emerging and reemerging viral diseases
Tài liệu Báo cáo khoa học: Angiopoietin-like proteins: emerging targets for treatment of obesity and related metabolic diseases pptx
... focus on the roles of ANGPTL2 and ANGPTL6 ⁄ AGF in obesity and related metabolic diseases, and discuss whether these ANGPTLs could be targets for the prevention and treatment of these conditions ... ANGPTL2 and ANGPTL6 ⁄ AGF in obesity and related metabolic diseases The expression of ANGPTL2 and ANGPTL6 ⁄ AGF is induced in obese conditions ANGPTL2 induces chronic adipose tissue inflammation and ... ANGPTLs in obesity and related metabolic diseases T Kadomatsu et al ANGPTL2 receptor activity or intracellular signaling might constitute promising treatments for obesity and metabolic diseases associated...
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Báo cáo y học: "Incidence of Ocular Zoonoses referred to the Inflammatory and Autoimmune Ocular Diseases Service of the University of Parma - Italy"
... combination of medical treatment and surgery, with a final visual acuity of 40% in the affected eye [1] The only case of Lyme disease affected a 31 year-old farmer and his ocular manifestations...
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Tài liệu Báo cáo khoa học: Specific interaction between the classical swine fever virus NS5B protein and the viral genome pdf
... nucleotide fragment adjacent to the minus-strand 3¢ UTR), –RNAr2 (a random sequence corresponding to positions 2033–2500 of the minus-strand genome) and minus-strand 5¢ UTR Similarly, we found that the ... NS5B-binding sequence on the plusstrand 3¢ UTR or minus-strand 3¢ UTR (A) Various RNA templates containing the wild-type and the mutant plus-strand 3¢ UTR or minusstrand 3¢ UTR )RNA1 to )RNA5 represent, ... by the random sequence of coding region and the minus-strand 5¢ UTR, similar to the competitive experiment Ó FEBS 2004 towards the plus-genome Interestingly, when the plusstrand 3¢ UTR and the...
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Recommendations from the American Thoracic Society, CDC, and the Infectious Diseases Society of America docx
... services (2), and a clear understanding and acceptance of roles and responsibilities by an expanded group of participants in TB control will be needed to ensure that the clinical and public health ... state and local TB-control programs, and other organizations These partnerships have served the medical and public health communities and should be continued and strengthened • Financial and technical ... with TB and LTBI, and quality of the program’s databases for surveillance and case management To respond to the need for improved and standardized program evaluation activities, CDC and six state...
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Báo cáo khoa học: Therapeutic approaches for prion and Alzheimer’s diseases pot
... degradation and toxic to neurons Neurological symptoms in AD and prion disease are directly related to loss of neurons and synaptic connections Oligomeric and fibrillar Ab can be directly neurotoxic and ... in Great Britain, 21 in France, four in Ireland, three in the USA, two in the Netherlands and one each in Italy, Canada, Japan, Saudi Arabia, Portugal and Spain Most of the patients from these ... undergoing clinical trials Similar approaches are just emerging for prion diseases However, a greater understanding of the role of copper and other metals in the PrPC to PrPSc conversion is needed...
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Oncogenesis, Inflammatory and Parasitic Tropical Diseases of the Lung Edited by Jean-Marie Kayembe potx
... Dejan Maglic and Sinan Zhu Chapter Relationship Between Toxicogenomic and Environment and Lung Cancer 61 M Adonis, M Chahuan, A Zambrano, P Avaria, J Díaz, R Miranda, M Campos, H Benítez and L Gil ... Frontiers in the Diagnosis and Treatment of Chronic Neutrophilic Lung Diseases 99 T Andrew Guess, Amit Gaggar and Matthew T Hardison Chapter Expiratory Flow Limitation in Intra and Extrathoracic Respiratory ... other proteins and molecules (Fig 2) Oncogenesis, Inflammatory and Parasitic Tropical Diseases of the Lung Figure The binding of specific ligands to the receptor activates EGFR and generates a...
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Methylation - From DNA, RNA and Histones to Diseases and Treatment by Anica Dricu ppt
... distribution, and reproduction in any medium, provided the original work is properly cited 4 Methylation - From DNA, RNA and Histones to Diseases and Treatment From DNA, RNA and Histones to Diseases and ... promoters of indu‐ Methylation - From DNA, RNA and Histones to Diseases and Treatment From DNA, RNA and Histones to Diseases and Treatment cible genes and interacting with transcription initiation ... Methylation - From DNA, RNA and Histones to Diseases and Treatment From DNA, RNA and Histones to Diseases and Treatment GABP is a methylation-sensitive transcription factor [110] and its modulation is...
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The Management of Community-Acquired Pneumonia in Infants and Children Older Than 3 Months of Age: Clinical Practice Guidelines by the Pediatric Infectious Diseases Society and the Infectious Diseases Society of America pot
... multidisciplinary process, review of evidence, and documentation [26] Panel Composition The Pediatric Infectious Diseases Society (PIDS) and the IDSA Standards and Practice Guidelines Committee (SPGC) ... viral infections Viral and bacterial coinfections were detected in 23% of children with pneumonia evaluated at a tertiary-care children’s hospital [17] Randomized clinical trials [106, 107] and ... negative [113] Although positive tests for viral pathogens are helpful, the sensitivity and specificity of rapid viral tests are not 100%, and false-negative and false-positive tests occur For influenza,...
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báo cáo hóa học:" Social care and changes in occupational accidents and diseases - the situation in Eastern Europe in general and for skin diseases in particular" pptx
... registered occupational diseases in Estonia, Slovakia and Belarus, and decreases in Latvia, Croatia, Poland, Romania and the Czech Republic In 2004, a total of 49 occupational diseases were recorded ... premia and who has to pay these, in the guaranteed payments for total and partial invalidity and in additional payments, such as family and care allowances or pensions for dependents (Table and ... systems and the number of occupational diseases are not yet available Closed lists of occupational diseases exist in Albania, Bosnia-Herzegovina, Cyprus, Greece, Hungary, Poland, Serbia and Slovakia...
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Chapter 103. Polycythemia Vera and Other Myeloproliferative Diseases (Part 1) potx
... CNL, and CEL, which is usually measured in years, and their high rate of transformation into acute leukemia By contrast, the natural history of PV, IMF, and ET is usually measured in decades, and ... consequence of the balanced translocation between chromosomes and 22 [t(9;22)(q34;11)]; CNL has been associated with a t(15:19) translocation, and CEL with a deletion or balanced translocations involving ... IMF, and ET are characterized by expression of a JAK2 mutation, V617F, which causes constitutive activation of this tyrosine kinase that is essential for the function of the erythropoietin and...
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Chapter 103. Polycythemia Vera and Other Myeloproliferative Diseases (Part 2) doc
... induced in the erythropoietin and thrombopoietin receptors following binding to erythropoietin or thrombopoietin leads to JAK2 autophosphorylation, receptor phosphorylation, and phosphorylation of proteins ... the erythropoietinindependent erythroid colony formation, and the hypersensitivity of PV erythroid progenitor cells to erythropoietin and other hematopoietic growth factors, their resistance to ... terminal differentiation, and their increase in Bcl-XL expression, all of which are characteristic in PV Importantly, the JAK2 gene is located on the short arm of chromosome 9, and loss of heterozygosity...
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Chapter 103. Polycythemia Vera and Other Myeloproliferative Diseases (Part 3) pptx
... erythropoietin production, in which case assessment of pulmonary function and an abdominal CT scan to evaluate renal and hepatic anatomy are appropriate A normal erythropoietin level does not ... previous hemoglobin levels and a family study are important Other laboratory studies that may aid in diagnosis include the red cell count, mean corpuscular volume, and red cell distribution width ... erythrocytosis: β-thalassemia trait, hypoxic erythrocytosis, and PV With β-thalassemia trait the RDW is normal, whereas with hypoxic erythrocytosis and PV, the RDW is usually elevated due to iron deficiency...
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Chapter 103. Polycythemia Vera and Other Myeloproliferative Diseases (Part 5) pot
... of myelofibrosis and the extent of extramedullary hematopoiesis are also not related Fibrosis in this disorder is associated with overproduction of transforming growth factor and tissue inhibitors ... IMF are polyclonal and not part of the neoplastic clone Clinical Features No signs or symptoms are specific for chronic IMF Many patients are asymptomatic at presentation, and the disease is ... of splenic enlargement and/ or abnormal blood counts during a routine examination However, in contrast to its companion myeloproliferative disorders, night sweats, fatigue, and weight loss may be...
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Chapter 103. Polycythemia Vera and Other Myeloproliferative Diseases (Part 6) ppt
... cells, myelocytes, and promyelocytes establishes the presence of extramedullary hematopoiesis, while the presence of leukocytosis, thrombocytosis with large and bizarre platelets, and circulating ... will reveal a hypercellular marrow with trilineage hyperplasia and, in particular, increased numbers of megakaryocytes in clusters and with large, dysplastic nuclei However, there are no characteristic ... disorders PV and ET, express the JAK2 V617F mutation, often as homozygotes Such patients had a poorer survival in one retrospective study but not in another, where they were found to be older and to...
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Chapter 103. Polycythemia Vera and Other Myeloproliferative Diseases (Part 8) potx
... is, at best, temporarily palliative and associated with a significant risk of neutropenia and infection Allopurinol can control significant hyperuricemia, and hydroxyurea has proved useful for ... undefined and its side effects are more pronounced in the older individuals who are usually afflicted with this disorder Glucocorticoids have been used to control constitutional symptoms and autoimmune ... autoimmune complications and may ameliorate anemia alone or in combination with low dose thalidomide (50–100 mg/d) Allogeneic bone marrow transplantation is the only curative treatment and should be considered...
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Chapter 103. Polycythemia Vera and Other Myeloproliferative Diseases (Part 9) docx
... erythropoietin, thrombopoietin is produced in both the liver and the kidneys, and an inverse correlation exists between the platelet count and plasma thrombopoietic activity Like erythropoietin, plasma ... cause thrombocytosis, and absent marrow iron in the presence of marrow hypercellularity is a feature of PV Nonrandom cytogenetic abnormalities occur in ET but are uncommon, and no specific or consistent ... are specific for ET, but these patients can have hemorrhagic and thrombotic tendencies expressed as easy bruising for the former and microvascular occlusions for the latter, such as erythromelalgia,...
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Chapter 103. Polycythemia Vera and Other Myeloproliferative Diseases (Part 10) potx
... of high-molecular-weight von Willebrand multimers are removed from the circulation and destroyed by the platelets, resulting in an acquired form of von Willebrand disease This can be identified ... effects Hydroxyurea and aspirin are more effective than anagrelide and aspirin for prevention of TIAs but not more effective for the prevention of other types of arterial thrombosis and actually less ... Thrombosis and hemorrhage in polycythemia vera and essential thrombocythaemia Br J Haematol 128:275, 2005 Levine RL, Gilliland DG: JAK-2 mutations and their relevance to myeloproliferative disease...
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current situation and factors affecting hiv infection and sexually transmitted diseases in male homosexual sex worker group in hanoi, 2009-2010”
... have not understood correctly and sufficiently about ways of tranmission and risk-factors of HIV and STIs 4.2.3 Sexual behavior and drug use Having sex with both male and female partners Male homosexual ... numerous sex partners and using drugs Those researches have shown the importance of studying male homosexual sex worker group in limiting HIV infection and STIs However, in Vietnam and particularly ... behaviors, use of addictions and use of medical services among male homosexual sex worker in Hanoi, 2009-2010 Identify current HIV infection and sexually transmitted diseases rate in male homosexual...
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Báo cáo y học: "Autoantibodies against the replication protein A complex in systemic lupus erythematosus and other autoimmune diseases" pps
... lanes Ki and rP/Ki/his) and U1snRNP-A (U1-A, lanes nRNP and Ku/nRNP), RPA70 co-migrates with Ku p70 (lanes Ku/nRNP and Ku), and RPA14 co-migrates with histone H4 (lanes rP/Ki/his, Histones, and BM6.5) ... AR40391, AR050661, and M01R00082, and State of Florida funds to the Center for Autoimmune Diseases References Tan EM: Antinuclear antibodies: diagnostic markers for autoimmune diseases and probes for ... antibodies against DNA and proteins that interact with RPA seem to be quite common among patients with systemic rheumatic diseases, in particular in SLE and SjS (Figures 2b,e and 3b) The 'true' reactivity...
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