... molecules The first is the establishment ofthe relevance ofthe genetic basis of carcinogenesis Second is the determination ofthe specific oncogene to target Third is the determination ofthe specific ... methods, and screening for adverse 258 GENE THERAPYINTHETREATMENTOF CANCER effects related to vaccination including the induction of autoimmunity The approach of dendritic cell vaccination has been ... bypass intracellular processing to provide gene delivery to the nucleus Inthe context of gene therapy, the delivery of therapeutic genes by liposomes can also result inthe inhibition of angiogenesis...
... approximately 15 minutes, the physicist then loaded the corresponding radiation plan onto the controller unit contaminating the field The catheter end was passed through a hole inthe drape and a ... without Results The radiation oncologist then broke scrub, attached the XB controller to the catheter, and inserted the radiation source into the balloon The radiation therapy was then Figure and ... cavity through a small incision inthe lateral breast and inflated with exactly 40 cc of saline (Figure 1) The conformity ofthe CED to the surrounding breast tissue was then evaluated under direct...
... effects in 10 participants within the stretching group These effects included increased paininthe heel, calf and other areas ofthe lower limb There were no adverse effects reported from the control ... on the success of any intervention Research investigating the influence ofthe duration of plantar heel pain on its responsiveness to treatment, may therefore be helpful to those evaluating the ... effective than other interventions or control groups in relieving plantar heel painThe main pain- relieving benefits of stretching appear to occur within the first two weeks to four months There is...
... unwilling to stop taking pain medication other than the study medication (for arthritis or other types of pain) or is unwilling to stop taking other medications for thetreatmentof OA Any other ... withdrawn from the study (without penalty) if, inthe opinion ofthe treating physician, it was not inthe patient’s best interest to continue For instance, if during the course ofthe study a patient ... including glucosamine and chondroitin, one month prior to study and during the study, other than multivitamin and mineral supplements containing vitamins and minerals as the sole medicinal ingredients...
... Annals of General Psychiatry 2009, 8:16 thetreatmentof acute mania, the approval of quetiapine and the olanzapine-fluoxetine combination against acute bipolar depression and the approval of olanzapine, ... inthe aripiprazole group (41%) and 13 out ofthe 27 inthe placebo group (48.1%)) The only difference concerned manic relapses (nine inthe placebo and six inthe aripiprazole group) Again the ... inthe placebo group (35%) The mean aripiprazole dose at the end ofthe study was 17.6 mg daily The results suggest that in weeks to there was a significant reduction inthe MADRS scores in the...
... worst pain imaginable, during the activity Thepain after the activity can reach on a VAS but should have subsided by the following morning Pain and stiffness inthe Achilles tendon should not increase ... assessment using the following criteria [32-34]: (i) Insidious onset ofpaininthe Achilles tendon region that is aggravated by weightbearing activities and worse inthe morning, and/or during the initial ... exercises To maintain blinding of participants, they will be advised that they will receive one of two types of 'shoe inserts' during the study Data collection and the interventions will be administered...
... for PTSD is challenging due to the complexity ofthe symptoms and psychiatric comorbidities Psychotherapy and pharmacotherapy are the two main classes of PTSD treatmentInthe Cochrane systematic ... evaluated theefficacyof five categories of psychotherapeutic interventions: trauma-focused cognitive- behavioral therapy/ exposure therapy (TFCBT), stress management, other therapies (supportive therapy, ... Evidence oftreatmentefficacy was most convincing for the SSRIs Furthermore, medication was superior to placebo in reducing the severity ofthe three symptom clusters of PTSD, as well as alleviating...
... approved the final manuscript Competing interests The funding source had no influence on study design, inthe collection, analysis, and interpretation ofthe data, inthe writing ofthe manuscript, ... not satisfactory There are limitations inthe reimbursement of anti-HBV therapy, either inthe selection of agent or the duration of dosing Therefore, lamivudine and telbivudine with low costs ... systematic review, we focus on the comparison ofthe efficay of lamivudine and telbivudine inthe Figure Effect of telbivudine vs lamivudine at the end of one-year treatment on Therapeutic response Zhao...
... seven years ago the first meta-analysis appeared, showing theefficacyof CPAP inthetreatmentof ACPE [10] Since then, several RCTs comparing the use of CPAP and Available online http://ccforum.com/content/10/2/R69 ... meta-analysis of RCTs focusing on the effect of CPAP and NPPV inthetreatmentof ACPE was undertaken The methodological approach included the development of selection criteria, definition of search ... evidence of clinical efficacy into context, it is also important to take into account the costs and difficulties involved in implementing non-invasive ventilation in clinical practice and the logistic...
... Definition of non specific Thoracic spine pain [11] Definition of non specific Thoracic spine pain Midline back pain – for the purposes of this trial, thepain will be bound by the lateral margins ... literate inthe English language Are currently receiving care for thoracic pain from any other provider Figure Definition of thoracic spine pain area Definition of thoracic spine pain area Cannot ... horizontal line 10 cm long with the words "no pain" at one end and "pain as bad as it could be" at the other Participants are asked to indicate which point along the line best represents their pain intensity...
... double-blind taper and follow-up phase Efficacy Analyses The primary efficacy measure was the change from baseline to endpoint inthe total score ofthe 14-item, clinician-rated HAM-A inthe pregabalin ... to investigate theefficacyof pregabalin in short-term treatment and not to investigate efficacyin long-term treatment, for which a separate study would be needed Theefficacyof pregabalin ... who were not using a reliable method of contraception Other reasons for exclusion were the use of gabapentin or a benzodiazepine within week ofthe first baseline visit, the use of other psychotropic...
... 2004, of portacaval shunting, thereby decreasing first pass metabolism; decrease in quantities and affinity of plasma proteins, thereby increasing free-drug levels; increase in volume of distribution ... hrs following the post-dialysis dose There is a case report in which lithium levels were maintained inthe therapeutic range by intraperitoneal administration of lithium during continuous peritoneal ... an increase in HDL [34] This occurs during the initial weeks of therapy, persists throughout treatment and reverses inthe first few weeks after discontinuation A 5-year prospective study of...
... the angles ofthe dural opening The most significant step involves constructing small supporting pillars on the bilateral sides ofthe vessels as they pass the edge ofthe dural window (the pillars ... and in most reports the involved patient populations are small, these experiences are valuable At present, inthe absence of definite proof oftheefficacyof decompressive craniectomy inthetreatment ... craniectomy, which was introduced by Cushing,11 involves removing the part ofthe skull beneath the temporal muscle by opening the dura This was an important surgical method for thetreatmentof severe TBI...
... variations in working pressures ofthe main groups of muscles ofthe limbs whilst using compression mechanisms during exercising This is a new line of research that aims at developing facilitating devices ... technique aims at draining lymph (already inthe collectors) and stimulating the formation of lymph (the flow of interstice fluid to the lymphatic capillaries) Increases in interstice pressures, ... which can be used inthe control of exercising Eight devices have been developed that involve the main muscle groups with the objective of improving the mobility of joints and reducing trophic muscle...
... overstrain the clearance function ofthe V.A.C. -therapy, thus being probably the reason for the system failure inthe infection treatmentin case 10 One limitation of our study is that we cannot define ... reduction, the V.A.C.-system is not often used inthetreatmentof prosthesis – related infections Currently, there exist only four reports about the use ofthe V.A.C – system inthe infection ... components ofthe immune system to the infected area is facilitated, which leads to a significant reduction ofthe bacterial count Theefficacyofthe V.A.C therapy has been 245 proven inthe treatment...
... by the ratio in which the antibiotics are mixed into the cement and therefore, the total dose of antibiotics should not exceed 10% ofthe weight ofthe cement in order to avoid fracture ofthe ... safety The most commonly used antibiotics in ALC include tobramycin, gentamicin and vanco- 254 mycin [26] The combination of vancomycin and one ofthe aminoglycosides provides a broad spectrum of ... salvage ofthe infected hip: rationale for the use of gentamicin-impregnated cement and heads The hip proceedings ofthe thirteenth open scientific meeting ofthe hip society 1985; :65-94 Ensing...
... remove the femoral stem For loading ofthe bone cement, the combination of gentamicin and vancomycin was most frequently used followed by the combination of gentamicin and teicoplanin Data about the ... http://www.medsci.org Int J Med Sci 2009, sion ofthe haematoma is an indispensable premise inthe prevention of a wound infection Besides draining sinus, other infections during the two-stage protocol ... complications (draining sinus, pneumonia, etc.) Despite the retrospective design of our study and the limited possibility of interpreting these findings and their causes, this rate indicates that these patients...
... not localize to the same cells inthe brain, suggesting that they are functionally distinct Although Signaling mediators inthetreatmentof obesity CPT1c is highly expressed inthe hypothalamus, ... promoting an increase in proopiomelanocortin and cocaine and amphetamine regulated transcript Taken together, these findings provide a compelling argument for the role for malonyl-CoA in regulating ... needs to be explored further Other areas ofthe brain have also been shown to regulate feeding via AMPK [35,36] Of interest is the extensive use of fructose as a sweetener inthe human diet [37]...
... suggesting that these cyclin-dependent kinase inhibitors are important inthe regulation of adipocyte number The S-phase kinase-associated protein (Skp)1–CullinF-box protein (SCF) ubiquitin ligase ... at each phase ofthe cell cycle by various complexes of cell-cycle-related molecules, including cyclins, cyclin-dependent kinases, their inhibitors and the retinoblastoma protein (RB), as well ... clinical course of some types of obesity In this minireview, we focus on adipocyte hyperplasia as a novel therapeutic target for thetreatmentof obesity and discuss the merits of targeting recQ-mediated...