to the site will be downloading larger images than what is necessary and this can slow down the performance ... Conventions In this book, you will find a number of styles of text that distinguish between different kinds of information Here are some examples of these styles, and an explanation of their meaning Code ... Galleria can also display video and iframes inside the gallery The method by which this is accomplished is mostly the same as the way images are specified, with the only difference being that the image...
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Tài liệu An Historical Account of the Settlements of Scotch doc
... of these mountains is bold, rocky, dark and precipitous The land south of this line is called the Lowlands, and that to the north, including the range, the Highlands The maritime outline of the ... 843, ascended the Pictish throne The inhabitants of Ireland and the Highlands of Scotland were but branches of the same Keltic stock, and their language was substantially the same There was not ... column, the massacre of Glencoe and the distresses of the Scottish colonists in Darien On the appearance of this article the project was very properly and righteously abandoned The result of the...
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Tài liệu Taxes and the Economy: An Economic Analysis of the Top Tax Rates Since 1945 docx
... for the analysis (i.e., the one year change in the variable is used in the analysis) The other explanatory variables included in the analyses have been used by other researchers The right-hand ... changes in the top 0.1% of the income distribution, the focus of the analysis is on the top 0.1% Arguments are offered for and against reducing income inequality The classic argument against rising ... productivity is an index of output per hour; it can be affected not only by taxes but also by the quantity and quality of the labor force The indicators of the quantity and quality of the labor...
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Tìm thêm: xác định các mục tiêu của chương trình xác định các nguyên tắc biên soạn khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn xác định thời lượng học về mặt lí thuyết và thực tế tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu nội dung cụ thể cho từng kĩ năng ở từng cấp độ xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ lồng sóc các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 đặc tuyến hiệu suất h fi p2 đặc tuyến tốc độ rôto n fi p2 sự cần thiết phải đầu tư xây dựng nhà máy phần 3 giới thiệu nguyên liệu từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng 9 tr 25